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A correction has been published: N Engl J Med 2006;355(16):1746.

Previous Volume 350:1081-1092 March 11, 2004 Number 11 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Supplementary Material Editorial by Piccart-Gebhart, M. J. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article Related Article PubMed Citation

ABSTRACT

Background Tamoxifen, taken for five years, is the standard adjuvant treatment for postmenopausal women with primary, estrogen-receptor–positive breast cancer. Despite this treatment, however, some patients have a relapse.

Methods We conducted a double-blind, randomized trial to test whether, after two to three years of tamoxifen therapy, switching to exemestane was more effective than continuing tamoxifen therapy for the remainder of the five years of treatment. The primary end point was disease-free survival.

Results Of the 4742 patients enrolled, 2362 were randomly assigned to switch to exemestane, and 2380 to continue to receive tamoxifen. After a median follow-up of 30.6 months, 449 first events (local or metastatic recurrence, contralateral breast cancer, or death) were reported — 183 in the exemestane group and 266 in the tamoxifen group. The unadjusted hazard ratio in the exemestane group as compared with the tamoxifen group was 0.68 (95 percent confidence interval, 0.56 to 0.82; P<0.001 by the log-rank test), representing a 32 percent reduction in risk and corresponding to an absolute benefit in terms of disease-free survival of 4.7 percent (95 percent confidence interval, 2.6 to 6.8) at three years after randomization. Overall survival was not significantly different in the two groups, with 93 deaths occurring in the exemestane group and 106 in the tamoxifen group. Severe toxic effects of exemestane were rare. Contralateral breast cancer occurred in 20 patients in the tamoxifen group and 9 in the exemestane group (P=0.04).

Conclusions Exemestane therapy after two to three years of tamoxifen therapy significantly improved disease-free survival as compared with the standard five years of tamoxifen treatment.

Source Information

From the Department of Cancer Medicine, Imperial College and Charing Cross Hospital, London (R.C.C., L.J.G., C.F.S.); Institute of Cancer Research, Sutton (E.H., J.M.B.); South West Wales Cancer Institute, Swansea (G.B.); Cookridge Hospital, Leeds (D.D.); Cancer Research Centre, Weston Park Hospital, Sheffield (R.E.C.); Psychosocial Oncology Group, University of Sussex, Brighton (L.J.F.); Christie Hospital, Manchester (A.S.); and Ysbyty Gwynedd, Bangor, Gwynedd (N.S.) — all in the United Kingdom; Universitair Ziekenhuis, Leuven, Belgium (R.P.); Medical University of Gdansk, Gdansk, Poland (J.J.); Centre François Baclesse, Caen, France (T.D.); U.S. Oncology Research, Houston (S.E.J.); Hospital Donostia, San Sebastián, Spain (I.A.); University of Regensburg, Regensburg, Germany (O.O.); University of Sydney, Sydney, Australia (A.S.C.); Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy (E.B.); Instituto Angel Roffo, Buenos Aires, Argentina (E.M.); Århus University Hospital, Århus, Denmark (J.A.); Haukeland Hospital, University of Bergen, Bergen, Norway (P.E.L.); University Hospital, Parma, Italy (G.C.); and Pharmacia Italia, Pfizer Group, Nerviano, Italy (M.C., G.M.).

Address reprint requests to Dr. Coombes at the Department of Cancer Medicine, Imperial College London, 6th Fl., Cyclotron Bldg., Hammersmith Hospital, Du Cane Rd., London W12 0NN, United Kingdom.

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Related Letters:

Adjuvant Treatment of Breast Cancer with Exemestane
Kunkler I. H., Vakaet L. A.M.L., De Neve W., Tanvetyanon T., Coombes R. C., Bliss J. M., Hall E.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:100-102, Jul 1, 2004. Correspondence

