Docetaxel plus Prednisone or Mitoxantrone plus Prednisone for Advanced Prostate Cancer
Ian F. Tannock, M.D., Ph.D., Ronald de Wit, M.D., William R. Berry, M.D., Jozsef Horti, M.D., Anna Pluzanska, M.D., Kim N. Chi, M.D., Stephane Oudard, M.D., Christine Théodore, M.D., Nicholas D. James, M.D., Ph.D., Ingela Turesson, M.D., Ph.D., Mark A. Rosenthal, M.D., Ph.D., Mario A. Eisenberger, M.D., for the TAX 327 Investigators
Background Mitoxantrone plus prednisone reduces pain and improvesthe quality of life in men with advanced, hormone-refractoryprostate cancer, but it does not improve survival. We comparedsuch treatment with docetaxel plus prednisone in men with thisdisease.
Methods From March 2000 through June 2002, 1006 men with metastatichormone-refractory prostate cancer received 5 mg of prednisonetwice daily and were randomly assigned to receive 12 mg of mitoxantroneper square meter of body-surface area every three weeks, 75mg of docetaxel per square meter every three weeks, or 30 mgof docetaxel per square meter weekly for five of every six weeks.The primary end point was overall survival. Secondary end pointswere pain, prostate-specific antigen (PSA) levels, and the qualityof life. All statistical comparisons were against mitoxantrone.
Results As compared with the men in the mitoxantrone group,men in the group given docetaxel every three weeks had a hazardratio for death of 0.76 (95 percent confidence interval, 0.62to 0.94; P=0.009 by the stratified log-rank test) and thosegiven weekly docetaxel had a hazard ratio for death of 0.91(95 percent confidence interval, 0.75 to 1.11; P=0.36). Themedian survival was 16.5 months in the mitoxantrone group, 18.9months in the group given docetaxel every 3 weeks, and 17.4months in the group given weekly docetaxel. Among these threegroups, 32 percent, 45 percent, and 48 percent of men, respectively,had at least a 50 percent decrease in the serum PSA level (P<0.001for both comparisons with mitoxantrone); 22 percent, 35 percent(P=0.01), and 31 percent (P=0.08) had predefined reductionsin pain; and 13 percent, 22 percent (P=0.009), and 23 percent(P=0.005) had improvements in the quality of life. Adverse eventswere also more common in the groups that received docetaxel.
Conclusions When given with prednisone, treatment with docetaxelevery three weeks led to superior survival and improved ratesof response in terms of pain, serum PSA level, and quality oflife, as compared with mitoxantrone plus prednisone.
Source Information
From the Department of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto (I.F.T.); the Department of Medical Oncology, Erasmus University Medical Centre, Rotterdam, the Netherlands (R.W.); Raleigh Hematology Oncology Associates, Cary, N.C. (W.R.B.); the Department of Chemotherapy and Clinical Pharmacology, National Institute of Oncology, Budapest, Hungary (J.H.); the Department of Chemotherapy, Medical University, Lodz, Poland (A.P.); BC Cancer Agency, Vancouver, B.C., Canada (K.N.C.); Hôpital Européen Georges Pompidou, Paris (S.O.); Institut Gustav Roussy, Villejuif, France (C.T.); Cancer Research UK Institute for Cancer Studies, Birmingham, United Kingdom (N.D.J.); the Section of Oncology, Uppsala University Hospital, Uppsala, Sweden (I.T.); Cancer Trials Australia, Victoria, Australia (M.A.R.); and the Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore (M.A.E.).
Address reprint requests to Dr. Tannock at the Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Ave., Toronto, ON M5G 2M9, Canada, or at ian.tannock{at}uhn.on.ca.
Regan, M. M., O'Donnell, E. K., Kelly, W. K., Halabi, S., Berry, W., Urakami, S., Kikuno, N., Oh, W. K.
