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Previous Volume 352:666-675 February 17, 2005 Number 7 Next

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ABSTRACT

Background The level of the inactive N-terminal fragment of pro–brain (B-type) natriuretic peptide (BNP) is a strong predictor of mortality among patients with acute coronary syndromes and may be a strong prognostic marker in patients with chronic coronary heart disease as well. We assessed the relationship between N-terminal pro-BNP (NT-pro-BNP) levels and long-term mortality from all causes in a large cohort of patients with stable coronary heart disease.

Methods NT-pro-BNP was measured in baseline serum samples from 1034 patients referred for angiography because of symptoms or signs of coronary heart disease. The rate of death from all causes was determined after a median follow-up of nine years.

Results At follow-up, 288 patients had died. The median NT-pro-BNP level was significantly lower among patients who survived than among those who died (120 pg per milliliter [interquartile range, 50 to 318] vs. 386 pg per milliliter [interquartile range, 146 to 897], P<0.001). Patients with NT-pro-BNP levels in the highest quartile were older, had a lower left ventricular ejection fraction (LVEF) and a lower creatinine clearance rate, and were more likely to have a history of myocardial infarction, clinically significant coronary artery disease, and diabetes than patients with NT-pro-BNP levels in the lowest quartile. In a multivariable Cox regression model, the hazard ratio for death from any cause for the patients with NT-pro-BNP levels in the fourth quartile as compared with those in the first quartile was 2.4 (95 percent confidence interval, 1.5 to 4.0; P<0.001); the NT-pro-BNP level added prognostic information beyond that provided by conventional risk factors, including the patient's age; sex; family history with respect to ischemic heart disease; the presence or absence of a history of myocardial infarction, angina, hypertension, diabetes, or chronic heart failure; creatinine clearance rate; body-mass index; smoking status; plasma lipid levels; LVEF; and the presence or absence of clinically significant coronary artery disease on angiography.

Conclusions NT-pro-BNP is a marker of long-term mortality in patients with stable coronary disease and provides prognostic information above and beyond that provided by conventional cardiovascular risk factors and the degree of left ventricular systolic dysfunction.

Source Information

From the Department of Cardiology and Endocrinology, Frederiksberg Hospital, Frederiksberg (C.K., B.G., P.H.); the Department of Cardiology, Rigshospitalet, Copenhagen (L.K.); and the Department of Cardiology, Hillerød University Hospital, Copenhagen (R.S.) — all in Denmark.

Address reprint requests to Dr. Kragelund at the Department of Cardiology and Endocrinology, Frederiksberg Hospital, University of Copenhagen, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark, or at kragelund{at}dadlnet.dk.

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N-Terminal Pro–B-Type Natriuretic Peptide and Mortality in Coronary Heart Disease
Pöge U., Gerhardt T. M., Woitas R. P., Kragelund C., Køber L., Hildebrandt P.
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N Engl J Med 2005; 352:2025-2026, May 12, 2005. Correspondence

