FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:1937-1944 May 6, 2004 Number 19 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Saunders, M. I. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Despite the use of resection and postoperative radiotherapy, high-risk squamous-cell carcinoma of the head and neck frequently recurs in the original tumor bed. We tested the hypothesis that concurrent postoperative administration of cisplatin and radiotherapy would improve the rate of local and regional control.

Methods Between September 9, 1995, and April 28, 2000, 459 patients were enrolled. After undergoing total resection of all visible and palpable disease, 231 patients were randomly assigned to receive radiotherapy alone (60 to 66 Gy in 30 to 33 fractions over a period of 6 to 6.6 weeks) and 228 patients to receive the identical treatment plus concurrent cisplatin (100 mg per square meter of body-surface area intravenously on days 1, 22, and 43).

Results After a median follow-up of 45.9 months, the rate of local and regional control was significantly higher in the combined-therapy group than in the group given radiotherapy alone (hazard ratio for local or regional recurrence, 0.61; 95 percent confidence interval, 0.41 to 0.91; P=0.01). The estimated two-year rate of local and regional control was 82 percent in the combined-therapy group, as compared with 72 percent in the radiotherapy group. Disease-free survival was significantly longer in the combined-therapy group than in the radiotherapy group (hazard ratio for disease or death, 0.78; 95 percent confidence interval, 0.61 to 0.99; P=0.04), but overall survival was not (hazard ratio for death, 0.84; 95 percent confidence interval, 0.65 to 1.09; P=0.19). The incidence of acute adverse effects of grade 3 or greater was 34 percent in the radiotherapy group and 77 percent in the combined-therapy group (P<0.001). Four patients who received combined therapy died as a direct result of the treatment.

Conclusions Among high-risk patients with resected head and neck cancer, concurrent postoperative chemotherapy and radiotherapy significantly improve the rates of local and regional control and disease-free survival. However, the combined treatment is associated with a substantial increase in adverse effects.

Source Information

From New York University Medical Center, New York (J.S.C.); Radiation Therapy Oncology Group Headquarters, Philadelphia (T.F.P.); Johns Hopkins Oncology Center, Baltimore (A.A.F.); Wayne State University School of Medicine, Detroit (J.J., H.E.K., J.F.E.); Medical College of Wisconsin, Milwaukee (B.H.C., C.J.S.); National Cancer Institute, Bethesda, Md. (S.B.S.); H. Lee Moffitt Cancer Center, Tampa, Fla. (J.A.K.); Vanderbilt Cancer Center, Nashville (A.J.C.); State University of New York Health Center at Brooklyn, Brooklyn (M.R.); University of Pennsylvania Health System, Philadelphia (M.M.); Mallinckrodt Institute of Radiology, St. Louis (K.S.C.C.); and the University of California, San Francisco, San Francisco (N.L., K.K.F.).

