Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer
Arlene A. Forastiere, M.D., Helmuth Goepfert, M.D., Moshe Maor, M.D., Thomas F. Pajak, Ph.D., Randal Weber, M.D., William Morrison, M.D., Bonnie Glisson, M.D., Andy Trotti, M.D., John A. Ridge, M.D., Ph.D., Clifford Chao, M.D., Glen Peters, M.D., Ding-Jen Lee, M.D., Ph.D., Andrea Leaf, M.D., John Ensley, M.D., and Jay Cooper, M.D.
Background Induction chemotherapy with cisplatin plus fluorouracilfollowed by radiotherapy is the standard alternative to totallaryngectomy for patients with locally advanced laryngeal cancer.The value of adding chemotherapy to radiotherapy and the optimaltiming of chemotherapy are unknown.
Methods We randomly assigned patients with locally advancedcancer of the larynx to one of three treatments: induction cisplatinplus fluorouracil followed by radiotherapy, radiotherapy withconcurrent administration of cisplatin, or radiotherapy alone.The primary end point was preservation of the larynx.
Results A total of 547 patients were randomly assigned to oneof the three study groups. The median follow-up period was 3.8years. At two years, the proportion of patients who had an intactlarynx after radiotherapy with concurrent cisplatin (88 percent)differed significantly from the proportions in the groups giveninduction chemotherapy followed by radiotherapy (75 percent,P=0.005) or radiotherapy alone (70 percent, P<0.001). Therate of locoregional control was also significantly better withradiotherapy and concurrent cisplatin (78 percent, vs. 61 percentwith induction cisplatin plus fluorouracil followed by radiotherapyand 56 percent with radiotherapy alone). Both of the chemotherapy-basedregimens suppressed distant metastases and resulted in betterdisease-free survival than radiotherapy alone. However, overallsurvival rates were similar in all three groups. The rate ofhigh-grade toxic effects was greater with the chemotherapy-basedregimens (81 percent with induction cisplatin plus fluorouracilfollowed by radiotherapy and 82 percent with radiotherapy withconcurrent cisplatin, vs. 61 percent with radiotherapy alone).The mucosal toxicity of concurrent radiotherapy and cisplatinwas nearly twice as frequent as the mucosal toxicity of theother two treatments during radiotherapy.
Conclusions In patients with laryngeal cancer, radiotherapywith concurrent administration of cisplatin is superior to inductionchemotherapy followed by radiotherapy or radiotherapy alonefor laryngeal preservation and locoregional control.
Source Information
From the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (A.A.F., D.-J.L.); the University of Texas M.D. Anderson Cancer Center, Houston (H.G., M.M., R.W., W.M., B.G., C.C.); Radiation Therapy Oncology Group Headquarters, Philadelphia (T.F.P.); the H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa (A.T.); Fox Chase Cancer Center, Philadelphia (J.A.R.); the Department of Radiation Oncology, University of Alabama, Birmingham (G.P.); the Department of Veterans Affairs New York Harbor Healthcare System, Brooklyn (A.L.); the Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit (J.E.); and the Department of Radiation Oncology, New York University Medical Center, New York (J.C.).
Address reprint requests to Dr. Forastiere at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St., Suite G90, Baltimore, MD 21231-1000, or at af{at}jhmi.edu.
Ajani, J. A., Winter, K. A., Gunderson, L. L.
(2008). Chemotherapy and Radiotherapy for Anal Canal Carcinoma--Reply. JAMA
300: 1411-1411
[Full Text]
Musio, D., Codacci-Pisanelli, G.
(2008). Chemotherapy and Radiotherapy for Anal Canal Carcinoma. JAMA
300: 1410-1411
[Full Text]
Haddad, R. I., Shin, D. M.
(2008). Recent Advances in Head and Neck Cancer. NEJM
359: 1143-1154
[Full Text]
Knab, B. R., Salama, J. K., Solanki, A., Stenson, K. M., Cohen, E. E., Witt, M. E., Haraf, D. J., Vokes, E. E.
