FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 352:1539-1549 April 14, 2005 Number 15 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Jarcho, J. A. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Cardiac resynchronization reduces symptoms and improves left ventricular function in many patients with heart failure due to left ventricular systolic dysfunction and cardiac dyssynchrony. We evaluated its effects on morbidity and mortality.

Methods Patients with New York Heart Association class III or IV heart failure due to left ventricular systolic dysfunction and cardiac dyssynchrony who were receiving standard pharmacologic therapy were randomly assigned to receive medical therapy alone or with cardiac resynchronization. The primary end point was the time to death from any cause or an unplanned hospitalization for a major cardiovascular event. The principal secondary end point was death from any cause.

Results A total of 813 patients were enrolled and followed for a mean of 29.4 months. The primary end point was reached by 159 patients in the cardiac-resynchronization group, as compared with 224 patients in the medical-therapy group (39 percent vs. 55 percent; hazard ratio, 0.63; 95 percent confidence interval, 0.51 to 0.77; P<0.001). There were 82 deaths in the cardiac-resynchronization group, as compared with 120 in the medical-therapy group (20 percent vs. 30 percent; hazard ratio 0.64; 95 percent confidence interval, 0.48 to 0.85; P<0.002). As compared with medical therapy, cardiac resynchronization reduced the interventricular mechanical delay, the end-systolic volume index, and the area of the mitral regurgitant jet; increased the left ventricular ejection fraction; and improved symptoms and the quality of life (P<0.01 for all comparisons).

Conclusions In patients with heart failure and cardiac dyssynchrony, cardiac resynchronization improves symptoms and the quality of life and reduces complications and the risk of death. These benefits are in addition to those afforded by standard pharmacologic therapy. The implantation of a cardiac-resynchronization device should routinely be considered in such patients.

Source Information

From the Department of Cardiology, Castle Hill Hospital, Kingston-upon-Hull, United Kingdom (J.G.F.C.); the Department of Cardiology, Hôpital Pontchaillou, Rennes, France (J.-C.D.); Klinik III für Innere Medizin der Universität zu Köln, Cologne, Germany (E.E.); the University of Birmingham, Edgbaston, United Kingdom (N.F.); Nouvelles Cliniques Nantaises, Nantes, France (D.G.); the Division of Cardiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (L.K.); and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy (L.T.).

This article was published at www.nejm.org on March 7, 2004.

Address reprint requests to Dr. Cleland at the Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, United Kingdom, or at j.g.cleland{at}hull.ac.uk.

Full Text of this Article

Related Letters:

Cardiac-Resynchronization Therapy in Heart Failure
Kirkorian G. A., Burri H., Cleland J. G.F., Daubert J.-C., Tavazzi L., the CARE-HF Study Investigators
Extract | Full Text | PDF  
N Engl J Med 2005; 353:205-206, Jul 14, 2005. Correspondence

This article has been cited by other articles:

