Avian Influenza A (H5N1) Infection in Eastern Turkey in 2006
Ahmet Faik Oner, M.D., Ali Bay, M.D., Sukru Arslan, M.D., Hayrettin Akdeniz, M.D., Huseyin Avni Sahin, M.D., Yasar Cesur, M.D., Serdar Epcacan, M.D., Neziha Yilmaz, M.D., Ibrahim Deger, M.D., Baran Kizilyildiz, M.D., Hasan Karsen, M.D., and Mehmet Ceyhan, M.D.
Background An outbreak of highly pathogenic avian influenzaA (H5N1) that had previously been detected throughout Asia,with major economic and health repercussions, extended to easternTurkey in late December 2005 and early January 2006.
Methods We documented the epidemiologic, clinical, and radiologicfeatures of all cases of confirmed H5N1 virus infection in patientswho were admitted to Yuzuncu Yil University Hospital in Van,Turkey, between December 31, 2005, and January 10, 2006.
Results H5N1 virus infection was diagnosed in eight patients.The patients were 5 to 15 years of age, and all eight had ahistory of close contact with diseased or dead chickens. Themean (±SD) time between exposure and the onset of illnesswas 5.0±1.3 days. All the patients had fever, and sevenhad clinical and radiologic evidence of pneumonia at presentation;four patients died. Results of enzyme-linked immunosorbent assayand rapid influenza tests were negative in all patients, andthe diagnosis was made by means of a polymerase-chain-reactionassay.
Conclusions H5N1, which causes a spectrum of illnesses in humans,including severe and fatal respiratory disease, can be difficultto diagnose.
Source Information
From the Faculty of Medicine, Yuzuncu Yil University, Van (A.F.O., A.B., S.A., H.A., H.A.S., Y.C., S.E., I.D., B.K., H.K.); Refik Saydam Hygiene Institute, Ankara (N.Y.); and the Faculty of Medicine, Hacettepe University, Ankara (M.C.) — all in Turkey.
Address reprint requests to Dr. Oner at Arastirma hst. Cocuk hst.srv. Van, Turkey, or at afo59{at}yahoo.com.
Human H5N1 Influenza
Goicoechea M., Pawitan J. A., Dudley J. P., Oner A. F., Ceyhan M., Akdeniz H., Kandun I. N., Sedyaningsih E. R., Uyeki T. M., Webster R. G., Govorkova E. A.
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N Engl J Med 2007;
356:1375-1377, Mar 29, 2007.
Correspondence
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