(2008). Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma. Ann Oncol
19: 1650-1654
[Abstract][Full Text]
Langendijk, J. A., Doornaert, P., Verdonck-de Leeuw, I. M., Leemans, C. R., Aaronson, N. K., Slotman, B. J.
(2008). Impact of Late Treatment-Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy. JCO
26: 3770-3776
[Abstract][Full Text]
Ang, K. K.
(2008). Multidisciplinary Management of Locally Advanced SCCHN: Optimizing Treatment Outcomes. The Oncologist
13: 899-910
[Abstract][Full Text]
Russo, G., Haddad, R., Posner, M., Machtay, M.
(2008). Radiation Treatment Breaks and Ulcerative Mucositis in Head and Neck Cancer. The Oncologist
13: 886-898
[Abstract][Full Text]
Machtay, M., Moughan, J., Trotti, A., Garden, A. S., Weber, R. S., Cooper, J. S., Forastiere, A., Ang, K. K.
(2008). Factors Associated With Severe Late Toxicity After Concurrent Chemoradiation for Locally Advanced Head and Neck Cancer: An RTOG Analysis. JCO
26: 3582-3589
[Abstract][Full Text]
Singh, B., Pfister, D. G.
(2008). Individualized Treatment Selection in Patients With Head and Neck Cancer: Do Molecular Markers Meet the Challenge?. JCO
26: 3114-3116
[Full Text]
Adelstein, D. J.
(2008). Redefining the Role of Induction Chemotherapy in Head and Neck Cancer. JCO
26: 3117-3119
[Full Text]
Wang, S. X., Bao, A., Herrera, S. J., Phillips, W. T., Goins, B., Santoyo, C., Miller, F. R., Otto, R. A.
(2008). Intraoperative 186Re-Liposome Radionuclide Therapy in a Head and Neck Squamous Cell Carcinoma Xenograft Positive Surgical Margin Model. Clin. Cancer Res.
14: 3975-3983
[Abstract][Full Text]
CHEN, Y-H, JIAN, J J-M, CHAN, K-Y, TSAI, S Y, CHENG, S H, YEN, K-C L, CHENG, J C-H
(2008). Definitive chemoirradiation for resectable head and neck cancer: treatment outcome and prognostic significance of MRI findings. Br. J. Radiol.
81: 490-498
[Abstract][Full Text]
Wang, J., Seethala, R. R., Zhang, Q., Gooding, W., van Waes, C., Hasegawa, H., Ferris, R. L.
(2008). Autocrine and Paracrine Chemokine Receptor 7 Activation in Head and Neck Cancer: Implications for Therapy. JNCI J Natl Cancer Inst
100: 502-512
[Abstract][Full Text]
Yang, S.-F., Yang, W.-E., Chang, H.-R., Chu, S.-C., Hsieh, Y.-S.
(2008). Luteolin Induces Apoptosis in Oral Squamous Cancer Cells. J. Dent. Res.
87: 401-406
[Abstract][Full Text]
Ong, S. C., Schoder, H., Lee, N. Y., Patel, S. G., Carlson, D., Fury, M., Pfister, D. G., Shah, J. P., Larson, S. M., Kraus, D. H.
(2008). Clinical Utility of 18F-FDG PET/CT in Assessing the Neck After Concurrent Chemoradiotherapy for Locoregional Advanced Head and Neck Cancer. JNM
49: 532-540
[Abstract][Full Text]
Forastiere, A., Weber, R., Ang, K., Trotti, A. III, Pajak, T. F., Ridge, J. A., Saghir, F., Feldman, L. E., Nutting, C. M., Bhide, S. A., Harrington, K. J., Posner, M. R., Haddad, R. I., Tishler, R. B.
(2008). Treatment of head and neck cancer.. NEJM
358: 1076-1076
[Full Text]
Hutcheson, K. A., Barringer, D. A., Rosenthal, D. I., May, A. H., Roberts, D. B., Lewin, J. S.
