Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis
Geoffrey A. Block, M.D., Kevin J. Martin, M.B., B.Ch., Angel L.M. de Francisco, M.D., Stewart A. Turner, Ph.D., Morrell M. Avram, M.D., Michael G. Suranyi, M.D., Gavril Hercz, M.D., John Cunningham, D.M., Ali K. Abu-Alfa, M.D., Piergiorgio Messa, M.D., Daniel W. Coyne, M.D., Francesco Locatelli, M.D., Raphael M. Cohen, M.D., Pieter Evenepoel, M.D., Sharon M. Moe, M.D., Albert Fournier, M.D., Johann Braun, M.D., Laura C. McCary, Ph.D., Valter J. Zani, Ph.D., Kurt A. Olson, M.S., Tilman B. Drüeke, M.D., and William G. Goodman, M.D.
Background Treatment of secondary hyperparathyroidism with vitaminD and calcium in patients receiving dialysis is often complicatedby hypercalcemia and hyperphosphatemia, which may contributeto cardiovascular disease and adverse clinical outcomes. Calcimimeticstarget the calcium-sensing receptor and lower parathyroid hormonelevels without increasing calcium and phosphorus levels. Wereport the results of two identical randomized, double-blind,placebo-controlled trials evaluating the safety and effectivenessof the calcimimetic agent cinacalcet hydrochloride.
Methods Patients who were receiving hemodialysis and who hadinadequately controlled secondary hyperparathyroidism despitestandard treatment were randomly assigned to receive cinacalcet(371 patients) or placebo (370 patients) for 26 weeks. Once-dailydoses were increased from 30 mg to 180 mg to achieve intactparathyroid hormone levels of 250 pg per milliliter or less.The primary end point was the percentage of patients with valuesin this range during a 14-week efficacy-assessment phase.
Results Forty-three percent of the cinacalcet group reachedthe primary end point, as compared with 5 percent of the placebogroup (P<0.001). Overall, mean parathyroid hormone valuesdecreased 43 percent in those receiving cinacalcet but increased9 percent in the placebo group (P<0.001). The serum calcium–phosphorusproduct declined by 15 percent in the cinacalcet group and remainedunchanged in the placebo group (P<0.001). Cinacalcet effectivelyreduced parathyroid hormone levels independently of diseaseseverity or changes in vitamin D sterol dose.
Conclusions Cinacalcet lowers parathyroid hormone levels andimproves calcium–phosphorus homeostasis in patients receivinghemodialysis who have uncontrolled secondary hyperparathyroidism.
Source Information
From Denver Nephrologists, Denver (G.A.B.); Saint Louis University, St. Louis (K.J.M.); Hospital Marqués de Valdecilla, Santander, Spain (A.L.M.F.); Amgen, Thousand Oaks, Calif. (S.A.T., L.C.M., V.J.Z., K.A.O.); Long Island College Hospital, Brooklyn, N.Y. (M.M.A.); Liverpool Hospital, Liverpool, NSW, Australia (M.G.S.); Humber River Regional Hospital, Toronto (G.H.); University College London Hospitals, London (J.C.); Yale University School of Medicine, New Haven, Conn. (A.K.A.-A.); Ospedale Civile S. Andrea, La Spezia, Italy (P.M.); Washington University School of Medicine, St. Louis (D.W.C.); Ospedale Manzoni, Lecco, Italy (F.L.); Presbyterian Medical Center, Philadelphia (R.M.C.); Universitaire Ziekenhuis Gasthuisberg, Leuven, Belgium (P.E.); Indiana University School of Medicine, Indianapolis (S.M.M.); Centre Hospitalier Universitaire d'Amiens, Amiens, France (A.F.); Kuratorium für Dialyse, Nuremberg, Germany (J.B.); Necker Hospital, Paris (T.B.D.); and UCLA School of Medicine, Los Angeles (W.G.G.).