Full Text of this Article

Related Letters:

Treatment of Advanced Head and Neck Cancer
Fortin A., Audet N., Caouette R., Yalçn B., Büyükçelik A., Utkan G., Sonpavde G., Cooper J. S., Forastiere A. A., Jacobs J., Bernier J., the European Organization for Research and Treatment of Cancer
Extract | Full Text | PDF  
N Engl J Med 2004; 351:829-831, Aug 19, 2004. Correspondence

This article has been cited by other articles:

• Schoder, H., Fury, M., Lee, N., Kraus, D. (2009). PET Monitoring of Therapy Response in Head and Neck Squamous Cell Carcinoma. JNM 50: 74S-88S [Abstract] [Full Text]  
• Licitra, L., Felip, E., On behalf of the ESMO Guidelines Working Group, (2009). Squamous cell carcinoma of the head and neck: ESMO Clinical Recommendations for diagnosis, treatment and follow-up. Ann Oncol 20: iv121-iv122 [Full Text]  
• Sak, A., Grehl, S., Engelhard, M., Wierlemann, A., Kaelberlah, H.-P., Erichsen, P., Pottgen, C., Groneberg, M., Stuschke, M. (2009). Long-Term In vivo Effects of Cisplatin on {gamma}-H2AX Foci Signaling in Peripheral Lymphocytes of Tumor Patients After Irradiation. Clin. Cancer Res. 15: 2927-2934 [Abstract] [Full Text]  
• Ando, M., Asai, M., Asakage, T., Oyama, W., Saikawa, M., Yamazaki, M., Miyazaki, M., Ugumori, T., Daiko, H., Hayashi, R. (2009). Metastatic Neck Disease Beyond the Limits of a Neck Dissection: Attention to the 'Para-hyoid' Area in T1/2 Oral Tongue Cancer. Jpn J Clin Oncol 39: 231-236 [Abstract] [Full Text]  
• El-Deiry, M. W., Futran, N. D., McDowell, J. A., Weymuller, E. A. Jr, Yueh, B. (2009). Influences and Predictors of Long-term Quality of Life in Head and Neck Cancer Survivors. Arch Otolaryngol Head Neck Surg 135: 380-384 [Abstract] [Full Text]  
• Harrington, K. J., El-Hariry, I. A., Holford, C. S., Lusinchi, A., Nutting, C. M., Rosine, D., Tanay, M., Deutsch, E., Matthews, J., D'Ambrosio, C., Turner, S. J., Pandeshwara, J. S., Bourhis, J. (2009). Phase I Study of Lapatinib in Combination With Chemoradiation in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck. JCO 27: 1100-1107 [Abstract] [Full Text]  
• Liao, C.-T., Huang, S.-F., Chen, I-H., Chang, J. T.-C., Wang, H.-M., Ng, S.-H., Hsueh, C., Lee, L.-Y., Lin, C.-H., Cheng, A.-J., Yen, T.-C. (2009). Risk Stratification of Patients with Oral Cavity Squamous Cell Carcinoma and Contralateral Neck Recurrence Following Radical Surgery. Ann. Surg. Oncol. 16: 159-170 [Abstract] [Full Text]  
• Smith, G. L., Smith, B. D., Buchholz, T. A., Giordano, S. H., Garden, A. S., Woodward, W. A., Krumholz, H. M., Weber, R. S., Ang, K.-K., Rosenthal, D. I. (2008). Cerebrovascular Disease Risk in Older Head and Neck Cancer Patients After Radiotherapy. JCO 26: 5119-5125 [Abstract] [Full Text]  
• Salama, J. K., Stenson, K. M., List, M. A., Mell, L. K., MacCracken, E., Cohen, E. E., Blair, E., Vokes, E. E., Haraf, D. J. (2008). Characteristics Associated With Swallowing Changes After Concurrent Chemotherapy and Radiotherapy in Patients With Head and Neck Cancer. Arch Otolaryngol Head Neck Surg 134: 1060-1065 [Abstract] [Full Text]  
