FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 356:1020-1029 March 8, 2007 Number 10 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Supplementary Material Perspective by Maisel, W. H. Perspective by Farb, A. Editorial by Curfman, G. D. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Maisel, W. H. Related Article by Farb, A. PubMed Citation

ABSTRACT

Background Definitions of stent thrombosis that have been used in clinical trials of drug-eluting stents have been restrictive and have not been used in a uniform manner.

Methods We applied a hierarchical classification of stent thrombosis set by the Academic Research Consortium (ARC) across randomized trials involving 878 patients treated with sirolimus-eluting stents, 1400 treated with paclitaxel-eluting stents, and 2267 treated with bare-metal stents. We then pooled 4 years of follow-up data. All events were adjudicated by an independent clinical-events committee.

Results The cumulative incidence of stent thrombosis according to the original protocol definitions was 1.2% in the sirolimus-stent group versus 0.6% in the bare-metal–stent group (P=0.20; 95% confidence interval [CI], –0.4 to 1.5) and 1.3% in the paclitaxel-stent group versus 0.8% in the bare-metal–stent group (P=0.24; 95% CI, –0.3 to 1.4). The incidence of definite or probable stent thrombosis as defined by the ARC was 1.5% in the sirolimus-stent group versus 1.7% in the bare-metal–stent group (P=0.70; 95% CI, –1.5 to 1.0) and 1.8% in the paclitaxel-stent group versus 1.4% in the bare-metal–stent group (P=0.52; 95% CI, –0.7 to 1.4). The incidence of definite or probable events occurring 1 to 4 years after implantation was 0.9% in the sirolimus-stent group versus 0.4% in the bare-metal–stent group and 0.9% in the paclitaxel-stent group versus 0.6% in the bare-metal–stent group.

Conclusions The incidence of stent thrombosis did not differ significantly between patients with drug-eluting stents and those with bare-metal stents in randomized clinical trials, although the power to detect small differences in rates was limited.

Source Information

From Brigham and Women's Hospital (L.M.), Harvard Clinical Research Institute (L.M., W.H., J.M.M., K.K.L.H., R.D., D.E.C.), Beth Israel Deaconess Medical Center (K.K.L.H., D.E.C.), Harvard Medical School (L.M., K.K.L.H., D.E.C.), and Boston University (J.M.M., R.D.) — all in Boston.

This article (10.1056/NEJMoa067731) was published at www.nejm.org on February 12, 2007.

Address reprint requests to Dr. Cutlip at Beth Israel Deaconess Medical Center, Baker 4, 185 Pilgrim Rd., Boston, MA 02215, or at don.cutlip{at}hcri.harvard.edu.

Full Text of this Article

This article has been cited by other articles:

