Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study
R. Sacha Bhatia, M.D., M.B.A., Jack V. Tu, M.D., Ph.D., Douglas S. Lee, M.D., Ph.D., Peter C. Austin, Ph.D., Jiming Fang, Ph.D., Annick Haouzi, M.D., Yanyan Gong, M.Sc., and Peter P. Liu, M.D.
Background The importance of heart failure with preserved ejectionfraction is increasingly recognized. We conducted a study toevaluate the epidemiologic features and outcomes of patientswith heart failure with preserved ejection fraction and to comparethe findings with those from patients who had heart failurewith reduced ejection fraction.
Methods From April 1, 1999, through March 31, 2001, we studied2802 patients admitted to 103 hospitals in the province of Ontario,Canada, with a discharge diagnosis of heart failure whose ejectionfraction had also been assessed. The patients were categorizedin three groups: those with an ejection fraction of less than40 percent (heart failure with reduced ejection fraction), thosewith an ejection fraction of 40 to 50 percent (heart failurewith borderline ejection fraction), and those with an ejectionfraction of more than 50 percent (heart failure with preservedejection fraction). Two groups were studied in detail: thosewith an ejection fraction of less than 40 percent and thosewith an ejection fraction of more than 50 percent. The mainoutcome measures were death within one year and readmissionto the hospital for heart failure.
Results Thirty-one percent of the patients had an ejection fractionof more than 50 percent. Patients with heart failure with preservedejection fraction were more likely to be older and female andto have a history of hypertension and atrial fibrillation. Thepresenting history and clinical examination findings were similarfor the two groups. The unadjusted mortality rates for patientswith an ejection fraction of more than 50 percent were not significantlydifferent from those for patients with an ejection fractionof less than 40 percent at 30 days (5 percent vs. 7 percent,P=0.08) and at 1 year (22 percent vs. 26 percent, P=0.07); theadjusted one-year mortality rates were also not significantlydifferent in the two groups (hazard ratio, 1.13; 95 percentconfidence interval, 0.94 to 1.36; P=0.18). The rates of readmissionfor heart failure and of in-hospital complications did not differbetween the two groups.
Conclusions Among patients presenting with new-onset heart failure,a substantial proportion had an ejection fraction of more than50 percent. The survival of patients with heart failure withpreserved ejection fraction was similar to that of patientswith reduced ejection fraction.
Source Information
From the Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, and the Division of Cardiology, Toronto General Hospital, University Health Network (R.S.B., J.V.T., D.S.L., A.H., P.P.L.); the Division of General Internal Medicine, Sunnybrook and Women's College Health Sciences Centre, University of Toronto (R.S.B., J.V.T.); and the Institute for Clinical Evaluative Sciences (J.V.T., D.S.L., P.C.A., J.F., Y.G.) — all in Toronto; and the National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass. (D.S.L.). Drs. Tu and Liu contributed equally to this article.
Address reprint requests to Dr. Liu at the Heart & Stroke/Richard Lewar Centre of Excellence, NCSB 11-1266, Toronto General Hospital, 200 Elizabeth St., Toronto, ON M5G 2C4, Canada, or at peter.liu{at}utoronto.ca.
Heart Failure with Preserved Ejection Fraction
Fiack C. A., Farber H. W., Arias M. A., Alonso-Fernández A., García-Río F., Kessler K. M., Ahmed A., Fleg J. L., Gheorghiade M., Owan T. E., Redfield M. M., Liu P. P., Lee D. S., Tu J. V., Ph.D. M.D.
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N Engl J Med 2006;
355:1828-1831, Oct 26, 2006.
Correspondence
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McIntyre, H. F
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360: 1256-1259
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Setoguchi, S., Nohria, A., Rassen, J. A., Stevenson, L. W., Schneeweiss, S.
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[Abstract][Full Text]
Maeder, M. T., Kaye, D. M.
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53: 905-918
[Abstract][Full Text]
Tzanetos, K., Leong, D., Wu, R. C.
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180: 520-527
[Full Text]
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[Abstract][Full Text]
Sorrell, V. L., Kalra, N., Ramaraj, R.
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[Abstract][Full Text]
Donal, E., Lund, L. H., Linde, C., Edner, M., Lafitte, S., Persson, H., Bauer, F., Ohrvik, J., Ennezat, P.-V., Hage, C., Lofman, I., Juilliere, Y., Logeart, D., Derumeaux, G., Gueret, P., Daubert, J.-C.
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[Abstract][Full Text]
Kamalesh, M.