• Schumaker, L., Nikitakis, N., Goloubeva, O., Tan, M., Taylor, R., Cullen, K. J. (2008). Elevated Expression of Glutathione S-Transferase {pi} and p53 Confers Poor Prognosis in Head and Neck Cancer Patients Treated with Chemoradiotherapy but not Radiotherapy Alone. Clin. Cancer Res. 14: 5877-5883 [Abstract] [Full Text]  
• Haddad, R. I., Shin, D. M. (2008). Recent Advances in Head and Neck Cancer. NEJM 359: 1143-1154 [Full Text]  
• Lai, K.-C., Chang, K.-W., Liu, C.-J., Kao, S.-Y., Lee, T.-C. (2008). IFN-Induced Protein with Tetratricopeptide Repeats 2 Inhibits Migration Activity and Increases Survival of Oral Squamous Cell Carcinoma. Mol Cancer Res 6: 1431-1439 [Abstract] [Full Text]  
• Knab, B. R., Salama, J. K., Solanki, A., Stenson, K. M., Cohen, E. E., Witt, M. E., Haraf, D. J., Vokes, E. E. (2008). Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma. Ann Oncol 19: 1650-1654 [Abstract] [Full Text]  
• Ang, K. K. (2008). Multidisciplinary Management of Locally Advanced SCCHN: Optimizing Treatment Outcomes. The Oncologist 13: 899-910 [Abstract] [Full Text]  
• Russo, G., Haddad, R., Posner, M., Machtay, M. (2008). Radiation Treatment Breaks and Ulcerative Mucositis in Head and Neck Cancer. The Oncologist 13: 886-898 [Abstract] [Full Text]  
• Worden, F. P., Kumar, B., Lee, J. S., Wolf, G. T., Cordell, K. G., Taylor, J. M.G., Urba, S. G., Eisbruch, A., Teknos, T. N., Chepeha, D. B., Prince, M. E., Tsien, C. I., D'Silva, N. J., Yang, K., Kurnit, D. M., Mason, H. L., Miller, T. H., Wallace, N. E., Bradford, C. R., Carey, T. E. (2008). Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number. JCO 26: 3138-3146 [Abstract] [Full Text]  
• Yoo, G. H., Subramanian, G., Piechocki, M. P., Ensley, J. F., Kucuk, O., Tulunay, O. E., Lonardo, F., Kim, H., Won, J., Stevens, T., Lin, H.-S. (2008). Effect of Docetaxel on the Surgical Tumor Microenvironment of Head and Neck Cancer in Murine Models. Arch Otolaryngol Head Neck Surg 134: 735-742 [Abstract] [Full Text]  
• Wang, S. X., Bao, A., Herrera, S. J., Phillips, W. T., Goins, B., Santoyo, C., Miller, F. R., Otto, R. A. (2008). Intraoperative 186Re-Liposome Radionuclide Therapy in a Head and Neck Squamous Cell Carcinoma Xenograft Positive Surgical Margin Model. Clin. Cancer Res. 14: 3975-3983 [Abstract] [Full Text]  
• Goldstein, N. E., Genden, E., Morrison, R. S. (2008). Palliative Care for Patients With Head and Neck Cancer: "I Would Like a Quick Return to a Normal Lifestyle". JAMA 299: 1818-1825 [Abstract] [Full Text]  
• Wang, J., Seethala, R. R., Zhang, Q., Gooding, W., van Waes, C., Hasegawa, H., Ferris, R. L. (2008). Autocrine and Paracrine Chemokine Receptor 7 Activation in Head and Neck Cancer: Implications for Therapy. JNCI J Natl Cancer Inst 100: 502-512 [Abstract] [Full Text]  
• Marur, S., Forastiere, A. A. (2008). Head and Neck Cancer: Changing Epidemiology, Diagnosis, and Treatment. Mayo Clin Proc. 83: 489-501 [Abstract] [Full Text]  
• Choi, S., Myers, J.N. (2008). Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy. JDR 87: 14-32 [Abstract] [Full Text]  