• American College of Cardiology Foundation, , American Heart Association Task Force on Practice, , American Society of Echocardiography, , American Society of Nuclear Cardiology, , Heart Rhythm Society, , Society of Cardiovascular Anesthesiologists, , Society for Cardiovascular Angiography and Interve, , Society for Vascular Medicine, , Society for Vascular Surgery, , Fleisher, L. A., Beckman, J. A., Brown, K. A., Calkins, H., Chaikof, E. L., Fleischmann, K. E., Freeman, W. K., Froehlich, J. B., Kasper, E. K., Kersten, J. R., Riegel, B., Robb, J. F. (2009). 2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery. J Am Coll Cardiol 0: j.jacc.2009.07.010v1-15023 [Full Text]  
• RAYMOND, C., MENON, V. (2009). Dual antiplatelet therapy in coronary artery disease: A case-based approach. Cleveland Clinic Journal of Medicine 76: 663-670 [Abstract] [Full Text]  
• Silber, S., Colombo, A., Banning, A. P., Hauptmann, K., Drzewiecki, J., Grube, E., Dudek, D., Baim, D. S. (2009). Final 5-Year Results of the TAXUS II Trial: A Randomized Study to Assess the Effectiveness of Slow- and Moderate-Release Polymer-Based Paclitaxel-Eluting Stents for De Novo Coronary Artery Lesions. Circulation 120: 1498-1504 [Abstract] [Full Text]  
• Lagerqvist, B., Carlsson, J., Frobert, O., Lindback, J., Schersten, F., Stenestrand, U., James, S. K., for the Swedish Coronary Angiography and Angioplas, (2009). Stent Thrombosis in Sweden: A Report From the Swedish Coronary Angiography and Angioplasty Registry. Circ Cardiovasc Interv 2: 401-408 [Abstract] [Full Text]  
• Wang, Z J, Zhou, Y J, Liu, Y Y, Yu, M, Shi, D M, Zhao, Y X, Guo, Y H, Cheng, W J, Nie, B, Ge, H L, Jia, D A, Yang, S W, Yan, Z X (2009). Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents. Heart 95: 1587-1592 [Abstract] [Full Text]  
• Wykrzykowska, J. J., Serruys, P. W., Onuma, Y., de Vries, T., van Es, G.-A., Buszman, P., Linke, A., Ischinger, T., Klauss, V., Corti, R., Eberli, F., Wijns, W., Morice, M.-C., di Mario, C., van Geuns, R. J., Juni, P., Windecker, S. (2009). Impact of Vessel Size on Angiographic and Clinical Outcomes of Revascularization With Biolimus-Eluting Stent With Biodegradable Polymer and Sirolimus-Eluting Stent With Durable Polymer: The LEADERS Trial Substudy. J Am Coll Cardiol Intv 2: 861-870 [Abstract] [Full Text]  
• Roe, M. T., Chen, A. Y., Cannon, C. P., Rao, S., Rumsfeld, J., Magid, D. J., Brindis, R., Klein, L. W., Gibler, W. B., Ohman, E. M., Peterson, E. D., on behalf of the CRUSADE and ACTION-GWTG Registry, (2009). Temporal Changes in the Use of Drug-Eluting Stents for Patients With Non-ST-Segment-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention From 2006 to 2008: Results From the Can Rapid risk stratification of Unstable angina patients Supress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) and Acute Coronary Treatment and Intervention Outcomes Network-Get With The Guidelines (ACTION-GWTG) Registries. Circ Cardiovasc Qual Outcomes 2: 414-420 [Abstract] [Full Text]  
• Lee, J. Y., Park, D.-W., Yun, S.-C., Lee, S.-W., Kim, Y.-H., Lee, C. W., Hong, M.-K., Park, S.-W., Park, S.-J. (2009). Long-Term Clinical Outcomes of Sirolimus- Versus Paclitaxel-Eluting Stents for Patients With Unprotected Left Main Coronary Artery Disease Analysis of the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) Registry.. J Am Coll Cardiol 54: 853-859 [Abstract] [Full Text]  