• Ding, L., Hua, W., Niu, H., Chen, K., Zhang, S. (2008). Primary prevention of sudden cardiac death using implantable cardioverter defibrillators. Europace 10: 1034-1041 [Abstract] [Full Text]  
• Simantirakis, E. N., Schiza, S. E., Siafakas, N. S., Vardas, P. E. (2008). Sleep-disordered breathing in heart failure and the effect of cardiac resynchronization therapy. Europace 10: 1029-1033 [Abstract] [Full Text]  
• Stanton, T., Hawkins, N. M., Hogg, K. J., Goodfield, N. E.R., Petrie, M. C., McMurray, J. J.V. (2008). How should we optimize cardiac resynchronization therapy?. Eur Heart J 0: ehn380v1-15 [Abstract] [Full Text]  
• Valzania, C., Eriksson, M. J., Boriani, G., Gadler, F. (2008). Cardiac resynchronization therapy during rest and exercise: comparison of two optimization methods. Europace 0: eun216v1-9 [Abstract] [Full Text]  
• Piccini, J. P., Hernandez, A. F., Dai, D., Thomas, K. L., Lewis, W. R., Yancy, C. W., Peterson, E. D., Fonarow, G. C., for the Get With the Guidelines Steering Committee, (2008). Use of Cardiac Resynchronization Therapy in Patients Hospitalized With Heart Failure. Circulation 118: 926-933 [Abstract] [Full Text]  
• Szilagyi, S., Merkely, B., Zima, E., Kutyifa, V., Szucs, G., Fulop, G., Molnar, L., Szabolcs, Z., Geller, L. (2008). Minimal invasive coronary sinus lead reposition technique for the treatment of phrenic nerve stimulation. Europace 0: eun207v1-4 [Abstract] [Full Text]  
• Buck, S., Maass, A. H., Nieuwland, W., Anthonio, R. L., Van Veldhuisen, D. J., Van Gelder, I. C. (2008). Impact of interventricular lead distance and the decrease in septal-to-lateral delay on response to cardiac resynchronization therapy. Europace 0: eun208v1-7 [Abstract] [Full Text]  
• Cleland, J., Freemantle, N., Ghio, S., Fruhwald, F., Shankar, A., Marijanowski, M., Verboven, Y., Tavazzi, L. (2008). Predicting the Long-Term Effects of Cardiac Resynchronization Therapy on Mortality From Baseline Variables and the Early Response: A Report From the CARE-HF (Cardiac Resynchronization in Heart Failure) Trial. J Am Coll Cardiol 52: 438-445 [Abstract] [Full Text]  
• Cleland, J. G F, Tageldien, A., Maarouf, N., Hobson, N. (2008). Patients with heart failure who require an implantable defibrillator should have cardiac resynchronisation routinely. Heart 94: 963-966 [Full Text]  
• Chung, R, Sutton, R, Henein, M Y (2008). Beyond dyssynchrony in cardiac resynchronisation therapy. Heart 94: 991-994 [Abstract] [Full Text]  
• Chang, S-A, Kim, H-K, Lee, H-Y, Choi, S-Y, Koo, B-K, Kim, Y-J, Sohn, D-W, Oh, B-H, Park, Y-B, Choi, Y-S, Kang, H-J, Kim, H-S (2008). Restoration of left ventricular synchronous contraction after acute myocardial infarction by stem cell therapy: new insights into the therapeutic implication of stem cell therapy for acute myocardial infarction. Heart 94: 995-1001 [Abstract] [Full Text]  
• Bordachar, P., Iriart, X., Chabaneix, J., Sacher, F., Lafitte, S., Jais, P., Haissaguerre, M., Clementy, J., Dos Santos, P., Thambo, J.-B. (2008). Presence of ventricular dyssynchrony and haemodynamic impact of right ventricular pacing in adults with repaired Tetralogy of Fallot and right bundle branch block. Europace 10: 967-971 [Abstract] [Full Text]  
• Lim, S. H., Lip, G. Y.H., Sanderson, J. E. (2008). Ventricular optimization of biventricular pacing: a systematic review. Europace 10: 901-906 [Abstract] [Full Text]  
• Gradaus, R, Stuckenborg, V, Loher, A, Kobe, J, Reinke, F, Gunia, S, Vahlhaus, C, Breithardt, G, Bruch, C (2008). Diastolic filling pattern and left ventricular diameter predict response and prognosis after cardiac resynchronisation therapy. Heart 94: 1026-1031 [Abstract] [Full Text]  
• Mullens, W., Abrahams, Z., Francis, G. S., Skouri, H. N., Starling, R. C., Young, J. B., Taylor, D. O., Tang, W.H. W. (2008). Sodium nitroprusside for advanced low-output heart failure.. J Am Coll Cardiol 52: 200-207 [Abstract] [Full Text]  
