FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 353:156-163 July 14, 2005 Number 2 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

SUMMARY

We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.

Source Information

From the Università Vita-Salute San Raffaele School of Medicine, Milan (L.D., M.G.S.); the Units of Human Virology (L.D., F.B., P.L., M.S.M.) and Rheumatology and Clinical Immunology (L.P., M.G.S.), the Department of Pathology (C.T.P.), and the Laboratory of Tumor Immunology (M.F.), San Raffaele Scientific Institute, Milan; the Department of Public Health, University Tor Vergata, Rome (L.S.); and the Department of Biomedical Sciences, University of Cagliari, Cagliari (P.L.) — all in Italy.

Address reprint requests to Dr. Dagna at the Università Vita-Salute San Raffaele School of Medicine, Unit of Human Virology, P2/P3 Labs — DIBIT, Via Olgettina 58, I-20132 Milan, Italy, or at lorenzo.dagna{at}hsr.it.

Full Text of this Article

Related Letters:

A Relapsing Inflammatory Syndrome and HHV-8
Dogan A., Du M.-Q., Isaacson P. G., Dagna L., Rosai J., Lusso P.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:1746-1747, Oct 20, 2005. Correspondence

This article has been cited by other articles:

• Wolf, T., Rickerts, V., Staszewski, S., Kriener, S., Wassmann, B., Bug, G., Bickel, M., Gute, P., Brodt, H.R., Martin, H. (2007). First case of successful allogeneic stem cell transplantation in an HIV-patient who acquired severe Aplastic Anemia. haematol 92: e56-e58 [Abstract] [Full Text]  
• Dogan, A., Du, M.-Q., Isaacson, P. G., Dagna, L., Rosai, J., Lusso, P. (2005). A relapsing inflammatory syndrome and HHV-8.. NEJM 353: 1746-1747 [Full Text]