• O'Donoghue, M., Antman, E. M., Braunwald, E., Murphy, S. A., Steg, P. G., Finkelstein, A., Penny, W. F., Fridrich, V., McCabe, C. H., Sabatine, M. S., Wiviott, S. D. (2009). The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis In Myocardial Infarction 38) Analysis.. J Am Coll Cardiol 54: 678-685 [Abstract] [Full Text]  
• Di Sciascio, G., Patti, G., Pasceri, V., Gaspardone, A., Colonna, G., Montinaro, A. (2009). Efficacy of Atorvastatin Reload in Patients on Chronic Statin Therapy Undergoing Percutaneous Coronary Intervention: Results of the ARMYDA-RECAPTURE (Atorvastatin for Reduction of Myocardial Damage During Angioplasty) Randomized Trial. J Am Coll Cardiol 54: 558-565 [Abstract] [Full Text]  
• Kim, Y.-H., Park, D.-W., Lee, S.-W., Yun, S.-C., Lee, C. W., Hong, M.-K., Park, S.-W., Seung, K. B., Gwon, H.-C., Jeong, M.-H., Jang, Y., Kim, H.-S., Seong, I.-W., Park, H. S., Ahn, T., Chae, I.-H., Tahk, S.-J., Chung, W.-S., Park, S.-J., for the Revascularization for Unprotected Left Mai, (2009). Long-Term Safety and Effectiveness of Unprotected Left Main Coronary Stenting With Drug-Eluting Stents Compared With Bare-Metal Stents. Circulation 120: 400-407 [Abstract] [Full Text]  
• Cook, S., Ladich, E., Nakazawa, G., Eshtehardi, P., Neidhart, M., Vogel, R., Togni, M., Wenaweser, P., Billinger, M., Seiler, C., Gay, S., Meier, B., Pichler, W. J., Juni, P., Virmani, R., Windecker, S. (2009). Correlation of Intravascular Ultrasound Findings With Histopathological Analysis of Thrombus Aspirates in Patients With Very Late Drug-Eluting Stent Thrombosis. Circulation 120: 391-399 [Abstract] [Full Text]  
• Adlam, D., Ayers, R., Channon, K. M. (2009). Intimal Dissection Causing Late Thrombosis of a Covered Stent: Optical Coherence Tomography Appearances. Circ Cardiovasc Interv 2: 359-360 [Full Text]  
• Holmes, D. R. Jr, Kereiakes, D. J., Kleiman, N. S., Moliterno, D. J., Patti, G., Grines, C. L. (2009). Combining Antiplatelet and Anticoagulant Therapies.. J Am Coll Cardiol 54: 95-109 [Abstract] [Full Text]  
• Chen, J. P., Hou, D., Pendyala, L., Goudevenos, J. A., Kounis, N. G. (2009). Drug-Eluting Stent Thrombosis: The Kounis Hypersensitivity-Associated Acute Coronary Syndrome Revisited. J Am Coll Cardiol Intv 2: 583-593 [Abstract] [Full Text]  
• Camici, G. G., Steffel, J., Amanovic, I., Breitenstein, A., Baldinger, J., Keller, S., Luscher, T. F., Tanner, F. C. (2009). Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents. Eur Heart J 0: ehp259v1-ehp259 [Abstract] [Full Text]  
• Unverdorben, M., Vallbracht, C., Cremers, B., Heuer, H., Hengstenberg, C., Maikowski, C., Werner, G. S., Antoni, D., Kleber, F. X., Bocksch, W., Leschke, M., Ackermann, H., Boxberger, M., Speck, U., Degenhardt, R., Scheller, B. (2009). Paclitaxel-Coated Balloon Catheter Versus Paclitaxel-Coated Stent for the Treatment of Coronary In-Stent Restenosis. Circulation 119: 2986-2994 [Abstract] [Full Text]  
• Alfonso, F., Perez-Vizcayno, M.-J., Ruiz, M., Suarez, A., Cazares, M., Hernandez, R., Escaned, J., Banuelos, C., Jimenez-Quevedo, P., Macaya, C. (2009). Coronary aneurysms after drug-eluting stent implantation clinical, angiographic, and intravascular ultrasound findings.. J Am Coll Cardiol 53: 2053-2060 [Abstract] [Full Text]  
• Chacko, R., Mulhearn, M., Novack, V., Novack, L., Mauri, L., Cohen, S. A., Moses, J., Leon, M. B., Cutlip, D. E. (2009). Impact of Target Lesion and Nontarget Lesion Cardiac Events on 5-Year Clinical Outcomes After Sirolimus-Eluting or Bare-Metal Stenting. J Am Coll Cardiol Intv 2: 498-503 [Abstract] [Full Text]  
