Estrogen plus Progestin and the Risk of Coronary Heart Disease
JoAnn E. Manson, M.D., Dr.P.H., Judith Hsia, M.D., Karen C. Johnson, M.D., M.P.H., Jacques E. Rossouw, M.D., Annlouise R. Assaf, Ph.D., Norman L. Lasser, M.D., Ph.D., Maurizio Trevisan, M.D., Henry R. Black, M.D., Susan R. Heckbert, M.D., Ph.D., Robert Detrano, M.D., Ph.D., Ora L. Strickland, Ph.D., Nathan D. Wong, Ph.D., John R. Crouse, M.D., Evan Stein, M.D., Mary Cushman, M.D., for the Women's Health Initiative Investigators
Background Recent randomized clinical trials have suggestedthat estrogen plus progestin does not confer cardiac protectionand may increase the risk of coronary heart disease (CHD). Inthis report, we provide the final results with regard to estrogenplus progestin and CHD from the Women's Health Initiative (WHI).
Methods The WHI included a randomized primary-prevention trialof estrogen plus progestin in 16,608 postmenopausal women whowere 50 to 79 years of age at base line. Participants were randomlyassigned to receive conjugated equine estrogens (0.625 mg perday) plus medroxyprogesterone acetate (2.5 mg per day) or placebo.The primary efficacy outcome of the trial was CHD (nonfatalmyocardial infarction or death due to CHD).
Results After a mean follow-up of 5.2 years (planned duration,8.5 years), the data and safety monitoring board recommendedterminating the estrogen-plus-progestin trial because the overallrisks exceeded the benefits. Combined hormone therapy was associatedwith a hazard ratio for CHD of 1.24 (nominal 95 percent confidenceinterval, 1.00 to 1.54; 95 percent confidence interval afteradjustment for sequential monitoring, 0.97 to 1.60). The elevationin risk was most apparent at one year (hazard ratio, 1.81 [95percent confidence interval, 1.09 to 3.01]). Although higherbase-line levels of low-density lipoprotein cholesterol wereassociated with an excess risk of CHD among women who receivedhormone therapy, higher base-line levels of C-reactive protein,other biomarkers, and other clinical characteristics did notsignificantly modify the treatment-related risk of CHD.
Conclusions Estrogen plus progestin does not confer cardiacprotection and may increase the risk of CHD among generallyhealthy postmenopausal women, especially during the first yearafter the initiation of hormone use. This treatment should notbe prescribed for the prevention of cardiovascular disease.
Source Information
From the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (J.E.M.); the Department of Medicine, George Washington University, Washington, D.C. (J.H.); the Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); the Program Office, National Heart, Lung, and Blood Institute, Bethesda, Md. (J.E.R.); Memorial Hospital, Brown Medical School, Pawtucket, R.I. (A.R.A.); the Preventive Cardiology Program, New Jersey Medical School, Newark (N.L.L.); the Department of Social and Preventive Medicine, University at Buffalo, Buffalo, N.Y. (M.T.); the Department of Preventive Medicine, RushPresbyterianSt. Luke's Medical Center, Chicago (H.R.B.); the Department of Epidemiology, University of Washington, Seattle (S.R.H.); the Division of Cardiology, HarborUCLA Research and Education Institute, Torrance, Calif. (R.D.); the Woodruff School of Nursing, Emory University, Atlanta (O.L.S.); the Heart Disease Prevention Program, University of California, Irvine (N.D.W.); the Department of Medicine, Wake Forest University, Winston-Salem, N.C. (J.R.C.); Medical Research Laboratories International, Highland Heights, Ky. (E.S.); and the Departments of Medicine and Pathology, University of Vermont, Burlington (M.C.).
Address reprint requests to Dr. Manson at the Divison of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston, MA 02215, or at jmanson{at}rics.bwh.harvard.edu.
Ding, C., Parameswaran, V., Udayan, R., Burgess, J., Jones, G.