(2010). Efficacy of carboplatin-taxane combinations in the management of castration-resistant prostate cancer: a pooled analysis of seven prospective clinical trials. Ann Oncol
21: 312-318
[Abstract][Full Text]
Michels, J., Ellard, S. L., Le, L., Kollmannsberger, C., Murray, N., Tomlinson Guns, E. S., Carr, R., Chi, K. N.
(2010). A phase IB study of ABT-751 in combination with docetaxel in patients with advanced castration-resistant prostate cancer. Ann Oncol
21: 305-311
[Abstract][Full Text]
Sonpavde, G., Periman, P. O., Bernold, D., Weckstein, D., Fleming, M. T., Galsky, M. D., Berry, W. R., Zhan, F., Boehm, K. A., Asmar, L., Hutson, T. E.
(2010). Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy. Ann Oncol
21: 319-324
[Abstract][Full Text]
Hofland, J., van Weerden, W. M., Dits, N. F.J., Steenbergen, J., van Leenders, G. J.L.H., Jenster, G., Schroder, F. H., de Jong, F. H.
(2010). Evidence of Limited Contributions for Intratumoral Steroidogenesis in Prostate Cancer. Cancer Res.
70: 1256-1264
[Abstract][Full Text]
Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S. G., Biswal, S.
(2010). Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth. Molecular Cancer Therapeutics
9: 336-346
[Abstract][Full Text]
Ide, H., Kikuchi, E., Kono, H., Nagata, H., Miyajima, A., Nakagawa, K., Ohigashi, T., Nakashima, J., Oya, M.
(2010). Docetaxel in Combination with Prednisolone for Hormone Refractory Prostate Cancer. Jpn J Clin Oncol
40: 79-84
[Abstract][Full Text]
Molife, L. R., Attard, G., Fong, P. C., Karavasilis, V., Reid, A. H. M., Patterson, S., Riggs, C. E. Jr, Higano, C., Stadler, W. M., McCulloch, W., Dearnaley, D., Parker, C., de Bono, J. S.
(2010). Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC). Ann Oncol
21: 109-113
[Abstract][Full Text]
Kohli, M., Tindall, D. J.
(2010). New Developments in the Medical Management of Prostate Cancer. Mayo Clin Proc.
85: 77-86
[Abstract][Full Text]
Armstrong, A. J., Garrett-Mayer, E., de Wit, R., Tannock, I., Eisenberger, M.
(2010). Prediction of Survival following First-Line Chemotherapy in Men with Castration-Resistant Metastatic Prostate Cancer. Clin. Cancer Res.
16: 203-211
[Abstract][Full Text]
Hahn, N. M., Zon, R. T., Yu, M., Ademuyiwa, F. O., Jones, T., Dugan, W., Whalen, C., Shanmugam, R., Skaar, T., Sweeney, C. J.
(2009). A phase II study of pemetrexed as second-line chemotherapy for the treatment of metastatic castrate-resistant prostate cancer (CRPC); Hoosier Oncology Group GU03-67. Ann Oncol
20: 1971-1976
[Abstract][Full Text]
Romanuik, T. L., Ueda, T., Le, N., Haile, S., Yong, T. M.K., Thomson, T., Vessella, R. L., Sadar, M. D.
(2009). Novel Biomarkers for Prostate Cancer Including Noncoding Transcripts. Am. J. Pathol.
175: 2264-2276
[Abstract][Full Text]
Yu, E. Y., Wilding, G., Posadas, E., Gross, M., Culine, S., Massard, C., Morris, M. J., Hudes, G., Calabro, F., Cheng, S., Trudel, G. C., Paliwal, P., Sternberg, C. N.
(2009). Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer. Clin. Cancer Res.
15: 7421-7428
[Abstract][Full Text]
Khasraw, M., Pavlakis, N., McCowatt, S., Underhill, C., Begbie, S., de Souza, P., Boyce, A., Parnis, F., Lim, V., Harvie, R., Marx, G.
