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Previous Volume 351:1838-1848 October 28, 2004 Number 18 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Supplementary Material Perspective by Mukherjee, S. Perspective by Ofri, D. Editorial by Drazen, J. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors.

Methods We conducted a prospective, randomized study comparing the rates of serious medical errors made by interns while they were working according to a traditional schedule with extended (24 hours or more) work shifts every other shift (an "every third night" call schedule) and while they were working according to an intervention schedule that eliminated extended work shifts and reduced the number of hours worked per week. Incidents were identified by means of a multidisciplinary, four-pronged approach that included direct, continuous observation. Two physicians who were unaware of the interns' schedule assignments independently rated each incident.

Results During a total of 2203 patient-days involving 634 admissions, interns made 35.9 percent more serious medical errors during the traditional schedule than during the intervention schedule (136.0 vs. 100.1 per 1000 patient-days, P<0.001), including 56.6 percent more nonintercepted serious errors (P<0.001). The total rate of serious errors on the critical care units was 22.0 percent higher during the traditional schedule than during the intervention schedule (193.2 vs. 158.4 per 1000 patient-days, P<0.001). Interns made 20.8 percent more serious medication errors during the traditional schedule than during the intervention schedule (99.7 vs. 82.5 per 1000 patient-days, P=0.03). Interns also made 5.6 times as many serious diagnostic errors during the traditional schedule as during the intervention schedule (18.6 vs. 3.3 per 1000 patient-days, P<0.001).

Conclusions Interns made substantially more serious medical errors when they worked frequent shifts of 24 hours or more than when they worked shorter shifts. Eliminating extended work shifts and reducing the number of hours interns work per week can reduce serious medical errors in the intensive care unit.

Source Information

From the Divisions of Sleep Medicine (C.P.L., J.W.C., S.W.L., C.A.C.), General Internal Medicine (J.M.R., R.K., E.B., D.W.B.), Infectious Disease (J.T.K.), Pulmonary and Critical Care Medicine (J.W.C., C.M.L.), and Cardiology (P.H.S.) and the Internal Medicine Residency Program (J.T.K.), Department of Medicine, Brigham and Women's Hospital; the Division of Sleep Medicine, Harvard Medical School (C.P.L., J.W.C., S.W.L., C.A.C.); and the Division of General Pediatrics, Department of Medicine, Children's Hospital Boston and Harvard Medical School (C.P.L.) — all in Boston.

Address reprint requests to Dr. Landrigan at the Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115, or at clandrigan{at}rics.bwh.harvard.edu.

Full Text of this Article

Related Letters:

Interns' Work Hours
Pennell N. A., Liu J. F., Mazzini M. J., Harnik I. G., Fessler H. E., Brotman D. J., Dwyer J. P., Cohen M. D., Evans A. T., Landrigan C. P., Lockley S. W., Czeisler C. A., the Harvard Work Hours, Health, and Safety Group
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N Engl J Med 2005; 352:726-728, Feb 17, 2005. Correspondence

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