(2008). Circulating Levels of Inflammatory Markers Predict Change in Bone Mineral Density and Resorption in Older Adults: A Longitudinal Study. J. Clin. Endocrinol. Metab.
93: 1952-1958
[Abstract][Full Text]
Grodstein, F., Manson, J. E., Stampfer, M. J., Rexrode, K.
(2008). Postmenopausal Hormone Therapy and Stroke: Role of Time Since Menopause and Age at Initiation of Hormone Therapy. Arch Intern Med
168: 861-866
[Abstract][Full Text]
BARLOW, D. H.
(2008). The Medical Management of Menopause: To Treat or Not To Treat?. Ann. N. Y. Acad. Sci.
1127: 134-139
[Abstract][Full Text]
Fu, X.-D., Flamini, M., Sanchez, A. M., Goglia, L., Giretti, M. S., Genazzani, A. R., Simoncini, T.
(2008). Progestogens regulate endothelial actin cytoskeleton and cell movement via the actin-binding protein moesin. Mol Hum Reprod
14: 225-234
[Abstract][Full Text]
Coylewright, M., Reckelhoff, J. F., Ouyang, P.
(2008). Menopause and Hypertension: An Age-Old Debate. Hypertension
51: 952-959
[Full Text]
Heiss, G., Wallace, R., Anderson, G. L., Aragaki, A., Beresford, S. A. A., Brzyski, R., Chlebowski, R. T., Gass, M., LaCroix, A., Manson, J. E., Prentice, R. L., Rossouw, J., Stefanick, M. L., for the WHI Investigators,
(2008). Health Risks and Benefits 3 Years After Stopping Randomized Treatment With Estrogen and Progestin. JAMA
299: 1036-1045
[Abstract][Full Text]
Schulkin, J.
(2008). Hormone Therapy, Dilemmas, Medical Decisions.. J Law Med Ethics
36: 73-88
Rees, M., Stevenson, J., on behalf of the British Menopause Society Council,
(2008). Primary prevention of coronary heart disease in women. Menopause Int
14: 40-45
[Abstract][Full Text]
Lee, T.-M., Lin, M.-S., Chang, N.-C.
(2008). Physiological Concentration of 17{beta}-Estradiol on Sympathetic Reinnervation in Ovariectomized Infarcted Rats. Endocrinology
149: 1205-1213
[Abstract][Full Text]
Lee, S-S., Singh, S., Magder, L., Petri, M.
(2008). Predictors of high sensitivity C-reactive protein levels in patients with systemic lupus erythematosus. Lupus
17: 114-123
[Abstract]
Si, H., Liu, D.
(2008). Genistein, a Soy Phytoestrogen, Upregulates the Expression of Human Endothelial Nitric Oxide Synthase and Lowers Blood Pressure in Spontaneously Hypertensive Rats. J. Nutr.
138: 297-304
[Abstract][Full Text]
Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K., Benjamin, E. J., D'Agostino, R. B., Wolf, M., Vasan, R. S.
(2008). Vitamin D Deficiency and Risk of Cardiovascular Disease. Circulation
117: 503-511
[Abstract][Full Text]
Weiss, N. S., Koepsell, T. D., Psaty, B. M.
(2008). Generalizability of the Results of Randomized Trials. Arch Intern Med
168: 133-135
[Full Text]
Rosenberg, L.
(2007). RE: "INVITED COMMENTARY: HORMONE THERAPY AND RISK OF CORONARY HEART DISEASE WHY RENEW THE FOCUS ON THE EARLY YEARS OF MENOPAUSE?". Am J Epidemiol
166: 1480-1481
[Full Text]
Wells Pence, B., Nyarko, P., Phillips, J. F., Debpuur, C.
(2007). The effect of community nurses and health volunteers on child mortality: The Navrongo Community Health and Family Planning Project. Scand J Public Health
35: 599-608
[Abstract]
Zhang, H., Chen, X., Aravindakshan, J., Sairam, M. R.