(2009). Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol
0: mdp524v1-mdp524
[Abstract][Full Text]
Sternberg, C. N., Petrylak, D. P., Sartor, O., Witjes, J. A., Demkow, T., Ferrero, J.-M., Eymard, J.-C., Falcon, S., Calabro, F., James, N., Bodrogi, I., Harper, P., Wirth, M., Berry, W., Petrone, M. E., McKearn, T. J., Noursalehi, M., George, M., Rozencweig, M.
(2009). Multinational, Double-Blind, Phase III Study of Prednisone and Either Satraplatin or Placebo in Patients With Castrate-Refractory Prostate Cancer Progressing After Prior Chemotherapy: The SPARC Trial. JCO
27: 5431-5438
[Abstract][Full Text]
Gan, L., Chen, S., Wang, Y., Watahiki, A., Bohrer, L., Sun, Z., Wang, Y., Huang, H.
(2009). Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer. Cancer Res.
69: 8386-8394
[Abstract][Full Text]
Zhao, L., Lee, B. Y., Brown, D. A., Molloy, M. P., Marx, G. M., Pavlakis, N., Boyer, M. J., Stockler, M. R., Kaplan, W., Breit, S. N., Sutherland, R. L., Henshall, S. M., Horvath, L. G.
(2009). Identification of Candidate Biomarkers of Therapeutic Response to Docetaxel by Proteomic Profiling. Cancer Res.
69: 7696-7703
[Abstract][Full Text]
Iljin, K., Ketola, K., Vainio, P., Halonen, P., Kohonen, P., Fey, V., Grafstrom, R. C., Perala, M., Kallioniemi, O.
(2009). High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth. Clin. Cancer Res.
15: 6070-6078
[Abstract][Full Text]
Dorff, T. B., Tangen, C. M., Crawford, E. D., Petrylak, D. P., Higano, C. S., Raghavan, D., Quinn, D. I., Vogelzang, N. J., Thompson, I. M.
(2009). Review: Cooperative group trials -- Southwest Oncology Group (SWOG) innovations in advanced prostate cancer. Therapeutic Advances in Medical Oncology
1: 69-77
[Abstract]
Drake, C. G.
(2009). Immunotherapy for Prostate Cancer: Walk, Don't Run. JCO
27: 4035-4037
[Full Text]
SRINIVAS, S., FELDMAN, D.
(2009). A Phase II Trial of Calcitriol and Naproxen in Recurrent Prostate Cancer. Anticancer Res
29: 3605-3610
[Abstract][Full Text]
Fung, A. S., Wu, L., Tannock, I. F.
(2009). Concurrent and Sequential Administration of Chemotherapy and the Mammalian Target of Rapamycin Inhibitor Temsirolimus in Human Cancer Cells and Xenografts. Clin. Cancer Res.
15: 5389-5395
[Abstract][Full Text]
Lee, C. Y. F., Rennie, P. S., Jia, W. W.G.
(2009). MicroRNA Regulation of Oncolytic Herpes Simplex Virus-1 for Selective Killing of Prostate Cancer Cells. Clin. Cancer Res.
15: 5126-5135
[Abstract][Full Text]
Fontana, A., Galli, L., Fioravanti, A., Orlandi, P., Galli, C., Landi, L., Bursi, S., Allegrini, G., Fontana, E., Di Marsico, R., Antonuzzo, A., D'Arcangelo, M., Danesi, R., Del Tacca, M., Falcone, A., Bocci, G.
(2009). Clinical and Pharmacodynamic Evaluation of Metronomic Cyclophosphamide, Celecoxib, and Dexamethasone in Advanced Hormone-refractory Prostate Cancer. Clin. Cancer Res.
15: 4954-4962
[Abstract][Full Text]
Sarker, D., Reid, A. H.M., Yap, T. A., de Bono, J. S.
(2009). Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer. Clin. Cancer Res.
15: 4799-4805
[Abstract][Full Text]
Tu, S.-M., Mathew, P., Wong, F. C., Jones, D., Johnson, M. M., Logothetis, C. J.
