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Previous Volume 353:362-368 July 28, 2005 Number 4 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Supplementary Material Editorial by Berger, J. R. Editorial by Drazen, J. M. Letters Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

SUMMARY

The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's disease treated with natalizumab, a monoclonal antibody against ₄ integrins, was reclassified as JC virus–related progressive multifocal leukoencephalopathy (PML). Analysis of frozen serum samples showed that JC virus DNA had appeared in the serum three months after the initiation of open-label natalizumab monotherapy and two months before the appearance of symptomatic PML. There was staining of the brain lesion for polyomavirus. This case report, along with two others, suggests that anti–₄-integrin therapy can result in JC virus–induced PML.

Source Information

From the Division of Gastroenterology (G.V.A., S.V., M.N., P.R.), the Laboratory of Clinical and Epidemiological Virology (M.V.R., J.V.), and the Departments of Morphology and Molecular Pathology (R.S., K.G.) and Neurology (B.D., W.R.), University of Leuven Hospitals, Leuven, Belgium.

This article was published at www.nejm.org on June 9, 2005.

Address reprint requests to Dr. Rutgeerts at the Division of Gastroenterology, University of Leuven Hospitals, 49 Herestraat, B-3000 Leuven, Belgium, or at paul.rutgeerts{at}uz.kuleuven.ac.be.

Full Text of this Article

Related Letters:

Progressive Multifocal Leukoencephalopathy, Natalizumab, and Multiple Sclerosis
Berger T., Deisenhammer F., Álvarez-Cermeño J. C., Masjuan J., Villar L. M., Kleinschmidt-DeMasters B.K., Tyler K. L., Langer-Gould A., Atlas S. W., Pelletier D.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:1744-1746, Oct 20, 2005. Correspondence

Natalizumab and Progressive Multifocal Leukoencephalopathy
Adelman B., Sandrock A., Panzara M. A.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:432-433, Jul 28, 2005; published at www.nejm.org on Jun 9, 2005 (10.1056/NEJMc055235). Correspondence

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