Address reprint requests to Dr. Block at Denver Nephrologists, 1601 E. 19th Ave. #4300, Denver, CO 80218, or at gablock{at}denverneph.net.
Komaba, H., Shin, J., Fukagawa, M.
(2009). Restoration of reversed whole PTH/intact PTH ratio and reduction in parathyroid gland vascularity during cinacalcet therapy for severe hyperparathyroidism in a uraemic patient. Nephrol Dial Transplant
0: gfp578v1-gfp578
[Abstract][Full Text]
Drueke, T. B., Touam, M.
(2009). Calcium balance in haemodialysis--do not lower the dialysate calcium concentration too much (con part). Nephrol Dial Transplant
24: 2990-2993
[Abstract][Full Text]
Urena, P., Jacobson, S. H., Zitt, E., Vervloet, M., Malberti, F., Ashman, N., Leavey, S., Rix, M., Os, I., Saha, H., Ryba, M., Bencova, V., Banos, A., Zani, V., Fouque, D.
(2009). Cinacalcet and achievement of the NKF/K-DOQITM recommended target values for bone and mineral metabolism in real-world clinical practice--the ECHO observational study. Nephrol Dial Transplant
24: 2852-2859
[Abstract][Full Text]
Yokoyama, K.
(2009). Cinacalcet Hydrochloride in Chronic Kidney Disease-Mineral Bone Disorder. CJASN
4: 1405-1408
[Full Text]
Sprague, S. M., Evenepoel, P., Curzi, M. P., Gonzalez, M. T., Husserl, F. E., Kopyt, N., Sterling, L. R., Mix, C., Wong, G.
(2009). Simultaneous Control of PTH and CaxP Is Sustained over Three Years of Treatment with Cinacalcet HCl. CJASN
4: 1465-1476
[Abstract][Full Text]
Marcocci, C., Chanson, P., Shoback, D., Bilezikian, J., Fernandez-Cruz, L., Orgiazzi, J., Henzen, C., Cheng, S., Sterling, L. R., Lu, J., Peacock, M.
(2009). Cinacalcet Reduces Serum Calcium Concentrations in Patients with Intractable Primary Hyperparathyroidism. J. Clin. Endocrinol. Metab.
94: 2766-2772
[Abstract][Full Text]
Schiller, B., Wong, A., Blair, M., Moran, J.
(2009). False low parathyroid hormone values secondary to sample contamination with the tissue plasminogen activator. Nephrol Dial Transplant
24: 2240-2243
[Abstract][Full Text]
Lopez, I., Mendoza, F. J., Guerrero, F., Almaden, Y., Henley, C., Aguilera-Tejero, E., Rodriguez, M.
(2009). The calcimimetic AMG 641 accelerates regression of extraosseous calcification in uremic rats. Am. J. Physiol. Renal Physiol.
296: F1376-F1385
[Abstract][Full Text]
Connor, A
(2009). Novel therapeutic agents and strategies for the management of chronic kidney disease mineral and bone disorder. Postgrad. Med. J.
85: 274-279
[Abstract][Full Text]
Nechama, M., Ben-Dov, I. Z., Silver, J., Naveh-Many, T.
(2009). Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD. Am. J. Physiol. Renal Physiol.
296: F795-F800
[Abstract][Full Text]
Komaba, H., Fukagawa, M.
(2009). Regression of parathyroid hyperplasia by calcimimetics--fact or illusion?. Nephrol Dial Transplant
24: 707-709
[Full Text]
Meola, M., Petrucci, I., Barsotti, G.
(2009). Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism. Nephrol Dial Transplant
24: 982-989
[Abstract][Full Text]
Belozeroff, V., Goodman, W. G., Ren, L., Kalantar-Zadeh, K.
(2009). Cinacalcet Lowers Serum Alkaline Phosphatase in Maintenance Hemodialysis Patients. CJASN
4: 673-679
[Abstract][Full Text]
St. Peter, W. L., Li, Q., Liu, J., Persky, M., Nieman, K., Arko, C., Block, G. A.