(2008). Swallowing Outcomes After Radiotherapy for Laryngeal Carcinoma. Arch Otolaryngol Head Neck Surg
134: 178-183
[Abstract][Full Text]
Choong, N., Vokes, E.
(2008). Expanding Role of the Medical Oncologist in the Management of Head and Neck Cancer. CA Cancer J Clin
58: 32-53
[Abstract][Full Text]
Kies, M. S., Blumenschein, G. R. Jr., Rosenthal, D. I.
(2008). Sequential Chemoradiation for Squamous Cell Carcinoma of the Head and Neck. Am Soc Clin Oncol Ed Book
2008: 235-238
[Abstract][Full Text]
Hinni, M. L., Salassa, J. R., Grant, D. G., Pearson, B. W., Hayden, R. E., Martin, A., Christiansen, H., Haughey, B. H., Nussenbaum, B., Steiner, W.
(2007). Transoral Laser Microsurgery for Advanced Laryngeal Cancer. Arch Otolaryngol Head Neck Surg
133: 1198-1204
[Abstract][Full Text]
Chen, A. Y., Halpern, M.
(2007). Factors Predictive of Survival in Advanced Laryngeal Cancer. Arch Otolaryngol Head Neck Surg
133: 1270-1276
[Abstract][Full Text]
Patel, R. S., Clark, J., Wyten, R., Gao, K., O'Brien, C. J.
(2007). Squamous Cell Carcinoma From an Unknown Head and Neck Primary Site: A "Selective Treatment" Approach. Arch Otolaryngol Head Neck Surg
133: 1282-1287
[Abstract][Full Text]
Glynne-Jones, R., Hoskin, P.
(2007). Neoadjuvant Cisplatin Chemotherapy Before Chemoradiation: A Flawed Paradigm?. JCO
25: 5281-5286
[Abstract][Full Text]
Gibcus, J. H., Menkema, L., Mastik, M. F., Hermsen, M. A., de Bock, G. H., van Velthuysen, M.-L. F., Takes, R. P., Kok, K., Alvarez Marcos, C. A., van der Laan, B. F.A.M., van den Brekel, M. W.M., Langendijk, J. A., Kluin, P. M., van der Wal, J. E., Schuuring, E.
(2007). Amplicon Mapping and Expression Profiling Identify the Fas-Associated Death Domain Gene as a New Driver in the 11q13.3 Amplicon in Laryngeal/Pharyngeal Cancer. Clin. Cancer Res.
13: 6257-6266
[Abstract][Full Text]
Posner, M. R., Hershock, D. M., Blajman, C. R., Mickiewicz, E., Winquist, E., Gorbounova, V., Tjulandin, S., Shin, D. M., Cullen, K., Ervin, T. J., Murphy, B. A., Raez, L. E., Cohen, R. B., Spaulding, M., Tishler, R. B., Roth, B., Viroglio, R. d. C., Venkatesan, V., Romanov, I., Agarwala, S., Harter, K. W., Dugan, M., Cmelak, A., Markoe, A. M., Read, P. W., Steinbrenner, L., Colevas, A. D., Norris, C. M. Jr., Haddad, R. I., the TAX 324 Study Group,
(2007). Cisplatin and Fluorouracil Alone or with Docetaxel in Head and Neck Cancer. NEJM
357: 1705-1715
[Abstract][Full Text]
Zenda, S., Onozawa, Y., Tahara, M., Kawashima, M., Shikama, N., Sasaki, S., Boku, N.
(2007). Feasibility Study of Single Agent Cisplatin and Concurrent Radiotherapy in Japanese Patients with Squamous Cell Carcinoma of the Head and Neck: Preliminary Results. Jpn J Clin Oncol
0: hym106v1-5
[Abstract][Full Text]
Salama, J. K., Seiwert, T. Y., Vokes, E. E.