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95: 178-179
[Full Text]
Pfisterer, M., Buser, P., Rickli, H., Gutmann, M., Erne, P., Rickenbacher, P., Vuillomenet, A., Jeker, U., Dubach, P., Beer, H., Yoon, S.-I., Suter, T., Osterhues, H. H., Schieber, M. M., Hilti, P., Schindler, R., Brunner-La Rocca, H.-P., for the TIME-CHF Investigators,
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301: 383-392
[Abstract][Full Text]
Quinones, M. A.
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[Full Text]
Kurt, M., Wang, J., Torre-Amione, G., Nagueh, S. F.
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[Abstract][Full Text]
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[Abstract][Full Text]
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Alsaddique, A. A.
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[Abstract][Full Text]
Stork, S., Hense, H. W., Zentgraf, C., Uebelacker, I., Jahns, R., Ertl, G., Angermann, C. E.
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Lenihan, D. J.
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[Full Text]
Ronco, C., Haapio, M., House, A. A., Anavekar, N., Bellomo, R.
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52: 1527-1539
[Abstract][Full Text]
Guazzi, M., Myers, J., Peberdy, M. A., Bensimhon, D., Chase, P., Arena, R.
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[Abstract][Full Text]
Tribouilloy, C, Rusinaru, D, Mahjoub, H, Tartiere, J-M, Kesri-Tartiere, L, Godard, S, Peltier, M
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94: 1450-1455
[Abstract][Full Text]
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(2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J
29: 2388-2442
[Full Text]
Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J. J.V., Ponikowski, P., Poole-Wilson, P. A., Stromberg, A., van Veldhuisen, D. J., Atar, D., Hoes, A. W., Keren, A., Mebazaa, A., Nieminen, M., Priori, S. G., Swedberg, K.
(2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail
10: 933-989
[Full Text]
Werner, C., Hanhoun, M., Widmann, T., Kazakov, A., Semenov, A., Poss, J., Bauersachs, J., Thum, T., Pfreundschuh, M., Muller, P., Haendeler, J., Bohm, M., Laufs, U.
(2008). Effects of Physical Exercise on Myocardial Telomere-Regulating Proteins, Survival Pathways, and Apoptosis. J Am Coll Cardiol
52: 470-482
[Abstract][Full Text]
Meta-analysis Research Group in Echocardiography (,
(2008). Independence of restrictive filling pattern and LV ejection fraction with mortality in heart failure: An individual patient meta-analysis. Eur J Heart Fail
10: 786-792
[Abstract][Full Text]
Matsui, H., Ando, K., Kawarazaki, H., Nagae, A., Fujita, M., Shimosawa, T., Nagase, M., Fujita, T.
(2008). Salt Excess Causes Left Ventricular Diastolic Dysfunction in Rats With Metabolic Disorder. Hypertension
52: 287-294
[Abstract][Full Text]
Shah, S. J., Gheorghiade, M.
(2008). Heart Failure With Preserved Ejection Fraction: Treat Now by Treating Comorbidities. JAMA
300: 431-433
[Full Text]
Henkel, D. M., Redfield, M. M., Weston, S. A., Gerber, Y., Roger, V. L.
(2008). Death in Heart Failure: A Community Perspective. Circ Heart Fail
1: 91-97
[Abstract][Full Text]
Butler, J., Kalogeropoulos, A., Georgiopoulou, V., Belue, R., Rodondi, N., Garcia, M., Bauer, D. C., Satterfield, S., Smith, A. L., Vaccarino, V., Newman, A. B., Harris, T. B., Wilson, P. W.F., Kritchevsky, S. B., for the Health ABC Study,
(2008). Incident Heart Failure Prediction in the Elderly: The Health ABC Heart Failure Score. Circ Heart Fail
1: 125-133
[Abstract][Full Text]
Akkan, D., Kjaergaard, J., Moller, J. E., Hassager, C., Torp-Pedersen, C., Kober, L., EchoCardiography and Heart Outcome Study (ECHOS) i,
(2008). Prognostic importance of a short deceleration time in symptomatic congestive heart failure. Eur J Heart Fail
10: 689-695
[Abstract][Full Text]
Rusinaru, D., Leborgne, L., Peltier, M., Tribouilloy, C.
(2008). Effect of atrial fibrillation on long-term survival in patients hospitalised for heart failure with preserved ejection fraction. Eur J Heart Fail
10: 566-572
[Abstract][Full Text]
Westermann, D., Kasner, M., Steendijk, P., Spillmann, F., Riad, A., Weitmann, K., Hoffmann, W., Poller, W., Pauschinger, M., Schultheiss, H.-P., Tschope, C.
(2008). Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction. Circulation
117: 2051-2060
[Abstract][Full Text]
MacIver, D H, Townsend, M
(2008). A novel mechanism of heart failure with normal ejection fraction. Heart
94: 446-449
[Abstract][Full Text]
Grewal, J., McKelvie, R., Lonn, E., Tait, P., Carlsson, J., Gianni, M., Jarnert, C., Persson, H.