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• Leuchte, H. H., El Nounou, M., Tuerpe, J. C., Hartmann, B., Baumgartner, R. A., Vogeser, M., Muehling, O., Behr, J. (2007). N-terminal Pro-Brain Natriuretic Peptide and Renal Insufficiency as Predictors of Mortality in Pulmonary Hypertension. Chest 131: 402-409 [Abstract] [Full Text]  
• Feringa, H. H H, Schouten, O., Dunkelgrun, M., Bax, J. J, Boersma, E., Elhendy, A., de Jonge, R., Karagiannis, S. E, Vidakovic, R., Poldermans, D. (2007). Plasma N-terminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery. Heart 93: 226-231 [Abstract] [Full Text]  
• Schou, M., Gustafsson, F., Kjaer, A., Hildebrandt, P. R. (2007). Long-term clinical variation of NT-proBNP in stable chronic heart failure patients. Eur Heart J 0: ehl449v1-6 [Abstract] [Full Text]  
• Bibbins-Domingo, K., Gupta, R., Na, B., Wu, A. H. B., Schiller, N. B., Whooley, M. A. (2007). N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP), Cardiovascular Events, and Mortality in Patients With Stable Coronary Heart Disease. JAMA 297: 169-176 [Abstract] [Full Text]  
• Konstam, M. A. (2007). Natriuretic Peptides and Cardiovascular Events: More Than a Stretch. JAMA 297: 212-214 [Full Text]  
• Wang, T. J., Gona, P., Larson, M. G., Tofler, G. H., Levy, D., Newton-Cheh, C., Jacques, P. F., Rifai, N., Selhub, J., Robins, S. J., Benjamin, E. J., D'Agostino, R. B., Vasan, R. S. (2006). Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death. NEJM 355: 2631-2639 [Abstract] [Full Text]  
• de Lemos, J. A. (2006). The Latest and Greatest New Biomarkers: Which Ones Should We Measure for Risk Prediction in Our Practice?. Arch Intern Med 166: 2428-2430 [Full Text]  
• Rothenbacher, D., Koenig, W., Brenner, H. (2006). Comparison of N-Terminal Pro-B-Natriuretic Peptide, C-Reactive Protein, and Creatinine Clearance for Prognosis in Patients With Known Coronary Heart Disease. Arch Intern Med 166: 2455-2460 [Abstract] [Full Text]  
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• Machado, R. F., Anthi, A., Steinberg, M. H., Bonds, D., Sachdev, V., Kato, G. J., Taveira-DaSilva, A. M., Ballas, S. K., Blackwelder, W., Xu, X., Hunter, L., Barton, B., Waclawiw, M., Castro, O., Gladwin, M. T., for the MSH Investigators, (2006). N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease.. JAMA 296: 310-318 [Abstract] [Full Text]  
• Kistorp, C. (2006). Risk Stratification in Secondary Prevention: Advances in Multimarker Profiles, or Back to Basics?. Circulation 114: 184-186 [Full Text]  
• Hammerer-Lercher, A., Geiger, R., Mair, J., Url, C., Tulzer, G., Lechner, E., Puschendorf, B., Sommer, R. (2006). Utility of N-Terminal Pro-B-Type Natriuretic Peptide to Differentiate Cardiac Diseases from Noncardiac Diseases in Young Pediatric Patients. Clin. Chem. 52: 1415-1419 [Abstract] [Full Text]  
• Kragelund, C., Gustafsson, I., Omland, T., Gronning, B., Kober, L., Faber, J., Strande, S., Steffensen, R., Hildebrandt, P. (2006). Prognostic Value of NH2-Terminal Pro B-Type Natriuretic Peptide in Patients With Diabetes and Stable Coronary Heart Disease.. Diabetes Care 29: 1411-1413 [Full Text]  
• Weber, M., Hamm, C. (2006). Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine.. Heart 92: 843-849 [Full Text]  
• Authors/Task Force Members, , Fox, K., Garcia, M. A. A., Ardissino, D., Buszman, P., Camici, P. G., Crea, F., Daly, C., De Backer, G., Hjemdahl, P., Lopez-Sendon, J., Marco, J., Morais, J., Pepper, J., Sechtem, U., Simoons, M., Thygesen, K., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Zamorano, J. L, Andreotti, F., Becher, H., Dietz, R., Fraser, A., Gray, H., Antolin, R. A. H., Huber, K., Kremastinos, D. T., Maseri, A., Nesser, H.-J., Pasierski, T., Sigwart, U., Tubaro, M., Weis, M. (2006). Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J 27: 1341-1381 [Full Text]  
• Almog, Y., Novack, V., Megralishvili, R., Kobal, S., Barski, L., King, D., Zahger, D. (2006). Plasma level of N terminal pro-brain natriuretic Peptide as a prognostic marker in critically ill patients.. Anesth. Analg. 102: 1809-1815 [Abstract] [Full Text]  
• Vasan, R. S. (2006). Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations. Circulation 113: 2335-2362 [Full Text]  
• Minoretti, P., Falcone, C., Calcagnino, M., Emanuele, E., Buzzi, M. P., Coen, E., Geroldi, D. (2006). Prognostic significance of plasma osteopontin levels in patients with chronic stable angina. Eur Heart J 27: 802-807 [Abstract] [Full Text]  
• Wolber, T., Maeder, M. (2006). Normal range of N-terminal pro-brain natriuretic peptide: a note of caution. Eur Heart J 27: 622-622 [Full Text]  
• Galasko, G., Senior, R. (2006). Normal range of N-terminal pro-brain natriuretic peptide: a note of caution: reply. Eur Heart J 27: 622-623 [Full Text]  
• Januzzi, J. L. Jr, Sakhuja, R., O'Donoghue, M., Baggish, A. L., Anwaruddin, S., Chae, C. U., Cameron, R., Krauser, D. G., Tung, R., Camargo, C. A. Jr, Lloyd-Jones, D. M. (2006). Utility of amino-terminal pro-brain natriuretic Peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department.. Arch Intern Med 166: 315-320 [Abstract] [Full Text]  
• Schnabel, R., Lubos, E., Rupprecht, H. J., Espinola-Klein, C., Bickel, C., Lackner, K. J., Cambien, F., Tiret, L., Munzel, T., Blankenberg, S. (2006). B-Type Natriuretic Peptide and the Risk of Cardiovascular Events and Death in Patients With Stable Angina: Results From the AtheroGene Study. J Am Coll Cardiol 47: 552-558 [Abstract] [Full Text]  
• De Sutter, J., De Bacquer, D., Cuypers, S., Delanghe, J., De Buyzere, M., Kornitzer, M., De Backer, G. (2005). Plasma N-terminal pro-brain natriuretic peptide concentration predicts coronary events in men at work: a report from the BELSTRESS study. Eur Heart J 26: 2644-2649 [Abstract] [Full Text]  
• Goetze, J. P. (2005). Coronary artery disease, heart failure, and cardiac natriuretic peptides in the middle. Eur Heart J 26: 2603-2604 [Full Text]  
• Schou, M., Dalsgaard, M. K., Clemmesen, O., Dawson, E. A., Yoshiga, C. C., Nielsen, H. B., Gustafsson, F., Hildebrandt, P. R., Secher, N. H. (2005). Kidneys extract BNP and NT-proBNP in healthy young men. J. Appl. Physiol. 99: 1676-1680 [Abstract] [Full Text]  
• Ginsburg, G. S., Donahue, M. P., Newby, L. K. (2005). Prospects for Personalized Cardiovascular Medicine: The Impact of Genomics. J Am Coll Cardiol 46: 1615-1627 [Abstract] [Full Text]  
• Conti, E., Volpe, M., Carrozza, C., Marzo, F., Zuppi, C., Crea, F., Andreotti, F. (2005). Pregnancy-Associated Plasma Protein-A and Acute Coronary Syndromes: Cause or Consequence?. J Am Coll Cardiol 46: 1583-1584 [Full Text]  
• Ndrepepa, G., Braun, S., Niemoller, K., Mehilli, J., von Beckerath, N., von Beckerath, O., Vogt, W., Schomig, A., Kastrati, A. (2005). Prognostic Value of N-Terminal Pro-Brain Natriuretic Peptide in Patients With Chronic Stable Angina. Circulation 112: 2102-2107 [Abstract] [Full Text]  
• (2005). Other articles noted. Evid. Based Med. 10: 157-158 [Full Text]  
• Struthers, A.D., Davies, J. (2005). B-type natriuretic peptide: a simple new test to identify coronary artery disease?. QJM 98: 765-769 [Abstract] [Full Text]  
• Mockel, M., Muller, R., Vollert, J. O., Muller, C., Carl, A., Peetz, D., Post, F., Kohse, J. K., Lackner, K. J. (2005). Role of N-Terminal Pro-B-Type Natriuretic Peptide in Risk Stratification in Patients Presenting in the Emergency Room. Clin. Chem. 51: 1624-1631 [Abstract] [Full Text]  
• Abrams, J. (2005). Chronic Stable Angina. NEJM 352: 2524-2533 [Full Text]  
• Poge, U., Gerhardt, T. M., Woitas, R. P., Kragelund, C., Kober, L., Hildebrandt, P. (2005). N-Terminal Pro-B-Type Natriuretic Peptide and Mortality in Coronary Heart Disease. NEJM 352: 2025-2026 [Full Text]  
• (2005). N-Terminal pro-BNP Predicts Death in Stable CAD. Journal Watch Cardiology 2005: 3-3 [Full Text]  
• Malik, I. (2005). JournalScan. Heart 91: 703-704 [Full Text]