Background On the basis of a previous meta-analysis, the InternationalAdjuvant Lung Cancer Trial was designed to evaluate the effectof cisplatin-based adjuvant chemotherapy on survival after completeresection of non–small-cell lung cancer.
Methods We randomly assigned patients either to three or fourcycles of cisplatin-based chemotherapy or to observation. Beforerandomization, each center determined the pathological stagesto include, its policy for chemotherapy (the dose of cisplatinand the drug to be combined with cisplatin), and its postoperativeradiotherapy policy. The main end point was overall survival.
The writing committee for the International Adjuvant Lung Cancer Trial (IALT) (Rodrigo Arriagada, M.D., Instituto de Radiomedicina, Santiago, Chile; Bengt Bergman, M.D., Sahlgrenska Hospital, Göteborg, Sweden; Ariane Dunant, M.S., Thierry Le Chevalier, M.D., and Jean-Pierre Pignon, M.D., Ph.D., Institut Gustave-Roussy, Villejuif, France; and Johan Vansteenkiste, M.D., Ph.D., University Hospital Gasthuisberg, Leuven, Belgium) takes responsibility for the content of this article.
Address reprint requests to the IALT Secretariat, Department of Biostatistics and Epidemiology, Institut Gustave-Roussy, 94805 Villejuif, France.
Adjuvant Chemotherapy for Lung Cancer
Ikhlaque N., Baumann M. A., Büyükçelik A., Utkan G., Yalçin B., Feliu J., Espinosa E., Sánchez J. J., Sauter C., Morgan G. W., Dunant A., Pignon J.-P., Le Chevalier T.
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N Engl J Med 2004;
350:1681-1683, Apr 15, 2004.
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Ng, R., Hasan, B., Mittmann, N., Florescu, M., Shepherd, F. A., Ding, K., Butts, C. A., Cormier, Y., Darling, G., Goss, G. D., Inculet, R., Seymour, L., Winton, T. L., Evans, W. K., Leighl, N. B.
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Pepe, C., Hasan, B., Winton, T. L., Seymour, L., Graham, B., Livingston, R. B., Johnson, D. H., Rigas, J. R., Ding, K., Shepherd, F. A.
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Petersen, R. P., Pham, D., Burfeind, W. R., Hanish, S. I., Toloza, E. M., Harpole, D. H. Jr, D'Amico, T. A.
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Le Pechoux, C., Dunant, A., Pignon, J.-P., De Ruysscher, D., Mornex, F., Senan, S., Casas, F., Price, A., Milleron, B.
(2007). Need for a New Trial to Evaluate Adjuvant Postoperative Radiotherapy in Non-Small-Cell Lung Cancer Patients With N2 Mediastinal Involvement. JCO
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Otterson, G. A., Villalona-Calero, M. A., Sharma, S., Kris, M. G., Imondi, A., Gerber, M., White, D. A., Ratain, M. J., Schiller, J. H., Sandler, A., Kraut, M., Mani, S., Murren, J. R.
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