(2007). Chemoradiotherapy for Locally Advanced Head and Neck Cancer. JCO
25: 4118-4126
[Full Text]
Ljumanovic, R., Pouwels, P.J.W., Langendijk, J.A., Knol, D.L., van der Valk, P., Leemans, C.R., Castelijns, J.A.
(2007). Has the Degree of Contrast Enhancement with MR Imaging in Laryngeal Carcinoma Added Value to Anatomic Parameters Regarding Prediction of Response to Radiation Therapy?. Am. J. Neuroradiol.
28: 1540-1546
[Abstract][Full Text]
Chen, A. Y., Schrag, N. M., Halpern, M., Stewart, A., Ward, E. M.
(2007). Health Insurance and Stage at Diagnosis of Laryngeal Cancer: Does Insurance Type Predict Stage at Diagnosis?. Arch Otolaryngol Head Neck Surg
133: 784-790
[Abstract][Full Text]
Posner, M.
(2007). Evolving Strategies for Combined-Modality Therapy for Locally Advanced Head and Neck Cancer. The Oncologist
12: 967-974
[Abstract][Full Text]
Zenda, S., Onozawa, Y., Boku, N., Iida, Y., Ebihara, M., Onitsuka, T.
(2007). Single-agent Docetaxel in Patients with Platinum-refractory Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck (SCCHN). Jpn J Clin Oncol
37: 477-481
[Abstract][Full Text]
Kawashima, M., Hayashi, R., Tahara, M., Yamazaki, M., Miyazaki, M., Arahira, S., Ogino, T.
(2007). Accelerated Radiotherapy and Larynx Preservation in Favorable-risk Patients with T2 or Worse Hypopharyngeal Cancer. Jpn J Clin Oncol
0: hym040v1-8
[Abstract][Full Text]
Allen, A. M., Tishler, R. B.
(2007). Commentary: IMRT for Head and Neck Cancer: Many Chapters Left to Write. The Oncologist
12: 565-568
[Abstract][Full Text]
Hoshitani, Y., Ishida, H., Otsuki, N., Shirakawa, T., Gotoh, A., Nibu, K.-i.
(2007). Induction of Immunological Antitumor Effects by Adenovirus-Mediated Gene Transfer of B7-1 in a Murine Squamous Cell Carcinoma Cell Line. Arch Otolaryngol Head Neck Surg
133: 270-275
[Abstract][Full Text]
Konski, A. A., Pajak, T. F., Movsas, B., Coyne, J., Harris, J., Gwede, C., Garden, A., Spencer, S., Jones, C., Watkins-Bruner, D.
(2006). Disadvantage of Men Living Alone Participating in Radiation Therapy Oncology Group Head and Neck Trials. JCO
24: 4177-4183
[Abstract][Full Text]
Mendenhall, W. M., Hinerman, R. W., Amdur, R. J., Malyapa, R. S., Lansford, C. D., Werning, J. W., Villaret, D. B.
(2006). Postoperative radiotherapy for squamous cell carcinoma of the head and neck.. Clin Med Res
4: 200-208
[Abstract][Full Text]
Pfister, D. G., Laurie, S. A., Weinstein, G. S., Mendenhall, W. M., Adelstein, D. J., Ang, K. K., Clayman, G. L., Fisher, S. G., Forastiere, A. A., Harrison, L. B., Lefebvre, J.-L., Leupold, N., List, M. A., O'Malley, B. O., Patel, S., Posner, M. R., Schwartz, M. A., Wolf, G. T.
(2006). American Society of Clinical Oncology Clinical Practice Guideline for the Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer. JCO
24: 3693-3704
[Abstract][Full Text]
Cohen, E. E.W., Haraf, D. J., List, M. A., Kocherginsky, M., Mittal, B. B., Rosen, F., Brockstein, B., Williams, R., Witt, M. E., Stenson, K. M., Kies, M. S., Vokes, E. E.
(2006). High Survival and Organ Function Rates After Primary Chemoradiotherapy for Intermediate-Stage Squamous Cell Carcinoma of the Head and Neck Treated in a Multicenter Phase II Trial. JCO
24: 3438-3444
[Abstract][Full Text]
Forastiere, A. A., Trotti, A., Pfister, D. G., Grandis, J. R.