(2009). Cinacalcet Use Patterns and Effect on Laboratory Values and Other Medications in a Large Dialysis Organization, 2004 through 2006. CJASN
4: 354-360
[Abstract][Full Text]
Alam, M.-u., Kirton, J. P., Wilkinson, F. L., Towers, E., Sinha, S., Rouhi, M., Vizard, T. N., Sage, A. P., Martin, D., Ward, D. T., Alexander, M. Y., Riccardi, D., Canfield, A. E.
(2009). Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res
81: 260-268
[Abstract][Full Text]
Drueke, T. B., Ritz, E.
(2009). Treatment of Secondary Hyperparathyroidism in CKD Patients with Cinacalcet and/or Vitamin D Derivatives. CJASN
4: 234-241
[Abstract][Full Text]
Valle, C., Rodriguez, M., Santamaria, R., Almaden, Y., Rodriguez, M. E., Canadillas, S., Martin-Malo, A., Aljama, P.
(2008). Cinacalcet Reduces the Set Point of the PTH-Calcium Curve. J. Am. Soc. Nephrol.
19: 2430-2436
[Abstract][Full Text]
Raeder, H., Shaw, N., Netelenbos, C., Bjerknes, R.
(2008). A case of X-linked hypophosphatemic rickets: complications and the therapeutic use of cinacalcet. Eur J Endocrinol
159: S101-S105
[Abstract][Full Text]
Shinaberger, C. S., Kopple, J. D., Kovesdy, C. P., McAllister, C. J., van Wyck, D., Greenland, S., Kalantar-Zadeh, K.
(2008). Ratio of Paricalcitol Dosage to Serum Parathyroid Hormone Level and Survival in Maintenance Hemodialysis Patients. CJASN
3: 1769-1776
[Abstract][Full Text]
Regidor, D. L., Kovesdy, C. P., Mehrotra, R., Rambod, M., Jing, J., McAllister, C. J., Van Wyck, D., Kopple, J. D., Kalantar-Zadeh, K.
(2008). Serum Alkaline Phosphatase Predicts Mortality among Maintenance Hemodialysis Patients. J. Am. Soc. Nephrol.
19: 2193-2203
[Abstract][Full Text]
Miller, P. D.
(2008). The Role of Bone Biopsy in Patients with Chronic Renal Failure. CJASN
3: S140-S150
[Abstract][Full Text]
Goto, S., Komaba, H., Fukagawa, M.
(2008). Pathophysiology of parathyroid hyperplasia in chronic kidney disease: preclinical and clinical basis for parathyroid intervention. NDT Plus
1: iii2-iii8
[Abstract][Full Text]
Ogata, H., Mizobuchi, M., Koiwa, F., Kinugasa, E., Akizawa, T.
(2008). Clinical significance of parathyroid intervention on CKD-MBD management. NDT Plus
1: iii9-iii13
[Abstract][Full Text]
Tanaka, M., Nakanishi, S., Komaba, H., Itoh, K., Matsushita, K., Fukagawa, M.
(2008). Association between long-term efficacy of cinacalcet and parathyroid gland volume in haemodialysis patients with secondary hyperparathyroidism. NDT Plus
1: iii49-iii53
[Abstract][Full Text]
Block, G. A., Zeig, S., Sugihara, J., Chertow, G. M., Chi, E. M., Turner, S. A., Bushinsky, D. A., for the TARGET Investigators,
(2008). Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism. Nephrol Dial Transplant
23: 2311-2318
[Abstract][Full Text]
How, P. P., Mason, D. L., Lau, A. H.
(2008). Current Approaches in the Treatment of Chronic Kidney Disease Mineral and Bone Disorder. Journal of Pharmacy Practice
21: 196-213
[Abstract]
Alon, U. S., Levy-Olomucki, R., Moore, W. V., Stubbs, J., Liu, S., Quarles, L. D.