• Miura, M., Wakayama, Y., Endoh, H., Nakano, M., Sugai, Y., Hirose, M., ter Keurs, H. E., Shimokawa, H. (2008). Spatial non-uniformity of excitation-contraction coupling can enhance arrhythmogenic-delayed afterdepolarizations in rat cardiac muscle. Cardiovasc Res 0: cvn162v2-7 [Abstract] [Full Text]  
• Popovic, Z. B., Thomas, J. D. (2008). In Search of a Holy Grail: Predicting Cardiac Resynchronization Therapy Outcomes by Echocardiography. Circ Cardiovasc Imaging 1: 3-5 [Full Text]  
• Miyazaki, C., Lin, G., Powell, B. D., Espinosa, R. E., Bruce, C. J., Miller, F. A. Jr, Karon, B. L., Rea, R. F., Hayes, D. L., Oh, J. K. (2008). Strain Dyssynchrony Index Correlates With Improvement in Left Ventricular Volume After Cardiac Resynchronization Therapy Better Than Tissue Velocity Dyssynchrony Indexes. Circ Cardiovasc Imaging 1: 14-22 [Abstract] [Full Text]  
• Prinzen, F. W., Auricchio, A. (2008). Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy?: Echocardiography Is Not Useful Before Cardiac Resynchronization Therapy if QRS Duration Is Available. Circ Cardiovasc Imaging 1: 70-78 [Full Text]  
• Abraham, J., Abraham, T. P. (2008). Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy?: Echocardiography Is Useful Before Cardiac Resynchronization Therapy if QRS Duration Is Available. Circ Cardiovasc Imaging 1: 79-85 [Full Text]  
• Fonarow, G. C., Yancy, C. W., Albert, N. M., Curtis, A. B., Stough, W. G., Gheorghiade, M., Heywood, J. T., McBride, M. L., Mehra, M. R., O'Connor, C. M., Reynolds, D., Walsh, M. N. (2008). Heart Failure Care in the Outpatient Cardiology Practice Setting: Findings From IMPROVE HF. Circ Heart Fail 1: 98-106 [Abstract] [Full Text]  
• Gasparini, M., Auricchio, A., Metra, M., Regoli, F., Fantoni, C., Lamp, B., Curnis, A., Vogt, J., Klersy, C., for the Multicentre Longitudinal Observational Stu, (2008). Long-term survival in patients undergoing cardiac resynchronization therapy: the importance of performing atrio-ventricular junction ablation in patients with permanent atrial fibrillation. Eur Heart J 29: 1644-1652 [Abstract] [Full Text]  
• Khadjooi, K, Foley, P W, Chalil, S, Anthony, J, Smith, R E A, Frenneaux, M P, Leyva, F (2008). Long-term effects of cardiac resynchronisation therapy in patients with atrial fibrillation. Heart 94: 879-883 [Abstract] [Full Text]  
• Ferreira, A. M., Adragao, P., Cavaco, D. M., Candeias, R., Morgado, F. B., Santos, K. R., Santos, E., Silva, J. A. (2008). Benefit of cardiac resynchronization therapy in atrial fibrillation patients vs. patients in sinus rhythm: the role of atrioventricular junction ablation. Europace 10: 809-815 [Abstract] [Full Text]  
• Szili-Torok, T., Mihalcz, A., Jordaens, L. (2008). The 'Happy Ending Problem' of cardiac pacing? Cardiac resynchronization therapy for patients with atrial fibrillation and heart failure after atrioventricular junction ablation. Europace 10: 779-781 [Full Text]  
• Jansen, A. H.M., Bracke, F., van Dantzig, J. m., Peels, K. H., Post, J. C., van den Bosch, H. C.M., van Gelder, B., Meijer, A., Korsten, H. H.M., de Vries, J., van Hemel, N. M. (2008). The influence of myocardial scar and dyssynchrony on reverse remodeling in cardiac resynchronization therapy. Eur J Echocardiogr 9: 483-488 [Abstract] [Full Text]  
• Manisty, C. H., Willson, K., Davies, J. E. R., Whinnett, Z. I., Baruah, R., Mebrate, Y., Kanagaratnam, P., Peters, N. S., Hughes, A. D., Mayet, J., Francis, D. P. (2008). Induction of oscillatory ventilation pattern using dynamic modulation of heart rate through a pacemaker. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295: R219-R227 [Abstract] [Full Text]  