(2006). Head and Neck Cancer: Recent Advances and New Standards of Care. JCO
24: 2603-2605
[Full Text]
Brizel, D. M., Esclamado, R.
(2006). Concurrent Chemoradiotherapy for Locally Advanced, Nonmetastatic, Squamous Carcinoma of the Head and Neck: Consensus, Controversy, and Conundrum. JCO
24: 2612-2617
[Abstract][Full Text]
Adelstein, D. J., LeBlanc, M.
(2006). Does Induction Chemotherapy Have a Role in the Management of Locoregionally Advanced Squamous Cell Head and Neck Cancer?. JCO
24: 2624-2628
[Abstract][Full Text]
Rosenthal, D. I., Lewin, J. S., Eisbruch, A.
(2006). Prevention and Treatment of Dysphagia and Aspiration After Chemoradiation for Head and Neck Cancer. JCO
24: 2636-2643
[Abstract][Full Text]
Wong, S. J., Machtay, M., Li, Y.
(2006). Locally Recurrent, Previously Irradiated Head and Neck Cancer: Concurrent Re-Irradiation and Chemotherapy, or Chemotherapy Alone?. JCO
24: 2653-2658
[Abstract][Full Text]
Haddad, R., Tishler, R., Wirth, L., Norris, C. M., Goguen, L., Sullivan, C., O'Donnell, L., Li, Y., Posner, M.
(2006). Rate of pathologic complete responses to docetaxel, Cisplatin, and Fluorouracil induction chemotherapy in patients with squamous cell carcinoma of the head and neck.. Arch Otolaryngol Head Neck Surg
132: 678-681
[Abstract][Full Text]
Lu, S.-L., Herrington, H., Reh, D., Weber, S., Bornstein, S., Wang, D., Li, A. G., Tang, C.-F., Siddiqui, Y., Nord, J., Andersen, P., Corless, C. L., Wang, X.-J.
(2006). Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.. Genes Dev.
20: 1331-1342
[Abstract][Full Text]
Goguen, L. A., Posner, M. R., Tishler, R. B., Wirth, L. J., Norris, C. M., Annino, D. J., Sullivan, C. A., Li, Y., Haddad, R. I.
(2006). Examining the need for neck dissection in the era of chemoradiation therapy for advanced head and neck cancer.. Arch Otolaryngol Head Neck Surg
132: 526-531
[Abstract][Full Text]
Gelbard, A., Garnett, C. T., Abrams, S. I., Patel, V., Gutkind, J. S., Palena, C., Tsang, K.-Y., Schlom, J., Hodge, J. W.
(2006). Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis.. Clin. Cancer Res.
12: 1897-1905
[Abstract][Full Text]
Alho, O.-P., Teppo, H., Mantyselka, P., Kantola, S.
(2006). Head and neck cancer in primary care: presenting symptoms and the effect of delayed diagnosis of cancer cases.. CMAJ
174: 779-784
[Abstract][Full Text]
Adelstein, D. J., Saxton, J. P., Rybicki, L. A., Esclamado, R. M., Wood, B. G., Strome, M., Lavertu, P., Lorenz, R. R., Carroll, M. A.
(2006). Multiagent Concurrent Chemoradiotherapy for Locoregionally Advanced Squamous Cell Head and Neck Cancer: Mature Results From a Single Institution. JCO
24: 1064-1071
[Abstract][Full Text]
Urba, S., Wolf, G., Eisbruch, A., Worden, F., Lee, J., Bradford, C., Teknos, T., Chepeha, D., Prince, M., Hogikyan, N., Taylor, J.
(2006). Single-Cycle Induction Chemotherapy Selects Patients With Advanced Laryngeal Cancer for Combined Chemoradiation: A New Treatment Paradigm. JCO
24: 593-598
[Abstract][Full Text]
Pfister, D. G., Ridge, J. A.