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• Brufsky, A., Harker, W. G., Beck, J. T., Carroll, R., Tan-Chiu, E., Seidler, C., Hohneker, J., Lacerna, L., Petrone, S., Perez, E. A. (2007). Zoledronic Acid Inhibits Adjuvant Letrozole-Induced Bone Loss in Postmenopausal Women With Early Breast Cancer. JCO 25: 829-836 [Abstract] [Full Text]  
• Kirkegaard, T., McGlynn, L. M., Campbell, F. M., Muller, S., Tovey, S. M., Dunne, B., Nielsen, K. V., Cooke, T. G., Bartlett, J. M.S. (2007). Amplified in Breast Cancer 1 in Human Epidermal Growth Factor Receptor-Positive Tumors of Tamoxifen-Treated Breast Cancer Patients. Clin. Cancer Res. 13: 1405-1411 [Abstract] [Full Text]  
• Cuzick, J., Forbes, J. F., Sestak, I., Cawthorn, S., Hamed, H., Holli, K., Howell, A. (2007). Long-Term Results of Tamoxifen Prophylaxis for Breast Cancer--96-Month Follow-up of the Randomized IBIS-I Trial. JNCI J Natl Cancer Inst 99: 272-282 [Abstract] [Full Text]  
• Coates, A. S., Keshaviah, A., Thurlimann, B., Mouridsen, H., Mauriac, L., Forbes, J. F., Paridaens, R., Castiglione-Gertsch, M., Gelber, R. D., Colleoni, M., Lang, I., Del Mastro, L., Smith, I., Chirgwin, J., Nogaret, J.-M., Pienkowski, T., Wardley, A., Jakobsen, E. H., Price, K. N., Goldhirsch, A. (2007). Five Years of Letrozole Compared With Tamoxifen As Initial Adjuvant Therapy for Postmenopausal Women With Endocrine-Responsive Early Breast Cancer: Update of Study BIG 1-98. JCO 25: 486-492 [Abstract] [Full Text]  
• Younis, T, Rayson, D, Dewar, R, Skedgel, C (2007). Modeling for cost-effective-adjuvant aromatase inhibitor strategies for postmenopausal women with breast cancer. Ann Oncol 18: 293-298 [Abstract] [Full Text]  
• Chew, H. K., Wun, T., Harvey, D. J., Zhou, H., White, R. H. (2007). Incidence of Venous Thromboembolism and the Impact on Survival in Breast Cancer Patients. JCO 25: 70-76 [Abstract] [Full Text]  
• Greenspan, S. L., Bhattacharya, R. K., Sereika, S. M., Brufsky, A., Vogel, V. G. (2007). Prevention of Bone Loss in Survivors of Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J. Clin. Endocrinol. Metab. 92: 131-136 [Abstract] [Full Text]  
• Kennecke, H., Olivotto, I., Speers, C, Norris, B, Chia, S., Bryce, C, Gelmon, K. (2007). Late risk of relapse and mortality among postmenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen. Ann Oncol 18: 45-51 [Abstract] [Full Text]  
• Perey, L, Paridaens, R, Hawle, H, Zaman, K, Nole, F, Wildiers, H, Fiche, M, Dietrich, D, Clement, P, Koberle, D, Goldhirsch, A, Thurlimann, B (2007). Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00). Ann Oncol 18: 64-69 [Abstract] [Full Text]  
• Delea, T., Karnon, J, Goss, P. (2007). Conclusions regarding relative cost-utility of alternative strategies for use of aromatase inhibitors in postmenopausal women with early breast cancer are premature. Ann Oncol 18: 197-198 [Full Text]  
• Chlebowski, R. T., Blackburn, G. L., Thomson, C. A., Nixon, D. W., Shapiro, A., Hoy, M. K., Goodman, M. T., Giuliano, A. E., Karanja, N., McAndrew, P., Hudis, C., Butler, J., Merkel, D., Kristal, A., Caan, B., Michaelson, R., Vinciguerra, V., Del Prete, S., Winkler, M., Hall, R., Simon, M., Winters, B. L., Elashoff, R. M. (2006). Dietary Fat Reduction and Breast Cancer Outcome: Interim Efficacy Results From the Women's Intervention Nutrition Study. JNCI J Natl Cancer Inst 98: 1767-1776 [Abstract] [Full Text]  
• Belosay, A., Brodie, A. M.H., Njar, V. C.O. (2006). Effects of Novel Retinoic Acid Metabolism Blocking Agent (VN/14-1) on Letrozole-Insensitive Breast Cancer Cells. Cancer Res. 66: 11485-11493 [Abstract] [Full Text]  
• Chien, A. J., Goss, P. E. (2006). Aromatase Inhibitors and Bone Health in Women With Breast Cancer. JCO 24: 5305-5312 [Full Text]  
• Wang, X., Chen, S. (2006). Aromatase Destabilizer: Novel Action of Exemestane, a Food and Drug Administration-Approved Aromatase Inhibitor. Cancer Res. 66: 10281-10286 [Abstract] [Full Text]  
• Moy, B, Tu, D, Pater, J., Ingle, J., Shepherd, L., Whelan, T., Goss, P. (2006). Clinical outcomes of ethnic minority women in MA.17: a trial of letrozole after 5 years of tamoxifen in postmenopausal women with early stage breast cancer. Ann Oncol 17: 1637-1643 [Abstract] [Full Text]  
• Ponzone, R, Montemurro, F, Maggiorotto, F, Robba, C, Gregori, D, Jacomuzzi, M., Kubatzki, F, Marenco, D, Dominguez, A, Biglia, N, Sismondi, P (2006). Clinical outcome of adjuvant endocrine treatment according to PR and HER-2 status in early breast cancer. Ann Oncol 17: 1631-1636 [Abstract] [Full Text]  
• Perez, E. A. (2006). Appraising Adjuvant Aromatase Inhibitor Therapy. The Oncologist 11: 1058-1069 [Abstract] [Full Text]  
• Guise, T. A. (2006). Bone Loss and Fracture Risk Associated with Cancer Therapy. The Oncologist 11: 1121-1131 [Abstract] [Full Text]  
• Hirbe, A., Morgan, E. A., Uluckan, O., Weilbaecher, K. (2006). Skeletal complications of breast cancer therapies.. Clin. Cancer Res. 12: 6309s-6314s [Abstract] [Full Text]  
• Kendall, A., Dowsett, M. (2006). Novel concepts for the chemoprevention of breast cancer through aromatase inhibition.. Endocr Relat Cancer 13: 827-837 [Abstract] [Full Text]  
• Chau, I, Cunningham, D (2006). Adjuvant therapy in colon cancer--what, when and how?. Ann Oncol 17: 1347-1359 [Abstract] [Full Text]