• Forman, D. E., Cox, D. A., Ellis, S. G., Lasala, J. M., Ormiston, J. A., Stone, G. W., Turco, M. A., Wei, J. Y., Joshi, A. A., Dawkins, K. D., Baim, D. S. (2009). Long-Term Paclitaxel-Eluting Stent Outcomes in Elderly Patients. Circ Cardiovasc Interv 2: 178-187 [Abstract] [Full Text]  
• Prasad, A., Holmes, D. R (2009). Update on dual antiplatelet therapy for percutaneous coronary intervention. Heart 95: 861-865 [Full Text]  
• Ko, D. T., Chiu, M., Guo, H., Austin, P. C., Goeree, R., Cohen, E., Labinaz, M., Tu, J. V. (2009). Safety and effectiveness of drug-eluting and bare-metal stents for patients with off- and on-label indications.. J Am Coll Cardiol 53: 1773-1782 [Abstract] [Full Text]  
• Stone, G. W., Lansky, A. J., Pocock, S. J., Gersh, B. J., Dangas, G., Wong, S. C., Witzenbichler, B., Guagliumi, G., Peruga, J. Z., Brodie, B. R., Dudek, D., Mockel, M., Ochala, A., Kellock, A., Parise, H., Mehran, R., the HORIZONS-AMI Trial Investigators, (2009). Paclitaxel-Eluting Stents versus Bare-Metal Stents in Acute Myocardial Infarction. NEJM 360: 1946-1959 [Abstract] [Full Text]  
• Douglas, P. S., Brennan, J. M., Anstrom, K. J., Sedrakyan, A., Eisenstein, E. L., Haque, G., Dai, D., Kong, D. F., Hammill, B., Curtis, L., Matchar, D., Brindis, R., Peterson, E. D. (2009). Clinical Effectiveness of Coronary Stents in Elderly Persons: Results From 262,700 Medicare Patients in the American College of Cardiology-National Cardiovascular Data Registry. J Am Coll Cardiol 53: 1629-1641 [Abstract] [Full Text]  
• Liu, X., Doi, H., Maehara, A., Mintz, G. S., de Ribamar Costa, J. Jr, Sano, K., Weisz, G., Dangas, G. D., Lansky, A. J., Kreps, E. M., Collins, M., Fahy, M., Stone, G. W., Moses, J. W., Leon, M. B., Mehran, R. (2009). A Volumetric Intravascular Ultrasound Comparison of Early Drug-Eluting Stent Thrombosis Versus Restenosis. J Am Coll Cardiol Intv 2: 428-434 [Abstract] [Full Text]  
• Weisz, G., Leon, M. B., Holmes, D. R. Jr, Kereiakes, D. J., Popma, J. J., Teirstein, P. S., Cohen, S. A., Wang, H., Cutlip, D. E., Moses, J. W. (2009). Five-year follow-up after sirolimus-eluting stent implantation results of the SIRIUS (Sirolimus-Eluting Stent in De-Novo Native Coronary Lesions) Trial.. J Am Coll Cardiol 53: 1488-1497 [Abstract] [Full Text]  
• Li, Y., Zheng, Z., Xu, B., Zhang, S., Li, W., Gao, R., Hu, S. (2009). Comparison of Drug-Eluting Stents and Coronary Artery Bypass Surgery for the Treatment of Multivessel Coronary Disease: Three-Year Follow-Up Results From a Single Institution. Circulation 119: 2040-2050 [Abstract] [Full Text]  
• Mehilli, J., Kastrati, A., Schulz, S., Frungel, S., Nekolla, S. G., Moshage, W., Dotzer, F., Huber, K., Pache, J., Dirschinger, J., Seyfarth, M., Martinoff, S., Schwaiger, M., Schomig, A., for the Bavarian Reperfusion Alternatives Evaluati, (2009). Abciximab in Patients With Acute ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention After Clopidogrel Loading: A Randomized Double-Blind Trial. Circulation 119: 1933-1940 [Abstract] [Full Text]  
• SABATINE, M. S. (2009). Novel antiplatelet strategies in acute coronary syndromes. Cleveland Clinic Journal of Medicine 76: S8-S15 [Abstract] [Full Text]  
• Han, Y., Jing, Q., Xu, B., Yang, L., Liu, H., Shang, X., Jiang, T., Li, