FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:239-248 January 15, 2004 Number 3 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Parsonnet, J. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Immunoproliferative small intestinal disease (also known as alpha chain disease) is a form of lymphoma that arises in small intestinal mucosa-associated lymphoid tissue (MALT) and is associated with the expression of a monotypic truncated immunoglobulin heavy chain without an associated light chain. Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent.

Methods We performed polymerase chain reaction (PCR), DNA sequencing, fluorescence in situ hybridization, and immunohistochemical studies on intestinal-biopsy specimens from a series of patients with immunoproliferative small intestinal disease.

Results Analysis of frozen intestinal tissue obtained from an index patient with immunoproliferative small intestinal disease who had a dramatic response to antibiotics revealed the presence of Campylobacter jejuni. A follow-up retrospective analysis of archival intestinal-biopsy specimens disclosed campylobacter species in four of six additional patients with immunoproliferative small intestinal disease.

Conclusions These results indicate that campylobacter and immunoproliferative small intestinal disease are associated and that C. jejuni should be added to the growing list of human pathogens responsible for immunoproliferative states.

Source Information

From Hôpital Avicenne (M.L., A.M., F.S., J.F., L.G., O.L.), Institut Pasteur (M.L., O.L.), Hôpital Necker (E.A., C.P., P.B.), Conservatoire National des Arts et Métiers (P.P.), Hôpital Saint-Louis (D.B.), and Hôpital Lariboisière (A.L.) — all in Paris; and Washington University School of Medicine, St. Louis (J.I.G.).

Address reprint requests to Dr. Lecuit at the Service des Maladies Infectieuses et Tropicales, Hôpital Necker–Enfants Malades, Université Paris V, 149 rue de Sèvres, 75743 Paris CEDEX 15, France, or at mlecuit{at}pasteur.fr.

Full Text of this Article

Related Letters:

Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni
Peterson M. C., Lecuit M., Suarez F., Lortholary O.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:1685-1686, Apr 15, 2004. Correspondence

This article has been cited by other articles:

• Howard, S. L., Jagannathan, A., Soo, E. C., Hui, J. P. M., Aubry, A. J., Ahmed, I., Karlyshev, A., Kelly, J. F., Jones, M. A., Stevens, M. P., Logan, S. M., Wren, B. W. (2009). Campylobacter jejuni Glycosylation Island Important in Cell Charge, Legionaminic Acid Biosynthesis, and Colonization of Chickens. Infect. Immun. 77: 2544-2556 [Abstract] [Full Text]  
• Purdue, M. P., Lan, Q., Wang, S. S., Kricker, A., Menashe, I., Zheng, T.-Z., Hartge, P., Grulich, A. E., Zhang, Y., Morton, L. M., Vajdic, C. M., Holford, T. R., Severson, R. K., Leaderer, B. P., Cerhan, J. R., Yeager, M., Cozen, W., Jacobs, K., Davis, S., Rothman, N., Chanock, S. J., Chatterjee, N., Armstrong, B. K. (2009). A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. Carcinogenesis 30: 275-281 [Abstract] [Full Text]  
• (2009). Image of the Month--Diagnosis. Arch Surg 144: 88-88 [Full Text]  
• Tuomisto, A., Sund, M., Tahkola, J., Latvanlehto, A., Savolainen, E.-R., Autio-Harmainen, H., Liakka, A., Sormunen, R., Vuoristo, J., West, A., Lahesmaa, R., Morse, H. C. III, Pihlajaniemi, T. (2008). A Mutant Collagen XIII Alters Intestinal Expression of Immune Response Genes and Predisposes Transgenic Mice to Develop B-Cell Lymphomas. Cancer Res. 68: 10324-10332 [Abstract] [Full Text]  
• Jaffe, E. S., Harris, N. L., Stein, H., Isaacson, P. G. (2008). Classification of lymphoid neoplasms: the microscope as a tool for disease discovery. Blood 112: 4384-4399 [Abstract] [Full Text]  
• Tu, Q. V., McGuckin, M. A., Mendz, G. L. (2008). Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. J Med Microbiol 57: 795-802 [Abstract] [Full Text]  
• Koubaa Mahjoub, W., Chaumette-Planckaert, M.-T., Penas, E. M. M., Dierlamm, J., Leroy, K., Delfau, M.-H., Loriau, J., Gaulard, P., Delchier, J.-C., Zafrani, E.-S., Copie-Bergman, C. (2008). Primary Hepatic Lymphoma of Mucosa-Associated Lymphoid Tissue Type: A Case Report With Cytogenetic Study. INT J SURG PATHOL 16: 301-307 [Abstract]  
• Schollkopf, C., Melbye, M., Munksgaard, L., Smedby, K. E., Rostgaard, K., Glimelius, B., Chang, E. T., Roos, G., Hansen, M., Adami, H.-O., Hjalgrim, H. (2008). Borrelia infection and risk of non-Hodgkin lymphoma. Blood 111: 5524-5529 [Abstract] [Full Text]  
• Munshi, N. C., Digumarthy, S., Rahemtullah, A. (2008). Case 13-2008 -- A 46-Year-Old Man with Rheumatoid Arthritis and Lymphadenopathy. NEJM 358: 1838-1848 [Full Text]  
• Ekstrom Smedby, K., Vajdic, C. M., Falster, M., Engels, E. A., Martinez-Maza, O., Turner, J., Hjalgrim, H., Vineis, P., Seniori Costantini, A., Bracci, P. M., Holly, E. A., Willett, E., Spinelli, J. J., La Vecchia, C., Zheng, T., Becker, N., De Sanjose, S., Chiu, B. C.-H., Dal Maso, L., Cocco, P., Maynadie, M., Foretova, L., Staines, A., Brennan, P., Davis, S., Severson, R., Cerhan, J. R., Breen, E. C., Birmann, B., Grulich, A. E., Cozen, W. (2008). Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood 111: 4029-4038 [Abstract] [Full Text]  
• Cohen, V. M L, Sweetenham, J., Singh, A. D (2008). Ocular adnexal lymphoma. What is the evidence for an infectious aetiology?. Br J Ophthalmol 92: 446-448 [Full Text]  
• Oh, D.-E., Kim, Y.-D. (2007). Lymphoproliferative Diseases of the Ocular Adnexa in Korea. Arch Ophthalmol 125: 1668-1673 [Abstract] [Full Text]  
• Bacon, C. M, Du, M.-Q., Dogan, A. (2007). Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists. J. Clin. Pathol. 60: 361-372 [Abstract] [Full Text]  
• Engels, E. A. (2007). Infectious Agents as Causes of Non-Hodgkin Lymphoma. Cancer Epidemiol. Biomarkers Prev. 16: 401-404 [Abstract] [Full Text]  
• Arcaini, L, Burcheri, S, Rossi, A, Paulli, M, Bruno, R, Passamonti, F, Brusamolino, E, Molteni, A, Pulsoni, A, Cox, M., Orsucci, L, Fabbri, A, Frezzato, M, Voso, M., Zaja, F, Montanari, F, Merli, M, Pascutto, C, Morra, E, Cortelazzo, S, Lazzarino, M (2007). Prevalence of HCV infection in nongastric marginal zone B-cell lymphoma of MALT. Ann Oncol 18: 346-350 [Abstract] [Full Text]  
• Chen, M. L., Ge, Z., Fox, J. G., Schauer, D. B. (2006). Disruption of Tight Junctions and Induction of Proinflammatory Cytokine Responses in Colonic Epithelial Cells by Campylobacter jejuni. Infect. Immun. 74: 6581-6589 [Abstract] [Full Text]  
• Ramakrishna, B S, Venkataraman, S, Mukhopadhya, A (2006). Tropical malabsorption. Postgrad. Med. J. 82: 779-787 [Abstract] [Full Text]  
• Smedby, K. E., Baecklund, E., Askling, J. (2006). Malignant Lymphomas in Autoimmunity and Inflammation: A Review of Risks, Risk Factors, and Lymphoma Characteristics.. Cancer Epidemiol. Biomarkers Prev. 15: 2069-2077 [Abstract] [Full Text]  
• Serra, S, Jani, P A (2006). An approach to duodenal biopsies. J. Clin. Pathol. 59: 1133-1150 [Abstract] [Full Text]  
• Cohen, S. M., Petryk, M., Varma, M., Kozuch, P. S., Ames, E. D., Grossbard, M. L. (2006). Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue. The Oncologist 11: 1100-1117 [Abstract] [Full Text]  
• Zucca, E., Bertoni, F. (2006). Chlamydia or not Chlamydia, that is the question: which is the microorganism associated with MALT lymphomas of the ocular adnexa?. JNCI J Natl Cancer Inst 98: 1348-1349 [Full Text]  
• Raderer, M, Streubel, B, Wohrer, S, Hafner, M, Chott, A (2006). Successful antibiotic treatment of Helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphomas. Gut 55: 616-618 [Abstract] [Full Text]  
• Suarez, F., Lortholary, O., Hermine, O., Lecuit, M. (2006). Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation. Blood 107: 3034-3044 [Abstract] [Full Text]  
• Grunberger, B., Hauff, W., Lukas, J., Wohrer, S., Zielinski, C. C., Streubel, B., Chott, A., Raderer, M. (2006). 'Blind' antibiotic treatment targeting Chlamydia is not effective in patients with MALT lymphoma of the ocular adnexa. Ann Oncol 17: 484-487 [Abstract] [Full Text]  
• Schottenfeld, D., Beebe-Dimmer, J. (2006). Chronic inflammation: a common and important factor in the pathogenesis of neoplasia.. CA Cancer J Clin 56: 69-83 [Abstract] [Full Text]  
• Ha, C. S., Medeiros, L. J., Charnsangavej, C., Crump, M., Gospodarowicz, M. K. (2006). Oncodiagnosis Panel: 2004: Lymphoma. RadioGraphics 26: 607-620 [Full Text]  
• Rosado, M. F., Byrne, G. E. Jr, Ding, F., Fields, K. A., Ruiz, P., Dubovy, S. R., Walker, G. R., Markoe, A., Lossos, I. S. (2006). Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci. Blood 107: 467-472 [Abstract] [Full Text]  
• Nambiar, P. R., Kirchain, S. M., Courmier, K., Xu, S., Taylor, N. S., Theve, E. J., Patterson, M. M., Fox, J. G. (2006). Progressive Proliferative and Dysplastic Typhlocolitis in Aging Syrian Hamsters Naturally Infected with Helicobacter spp.: A Spontaneous Model of Inflammatory Bowel Disease. Vet Pathol 43: 2-14 [Abstract] [Full Text]  
• Rivoal, K., Ragimbeau, C., Salvat, G., Colin, P., Ermel, G. (2005). Genomic Diversity of Campylobacter coli and Campylobacter jejuni Isolates Recovered from Free-Range Broiler Farms and Comparison with Isolates of Various Origins. Appl. Environ. Microbiol. 71: 6216-6227 [Abstract] [Full Text]  
• Bertoni, F., Zucca, E. (2005). State-of-the-Art Therapeutics: Marginal-Zone Lymphoma. JCO 23: 6415-6420 [Abstract] [Full Text]  
• Schmidt-Ott, R., Brass, F., Scholz, C., Werner, C., Gross, U. (2005). Improved serodiagnosis of Campylobacter jejuni infections using recombinant antigens. J Med Microbiol 54: 761-767 [Abstract] [Full Text]  
• Ferreri, A. J.M., Ponzoni, M., Guidoboni, M., De Conciliis, C., Resti, A. G., Mazzi, B., Lettini, A. A., Demeter, J., Dell'Oro, S., Doglioni, C., Villa, E., Boiocchi, M., Dolcetti, R. (2005). Regression of Ocular Adnexal Lymphoma After Chlamydia Psittaci-Eradicating Antibiotic Therapy. JCO 23: 5067-5073 [Abstract] [Full Text]  
• Ge, Z., Feng, Y., Whary, M. T., Nambiar, P. R., Xu, S., Ng, V., Taylor, N. S., Fox, J. G. (2005). Cytolethal Distending Toxin Is Essential for Helicobacter hepaticus Colonization in Outbred Swiss Webster Mice. Infect. Immun. 73: 3559-3567 [Abstract] [Full Text]  
• Bende, R. J., Aarts, W. M., Riedl, R. G., de Jong, D., Pals, S. T., van Noesel, C. J.M. (2005). Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. JEM 201: 1229-1241 [Abstract] [Full Text]  
• Ho, L., Davis, R. E., Conne, B., Chappuis, R., Berczy, M., Mhawech, P., Staudt, L. M., Schwaller, J. (2005). MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-{kappa}B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells. Blood 105: 2891-2899 [Abstract] [Full Text]  
• Al-Saleem, T., Al-Mondhiry, H. (2005). Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. Blood 105: 2274-2280 [Abstract] [Full Text]  
• Thieblemont, C. (2005). Clinical Presentation and Management of Marginal Zone Lymphomas. ASH Education Book 2005: 307-313 [Abstract] [Full Text]  
• Jaffe, E. S. (2004). Common Threads of Mucosa-Associated Lymphoid Tissue Lymphoma Pathogenesis: From Infection to Translocation. JNCI J Natl Cancer Inst 96: 571-573 [Full Text]  
• Peterson, M. C., Lecuit, M., Suarez, F., Lortholary, O. (2004). Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni. NEJM 350: 1685-1686 [Full Text]