• Choong, N., Vokes, E. (2008). Expanding Role of the Medical Oncologist in the Management of Head and Neck Cancer. CA Cancer J Clin 58: 32-53 [Abstract] [Full Text]  
• Kies, M. S., Blumenschein, G. R. Jr., Rosenthal, D. I. (2008). Sequential Chemoradiation for Squamous Cell Carcinoma of the Head and Neck. Am Soc Clin Oncol Ed Book 2008: 235-238 [Abstract] [Full Text]  
• Weinstein, G. S., O'Malley, B. W. Jr, Snyder, W., Sherman, E., Quon, H. (2007). Transoral Robotic Surgery: Radical Tonsillectomy. Arch Otolaryngol Head Neck Surg 133: 1220-1226 [Abstract] [Full Text]  
• Patel, R. S., Clark, J., Wyten, R., Gao, K., O'Brien, C. J. (2007). Squamous Cell Carcinoma From an Unknown Head and Neck Primary Site: A "Selective Treatment" Approach. Arch Otolaryngol Head Neck Surg 133: 1282-1287 [Abstract] [Full Text]  
• Posner, M. R., Hershock, D. M., Blajman, C. R., Mickiewicz, E., Winquist, E., Gorbounova, V., Tjulandin, S., Shin, D. M., Cullen, K., Ervin, T. J., Murphy, B. A., Raez, L. E., Cohen, R. B., Spaulding, M., Tishler, R. B., Roth, B., Viroglio, R. d. C., Venkatesan, V., Romanov, I., Agarwala, S., Harter, K. W., Dugan, M., Cmelak, A., Markoe, A. M., Read, P. W., Steinbrenner, L., Colevas, A. D., Norris, C. M. Jr., Haddad, R. I., the TAX 324 Study Group, (2007). Cisplatin and Fluorouracil Alone or with Docetaxel in Head and Neck Cancer. NEJM 357: 1705-1715 [Abstract] [Full Text]  
• Zenda, S., Onozawa, Y., Tahara, M., Kawashima, M., Shikama, N., Sasaki, S., Boku, N. (2007). Feasibility Study of Single Agent Cisplatin and Concurrent Radiotherapy in Japanese Patients with Squamous Cell Carcinoma of the Head and Neck: Preliminary Results. Jpn J Clin Oncol 0: hym106v1-5 [Abstract] [Full Text]  
• Salama, J. K., Seiwert, T. Y., Vokes, E. E. (2007). Chemoradiotherapy for Locally Advanced Head and Neck Cancer. JCO 25: 4118-4126 [Full Text]  
• Zuur, C. L., Simis, Y. J., Lansdaal, P. E., Hart, A. A., Schornagel, J. H., Dreschler, W. A., Rasch, C. R., Balm, A. J. (2007). Ototoxicity in a Randomized Phase III Trial of Intra-Arterial Compared With Intravenous Cisplatin Chemoradiation in Patients With Locally Advanced Head and Neck Cancer. JCO 25: 3759-3765 [Abstract] [Full Text]  
• Zenda, S., Onozawa, Y., Boku, N., Iida, Y., Ebihara, M., Onitsuka, T. (2007). Single-agent Docetaxel in Patients with Platinum-refractory Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck (SCCHN). Jpn J Clin Oncol 37: 477-481 [Abstract] [Full Text]  
• Kademani, D. (2007). Oral Cancer. Mayo Clin Proc. 82: 878-887 [Abstract] [Full Text]  
• Epstein, J.B., Elad, S., Eliav, E., Jurevic, R., Benoliel, R. (2007). Orofacial Pain in Cancer: Part II--Clinical Perspectives and Management. JDR 86: 506-518 [Abstract] [Full Text]  
• Allen, A. M., Tishler, R. B. (2007). Commentary: IMRT for Head and Neck Cancer: Many Chapters Left to Write. The Oncologist 12: 565-568 [Abstract] [Full Text]  
• Schuller, D. E., Ozer, E., Agrawal, A., Grecula, J. C., Rhoades, C. A., Young, D. C. (2007). Multimodal Intensification Regimens for Advanced, Resectable, Previously Untreated Squamous Cell Cancer of the Oral Cavity, Oropharynx, or Hypopharynx: A 12-Year Experience. Arch Otolaryngol Head Neck Surg 133: 320-326 [Abstract] [Full Text]  