(2008). Calcimimetics as an Adjuvant Treatment for Familial Hypophosphatemic Rickets. CJASN
3: 658-664
[Abstract][Full Text]
Zerbi, S., Ruggiero, P., Pedrini, L. A.
(2008). Massive Soft Tissue Calcifications and Cinacalcet. J. Clin. Endocrinol. Metab.
93: 1121-1122
[Full Text]
Diez, J. J., Miguel, J. L., Codoceo, R., Iglesias, P., Bajo, M. A., Sanchez, C., del Peso, G., Gil, F., Martinez-Ara, J., Gancedo, P. G., Selgas, R.
(2008). Effects of cinacalcet on gastrointestinal hormone release in patients with secondary hyperparathyroidism undergoing dialysis. Nephrol Dial Transplant
23: 1387-1395
[Abstract][Full Text]
Piecha, G., Kokeny, G., Nakagawa, K., Koleganova, N., Geldyyev, A., Berger, I., Ritz, E., Schmitt, C. P., Gross, M.-L.
(2008). Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats. Am. J. Physiol. Renal Physiol.
294: F748-F757
[Abstract][Full Text]
Schwartz, G. G.
(2008). Prostate Cancer, Serum Parathyroid Hormone, and the Progression of Skeletal Metastases. Cancer Epidemiol. Biomarkers Prev.
17: 478-483
[Abstract][Full Text]
Battistella, M., Hamandi, B., Pui, C., Oreopoulos, D., Richardson, R., Jassal, S. V.
(2008). Clinical remission as measured by a decrease in intact parathyroid hormone levels after administration of cinacalcet in patients with severe hyperparathyroidism. Nephrol Dial Transplant
23: 773-774
[Full Text]
Kunzendorf, U., Kramer, B. K., Arns, W., Braun, J., Grossmann, J., Pietruck, F., Schmidt-Gayk, H., Schwarz, A., Ziegler, E., Sperschneider, H., Wuthrich, R. P., Nonnast-Daniel, B., Schindler, R., Renders, L.
(2008). Bone disease after renal transplantation. Nephrol Dial Transplant
23: 450-458
[Full Text]
Messa, P., Macario, F., Yaqoob, M., Bouman, K., Braun, J., von Albertini, B., Brink, H., Maduell, F., Graf, H., Frazao, J. M., Bos, W. J., Torregrosa, V., Saha, H., Reichel, H., Wilkie, M., Zani, V. J., Molemans, B., Carter, D., Locatelli, F.
(2008). The OPTIMA Study: Assessing a New Cinacalcet (Sensipar/Mimpara) Treatment Algorithm for Secondary Hyperparathyroidism. CJASN
3: 36-45
[Abstract][Full Text]
Fukagawa, M., Yumita, S., Akizawa, T., Uchida, E., Tsukamoto, Y., Iwasaki, M., Koshikawa, S., KRN1493 study group,
(2008). Cinacalcet (KRN1493) effectively decreases the serum intact PTH level with favourable control of the serum phosphorus and calcium levels in Japanese dialysis patients. Nephrol Dial Transplant
23: 328-335
[Abstract][Full Text]
Mohammed, I. A., Sekar, V., Bubtana, A. J., Mitra, S., Hutchison, A. J.
(2008). Proximal calciphylaxis treated with calcimimetic 'cinacalcet'. Nephrol Dial Transplant
23: 387-389
[Abstract][Full Text]
Drueke, T. B., Martin, D., Rodriguez, M.
(2008). Reply. Nephrol Dial Transplant
23: 408-409
[Full Text]
Frazao, J., Rodriguez, M.
(2008). Secondary Hyperparathyroidism Disease Stabilization Following Calcimimetic Therapy. NDT Plus
1: i12-i17
[Abstract][Full Text]
Bushinsky, D. A., Messa, P.