(2007). Changes in Adiponectin and Inflammatory Genes in Response to Hormonal Imbalances in Female Mice and Exacerbation of Depot Selective Visceral Adiposity by High-Fat Diet: Implications for Insulin Resistance. Endocrinology
148: 5667-5679
[Abstract][Full Text]
Reid, R. L
(2007). Hormone therapy for younger women may not increase CHD risk during 5 7 years follow-up, but stroke risk was increased independent of age. Evid. Based Med.
12: 137-137
[Full Text]
Macdougall, I. C., Eckardt, K.-U., Locatelli, F.
(2007). Latest US KDOQI Anaemia Guidelines update what are the implications for Europe?. Nephrol Dial Transplant
22: 2738-2742
[Full Text]
Yumino, D., Bradley, T. D.
(2007). Pathogenesis of Atherosclerosis: Is Obstructive Sleep Apnea the New Kid on the Block?. Am. J. Respir. Crit. Care Med.
176: 634-635
[Full Text]
Chertow, G. M., Pupim, L. B., Block, G. A., Correa-Rotter, R., Drueke, T. B., Floege, J., Goodman, W. G., London, G. M., Mahaffey, K. W., Moe, S. M., Wheeler, D. C., Albizem, M., Olson, K., Klassen, P., Parfrey, P.
(2007). Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE): Rationale and Design Overview. CJASN
2: 898-905
[Abstract][Full Text]
Manson, J. E., Bassuk, S. S.
(2007). Invited Commentary: Hormone Therapy and Risk of Coronary Heart Disease Why Renew the Focus on the Early Years of Menopause?. Am J Epidemiol
166: 511-517
[Abstract][Full Text]
Barrett-Connor, E.
(2007). Hormones and Heart Disease in Women: The Timing Hypothesis. Am J Epidemiol
166: 506-510
[Abstract][Full Text]
Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B.
(2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol
50: e1-e157
[Full Text]
Vickers, M. R, MacLennan, A. H, Lawton, B., Ford, D., Martin, J., Meredith, S. K, DeStavola, B. L, Rose, S., Dowell, A., Wilkes, H. C, Darbyshire, J. H, Meade, T. W, WISDOM group,
(2007). Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women. BMJ
335: 239-239
[Abstract][Full Text]
Collins, P., Rosano, G., Casey, C., Daly, C., Gambacciani, M., Hadji, P., Kaaja, R., Mikkola, T., Palacios, S., Preston, R., Simon, T., Stevenson, J., Stramba-Badiale, M.
(2007). Management of cardiovascular risk in the peri-menopausal woman: a consensus statement of European cardiologists and gynaecologists. Eur Heart J
28: 2028-2040
[Abstract][Full Text]
Atteritano, M., Marini, H., Minutoli, L., Polito, F., Bitto, A., Altavilla, D., Mazzaferro, S., D'Anna, R., Cannata, M. L., Gaudio, A., Frisina, A., Frisina, N., Corrado, F., Cancellieri, F., Lubrano, C., Bonaiuto, M., Adamo, E. B., Squadrito, F.
(2007). Effects of the Phytoestrogen Genistein on Some Predictors of Cardiovascular Risk in Osteopenic, Postmenopausal Women: A Two-Year Randomized, Double-Blind, Placebo-Controlled Study. J. Clin. Endocrinol. Metab.
92: 3068-3075
[Abstract][Full Text]
Simoncini, T., Fu, X-D., Caruso, A., Garibaldi, S., Baldacci, C., Giretti, M.S., Mannella, P., Flamini, M.I., Sanchez, A.M., Genazzani, A.R.
(2007). Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Hum Reprod
22: 2325-2334
[Abstract][Full Text]
Sherwood, A., Bower, J. K., McFetridge-Durdle, J., Blumenthal, J. A., Newby, L. K., Hinderliter, A. L.
(2007). Age Moderates the Short-Term Effects of Transdermal 17{beta}-Estradiol on Endothelium-Dependent Vascular Function in Postmenopausal Women. Arterioscler. Thromb. Vasc. Bio.