• Molling, J. W., Langius, J. A.E., Langendijk, J. A., Leemans, C. R., Bontkes, H. J., van der Vliet, H. J.J., von Blomberg, B. M. E., Scheper, R. J., van den Eertwegh, A. J.M. (2007). Low Levels of Circulating Invariant Natural Killer T Cells Predict Poor Clinical Outcome in Patients With Head and Neck Squamous Cell Carcinoma. JCO 25: 862-868 [Abstract] [Full Text]  
• Petrik, D., Lavori, P. W., Cao, H., Zhu, Y., Wong, P., Christofferson, E., Kaplan, M. J., Pinto, H. A., Sutphin, P., Koong, A. C., Giaccia, A. J., Le, Q.-T. (2006). Plasma Osteopontin Is an Independent Prognostic Marker for Head and Neck Cancers. JCO 24: 5291-5297 [Abstract] [Full Text]  
• Yousem, D.M., Gad, K., Tufano, R.P. (2006). Resectability Issues with Head and Neck Cancer. Am. J. Neuroradiol. 27: 2024-2036 [Abstract] [Full Text]  
• Mendenhall, W. M., Hinerman, R. W., Amdur, R. J., Malyapa, R. S., Lansford, C. D., Werning, J. W., Villaret, D. B. (2006). Postoperative radiotherapy for squamous cell carcinoma of the head and neck.. Clin Med Res 4: 200-208 [Abstract] [Full Text]  
• Pfister, D. G., Laurie, S. A., Weinstein, G. S., Mendenhall, W. M., Adelstein, D. J., Ang, K. K., Clayman, G. L., Fisher, S. G., Forastiere, A. A., Harrison, L. B., Lefebvre, J.-L., Leupold, N., List, M. A., O'Malley, B. O., Patel, S., Posner, M. R., Schwartz, M. A., Wolf, G. T. (2006). American Society of Clinical Oncology Clinical Practice Guideline for the Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer. JCO 24: 3693-3704 [Abstract] [Full Text]  
• Cohen, E. E.W., Haraf, D. J., List, M. A., Kocherginsky, M., Mittal, B. B., Rosen, F., Brockstein, B., Williams, R., Witt, M. E., Stenson, K. M., Kies, M. S., Vokes, E. E. (2006). High Survival and Organ Function Rates After Primary Chemoradiotherapy for Intermediate-Stage Squamous Cell Carcinoma of the Head and Neck Treated in a Multicenter Phase II Trial. JCO 24: 3438-3444 [Abstract] [Full Text]  
• Saussez, S., Cucu, D.-R., Decaestecker, C., Chevalier, D., Kaltner, H., Andre, S., Wacreniez, A., Toubeau, G., Camby, I., Gabius, H.-J., Kiss, R. (2006). Galectin 7 (p53-Induced Gene 1): A New Prognostic Predictor of Recurrence and Survival in Stage IV Hypopharyngeal Cancer. Ann. Surg. Oncol. 13: 999-1009 [Abstract] [Full Text]  
• Garavello, W., Ciardo, A., Spreafico, R., Gaini, R. M. (2006). Risk factors for distant metastases in head and neck squamous cell carcinoma.. Arch Otolaryngol Head Neck Surg 132: 762-766 [Abstract] [Full Text]  
• Forastiere, A. A., Trotti, A., Pfister, D. G., Grandis, J. R. (2006). Head and Neck Cancer: Recent Advances and New Standards of Care. JCO 24: 2603-2605 [Full Text]  
• Brizel, D. M., Esclamado, R. (2006). Concurrent Chemoradiotherapy for Locally Advanced, Nonmetastatic, Squamous Carcinoma of the Head and Neck: Consensus, Controversy, and Conundrum. JCO 24: 2612-2617 [Abstract] [Full Text]  
• Adelstein, D. J., LeBlanc, M. (2006). Does Induction Chemotherapy Have a Role in the Management of Locoregionally Advanced Squamous Cell Head and Neck Cancer?. JCO 24: 2624-2628 [Abstract] [Full Text]  