(2008). Efficacy of Early Treatment with Calcimimetics in Combination with Reduced Doses of Vitamin D Sterols in Dialysis Patients. NDT Plus
1: i18-i23
[Abstract][Full Text]
de Francisco, A. L. M., Carrera, F.
(2008). A New Paradigm for the Treatment of Secondary Hyperparathyroidism. NDT Plus
1: i24-i28
[Abstract][Full Text]
Cunningham, J., Floege, J., London, G., Rodriguez, M., Shanahan, C. M.
(2008). Clinical Outcomes in Secondary Hyperparathyroidism and the Potential Role of Calcimimetics. NDT Plus
1: i29-i35
[Abstract][Full Text]
Chonchol, M., Wuthrich, R. P.
(2008). Potential Future Uses of Calcimimetics in Patients with Chronic Kidney Disease. NDT Plus
1: i36-i41
[Abstract][Full Text]
Joki, N., Nikolov, I. G., Drueke, T. B.
(2007). Optimal dialysate calcium and vascular calcification. Nephrol Dial Transplant
22: 3354-3354
[Full Text]
Fryer, R. M., Segreti, J. A., Widomski, D. L., Franklin, P. H., Banfor, P. N., Koch, K. A., Nakane, M., Wu-Wong, J. R., Cox, B. F., Reinhart, G. A.
(2007). Systemic Activation of the Calcium Sensing Receptor Produces Acute Effects on Vascular Tone and Circulatory Function in Uremic and Normal Rats: Focus on Central versus Peripheral Control of Vascular Tone and Blood Pressure by Cinacalcet. J. Pharmacol. Exp. Ther.
323: 217-226
[Abstract][Full Text]
Silverberg, S. J., Rubin, M. R., Faiman, C., Peacock, M., Shoback, D. M., Smallridge, R. C., Schwanauer, L. E., Olson, K. A., Klassen, P., Bilezikian, J. P.
(2007). Cinacalcet Hydrochloride Reduces the Serum Calcium Concentration in Inoperable Parathyroid Carcinoma. J. Clin. Endocrinol. Metab.
92: 3803-3808
[Abstract][Full Text]
Arenas, M. D.
(2007). Reply. Nephrol Dial Transplant
22: 3087-3088
[Full Text]
Nakashima, D., Takama, H., Ogasawara, Y., Kawakami, T., Nishitoba, T., Hoshi, S., Uchida, E., Tanaka, H.
(2007). Effect of Cinacalcet Hydrochloride, a New Calcimimetic Agent, on the Pharmacokinetics of Dextromethorphan: In Vitro and Clinical Studies. J Clin Pharmacol
47: 1311-1319
[Abstract][Full Text]
Chertow, G. M., Pupim, L. B., Block, G. A., Correa-Rotter, R., Drueke, T. B., Floege, J., Goodman, W. G., London, G. M., Mahaffey, K. W., Moe, S. M., Wheeler, D. C., Albizem, M., Olson, K., Klassen, P., Parfrey, P.
(2007). Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE): Rationale and Design Overview. CJASN
2: 898-905
[Abstract][Full Text]
Lomonte, C., Antonelli, M., Losurdo, N., Marchio, G., Giammaria, B., Basile, C.
(2007). Cinacalcet is effective in relapses of secondary hyperparathyroidism after parathyroidectomy. Nephrol Dial Transplant
22: 2056-2062
[Abstract][Full Text]
Jean, G., Chazot, C., Charra, B.
(2007). Six cases of successful cinacalcet cessation in haemodialysis patients treated for secondary hyperparathyroidism. Nephrol Dial Transplant
22: 2102-2103
[Full Text]
Arenas, M. D., Alvarez-Ude, F., Gil, M. T., Moledous, A., Malek, T., Nunez, C., Devesa, R., Carreton, M. A., Soriano, A.