(2006). Induction Chemotherapy for Larynx Preservation: Patient Selection or Therapeutic Effect?. JCO
24: 540-543
[Full Text]
Yang, M.-H., Chiang, W.-C., Chou, T.-Y., Chang, S.-Y., Chen, P.-M., Teng, S.-C., Wu, K.-J.
(2006). Increased NBS1 Expression Is a Marker of Aggressive Head and Neck Cancer and Overexpression of NBS1 Contributes to Transformation. Clin. Cancer Res.
12: 507-515
[Abstract][Full Text]
Adelstein, D. J.
(2005). Induction Redux: Once More With Taxanes. JCO
23: 8556-8558
[Full Text]
Hitt, R., Lopez-Pousa, A., Martinez-Trufero, J., Escrig, V., Carles, J., Rizo, A., Isla, D., Vega, M. E., Marti, J. L., Lobo, F., Pastor, P., Valenti, V., Belon, J., Sanchez, M. A., Chaib, C., Pallares, C., Anton, A., Cervantes, A., Paz-Ares, L., Cortes-Funes, H.
(2005). Phase III Study Comparing Cisplatin Plus Fluorouracil to Paclitaxel, Cisplatin, and Fluorouracil Induction Chemotherapy Followed by Chemoradiotherapy in Locally Advanced Head and Neck Cancer. JCO
23: 8636-8645
[Abstract][Full Text]
Rastogi, M., Srivastava, M., Chufal, K. S., Pant, M. C., Srivastava, K., Bhatt, M. B.
(2005). Mitomycin and Fluorouracil in Combination with Concomitant Radiotherapy: A Potentially Curable Approach for Locally Advanced Head and Neck Squamous Cell Carcinoma. Jpn J Clin Oncol
35: 572-579
[Abstract][Full Text]
El-Deiry, M., Funk, G. F., Nalwa, S., Karnell, L. H., Smith, R. B., Buatti, J. M., Hoffman, H. T., Clamon, G. H., Graham, S. M., Trask, D. K., Dornfeld, K. J., Yao, M.
(2005). Long-term Quality of Life for Surgical and Nonsurgical Treatment of Head and Neck Cancer. Arch Otolaryngol Head Neck Surg
131: 879-885
[Abstract][Full Text]
Posner, M. R.
(2005). Paradigm Shift in the Treatment of Head and Neck Cancer: The Role of Neoadjuvant Chemotherapy. The Oncologist
10: 11-19
[Abstract][Full Text]
Wee, J., Tan, E. H., Tai, B. C., Wong, H. B., Leong, S. S., Tan, T., Chua, E. T., Yang, E., Lee, K. M., Fong, K. W., Tan, H. S. K., Lee, K. S., Loong, S., Sethi, V., Chua, E. J., Machin, D.
(2005). Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety. JCO
23: 6730-6738
[Abstract][Full Text]
Enepekides, D. J.
(2005). Concurrent Chemoradiotherapy as the Most Appropriate Treatment for Most T3 Laryngeal Carcinomas. Arch Otolaryngol Head Neck Surg
131: 815-818
[Full Text]
Smith, R. B.
(2005). Concurrent Chemoradiation as a Treatment Option for Advanced-Stage Laryngeal Cancers. Arch Otolaryngol Head Neck Surg
131: 820-820
[Full Text]
Johnson, J. T.
(2005). American Head and Neck Society Presidential Address: Head and Neck Surgery in a New Era of Therapeutic Potential. Arch Otolaryngol Head Neck Surg
131: 549-550
[Full Text]
Gillespie, M. B., Brodsky, M. B., Day, T. A., Sharma, A. K., Lee, F.-s., Martin-Harris, B.
(2005). Laryngeal Penetration and Aspiration During Swallowing After the Treatment of Advanced Oropharyngeal Cancer. Arch Otolaryngol Head Neck Surg
131: 615-619
[Abstract][Full Text]
Yin, X., Zhang, H., Burrows, F., Zhang, L., Shores, C. G.