• Bernier, J., Vermorken, J. B., Koch, W. M. (2006). Adjuvant Therapy in Patients With Resected Poor-Risk Head and Neck Cancer. JCO 24: 2629-2635 [Abstract] [Full Text]  
• Wong, S. J., Machtay, M., Li, Y. (2006). Locally Recurrent, Previously Irradiated Head and Neck Cancer: Concurrent Re-Irradiation and Chemotherapy, or Chemotherapy Alone?. JCO 24: 2653-2658 [Abstract] [Full Text]  
• Alkureishi, L. W.T., de Bree, R., Ross, G. L. (2006). RADPLAT: An Alternative to Surgery?. The Oncologist 11: 469-480 [Abstract] [Full Text]  
• Ozer, E., Grecula, J. C., Agrawal, A., Rhoades, C. A., Schuller, D. E. (2006). Intensification regimen for advanced-stage resectable hypopharyngeal carcinoma.. Arch Otolaryngol Head Neck Surg 132: 385-389 [Abstract] [Full Text]  
• Gelbard, A., Garnett, C. T., Abrams, S. I., Patel, V., Gutkind, J. S., Palena, C., Tsang, K.-Y., Schlom, J., Hodge, J. W. (2006). Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis.. Clin. Cancer Res. 12: 1897-1905 [Abstract] [Full Text]  
• Adelstein, D. J., Saxton, J. P., Rybicki, L. A., Esclamado, R. M., Wood, B. G., Strome, M., Lavertu, P., Lorenz, R. R., Carroll, M. A. (2006). Multiagent Concurrent Chemoradiotherapy for Locoregionally Advanced Squamous Cell Head and Neck Cancer: Mature Results From a Single Institution. JCO 24: 1064-1071 [Abstract] [Full Text]  
• Urba, S., Wolf, G., Eisbruch, A., Worden, F., Lee, J., Bradford, C., Teknos, T., Chepeha, D., Prince, M., Hogikyan, N., Taylor, J. (2006). Single-Cycle Induction Chemotherapy Selects Patients With Advanced Laryngeal Cancer for Combined Chemoradiation: A New Treatment Paradigm. JCO 24: 593-598 [Abstract] [Full Text]  
• Pfister, D. G., Ridge, J. A. (2006). Induction Chemotherapy for Larynx Preservation: Patient Selection or Therapeutic Effect?. JCO 24: 540-543 [Full Text]  
• Adelstein, D. J. (2005). Induction Redux: Once More With Taxanes. JCO 23: 8556-8558 [Full Text]  
• El-Deiry, M., Funk, G. F., Nalwa, S., Karnell, L. H., Smith, R. B., Buatti, J. M., Hoffman, H. T., Clamon, G. H., Graham, S. M., Trask, D. K., Dornfeld, K. J., Yao, M. (2005). Long-term Quality of Life for Surgical and Nonsurgical Treatment of Head and Neck Cancer. Arch Otolaryngol Head Neck Surg 131: 879-885 [Abstract] [Full Text]  
• Wee, J., Tan, E. H., Tai, B. C., Wong, H. B., Leong, S. S., Tan, T., Chua, E. T., Yang, E., Lee, K. M., Fong, K. W., Tan, H. S. K., Lee, K. S., Loong, S., Sethi, V., Chua, E. J., Machin, D. (2005). Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety. JCO 23: 6730-6738 [Abstract] [Full Text]  
• Alter, B. P., Joenje, H., Oostra, A. B., Pals, G. (2005). Fanconi Anemia: Adult Head and Neck Cancer and Hematopoietic Mosaicism. Arch Otolaryngol Head Neck Surg 131: 635-639 [Full Text]  
• Yin, X., Zhang, H., Burrows, F., Zhang, L., Shores, C. G. (2005). Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo. Clin. Cancer Res. 11: 3889-3896 [Abstract] [Full Text]  