(2007). Implementation of 'K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease' after the introduction of cinacalcet in a population of patients on chronic haemodialysis. Nephrol Dial Transplant
22: 1639-1644
[Abstract][Full Text]
Rodriguez, M. E., Almaden, Y., Canadillas, S., Canalejo, A., Siendones, E., Lopez, I., Aguilera-Tejero, E., Martin, D., Rodriguez, M.
(2007). The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands. Am. J. Physiol. Renal Physiol.
292: F1390-F1395
[Abstract][Full Text]
Bazari, H., Jaff, M. R., Mannstadt, M., Yan, S.
(2007). Case 7-2007 -- A 59-Year-Old Woman with Diabetic Renal Disease and Nonhealing Skin Ulcers. NEJM
356: 1049-1057
[Full Text]
Raue, F., Frank-Raue, K.
(2007). Primary hyperparathyroidism--what the nephrologist should know--an update. Nephrol Dial Transplant
22: 696-699
[Full Text]
Dorsch, O.
(2007). Use of cinacalcet in a patient on long-term dialysis with end-stage renal failure and refractory secondary hyperparathyroidism. Nephrol Dial Transplant
22: 637-640
[Full Text]
Robinson, M. R., Augustine, J. J., Korman, N. J.
(2007). Cinacalcet for the Treatment of Calciphylaxis. Arch Dermatol
143: 152-154
[Full Text]
Achinger, S. G., Ayus, J. C.
(2006). Left Ventricular Hypertrophy: Is Hyperphosphatemia among Dialysis Patients a Risk Factor?. J. Am. Soc. Nephrol.
17: S255-S261
[Abstract][Full Text]
de Francisco, A. L.M., Pinera, C., Palomar, R., Arias, M.
(2006). Impact of Treatment with Calcimimetics on Hyperparathyroidism and Vascular Mineralization. J. Am. Soc. Nephrol.
17: S281-S285
[Abstract][Full Text]
Dennis, V. C, Albertson, G. L
(2006). Doxercalciferol Treatment of Secondary Hyperparathyroidism. The Annals of Pharmacotherapy
40: 1955-1965
[Abstract][Full Text]
Hudson, J. Q
(2006). Secondary Hyperparathyroidism in Chronic Kidney Disease: Focus on Clinical Consequences and Vitamin D Therapies. The Annals of Pharmacotherapy
40: 1584-1593
[Abstract][Full Text]
Velasco, N., MacGregor, M. S., Innes, A., MacKay, I. G.
(2006). Successful treatment of calciphylaxis with cinacalcet--an alternative to parathyroidectomy?. Nephrol Dial Transplant
21: 1999-2004
[Full Text]
Olgaard, K., Lewin, E.
(2006). Can Hyperparathyroid Bone Disease Be Arrested or Reversed?. CJASN
1: 367-373
[Abstract][Full Text]
Arakawa, T., D'Amour, P., Rousseau, L., Brossard, J.-H., Sakai, M., Kasumoto, H., Igaki, N., Goto, T., Cantor, T., Fukagawa, M.
(2006). Overproduction and Secretion of a Novel Amino-Terminal Form of Parathyroid Hormone from a Severe Type of Parathyroid Hyperplasia in Uremia. CJASN
1: 525-531
[Abstract][Full Text]
Schmitt, C. P., Odenwald, T., Ritz, E.
(2006). Calcium, Calcium Regulatory Hormones, and Calcimimetics: Impact on Cardiovascular Mortality. J. Am. Soc. Nephrol.
17: S78-S80
[Abstract][Full Text]
Srinivas, T. R., Schold, J. D., Womer, K. L., Kaplan, B., Howard, R. J., Bucci, C. M., Meier-Kriesche, H.-U.
