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Previous Volume 353:58-63 July 7, 2005 Number 1 Next

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SUMMARY

Monozygotic 24-year-old twins presented with discordant ovarian function. One had had premature ovarian failure at the age of 14 years, whereas her sister had normal ovaries and three naturally conceived children. After unsuccessful egg-donation therapy, the sterile twin received a transplant of ovarian cortical tissue from her sister by means of a minilaparotomy. Within three months after transplantation, the recipient's cycles resumed and serum gonadotropin levels fell to the normal range. During the second cycle, she conceived, and her pregnancy progressed uneventfully. At 38 weeks' gestation, she delivered a healthy-appearing female infant.

Source Information

From St. Luke's Hospital, St. Louis (S.J.S., K.M.L., D.J.L., J.A.P.); Paternity Testing, Columbia, Md. (K.S.G.); Greenwood Genetic Center, Greenwood, S.C. (M.J.F.); Sentara Hospital Cytogenetics Laboratory, Norfolk, Va. (E.C.C.); and Weill Medical College of Cornell University, New York (R.G.G.).

This article was published at www.nejm.org on June 7, 2005.

Address reprint requests to Dr. Silber at the Infertility Center of St. Louis, St. Luke's Hospital, 224 S. Woods Mill Rd., Suite 730, St. Louis, MO 63017, or at drsherm{at}aol.com or silber{at}infertile.com.

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