27: 1782-1787
[Abstract][Full Text]
(2007). Angeliq for Treatment of Menopausal Symptoms. Obstet Gynecol
110: 177-178
[Full Text]
Mendelsohn, M. E., Karas, R. H.
(2007). HRT and the Young at Heart. NEJM
356: 2639-2641
[Full Text]
Norman, P.E., Powell, J.T.
(2007). Abdominal Aortic Aneurysm: The Prognosis in Women Is Worse Than in Men. Circulation
115: 2865-2869
[Full Text]
Ferreri, N. R.
(2007). Estrogen-TNF interactions and vascular inflammation. Am. J. Physiol. Heart Circ. Physiol.
292: H2566-H2569
[Full Text]
Ding, E. L., Powe, N. R., Manson, J. E., Sherber, N. S., Braunstein, J. B.
(2007). Sex Differences in Perceived Risks, Distrust, and Willingness to Participate in Clinical Trials: A Randomized Study of Cardiovascular Prevention Trials. Arch Intern Med
167: 905-912
[Abstract][Full Text]
Roberts, H.
(2007). Managing the menopause. BMJ
334: 736-741
[Full Text]
Rossouw, J. E., Prentice, R. L., Manson, J. E., Wu, L., Barad, D., Barnabei, V. M., Ko, M., LaCroix, A. Z., Margolis, K. L., Stefanick, M. L.
(2007). Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause. JAMA
297: 1465-1477
[Abstract][Full Text]
Denes, P., Larson, J. C., Lloyd-Jones, D. M., Prineas, R. J., Greenland, P.
(2007). Major and Minor ECG Abnormalities in Asymptomatic Women and Risk of Cardiovascular Events and Mortality. JAMA
297: 978-985
[Abstract][Full Text]
Huxley, V. H.
(2007). Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differently. Adv. Physiol. Educ.
31: 17-22
[Abstract][Full Text]
Bray, P. F., Howard, T. D., Vittinghoff, E., Sane, D. C., Herrington, D. M.
(2007). Effect of genetic variations in platelet glycoproteins Ib{alpha} and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. Blood
109: 1862-1869
[Abstract][Full Text]
Hsia, J., Heiss, G., Ren, H., Allison, M., Dolan, N. C., Greenland, P., Heckbert, S. R., Johnson, K. C., Manson, J. E., Sidney, S., Trevisan, M., for the Women's Health Initiative Investigators,
(2007). Calcium/Vitamin D Supplementation and Cardiovascular Events. Circulation
115: 846-854
[Abstract][Full Text]
Cvoro, A., Paruthiyil, S., Jones, J. O., Tzagarakis-Foster, C., Clegg, N. J., Tatomer, D., Medina, R. T., Tagliaferri, M., Schaufele, F., Scanlan, T. S., Diamond, M. I., Cohen, I., Leitman, D. C.
(2007). Selective Activation of Estrogen Receptor-{beta} Transcriptional Pathways by an Herbal Extract. Endocrinology
148: 538-547
[Abstract][Full Text]
Rogers, J. L., Mitchell, A. R., Maric, C., Sandberg, K., Myers, A., Mulroney, S. E.
(2007). Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male rats. Am. J. Physiol. Regul. Integr. Comp. Physiol.
292: R794-R799
[Abstract][Full Text]
Suter, E., Verhoef, M. J., Bockmuehl, C., Forest, N., Bobey, M., Armitage, G. D.
(2007). Inquiring minds: Women's approaches to evaluating complementary and alternative therapies for menopausal symptoms. cfp
53: 84-90
[Abstract][Full Text]
Napoli, C., Lerman, L. O., de Nigris, F., Gossl, M., Balestrieri, M. L., Lerman, A.
(2006). Rethinking Primary Prevention of Atherosclerosis-Related Diseases. Circulation
114: 2517-2527
[Full Text]
MASTORAKOS, G., SAKKAS, E. GR., XYDAKIS, A. M., CREATSAS, G.