(2009). Phase I Study of Concurrent Weekly Docetaxel and Repeated Samarium-153 Lexidronam in Patients With Castration-Resistant Metastatic Prostate Cancer. JCO
27: 3319-3324
[Abstract][Full Text]
Sternberg, C. N., Dumez, H., Van Poppel, H., Skoneczna, I., Sella, A., Daugaard, G., Gil, T., Graham, J., Carpentier, P., Calabro, F., Collette, L., Lacombe, D., for the EORTC Genitourinary Tract Cancer Group,
(2009). Docetaxel plus oblimersen sodium (Bcl-2 antisense oligonucleotide): an EORTC multicenter, randomized phase II study in patients with castration-resistant prostate cancer. Ann Oncol
20: 1264-1269
[Abstract][Full Text]
Rosenberg, J. E., Ryan, C. J., Weinberg, V. K., Smith, D. C., Hussain, M., Beer, T. M., Ryan, C. W., Mathew, P., Pagliaro, L. C., Harzstark, A. L., Sharib, J., Small, E. J.
(2009). Phase I Study of Ixabepilone, Mitoxantrone, and Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Therapy: A Study of the Department of Defense Prostate Cancer Clinical Trials Consortium. JCO
27: 2772-2778
[Abstract][Full Text]
Halabi, S., Vogelzang, N. J., Ou, S.-S., Owzar, K., Archer, L., Small, E. J.
(2009). Progression-Free Survival as a Predictor of Overall Survival in Men With Castrate-Resistant Prostate Cancer. JCO
27: 2766-2771
[Abstract][Full Text]
Sundaram, S., Durairaj, C., Kadam, R., Kompella, U. B.
(2009). Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy. Molecular Cancer Therapeutics
8: 1655-1665
[Abstract][Full Text]
Fizazi, K., Beuzeboc, P., Lumbroso, J., Haddad, V., Massard, C., Gross-Goupil, M., Di Palma, M., Escudier, B., Theodore, C., Loriot, Y., Tournay, E., Bouzy, J., Laplanche, A.
(2009). Phase II Trial of Consolidation Docetaxel and Samarium-153 in Patients With Bone Metastases From Castration-Resistant Prostate Cancer. JCO
27: 2429-2435
[Abstract][Full Text]
Morris, M. J., Pandit-Taskar, N., Carrasquillo, J., Divgi, C. R., Slovin, S., Kelly, W. K., Rathkopf, D., Gignac, G. A., Solit, D., Schwartz, L., Stephenson, R. D., Hong, C., Delacruz, A., Curley, T., Heller, G., Jia, X., O'Donoghue, J., Larson, S., Scher, H. I.
(2009). Phase I Study of Samarium-153 Lexidronam With Docetaxel in Castration-Resistant Metastatic Prostate Cancer. JCO
27: 2436-2442
[Abstract][Full Text]
Sartor, O.
(2009). Radiopharmaceutical and Chemotherapy Combinations in Metastatic Castrate-Resistant Prostate Cancer: A New Beginning?. JCO
27: 2417-2418
[Full Text]
Attar, R. M., Takimoto, C. H., Gottardis, M. M.
(2009). Castration-Resistant Prostate Cancer: Locking Up the Molecular Escape Routes. Clin. Cancer Res.
15: 3251-3255
[Abstract][Full Text]
Dror Michaelson, M., Regan, M. M., Oh, W. K., Kaufman, D. S., Olivier, K., Michaelson, S. Z., Spicer, B., Gurski, C., Kantoff, P. W., Smith, M. R.
(2009). Phase II study of sunitinib in men with advanced prostate cancer. Ann Oncol
20: 913-920
[Abstract][Full Text]
Serrate, C., Loriot, Y., De La Motte Rouge, T., Gross-Goupil, M., Massard, C., Escudier, B., Bossi, A., Fizazi, K.