(2006). Improvement in Hypercalcemia with Cinacalcet after Kidney Transplantation. CJASN
1: 323-326
[Abstract][Full Text]
Chertow, G. M., Blumenthal, S., Turner, S., Roppolo, M., Stern, L., Chi, E. M., Reed, J., on behalf of the CONTROL Investigators,
(2006). Cinacalcet Hydrochloride (Sensipar) in Hemodialysis Patients on Active Vitamin D Derivatives with Controlled PTH and Elevated Calcium x Phosphate. CJASN
1: 305-312
[Abstract][Full Text]
Block, G.
(2006). Calcium, Calcimimetics and Clinical Outcomes. CJASN
1: 170-171
[Full Text]
Odenwald, T., Nakagawa, K., Hadtstein, C., Roesch, F., Gohlke, P., Ritz, E., Schaefer, F., Schmitt, C. P.
(2006). Acute Blood Pressure Effects and Chronic Hypotensive Action of Calcimimetics in Uremic Rats. J. Am. Soc. Nephrol.
17: 655-662
[Abstract][Full Text]
Jindal, K., Chan, C. T., Deziel, C., Hirsch, D., Soroka, S. D., Tonelli, M., Culleton, B. F.
(2006). CHAPTER 3: Mineral Metabolism. J. Am. Soc. Nephrol.
17: S11-S15
[Full Text]
Reichel, H.
(2006). Current treatment options in secondary renal hyperparathyroidism. Nephrol Dial Transplant
21: 23-28
[Full Text]
Levi, R., Ben-Dov, I. Z., Lavi-Moshayoff, V., Dinur, M., Martin, D., Naveh-Many, T., Silver, J.
(2006). Increased Parathyroid Hormone Gene Expression in Secondary Hyperparathyroidism of Experimental Uremia Is Reversed by Calcimimetics: Correlation with Posttranslational Modification of the Trans Acting Factor AUF1. J. Am. Soc. Nephrol.
17: 107-112
[Abstract][Full Text]
Wess, J.
(2005). Allosteric Binding Sites on Muscarinic Acetylcholine Receptors. Mol. Pharmacol.
68: 1506-1509
[Abstract][Full Text]
Silve, C., Petrel, C., Leroy, C., Bruel, H., Mallet, E., Rognan, D., Ruat, M.
(2005). Delineating a Ca2+ Binding Pocket within the Venus Flytrap Module of the Human Calcium-sensing Receptor. J. Biol. Chem.
280: 37917-37923
[Abstract][Full Text]
Qunibi, W. Y.
(2005). Reducing the Burden of Cardiovascular Calcification in Patients with Chronic Kidney Disease. J. Am. Soc. Nephrol.
16: S95-S102
[Abstract][Full Text]
Coladonato, J. A.
(2005). Control of Hyperphosphatemia among Patients with ESRD. J. Am. Soc. Nephrol.
16: S107-S114
[Abstract][Full Text]
Kawata, T., Imanishi, Y., Kobayashi, K., Kenko, T., Wada, M., Ishimura, E., Miki, T., Nagano, N., Inaba, M., Arnold, A., Nishizawa, Y.
(2005). Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism. Eur J Endocrinol
153: 587-594
[Abstract][Full Text]
Moe, S. M., Cunningham, J., Bommer, J., Adler, S., Rosansky, S. J., Urena-Torres, P., Albizem, M. B., Guo, M. D., Zani, V. J., Goodman, W. G., Sprague, S. M.
(2005). Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl. Nephrol Dial Transplant
20: 2186-2193
[Abstract][Full Text]
Kawata, T., Imanishi, Y., Kobayashi, K., Onoda, N., Takemoto, Y., Tahara, H., Okuno, S., Ishimura, E., Miki, T., Ishikawa, T., Inaba, M., Nishizawa, Y.
(2005). Direct in Vitro Evidence of Extracellular Ca2+-Induced Amino-Terminal Truncation of Human Parathyroid Hormone (1-84) by Human Parathyroid Cells. J. Clin. Endocrinol. Metab.
90: 5774-5778
[Abstract][Full Text]
Previous