(2008). BNP and NT-proBNP predict echocardiographic severity of diastolic dysfunction. Eur J Heart Fail
10: 252-259
[Abstract][Full Text]
Xu-Cai, Y. O., Brotman, D. J., Phillips, C. O., Michota, F. A., Tang, W. H. W., Whinney, C. M., Panneerselvam, A., Hixson, E. D., Garcia, M., Francis, G. S., Jaffer, A. K.
(2008). Outcomes of Patients With Stable Heart Failure Undergoing Elective Noncardiac Surgery. Mayo Clin Proc.
83: 280-288
[Abstract][Full Text]
Lester, S. J., Tajik, A. J., Nishimura, R. A., Oh, J. K., Khandheria, B. K., Seward, J. B.
(2008). Unlocking the Mysteries of Diastolic Function Deciphering the Rosetta Stone 10 Years Later.. J Am Coll Cardiol
51: 679-689
[Abstract][Full Text]
Hallerbach, M., Francoeur, A., Pomerantz, S. C., Oliner, C., Morris, D. L., Eiger, G., Cohn, J., Goldfinger, M.
(2008). Patterns and Predictors of Early Hospital Readmission in Patients With Congestive Heart Failure. American Journal of Medical Quality
23: 18-23
[Abstract]
Tribouilloy, C., Rusinaru, D., Mahjoub, H., Souliere, V., Levy, F., Peltier, M., Slama, M., Massy, Z.
(2008). Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study. Eur Heart J
29: 339-347
[Abstract][Full Text]
Nielsen, O. W., Kober, L., Torp-Pedersen, C.
(2008). Heart failure with preserved ejection fraction: dangerous, elusive, and difficult. Eur Heart J
29: 285-287
[Full Text]
McMurray, J. J.V., Carson, P. E., Komajda, M., McKelvie, R., Zile, M. R., Ptaszynska, A., Staiger, C., Donovan, J. M., Massie, B. M.
(2008). Heart failure with preserved ejection fraction: Clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial. Eur J Heart Fail
10: 149-156
[Abstract][Full Text]
Mahjoub, H., Rusinaru, D., Souliere, V., Durier, C., Peltier, M., Tribouilloy, C.
(2008). Long-term survival in patients older than 80 years hospitalised for heart failure. A 5-year prospective study. Eur J Heart Fail
10: 78-84
[Abstract][Full Text]
Camici, P. G., Prasad, S. K., Rimoldi, O. E.
(2008). Stunning, Hibernation, and Assessment of Myocardial Viability. Circulation
117: 103-114
[Full Text]
Lacombe, V. A., Viatchenko-Karpinski, S., Terentyev, D., Sridhar, A., Emani, S., Bonagura, J. D., Feldman, D. S., Gyorke, S., Carnes, C. A.
(2007). Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am. J. Physiol. Regul. Integr. Comp. Physiol.
293: R1787-R1797
[Abstract][Full Text]
Connelly, K.A., Kelly, D.J., Zhang, Y., Prior, D.L., Martin, J., Cox, A.J., Thai, K., Feneley, M.P., Tsoporis, J., White, K.E., Krum, H., Gilbert, R.E.
(2007). Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat. Cardiovasc Res
76: 280-291
[Abstract][Full Text]
Paulus, W. J., Tschope, C., Sanderson, J. E., Rusconi, C., Flachskampf, F. A., Rademakers, F. E., Marino, P., Smiseth, O. A., De Keulenaer, G., Leite-Moreira, A. F., Borbely, A., Edes, I., Handoko, M. L., Heymans, S., Pezzali, N., Pieske, B., Dickstein, K., Fraser, A. G., Brutsaert, D. L.
(2007). How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J
28: 2539-2550
[Abstract][Full Text]
Chaudhry, S. I., Wang, Y., Concato, J., Gill, T. M., Krumholz, H. M.
(2007). Patterns of Weight Change Preceding Hospitalization for Heart Failure. Circulation
116: 1549-1554
[Abstract][Full Text]
Balmain, S., Padmanabhan, N., Ferrell, W. R., Morton, J. J., McMurray, J. J.V.
(2007). Differences in arterial compliance, microvascular function and venous capacitance between patients with heart failure and either preserved or reduced left ventricular systolic function. Eur J Heart Fail
9: 865-871
[Abstract][Full Text]
Adamopoulos, C., Zannad, F., Fay, R., Mebazaa, A., Cohen-Solal, A., Guize, L., Juilliere, Y., Alla, F.