(2009). Diethylstilbestrol (DES) retains activity and is a reasonable option in patients previously treated with docetaxel for castration-resistant prostate cancer. Ann Oncol
20: 965-965
[Full Text]
Liu, G., Kelly, W. K., Wilding, G., Leopold, L., Brill, K., Somer, B.
(2009). An Open-Label, Multicenter, Phase I/II Study of Single-Agent AT-101 in Men with Castrate-Resistant Prostate Cancer. Clin. Cancer Res.
15: 3172-3176
[Abstract][Full Text]
Horwich, A., Parker, C., Kataja, V., On behalf of the ESMO Guidelines Working Group,
(2009). Prostate cancer: ESMO Clinical Recommendations for diagnosis, treatment and follow-up. Ann Oncol
20: iv76-iv78
[Full Text]
Loriot, Y., Massard, C., Gross-Goupil, M., Di Palma, M., Escudier, B., Bossi, A., Fizazi, K.
(2009). Combining carboplatin and etoposide in docetaxel-pretreated patients with castration-resistant prostate cancer: a prospective study evaluating also neuroendocrine features. Ann Oncol
20: 703-708
[Abstract][Full Text]
Chavin, G., Sheinin, Y., Crispen, P. L., Boorjian, S. A., Roth, T. J., Rangel, L., Blute, M. L., Sebo, T. J., Tindall, D. J., Kwon, E. D., Karnes, R. J.
(2009). Expression of Immunosuppresive B7-H3 Ligand by Hormone-Treated Prostate Cancer Tumors and Metastases. Clin. Cancer Res.
15: 2174-2180
[Abstract][Full Text]
Hussain, A., DiPaola, R. S., Baron, A. D., Higano, C. S., Tchekmedyian, N. S., Johri, A. R.
(2009). Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer. Ann Oncol
20: 492-497
[Abstract][Full Text]
Spitaleri, G., Matei, D. V., Curigliano, G., Detti, S., Verweij, F., Zambito, S., Scardino, E., Rocco, B., Nole, F., Ariu, L., De Pas, T., de Braud, F., De Cobelli, O.
(2009). Phase II trial of estramustine phosphate and oral etoposide in patients with hormone-refractory prostate cancer. Ann Oncol
20: 498-502
[Abstract][Full Text]
Ramachandran, K., Gopisetty, G., Gordian, E., Navarro, L., Hader, C., Reis, I. M., Schulz, W. A., Singal, R.
(2009). Methylation-Mediated Repression of GADD45{alpha} in Prostate Cancer and Its Role as a Potential Therapeutic Target. Cancer Res.
69: 1527-1535
[Abstract][Full Text]
Massard, C., Chauchereau, A., Fizazi, K.
(2009). The quest for the 'bony Grail' of detecting circulating tumour cells in patients with prostate cancer. Ann Oncol
20: 197-199
[Full Text]
PECTASIDES, D., PECTASIDES, E., PAPAXOINIS, G., KOUMARIANOU, A., PSYRRI, A., XIROS, N., TOUNTAS, N., KAMPOSIORAS, K., PAPATSIBAS, G., FLOROS, T., GOUVERIS, P., KARAGEORGOPOULOU, S., ECONOMOPOULOS, T.
(2009). Combination Chemotherapy with Docetaxel, Vinorelbine and Estramustine Phosphate in Metastatic Androgen-resistant Prostate Cancer: A Single Institution Experience. Anticancer Res
29: 769-775
[Abstract][Full Text]
Li, Y., Song, E., Abbas Rizvi, S. M., Power, C. A., Beretov, J., Raja, C., Cozzi, P. J., Morgenstern, A., Apostolidis, C., Allen, B. J., Russell, P. J.
(2009). Inhibition of Micrometastatic Prostate Cancer Cell Spread in Animal Models By 213Bilabeled Multiple Targeted {alpha} Radioimmunoconjugates. Clin. Cancer Res.