• Ang, K. K., Harris, J., Garden, A. S., Trotti, A., Jones, C. U., Carrascosa, L., Cheng, J. D., Spencer, S. S., Forastiere, A., Weber, R. S. (2005). Concomitant Boost Radiation Plus Concurrent Cisplatin for Advanced Head and Neck Carcinomas: Radiation Therapy Oncology Group Phase II Trial 99-14. JCO 23: 3008-3015 [Abstract] [Full Text]  
• Roh, J.-L., Kim, A.-Y., Cho, M. J. (2005). Xerostomia Following Radiotherapy of the Head and Neck Affects Vocal Function. JCO 23: 3016-3023 [Abstract] [Full Text]  
• Bucci, M. K., Bevan, A., Roach, M. III (2005). Advances in Radiation Therapy: Conventional to 3D, to IMRT, to 4D, and Beyond. CA Cancer J Clin 55: 117-134 [Abstract] [Full Text]  
• Posner, M. R. (2005). Adjuvant Post-Operative Chemoradiotherapy In Head and Neck Cancer: A Standard Of Care?. The Oncologist 10: 174-175 [Full Text]  
• Lefebvre, J.-L. (2005). Current clinical outcomes demand new treatment options for SCCHN. Ann Oncol 16: vi7-vi12 [Abstract] [Full Text]  
• Harari, P. M. (2005). Promising new advances in head and neck radiotherapy. Ann Oncol 16: vi13-vi19 [Abstract] [Full Text]  
• Vokes, E. (2005). Current treatments and promising investigations in a multidisciplinary setting. Ann Oncol 16: vi25-vi30 [Abstract] [Full Text]  
• Kvols, L. K. (2005). Radiation Sensitizers: A Selective Review of Molecules Targeting DNA and non-DNA Targets. JNM 46: 187S-190S [Abstract] [Full Text]  
• Ang, K. K. (2004). Concurrent Radiation Chemotherapy for Locally Advanced Head and Neck Carcinoma: Are We Addressing Burning Subjects?. JCO 22: 4657-4659 [Full Text]  
• Bradford, C. R. (2004). Selective Neck Dissection Is an Option for Early Node-Positive Disease. Arch Otolaryngol Head Neck Surg 130: 1436-1436 [Full Text]  
• Zorat, P. L., Paccagnella, A., Cavaniglia, G., Loreggian, L., Gava, A., Mione, C. A., Boldrin, F., Marchiori, C., Lunghi, F., Fede, A., Bordin, A., Da Mosto, M. C., Sileni, V. C., Orlando, A., Jirillo, A., Tomio, L., Pappagallo, G. L., Ghi, M. G. (2004). Randomized Phase III Trial of Neoadjuvant Chemotherapy in Head and Neck Cancer: 10-Year Follow-Up. JNCI J Natl Cancer Inst 96: 1714-1717 [Abstract] [Full Text]  
• (2004). Other articles noted. Evid. Based Med. 9: e5-e5 [Full Text]  
• Altundag, O., Altundag, K., Morandi, P., Gunduz, M. (2004). Cyclooxygenase-2 inhibitor and cisplatin combination as a radiosensitizer in the treatment of head and neck cancer patients. Ann Oncol 15: 1444-1445 [Full Text]  
• Fortin, A., Audet, N., Caouette, R., Yalcyn, B., Buyukcelik, A., Utkan, G., Sonpavde, G., Cooper, J. S., Forastiere, A. A., Jacobs, J., Bernier, J., the European Organization for Research and Treatme, (2004). Treatment of Advanced Head and Neck Cancer. NEJM 351: 829-831 [Full Text]  
• Bernier, J., Domenge, C., Ozsahin, M., Matuszewska, K., Lefebvre, J.-L., Greiner, R. H., Giralt, J., Maingon, P., Rolland, F., Bolla, M., Cognetti, F., Bourhis, J., Kirkpatrick, A., van Glabbeke, M., the European Organization for Research and Treatme, (2004). Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer. NEJM 350: 1945-1952 [Abstract] [Full Text]  
• Saunders, M. I., Rojas, A. M. (2004). Management of Cancer of the Head and Neck -- A Cocktail with Your PORT?. NEJM 350: 1997-1999 [Full Text]