(2007). Ejection fraction and blood pressure are important and interactive predictors of 4-week mortality in severe acute heart failure. Eur J Heart Fail
9: 935-941
[Abstract][Full Text]
Fonarow, G. C., Stough, W. G., Abraham, W. T., Albert, N. M., Gheorghiade, M., Greenberg, B. H., O'Connor, C. M., Sun, J. L., Yancy, C. W., Young, J. B., for the OPTIMIZE-HF Investigators and Hospitals,
(2007). Characteristics, Treatments, and Outcomes of Patients With Preserved Systolic Function Hospitalized for Heart Failure: A Report From the OPTIMIZE-HF Registry. J Am Coll Cardiol
50: 768-777
[Abstract][Full Text]
Gaasch, W. H., Little, W. C.
(2007). Assessment of Left Ventricular Diastolic Function and Recognition of Diastolic Heart Failure. Circulation
116: 591-593
[Full Text]
Kasner, M., Westermann, D., Steendijk, P., Gaub, R., Wilkenshoff, U., Weitmann, K., Hoffmann, W., Poller, W., Schultheiss, H.-P., Pauschinger, M., Tschope, C.
(2007). Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction: A Comparative Doppler-Conductance Catheterization Study. Circulation
116: 637-647
[Abstract][Full Text]
Fosbol, E. L., Seibaek, M., Brendorp, B., Moller, D. V., Ersboll, M., Torp-Pedersen, C., Kober, L., for the Danish Investigations and Arrhythmia ON Do,
(2007). Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction. Eur J Heart Fail
9: 814-819
[Abstract][Full Text]
Pirracchio, R., Cholley, B., De Hert, S., Solal, A. C., Mebazaa, A.
(2007). Diastolic heart failure in anaesthesia and critical care. Br J Anaesth
98: 707-721
[Abstract][Full Text]
Huang, C.-H., Chien, K.-L., Chen, W.-J., Sung, F.-C., Hsu, H.-C., Su, T.-C., Lee, Y.-T.
(2007). Impact of heart failure and left ventricular function on long-term survival -- Report of a community-based cohort study in Taiwan. Eur J Heart Fail
9: 587-593
[Abstract][Full Text]
Kjaergaard, J., Akkan, D., Iversen, K. K., Kober, L., Torp-Pedersen, C., Hassager, C.
(2007). Right ventricular dysfunction as an independent predictor of short- and long-term mortality in patients with heart failure. Eur J Heart Fail
9: 610-616
[Abstract][Full Text]
Riordan, M. M., Kovacs, S. J.
(2007). Stiffness- and relaxation-based quantitation of radial left ventricular oscillations: elucidation of regional diastolic function mechanisms. J. Appl. Physiol.
102: 1862-1870
[Abstract][Full Text]
De Ferrari, G. M., Klersy, C., Ferrero, P., Fantoni, C., Salerno-Uriarte, D., Manca, L., Devecchi, P., Molon, G., Revera, M., Curnis, A., Braga, S. S., Accardi, F., Salerno-Uriarte, J. A., ALPHA Study Group,
(2007). Atrial fibrillation in heart failure patients: Prevalence in daily practice and effect on the severity of symptoms. Data from the ALPHA study registry. Eur J Heart Fail
9: 502-509
[Abstract][Full Text]
Tang, W.H. W., Francis, G. S.
(2006). The Year in Heart Failure. J Am Coll Cardiol
48: 2575-2583
[Full Text]
Ahmed, A.
(2006). 1 year mortality after first hospital admission for heart failure was similar in patients with preserved or reduced ejection fraction. Evid. Based Med.
11: 185-185
[Full Text]
Jolobe, O. M. P.
(2006). Usefulness of Left Ventricular Ejection Fraction in Patients With Overt Heart Failure. Mayo Clin Proc.
81: 1638-1639
[Full Text]
Gheorghiade, M., Abraham, W. T., Albert, N. M., Greenberg, B. H., O'Connor, C. M., She, L., Stough, W. G., Yancy, C. W., Young, J. B., Fonarow, G. C., for the OPTIMIZE-HF Investigators and Coordinators,
(2006). Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure.. JAMA
296: 2217-2226
[Abstract][Full Text]
Fiack, C. A., Farber, H. W., Arias, M. A., Alonso-Fernandez, A., Garcia-Rio, F., Kessler, K. M., Ahmed, A., Fleg, J. L., Gheorghiade, M., Owan, T. E., Redfield, M. M., Liu, P. P., Lee, D. S., Tu, J. V., Ph.D., M.D.
(2006). Heart failure with preserved ejection fraction.. NEJM
355: 1828-1828
[Full Text]
Cleland, J. G.F., Tendera, M., Adamus, J., Freemantle, N., Polonski, L., Taylor, J., on behalf of PEP-CHF Investigators,
(2006). The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J
27: 2338-2345
[Abstract][Full Text]
Malik, I.
(2006). JournalScan. Heart
92: 1535-1536
[Full Text]
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