Serum Aldosterone and the Incidence of Hypertension in Nonhypertensive Persons
Ramachandran S. Vasan, M.D., Jane C. Evans, D.Sc., Martin G. Larson, Sc.D., Peter W.F. Wilson, M.D., James B. Meigs, M.D., M.P.H., Nader Rifai, Ph.D., Emelia J. Benjamin, M.D., and Daniel Levy, M.D.
Background Primary hyperaldosteronism is a well-recognized causeof secondary hypertension. It is unknown whether serum aldosteronelevels within the physiologic range influence the risk of hypertension.
Methods We investigated the relation of baseline serum aldosteronelevels to increases in blood pressure and the incidence of hypertensionafter four years in 1688 nonhypertensive participants in theFramingham Offspring Study (mean age, 55 years), 58 percentof whom were women. We defined an increase in blood pressureas an increment of at least one blood-pressure category (asdefined by the Joint National Committee on Prevention, Detection,Evaluation, and Treatment of High Blood Pressure) and definedhypertension as a systolic blood pressure of 140 mm Hg or higher,a diastolic blood pressure of 90 mm Hg or higher, or the useof antihypertensive medications.
From the National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass. (R.S.V., J.C.E., M.G.L., E.J.B., D.L.); the Cardiology Section (R.S.V., E.J.B.) and the Department of Preventive Medicine and Epidemiology (R.S.V., J.C.E., M.G.L., E.J.B., D.L.), Boston University School of Medicine, Boston; the Department of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston (P.W.F.W.); the Department of Medicine, Massachusetts General Hospital, Boston (J.B.M.); the Department of Laboratory Medicine, Children's Hospital, Boston (N.R.); and the National Heart, Lung, and Blood Institute, Bethesda, Md. (D.L.).
Address reprint requests to Dr. Vasan at the Framingham Heart Study, 73 Mount Wayte Ave., Suite 2, Framingham, MA 01702-5827, or at vasan{at}bu.edu.
Aldosterone Revisited
Haddy F. J., Kleta R., O'Brien K., Syed A. A., Redfern C. P.F., Weaver J. U., Vasan R. S., Benjamin E. J., Levy D., Dluhy R. G., Williams G. H.
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N Engl J Med 2004;
351:2131-2133, Nov 11, 2004.
Correspondence
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