• Donal, E., De Place, C., Kervio, G., Bauer, F., Gervais, R., Leclercq, C., Mabo, P., Daubert, J.-C. (2008). Mitral regurgitation in dilated cardiomyopathy: value of both regional left ventricular contractility and dyssynchrony. Eur J Echocardiogr 0: jen188v1-6 [Abstract] [Full Text]  
• Wang, N. C., Maggioni, A. P., Konstam, M. A., Zannad, F., Krasa, H. B., Burnett, J. C. Jr, Grinfeld, L., Swedberg, K., Udelson, J. E., Cook, T., Traver, B., Zimmer, C., Orlandi, C., Gheorghiade, M., for the Efficacy of Vasopressin Antagonism in Hear, (2008). Clinical Implications of QRS Duration in Patients Hospitalized With Worsening Heart Failure and Reduced Left Ventricular Ejection Fraction. JAMA 299: 2656-2666 [Abstract] [Full Text]  
• Sweeney, M. O., Prinzen, F. W. (2008). Ventricular Pump Function and Pacing: Physiological and Clinical Integration. Circ Arrhythmia Electrophysiol 1: 127-139 [Full Text]  
• Di Biase, L., Auricchio, A., Sorgente, A., Civello, K., Klersy, C., Faletra, F., Riedlbauchova, L., Patel, D., Arruda, M., Schweikert, R. A., Martin, D. O., Saliba, W. I., Moccetti, T., Wilkoff, B. L., Natale, A. (2008). The magnitude of reverse remodelling irrespective of aetiology predicts outcome of heart failure patients treated with cardiac resynchronization therapy. Eur Heart J 0: ehn221v1-9 [Abstract] [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol 51: e1-e62 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Mark Estes, N.A. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol 51: 2085-2105 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117: 2820-2840 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117: e350-e408 [Full Text]  
• Chung, E. S., Leon, A. R., Tavazzi, L., Sun, J.-P., Nihoyannopoulos, P., Merlino, J., Abraham, W. T., Ghio, S., Leclercq, C., Bax, J. J., Yu, C.-M., Gorcsan, J. III, St John Sutton, M., De Sutter, J., Murillo, J. (2008). Results of the Predictors of Response to CRT (PROSPECT) Trial. Circulation 117: 2608-2616 [Abstract] [Full Text]  
• Miyazaki, C., Powell, B. D., Bruce, C. J., Espinosa, R. E., Redfield, M. M., Miller, F. A., Hayes, D. L., Cha, Y.-M., Oh, J. K. (2008). Comparison of Echocardiographic Dyssynchrony Assessment by Tissue Velocity and Strain Imaging in Subjects With or Without Systolic Dysfunction and With or Without Left Bundle-Branch Block. Circulation 117: 2617-2625 [Abstract] [Full Text]  
• Eisen, H. J. (2008). Exercise Training and Myocardial Energetics in Patients With Heart Failure: When More Is Less. J Am Coll Cardiol 51: 1892-1895 [Full Text]  
• Lahiri, M. K., Kannankeril, P. J., Goldberger, J. J. (2008). Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications.. J Am Coll Cardiol 51: 1725-1733 [Abstract] [Full Text]  
• MacDonald, M.R., Hawkins, N.M., Balmain, S., Dalzell, J., McMurray, J.J.V., Petrie, M.C. (2008). Transthoracic echocardiography: a survey of current practice in the UK. QJM 101: 345-349 [Abstract] [Full Text]  
• Buck, S., Rienstra, M., Maass, A. H., Nieuwland, W., Van Veldhuisen, D. J., Van Gelder, I. C. (2008). Cardiac resynchronization therapy in patients with heart failure and atrial fibrillation: importance of new-onset atrial fibrillation and total atrial conduction time. Europace 10: 558-565 [Abstract] [Full Text]  
• Johansen, J. B., Pedersen, S. S., Spindler, H., Andersen, K., Nielsen, J. C., Mortensen, P. T. (2008). Symptomatic heart failure is the most important clinical correlate of impaired quality of life, anxiety, and depression in implantable cardioverter-defibrillator patients: a single-centre, cross-sectional study in 610 patients. Europace 10: 545-551 [Abstract] [Full Text]  
• Haghjoo, M., Bagherzadeh, A., Farahani, M. M., Haghighi, Z. O., Sadr-Ameli, M. A. (2008). Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects. Europace 10: 566-571 [Abstract] [Full Text]  