15: 865-875
[Abstract][Full Text]
Snoek, R., Cheng, H., Margiotti, K., Wafa, L. A., Wong, C. A., Wong, E. C., Fazli, L., Nelson, C. C., Gleave, M. E., Rennie, P. S.
(2009). In vivo Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors. Clin. Cancer Res.
15: 39-47
[Abstract][Full Text]
Millikan, R. E., Wen, S., Pagliaro, L. C., Brown, M. A., Moomey, B., Do, K.-A., Logothetis, C. J.
(2008). Phase III Trial of Androgen Ablation With or Without Three Cycles of Systemic Chemotherapy for Advanced Prostate Cancer. JCO
26: 5936-5942
[Abstract][Full Text]
Apolo, A. B., Pandit-Taskar, N., Morris, M. J.
(2008). Novel Tracers and Their Development for the Imaging of Metastatic Prostate Cancer. JNM
49: 2031-2041
[Abstract][Full Text]
Heath, E. I., Hillman, D. W., Vaishampayan, U., Sheng, S., Sarkar, F., Harper, F., Gaskins, M., Pitot, H. C., Tan, W., Ivy, S. P., Pili, R., Carducci, M. A., Erlichman, C., Liu, G.
(2008). A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Hormone-Refractory Metastatic Prostate Cancer. Clin. Cancer Res.
14: 7940-7946
[Abstract][Full Text]
Zhang, Y., Linn, D., Liu, Z., Melamed, J., Tavora, F., Young, C. Y., Burger, A. M., Hamburger, A. W.
(2008). EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Molecular Cancer Therapeutics
7: 3176-3186
[Abstract][Full Text]
Berthold, D. R., Pond, G. R., de Wit, R., Eisenberger, M., Tannock, I. F., On behalf of the TAX 327 investigators,
(2008). Survival and PSA response of patients in the TAX 327 study who crossed over to receive docetaxel after mitoxantrone or vice versa. Ann Oncol
19: 1749-1753
[Abstract][Full Text]
Armstrong, A. J., Creel, P., Turnbull, J., Moore, C., Jaffe, T. A., Haley, S., Petros, W., Yenser, S., Gockerman, J. P., Sleep, D., Hurwitz, H., George, D. J.
(2008). A Phase I-II Study of Docetaxel and Atrasentan in Men with Castration-Resistant Metastatic Prostate Cancer. Clin. Cancer Res.
14: 6270-6276
[Abstract][Full Text]
Narita, S., So, A., Ettinger, S., Hayashi, N., Muramaki, M., Fazli, L., Kim, Y., Gleave, M. E.
(2008). GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer. Clin. Cancer Res.
14: 5769-5777
[Abstract][Full Text]
Wilson, C., Wilson, T., Johnston, P. G., Longley, D. B., Waugh, D. J.J.
(2008). Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Molecular Cancer Therapeutics
7: 2649-2661
[Abstract][Full Text]
Gravis, G., Bladou, F., Salem, N., Goncalves, A., Esterni, B., Walz, J., Bagattini, S., Marcy, M., Brunelle, S., Viens, P.
(2008). Results from a monocentric phase II trial of erlotinib in patients with metastatic prostate cancer. Ann Oncol
19: 1624-1628
[Abstract][Full Text]
Haines, I. E., Stanley, R. M.
(2008). Perspective on "Chemotherapy for Advanced Prostate Cancer: 25 Years Later": Is It a Mirage or an Oasis?. JCO
26: 4049-4050
[Full Text]
Salama, J. K., Chmura, S. J., Mehta, N., Yenice, K. M., Stadler, W. M., Vokes, E. E., Haraf, D. J., Hellman, S., Weichselbaum, R. R.
(2008). An Initial Report of a Radiation Dose-Escalation Trial in Patients with One to Five Sites of Metastatic Disease. Clin. Cancer Res.
14: 5255-5259
[Abstract][Full Text]
Zemskova, M., Sahakian, E., Bashkirova, S., Lilly, M.
(2008). The PIM1 Kinase Is a Critical Component of a Survival Pathway Activated by Docetaxel and Promotes Survival of Docetaxel-treated Prostate Cancer Cells. J. Biol. Chem.
283: 20635-20644
[Abstract][Full Text]
Sissung, T. M., Baum, C. E., Deeken, J., Price, D. K., Aragon-Ching, J., Steinberg, S. M., Dahut, W., Sparreboom, A., Figg, W. D.
(2008). ABCB1 Genetic Variation Influences the Toxicity and Clinical Outcome of Patients with Androgen-Independent Prostate Cancer Treated with Docetaxel. Clin. Cancer Res.
14: 4543-4549
[Abstract][Full Text]
Pchejetski, D., Doumerc, N., Golzio, M., Naymark, M., Teissie, J., Kohama, T., Waxman, J., Malavaud, B., Cuvillier, O.
(2008). Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. Molecular Cancer Therapeutics
7: 1836-1845
[Abstract][Full Text]
Thuret, R., Massard, C., Gross-Goupil, M., Escudier, B., Di Palma, M., Bossi, A., de Crevoisier, R., Chauchereau, A., Fizazi, K.
(2008). The postchemotherapy PSA surge syndrome. Ann Oncol
19: 1308-1311
[Abstract][Full Text]
Miller, R. E., Roudier, M., Jones, J., Armstrong, A., Canon, J., Dougall, W. C.
(2008). RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis. Molecular Cancer Therapeutics
7: 2160-2169
[Abstract][Full Text]
Smith, M. R.
(2008). Rapid Testosterone Cycling and Chemotherapy for Prostate Cancer: A Way Forward or Return to the Past?. JCO
26: 2932-2933
[Full Text]
Rathkopf, D., Carducci, M. A., Morris, M. J., Slovin, S. F., Eisenberger, M. A., Pili, R., Denmeade, S. R., Kelsen, M., Curley, T., Halter, M., Collins, C., Fleisher, M., Heller, G., Baker, S. D., Scher, H. I.
(2008). Phase II Trial of Docetaxel With Rapid Androgen Cycling for Progressive Noncastrate Prostate Cancer. JCO
26: 2959-2965
[Abstract][Full Text]
Harrington, S. E., Smith, T. J.
(2008). The Role of Chemotherapy at the End of Life: "When Is Enough, Enough?". JAMA
299: 2667-2678
[Abstract][Full Text]
Maitland, N. J., Collins, A. T.
(2008). Prostate Cancer Stem Cells: A New Target for Therapy. JCO
26: 2862-2870
[Abstract][Full Text]
Hoskin, P.
(2008). Opioids in context: relieving the pain of cancer. The role of comprehensive cancer management. Palliat Med
22: 303-309
[Abstract]
Logothetis, C. J., Millikan, R.
(2008). Chemotherapy for Advanced Prostate Cancer: 25 Years Later. JCO
26: 2423-2424
[Full Text]
Halabi, S., Vogelzang, N. J., Kornblith, A. B., Ou, S.-S., Kantoff, P. W., Dawson, N. A., Small, E. J.
(2008). Pain Predicts Overall Survival in Men With Metastatic Castration-Refractory Prostate Cancer. JCO
26: 2544-2549
[Abstract][Full Text]
Nabhan, C.
(2008). Is Chemotherapy the Standard for Asymptomatic Androgen-Independent Prostate Cancer?. JCO
26: 2413-2414
[Full Text]
Armstrong, A. J., Garrett-Mayer, E. L., Eisenberger, M.
(2008). Re: Adaptive Therapy for Androgen-Independent Prostate Cancer: A Randomized Selection Trial of Four Regimens. JNCI J Natl Cancer Inst
100: 681-682
[Full Text]
Kim, M., Liao, J., Dowling, M. L., Voong, K. R., Parker, S. E., Wang, S., El-Deiry, W. S., Kao, G. D.
(2008). TRAIL Inactivates the Mitotic Checkpoint and Potentiates Death Induced by Microtubule-Targeting Agents in Human Cancer Cells. Cancer Res.
68: 3440-3449
[Abstract][Full Text]
Naito, S., Tsukamoto, T., Koga, H., Harabayashi, T., Sumiyoshi, Y., Hoshi, S., Akaza, H.
(2008). Docetaxel Plus Prednisolone for the Treatment of Metastatic Hormone-refractory Prostate Cancer: A Multicenter Phase II Trial in Japan. Jpn J Clin Oncol
38: 365-372
[Abstract][Full Text]
Galsky, M. D., Eisenberger, M., Moore-Cooper, S., Kelly, W. K., Slovin, S. F., DeLaCruz, A., Lee, Y., Webb, I. J., Scher, H. I.
(2008). Phase I Trial of the Prostate-Specific Membrane Antigen-Directed Immunoconjugate MLN2704 in Patients With Progressive Metastatic Castration-Resistant Prostate Cancer. JCO
26: 2147-2154
[Abstract][Full Text]
Berthold, D. R., Pond, G. R., Roessner, M., de Wit, R., Eisenberger, M., Tannock, a. I. F., on behalf of the TAX-327 investigators,
(2008). Treatment of Hormone-Refractory Prostate Cancer with Docetaxel or Mitoxantrone: Relationships between Prostate-Specific Antigen, Pain, and Quality of Life Response and Survival in the TAX-327 Study. Clin. Cancer Res.
14: 2763-2767
[Abstract][Full Text]
Attia, S., Eickhoff, J., Wilding, G., McNeel, D., Blank, J., Ahuja, H., Jumonville, A., Eastman, M., Shevrin, D., Glode, M., Alberti, D., Staab, M. J., Horvath, D., Straus, J., Marnocha, R., Liu, G.
(2008). Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer. Clin. Cancer Res.
14: 2437-2443
[Abstract][Full Text]
Mimeault, M., Mehta, P. P., Hauke, R., Batra, S. K.
(2008). Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies. Endocr. Rev.
29: 234-252
[Abstract][Full Text]
Chi, K. N., Ellard, S. L., Hotte, S. J., Czaykowski, P., Moore, M., Ruether, J. D., Schell, A. J., Taylor, S., Hansen, C., Gauthier, I., Walsh, W., Seymour, L.
(2008). A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer. Ann Oncol
19: 746-751
[Abstract][Full Text]
Choy, H., Park, C., Yao, M.
(2008). Current Status and Future Prospects for Satraplatin, an Oral Platinum Analogue. Clin. Cancer Res.
14: 1633-1638
[Abstract][Full Text]
Scher, H. I., Halabi, S., Tannock, I., Morris, M., Sternberg, C. N., Carducci, M. A., Eisenberger, M. A., Higano, C., Bubley, G. J., Dreicer, R., Petrylak, D., Kantoff, P., Basch, E., Kelly, W. K., Figg, W. D., Small, E. J., Beer, T. M., Wilding, G., Martin, A., Hussain, M.
(2008). Design and End Points of Clinical Trials for Patients With Progressive Prostate Cancer and Castrate Levels of Testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group. JCO
26: 1148-1159
[Abstract][Full Text]
Howard, D. N, Chambers, C., Cusano, F.
(2008). Efficacy vs. effectiveness -- docetaxel and prednisone in hormone refractory prostate cancer. J Oncol Pharm Pract
14: 45-49
[Abstract]
Hu, H., Li, G.-x., Wang, L., Watts, J., Combs, G. F. Jr., Lu, J.
(2008). Methylseleninic Acid Enhances Taxane Drug Efficacy against Human Prostate Cancer and Down-Regulates Antiapoptotic Proteins Bcl-XL and Survivin. Clin. Cancer Res.
14: 1150-1158
[Abstract][Full Text]