(2006). Pitfalls of the WHIs: Women's Health Initiative. Ann. N. Y. Acad. Sci.
1092: 331-340
[Abstract][Full Text]
Seli, E., Guzeloglu-Kayisli, O., Cakmak, H., Kayisli, U. A., Selam, B., Arici, A.
(2006). Estradiol Increases Apoptosis in Human Coronary Artery Endothelial Cells by Up-Regulating Fas and Fas Ligand Expression. J. Clin. Endocrinol. Metab.
91: 4995-5001
[Abstract][Full Text]
Rosenfeld, A. G.
(2006). State of the Heart: Building Science to Improve Women's Cardiovascular Health. Am J Crit Care
15: 556-566
[Abstract][Full Text]
ROSSOUW, J. E
(2006). Implications of Recent Clinical Trials of Postmenopausal Hormone Therapy for Management of Cardiovascular Disease. Ann. N. Y. Acad. Sci.
1089: 444-453
[Abstract][Full Text]
Hsia, J., Manson, J. E., Johnson, K. C., Hendrix, S. L., Heckbert, S. R., Crawford, S., Eaton, C. B., Kostis, J. B.
(2006). Estrogen and Heart Disease: Alternatives to a Paradigm in Crisis--Reply. Arch Intern Med
166: 2160-2160
[Full Text]
Hauptman, P. J., Schnitzler, M. A., Swindle, J., Burroughs, T. E.
(2006). Use of nesiritide before and after publications suggesting drug-related risks in patients with acute decompensated heart failure.. JAMA
296: 1877-1884
[Abstract][Full Text]
Simoncini, T., Caruso, A., Garibaldi, S., Fu, X.-D., Giretti, M. S., Baldacci, C., Scorticati, C., Fornari, L., Mannella, P., Genazzani, A. R.
(2006). Activation of nitric oxide synthesis in human endothelial cells using nomegestrol acetate.. Obstet Gynecol
108: 969-978
[Abstract][Full Text]
Ho, J. Y.-P., Chen, M.-J., Sheu, W. H.-H., Yi, Y.-C., Tsai, A. C.-W., Guu, H.-F., Ho, E. S.-C.
(2006). Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women. Hum Reprod
21: 2715-2720
[Abstract][Full Text]
Collins, P., Flather, M., Lees, B., Mister, R., Proudler, A. J., Stevenson, J. C., on behalf of the WHISP (Women's Hormone Interventi,
(2006). Randomized trial of effects of continuous combined HRT on markers of lipids and coagulation in women with acute coronary syndromes: WHISP Pilot Study. Eur Heart J
27: 2046-2053
[Abstract][Full Text]
The ESHRE Capri Workshop Group,
(2006). Hormones and cardiovascular health in women. Hum Reprod Update
12: 483-497
[Abstract][Full Text]
Zoma, W. D., Baker, R. S., Mershon, J. L., Clark, K. E.
(2006). Hemodynamic effects of acute and repeated exposure to raloxifene in ovariectomized sheep. Am. J. Physiol. Heart Circ. Physiol.
291: H1216-H1225
[Abstract][Full Text]
Madalinska, J. B., van Beurden, M., Bleiker, E. M.A., Valdimarsdottir, H. B., Hollenstein, J., Massuger, L. F., Gaarenstroom, K. N., Mourits, M. J.E., Verheijen, R. H.M., van Dorst, E. B.L., van der Putten, H., van der Velden, K., Boonstra, H., Aaronson, N. K.
(2006). The Impact of Hormone Replacement Therapy on Menopausal Symptoms in Younger High-Risk Women After Prophylactic Salpingo-Oophorectomy. JCO
24: 3576-3582
[Abstract][Full Text]
White, W. B., Hanes, V., Chauhan, V., Pitt, B.
(2006). Effects of a New Hormone Therapy, Drospirenone and 17-{beta}-Estradiol, in Postmenopausal Women With Hypertension. Hypertension
48: 246-253
[Abstract][Full Text]
Guo, J., Nikolic, D., Chadwick, L. R., Pauli, G. F., van Breemen, R. B.
(2006). IDENTIFICATION OF HUMAN HEPATIC CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF 8-PRENYLNARINGENIN AND ISOXANTHOHUMOL FROM HOPS (HUMULUS LUPULUS L.). Drug Metab. Dispos.
34: 1152-1159
[Abstract][Full Text]
Prentice, R. L., QI, L.
(2006). Aspects of the design and analysis of high-dimensional SNP studies for disease risk estimation. Biostatistics
7: 339-354
[Abstract][Full Text]
Stevenson, J. C., on behalf of the International Consensus Group on,
(2006). HRT, osteoporosis and regulatory authorities Quis custodiet ipsos custodes?. Hum Reprod
21: 1668-1671
[Abstract][Full Text]
Authors/Task Force Members, , Fox, K., Garcia, M. A. A., Ardissino, D., Buszman, P., Camici, P. G., Crea, F., Daly, C., De Backer, G., Hjemdahl, P., Lopez-Sendon, J., Marco, J., Morais, J., Pepper, J., Sechtem, U., Simoons, M., Thygesen, K., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Zamorano, J. L, Andreotti, F., Becher, H., Dietz, R., Fraser, A., Gray, H., Antolin, R. A. H., Huber, K., Kremastinos, D. T., Maseri, A., Nesser, H.-J., Pasierski, T., Sigwart, U., Tubaro, M., Weis, M.
(2006). Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J
27: 1341-1381
[Full Text]
Hemelaar, M., Kenemans, P., Schalkwijk, C.G., Braat, D.D.M., van der Mooren, M.J.
(2006). No increase in C-reactive protein levels during intranasal compared to oral hormone therapy in healthy post-menopausal women. Hum Reprod
21: 1635-1642
[Abstract][Full Text]
Kim, J., Evans, S., Smeeth, L., Pocock, S.
(2006). Hormone replacement therapy and acute myocardial infarction: a large observational study exploring the influence of age. Int J Epidemiol
35: 731-738
[Abstract][Full Text]
Stampfer, M. J
(2006). Commentary: Hormones, heart disease, and the definition of hormone 'initiation'. Int J Epidemiol
35: 738-739
[Full Text]
Willett, W. C., Manson, J. E., Grodstein, F., Stampfer, M. J., Colditz, G. A.
(2006). RE: "COMBINED POSTMENOPAUSAL HORMONE THERAPY AND CARDIOVASCULAR DISEASE: TOWARD RESOLVING THE DISCREPANCY BETWEEN OBSERVATIONAL STUDIES AND THE WOMEN'S HEALTH INITIATIVE CLINICAL TRIAL". Am J Epidemiol
163: 1067-1068
[Full Text]
Prentice, R. L., Stefanick, M. L., Howard, B. V., Barad, D., Kuller, L.
(2006). FIVE AUTHORS REPLY. Am J Epidemiol
163: 1068-1069
[Full Text]
(2006). The WHI and the Postmenopausal Woman: No Magic Bullet. JWatch Women's Health
2006: 1-1
[Full Text]
Maio, V., Hartmann, C. W., Poston, S., Liu-Chen, X., Diamond, J., Arenson, C.
(2006). Potentially inappropriate prescribing for elderly patients in 2 outpatient settings.. American Journal of Medical Quality
21: 162-168
[Abstract]
Schwartz, G. G., Blot, W. J.
(2006). Vitamin d status and cancer incidence and mortality: something new under the sun.. JNCI J Natl Cancer Inst
98: 428-430
[Full Text]
Prentice, R. L., Langer, R. D., Stefanick, M. L., Howard, B. V., Pettinger, M., Anderson, G. L., Barad, D., Curb, J. D., Kotchen, J., Kuller, L., Limacher, M., Wactawski-Wende, J., for the Women's Health Initiative Investigators,
(2006). Combined Analysis of Women's Health Initiative Observational and Clinical Trial Data on Postmenopausal Hormone Treatment and Cardiovascular Disease. Am J Epidemiol
163: 589-599
[Abstract][Full Text]
Koh, K. K., Yoon, B.-K.
(2006). Controversies regarding hormone therapy: Insights from inflammation and hemostasis. Cardiovasc Res
70: 22-30
[Abstract][Full Text]
James, A. H., Jamison, M. G., Biswas, M. S., Brancazio, L. R., Swamy, G. K., Myers, E. R.
(2006). Acute Myocardial Infarction in Pregnancy: A United States Population-Based Study. Circulation
113: 1564-1571
[Abstract][Full Text]
O'Malley, P. G., Greenland, P.
(2006). The proof for prevention: beyond observations.. Arch Intern Med
166: 486-486
[Full Text]
Bots, M. L., Evans, G. W., Riley, W., McBride, K. H., Paskett, E. D., Helmond, F. A., Grobbee, D. E., for the OPAL Investigators,
(2006). The effect of tibolone and continuous combined conjugated equine oestrogens plus medroxyprogesterone acetate on progression of carotid intima-media thickness: the Osteoporosis Prevention and Arterial effects of tiboLone (OPAL) study. Eur Heart J
27: 746-755
[Abstract][Full Text]
Lemaitre, R. N., Weiss, N. S., Smith, N. L., Psaty, B. M., Lumley, T., Larson, E. B., Heckbert, S. R.
(2006). Esterified estrogen and conjugated equine estrogen and the risk of incident myocardial infarction and stroke.. Arch Intern Med
166: 399-404
[Abstract][Full Text]
Hsia, J., Langer, R. D., Manson, J. E., Kuller, L., Johnson, K. C., Hendrix, S. L., Pettinger, M., Heckbert, S. R., Greep, N., Crawford, S., Eaton, C. B., Kostis, J. B., Caralis, P., Prentice, R., for the Women's Health Initiative Investigators,
(2006). Conjugated Equine Estrogens and Coronary Heart Disease: The Women's Health Initiative.. Arch Intern Med
166: 357-365
[Abstract][Full Text]
Howard, B. V., Van Horn, L., Hsia, J., Manson, J. E., Stefanick, M. L., Wassertheil-Smoller, S., Kuller, L. H., LaCroix, A. Z., Langer, R. D., Lasser, N. L., Lewis, C. E., Limacher, M. C., Margolis, K. L., Mysiw, W. J., Ockene, J. K., Parker, L. M., Perri, M. G., Phillips, L., Prentice, R. L., Robbins, J., Rossouw, J. E., Sarto, G. E., Schatz, I. J., Snetselaar, L. G., Stevens, V. J., Tinker, L. F., Trevisan, M., Vitolins, M. Z., Anderson, G. L., Assaf, A. R., Bassford, T., Beresford, S. A. A., Black, H. R., Brunner, R. L., Brzyski, R. G., Caan, B., Chlebowski, R. T., Gass, M., Granek, I., Greenland, P., Hays, J., Heber, D., Heiss, G., Hendrix, S. L., Hubbell, F. A., Johnson, K. C., Kotchen, J. M.
(2006). Low-Fat Dietary Pattern and Risk of Cardiovascular Disease: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA
295: 655-666
[Abstract][Full Text]
Gierach, G. L., Johnson, B. D., Bairey Merz, C. N., Kelsey, S. F., Bittner, V., Olson, M. B., Shaw, L. J., Mankad, S., Pepine, C. J., Reis, S. E., Rogers, W. J., Sharaf, B. L., Sopko, G., for the WISE Study Group,
(2006). Hypertension, Menopause, and Coronary Artery Disease Risk in the Women's Ischemia Syndrome Evaluation (WISE) Study. J Am Coll Cardiol
47: S50-S58
[Abstract][Full Text]
Purnell, J. Q., Bland, L. B., Garzotto, M., Lemmon, D., Wersinger, E. M., Ryan, C. W., Brunzell, J. D., Beer, T. M.