• Kypta, A., Steinwender, C., Kammler, J., Leisch, F., Hofmann, R. (2008). Long-term outcomes in patients with atrioventricular block undergoing septal ventricular lead implantation compared with standard apical pacing. Europace 10: 574-579 [Abstract] [Full Text]  
• Daubert, C., Leclercq, C., Miljoen, H., Paelinck, B. P., Vrints, C. J., Beshai, J. F., Grimm, R. A., Nagueh, S. F. (2008). Cardiac-Resynchronization Therapy. NEJM 358: 1865-1866 [Full Text]  
• Leclercq, C., Gadler, F., Kranig, W., Ellery, S., Gras, D., Lazarus, A., Clementy, J., Boulogne, E., Daubert, J.-C., for the TRIP-HF (Triple Resynchronization In Paced, (2008). A Randomized Comparison of Triple-Site Versus Dual-Site Ventricular Stimulation in Patients With Congestive Heart Failure. J Am Coll Cardiol 51: 1455-1462 [Abstract] [Full Text]  
• Moss, A. J. (2008). Life Versus Death. Circulation 117: 1912-1913 [Full Text]  
• Anderson, L. J., Miyazaki, C., Sutherland, G. R., Oh, J. K. (2008). Patient Selection and Echocardiographic Assessment of Dyssynchrony in Cardiac Resynchronization Therapy. Circulation 117: 2009-2023 [Full Text]  
• Squire, I. (2008). Assessing prognosis in heart failure: you can see a lot if you look, but more if you look again ... ... .... Eur Heart J 29: 959-960 [Full Text]  
• Daubert, J. C. (2008). Modulation of cardiac contractility. A potential treatment of heart failure?. Eur Heart J 29: 961-963 [Full Text]  
• Wellens, H. J. (2008). Forty Years of Invasive Clinical Electrophysiology: 1967-2007. Circ Arrhythmia Electrophysiol 1: 49-53 [Full Text]  
• Hill, J. A., Olson, E. N. (2008). Cardiac Plasticity. NEJM 358: 1370-1380 [Full Text]  
• Chakir, K., Daya, S. K., Tunin, R. S., Helm, R. H., Byrne, M. J., Dimaano, V. L., Lardo, A. C., Abraham, T. P., Tomaselli, G. F., Kass, D. A. (2008). Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization. Circulation 117: 1369-1377 [Abstract] [Full Text]  
• Cleland, J G F, Freemantle, N, Daubert, J-C, Toff, W D, Leisch, F, Tavazzi, L (2008). Long-term effect of cardiac resynchronisation in patients reporting mild symptoms of heart failure: a report from the CARE-HF study. Heart 94: 278-283 [Abstract] [Full Text]  
• Inage, T., Yoshida, T., Hiraki, T., Ohe, M., Takeuchi, T., Nagamoto, Y., Fukuda, Y., Gondo, T., Imaizumi, T. (2008). Chronic cardiac resynchronization therapy reverses cardiac remodelling and improves invasive haemodynamics of patients with severe heart failure on optimal medical treatment. Europace 10: 379-383 [Abstract] [Full Text]  
• Albertsen, A. E., Nielsen, J. C., Poulsen, S. H., Mortensen, P. T., Pedersen, A. K., Hansen, P. S., Jensen, H. K., Egeblad, H. (2008). Biventricular pacing preserves left ventricular performance in patients with high-grade atrio-ventricular block: a randomized comparison with DDD(R) pacing in 50 consecutive patients. Europace 10: 314-320 [Abstract] [Full Text]  
• Bordachar, P., Labrousse, L., Thambo, J.-B., Reant, P., Lafitte, S., O'Neill, M. D., Jais, P., Haissaguerre, M., Clementy, J., Dos Santos, P. (2008). Haemodynamic impact of the left ventricular pacing site during graded ischaemia in an open-chest pig model. Europace 10: 242-248 [Abstract] [Full Text]  
• Lin, G, Rea, R F, Hammill, S C, Hayes, D L, Brady, P A (2008). Effect of cardiac resynchronisation therapy on occurrence of ventricular arrhythmia in patients with implantable cardioverter defibrillators undergoing upgrade to cardiac resynchronisation therapy devices. Heart 94: 186-190 [Abstract] [Full Text]  
• Miller, W. L., Hartman, K. A., Grill, D. E., Burritt, M. F., Rodeheffer, R. J., Burnett, J. C. Jr, Jaffe, A. S. (2008). Response to Letter Regarding Article, "Serial Biomarker Measurements in Ambulatory Patients With Chronic Heart Failure: The Importance of Change Over Time". Circulation 117: e24-e24 [Full Text]  
• Kass, D. A. (2008). An epidemic of dyssynchrony: but what does it mean?. J Am Coll Cardiol 51: 12-17 [Abstract] [Full Text]  
• Tops, L. F., Krishnan, S. C., Schuijf, J. D., Schalij, M. J., Bax, J. J. (2008). Noncoronary Applications of Cardiac Multidetector Row Computed Tomography. J Am Coll Cardiol Img 1: 94-106 [Abstract] [Full Text]  
• Pu, M., Abraham, W. T (2008). Resynchronisation therapy in heart failure: searching for predictors. Heart 94: 4-5 [Full Text]  
• Stollberger, C., Blazek, G., Bucher, E., Finsterer, J. (2008). Cardiac resynchronization therapy in left ventricular hypertrabeculation/non-compaction and myopathy. Europace 10: 59-62 [Abstract] [Full Text]  
• Stockburger, M., Fateh-Moghadam, S., Nitardy, A., Celebi, O., Krebs, A., Habedank, D., Dietz, R. (2008). Baseline Doppler parameters are useful predictors of chronic left ventricular reduction in size by cardiac resynchronization therapy. Europace 10: 69-74 [Abstract] [Full Text]  
• Duray, G. Z., Israel, C. W., Pajitnev, D., Hohnloser, S. H. (2008). Upgrading to biventricular pacing/defibrillation systems in right ventricular paced congestive heart failure patients: prospective assessment of procedural parameters and response rate. Europace 10: 48-52 [Abstract] [Full Text]  
• Ritzema, J., Melton, I. C., Richards, A. M., Crozier, I. G., Frampton, C., Doughty, R. N., Whiting, J., Kar, S., Eigler, N., Krum, H., Abraham, W. T., Troughton, R. W. (2007). Direct Left Atrial Pressure Monitoring in Ambulatory Heart Failure Patients: Initial Experience With a New Permanent Implantable Device. Circulation 116: 2952-2959 [Abstract] [Full Text]  
• Beshai, J. F., Grimm, R. A., Nagueh, S. F., Baker, J. H. II, Beau, S. L., Greenberg, S. M., Pires, L. A., Tchou, P. J., the RethinQ Study Investigators, (2007). Cardiac-Resynchronization Therapy in Heart Failure with Narrow QRS Complexes. NEJM 357: 2461-2471 [Abstract] [Full Text]  
• Suma, H., Tanabe, H., Uejima, T., Suzuki, S., Horii, T., Isomura, T. (2007). Selected ventriculoplasty for idiopathic dilated cardiomyopathy with advanced congestive heart failure: midterm results and risk analysis. Eur. J. Cardiothorac. Surg. 32: 912-916 [Abstract] [Full Text]  
• Henneman, M. M., van der Wall, E. E., Ypenburg, C., Bleeker, G. B., van de Veire, N. R., Marsan, N. A., Chen, J., Garcia, E. V., Westenberg, J. J.M., Schalij, M. J., Bax, J. J. (2007). Nuclear Imaging in Cardiac Resynchronization Therapy. JNM 48: 2001-2010 [Abstract] [Full Text]  
• Leclercq, C., Bleeker, G. B., Linde, C., Donal, E., Bax, J. J., Schalij, M. J., Daubert, C. (2007). Cardiac resynchronization therapy: clinical results and evolution of candidate selection. Eur Heart J Suppl 9: I94-I106 [Abstract] [Full Text]  
• Biffi, M., Bertini, M., Ziacchi, M., Boriani, G. (2007). Left ventricular pacing by automatic capture verification. Europace 9: 1177-1181 [Abstract] [Full Text]  
• Emkanjoo, Z., Esmaeilzadeh, M., Mohammad Hadi, N., Alizadeh, A., Tayyebi, M., Sadr-ameli, M.A. (2007). Frequency of inter- and intraventricular dyssynchrony in patients with heart failure according to QRS width. Europace 9: 1171-1176 [Abstract] [Full Text]  
• Ritter, P., Cazeau, S., Gras, D., Daubert, J.-C. (2007). Cardiac resynchronization therapy implantation: a blend of skill and technology. Eur Heart J Suppl 9: I107-I112 [Abstract] [Full Text]  
• Jourdain, P., Jondeau, G., Juilliere, Y. (2007). Reply. J Am Coll Cardiol 50: 2098-2099 [Full Text]  
• Ypenburg, C., Lancellotti, P., Tops, L. F., Bleeker, G. B., Holman, E. R., Pierard, L. A., Schalij, M. J., Bax, J. J. (2007). Acute Effects of Initiation and Withdrawal of Cardiac Resynchronization Therapy on Papillary Muscle Dyssynchrony and Mitral Regurgitation. J Am Coll Cardiol 50: 2071-2077 [Abstract] [Full Text]