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ABSTRACT

Background Chronic obstructive pulmonary disease (COPD) is characterized by an incompletely reversible limitation in airflow. A physiological variable — the forced expiratory volume in one second (FEV₁) — is often used to grade the severity of COPD. However, patients with COPD have systemic manifestations that are not reflected by the FEV₁. We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients.

Methods We first evaluated 207 patients and found that four factors predicted the risk of death in this cohort: the body-mass index (B), the degree of airflow obstruction (O) and dyspnea (D), and exercise capacity (E), measured by the six-minute–walk test. We used these variables to construct the BODE index, a multidimensional 10-point scale in which higher scores indicate a higher risk of death. We then prospectively validated the index in a cohort of 625 patients, with death from any cause and from respiratory causes as the outcome variables.

Results There were 25 deaths among the first 207 patients and 162 deaths (26 percent) in the validation cohort. Sixty-one percent of the deaths in the validation cohort were due to respiratory insufficiency, 14 percent to myocardial infarction, 12 percent to lung cancer, and 13 percent to other causes. Patients with higher BODE scores were at higher risk for death; the hazard ratio for death from any cause per one-point increase in the BODE score was 1.34 (95 percent confidence interval, 1.26 to 1.42; P<0.001), and the hazard ratio for death from respiratory causes was 1.62 (95 percent confidence interval, 1.48 to 1.77; P<0.001). The C statistic for the ability of the BODE index to predict the risk of death was larger than that for the FEV₁ (0.74 vs. 0.65).

Conclusions The BODE index, a simple multidimensional grading system, is better than the FEV₁ at predicting the risk of death from any cause and from respiratory causes among patients with COPD.

Source Information

From the COPD Center at St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston (B.R.C., V.P.P.); Bay Pines Veterans Affairs Medical Center, Bay Pines, Fla. (C.G.C.); Hospital Miguel Servet, Zaragoza, Spain (J.M.M.); Hospital Nuestra Senora de La Candelaria, Tenerife, Spain (C.C.); Hospital Universitario de Caracas and Hospital Jose I. Baldo, Caracas, Venezuela (M.M.O., R.A.M.); and Boston University School of Public Health, Boston (H.J.C.).

Address reprint requests to Dr. Celli at Pulmonary and Critical Care Medicine, St. Elizabeth's Medical Center, 736 Cambridge St., Boston, MA 02135, or at bcelli{at}copdnet.org.

Full Text of this Article

Related Letters:

Predicting Outcomes in Chronic Obstructive Pulmonary Disease
Garcia-Pachon E., Padilla-Nava I., Kostianev S. S., Iluchev D. H., Sankaranarayanan V., Ziedalski T., Gould M. K., Ussetti P., Laporta R., Celli B. R.
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N Engl J Med 2004; 350:2308-2310, May 27, 2004. Correspondence

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