(2005). Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo. Clin. Cancer Res.
11: 3889-3896
[Abstract][Full Text]
Ang, K. K., Harris, J., Garden, A. S., Trotti, A., Jones, C. U., Carrascosa, L., Cheng, J. D., Spencer, S. S., Forastiere, A., Weber, R. S.
(2005). Concomitant Boost Radiation Plus Concurrent Cisplatin for Advanced Head and Neck Carcinomas: Radiation Therapy Oncology Group Phase II Trial 99-14. JCO
23: 3008-3015
[Abstract][Full Text]
Roh, J.-L., Kim, A.-Y., Cho, M. J.
(2005). Xerostomia Following Radiotherapy of the Head and Neck Affects Vocal Function. JCO
23: 3016-3023
[Abstract][Full Text]
Bucci, M. K., Bevan, A., Roach, M. III
(2005). Advances in Radiation Therapy: Conventional to 3D, to IMRT, to 4D, and Beyond. CA Cancer J Clin
55: 117-134
[Abstract][Full Text]
Posner, M. R.
(2005). Adjuvant Post-Operative Chemoradiotherapy In Head and Neck Cancer: A Standard Of Care?. The Oncologist
10: 174-175
[Full Text]
Garden, A. S.
(2005). Is There Still a Role for Induction Chemotherapy for Head and Neck Cancer?. JCO
23: 1059-1060
[Full Text]
Rischin, D., Peters, L., Fisher, R., Macann, A., Denham, J., Poulsen, M., Jackson, M., Kenny, L., Penniment, M., Corry, J., Lamb, D., McClure, B.
(2005). Tirapazamine, Cisplatin, and Radiation Versus Fluorouracil, Cisplatin, and Radiation in Patients With Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). JCO
23: 79-87
[Abstract][Full Text]
Urba, S. G., Moon, J., Giri, P.G. S., Adelstein, D. J., Hanna, E., Yoo, G. H., LeBlanc, M., Ensley, J. F., Schuller, D. E.
(2005). Organ Preservation for Advanced Resectable Cancer of the Base of Tongue and Hypopharynx: A Southwest Oncology Group Trial. JCO
23: 88-95
[Abstract][Full Text]
Lefebvre, J.-L.
(2005). Current clinical outcomes demand new treatment options for SCCHN. Ann Oncol
16: vi7-vi12
[Abstract][Full Text]
Ang, K. K.
(2004). Concurrent Radiation Chemotherapy for Locally Advanced Head and Neck Carcinoma: Are We Addressing Burning Subjects?. JCO
22: 4657-4659
[Full Text]
Forastiere, A. A.
(2004). Is There a New Role for Induction Chemotherapy in the Treatment of Head and Neck Cancer?. JNCI J Natl Cancer Inst
96: 1647-1649
[Full Text]
Zorat, P. L., Paccagnella, A., Cavaniglia, G., Loreggian, L., Gava, A., Mione, C. A., Boldrin, F., Marchiori, C., Lunghi, F., Fede, A., Bordin, A., Da Mosto, M. C., Sileni, V. C., Orlando, A., Jirillo, A., Tomio, L., Pappagallo, G. L., Ghi, M. G.
(2004). Randomized Phase III Trial of Neoadjuvant Chemotherapy in Head and Neck Cancer: 10-Year Follow-Up. JNCI J Natl Cancer Inst
96: 1714-1717
[Abstract][Full Text]
Dufour, X., Hans, S., De Mones, E., Brasnu, D., Menard, M., Laccourreye, O.
(2004). Local Control After Supracricoid Partial Laryngectomy for "Advanced" Endolaryngeal Squamous Cell Carcinoma Classified as T3. Arch Otolaryngol Head Neck Surg
130: 1092-1099
[Abstract][Full Text]
Psyrri, A., Kwong, M., DiStasio, S., Lekakis, L., Kassar, M., Sasaki, C., Wilson, L.D., Haffty, B.G., Son, Y.H., Ross, D.A., Weinberger, P.M., Chung, G.G., Zelterman, D., Burtness, B.A., Cooper, D.L.
(2004). Cisplatin, Fluorouracil, and Leucovorin Induction Chemotherapy Followed by Concurrent Cisplatin Chemoradiotherapy for Organ Preservation and Cure in Patients With Advanced Head and Neck Cancer: Long-Term Follow-Up. JCO
22: 3061-3069
[Abstract][Full Text]
Brockstein, B., Haraf, D. J., Rademaker, A. W., Kies, M. S., Stenson, K. M., Rosen, F., Mittal, B. B., Pelzer, H., Fung, B. B., Witt, M.-E., Wenig, B., Portugal, L., Weichselbaum, R. W., Vokes, E. E.
(2004). Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience. Ann Oncol
15: 1179-1186
[Abstract][Full Text]
Milano, M. T., Haraf, D. J., Stenson, K. M., Witt, M. E., Eng, C., Mittal, B. B., Argiris, A., Pelzer, H., Kozloff, M. F., Vokes, E. E.
(2004). Phase I Study of Concomitant Chemoradiotherapy with Paclitaxel, Fluorouracil, Gemcitabine, and Twice-Daily Radiation in Patients with Poor-Prognosis Cancer of the Head and Neck. Clin. Cancer Res.
10: 4922-4932
[Abstract][Full Text]
Garden, A.S., Harris, J., Vokes, E.E., Forastiere, A.A., Ridge, J.A., Jones, C., Horwitz, E.M., Glisson, B.S., Nabell, L., Cooper, J.S., Demas, W., Gore, E.
(2004). Preliminary Results of Radiation Therapy Oncology Group 97-03: A Randomized Phase II Trial of Concurrent Radiation and Chemotherapy for Advanced Squamous Cell Carcinomas of the Head and Neck. JCO
22: 2856-2864
[Abstract][Full Text]
Hanna, E., Alexiou, M., Morgan, J., Badley, J., Maddox, A. M., Penagaricano, J., Fan, C.-Y., Breau, R., Suen, J.
(2004). Intensive Chemoradiotherapy as a Primary Treatment for Organ Preservation in Patients With Advanced Cancer of the Head and Neck: Efficacy, Toxic Effects, and Limitations. Arch Otolaryngol Head Neck Surg
130: 861-867
[Abstract][Full Text]
Hanna, E., Sherman, A., Cash, D., Adams, D., Vural, E., Fan, C.-Y., Suen, J. Y.
(2004). Quality of Life for Patients Following Total Laryngectomy vs Chemoradiation for Laryngeal Preservation. Arch Otolaryngol Head Neck Surg
130: 875-879
[Abstract][Full Text]
Cooper, J. S., Pajak, T. F., Forastiere, A. A., Jacobs, J., Campbell, B. H., Saxman, S. B., Kish, J. A., Kim, H. E., Cmelak, A. J., Rotman, M., Machtay, M., Ensley, J. F., Chao, K.S. C., Schultz, C. J., Lee, N., Fu, K. K., the Radiation Therapy Oncology Group 9501/Intergro,
(2004). Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck. NEJM
350: 1937-1944
[Abstract][Full Text]
Cohen, E. E.W., Lingen, M. W., Vokes, E. E.
(2004). The Expanding Role of Systemic Therapy in Head and Neck Cancer. JCO
22: 1743-1752
[Abstract][Full Text]
Weinstein, G. S., Myers, E. N., Shapshay, S. M., Colvett, K. T., Gupta, T., Agarwal, J., Lashkar, S. G., Langer, M., Guntinas-Lichius, O., Haddad, R. I., Tishler, R. B., Posner, M. R., Forastiere, A. A., Pajak, T. F., Maor, M., Weber, R.
(2004). Nonsurgical Treatment of Laryngeal Cancer. NEJM
350: 1049-1053
[Full Text]
A correction has been published: N Engl J Med 2004;350(10):1049.
Previous
