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Previous Volume 351:2683-2693 December 23, 2004 Number 26 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Solomon, C. G. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown.

Methods The prospective, controlled Swedish Obese Subjects Study involved obese subjects who underwent gastric surgery and contemporaneously matched, conventionally treated obese control subjects. We now report follow-up data for subjects (mean age, 48 years; mean body-mass index, 41) who had been enrolled for at least 2 years (4047 subjects) or 10 years (1703 subjects) before the analysis (January 1, 2004). The follow-up rate for laboratory examinations was 86.6 percent at 2 years and 74.5 percent at 10 years.

Results After two years, the weight had increased by 0.1 percent in the control group and had decreased by 23.4 percent in the surgery group (P<0.001). After 10 years, the weight had increased by 1.6 percent and decreased by 16.1 percent, respectively (P<0.001). Energy intake was lower and the proportion of physically active subjects higher in the surgery group than in the control group throughout the observation period. Two- and 10-year rates of recovery from diabetes, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, hypertension, and hyperuricemia were more favorable in the surgery group than in the control group, whereas recovery from hypercholesterolemia did not differ between the groups. The surgery group had lower 2- and 10-year incidence rates of diabetes, hypertriglyceridemia, and hyperuricemia than the control group; differences between the groups in the incidence of hypercholesterolemia and hypertension were undetectable.

Conclusions As compared with conventional therapy, bariatric surgery appears to be a viable option for the treatment of severe obesity, resulting in long-term weight loss, improved lifestyle, and, except for hypercholesterolemia, amelioration in risk factors that were elevated at baseline.

Source Information

From the Departments of Body Composition and Metabolism (L.S., A.-K.L., B.C., K.N., M.S.) and Anesthesiology (B.L., C.D.S.), Sahlgrenska University Hospital, Göteborg, Nordic University of Public Health (H.W.), Göteborg; the Medical Department, Norra Älvsborgs Läns Hospital, Trollhättan (J.T.); and Börjegatan 10B, Uppsala (S.D.) — all in Sweden; the Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland (M.P.); and Pennington Biomedical Research Center, Louisiana State University, Baton Rouge (C.B.).

Address reprint requests to Dr. Lars Sjöström at SOS Secretariat, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden.

Full Text of this Article

Related Letters:

Long-Term Outcome of Bariatric Surgery
Vlassov V. V., Sjöström L.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:1495-1496, Apr 7, 2005. Correspondence

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