(2006). Effects of transdermal estrogen on levels of lipids, lipase activity, and inflammatory markers in men with prostate cancer. J. Lipid Res.
47: 349-355
[Abstract][Full Text]
Thomas, C. P., Liu, K. Z., Vats, H. S.
(2006). Medroxyprogesterone acetate binds the glucocorticoid receptor to stimulate {alpha}-ENaC and sgk1 expression in renal collecting duct epithelia. Am. J. Physiol. Renal Physiol.
290: F306-F312
[Abstract][Full Text]
Pentti, K., Honkanen, R., Tuppurainen, M. T, Sandini, L., Kroger, H., Saarikoski, S.
(2006). Hormone replacement therapy and mortality in 52- to 70-year-old women: the Kuopio Osteoporosis Risk Factor and Prevention Study. Eur J Endocrinol
154: 101-107
[Abstract][Full Text]
Bramson, C., Ouellet, D., Roman, D., Randinitis, E., Gardner, M. J.
(2006). A Single-Dose Pharmacokinetic Study of Lasofoxifene in Healthy Volunteers and Subjects With Mild and Moderate Hepatic Impairment. J Clin Pharmacol
46: 29-36
[Abstract][Full Text]
Ballard, V. L., Edelberg, J. M.
(2005). Harnessing Hormonal Signaling for Cardioprotection. Sci Aging Knowl Environ
2005: re6-re6
[Abstract][Full Text]
Karlsson, M. K., Gerdhem, P., Ahlborg, H. G.
(2005). The prevention of osteoporotic fractures. J Bone Joint Surg Br
87-B: 1320-1327
[Full Text]
Wang, D., Oparil, S., Chen, Y.-F., McCrory, M. A., Skibinski, G. A., Feng, W., Szalai, A. J.
(2005). Estrogen Treatment Abrogates Neointima Formation in Human C-Reactive Protein Transgenic Mice. Arterioscler. Thromb. Vasc. Bio.
25: 2094-2099
[Abstract][Full Text]
White, W. B., Pitt, B., Preston, R. A., Hanes, V.
(2005). Antihypertensive Effects of Drospirenone With 17{beta}-Estradiol, a Novel Hormone Treatment in Postmenopausal Women With Stage 1 Hypertension. Circulation
112: 1979-1984
[Abstract][Full Text]
Melby, M. K., Lock, M., Kaufert, P.
(2005). Culture and symptom reporting at menopause. Hum Reprod Update
11: 495-512
[Abstract][Full Text]
Prentice, R. L., Langer, R., Stefanick, M. L., Howard, B. V., Pettinger, M., Anderson, G., Barad, D., Curb, J. D., Kotchen, J., Kuller, L., Limacher, M., Wactawski-Wende, J., for the Women's Health Initiative Investigators,
(2005). Combined Postmenopausal Hormone Therapy and Cardiovascular Disease: Toward Resolving the Discrepancy between Observational Studies and the Women's Health Initiative Clinical Trial. Am J Epidemiol
162: 404-414
[Abstract][Full Text]
Miller, V. M., Clarkson, T. B., Harman, S. M., Brinton, E. A., Cedars, M., Lobo, R., Manson, J. E., Merriam, G. R., Naftolin, F., Santoro, N.
(2005). Women, hormones, and clinical trials: a beginning, not an end. J. Appl. Physiol.
99: 381-383
[Full Text]
Lonning, P. E., Geisler, J., Krag, L. E., Erikstein, B., Bremnes, Y., Hagen, A. I., Schlichting, E., Lien, E. A., Ofjord, E. S., Paolini, J., Polli, A., Massimini, G.
(2005). Effects of Exemestane Administered for 2 Years Versus Placebo on Bone Mineral Density, Bone Biomarkers, and Plasma Lipids in Patients With Surgically Resected Early Breast Cancer. JCO
23: 5126-5137
[Abstract][Full Text]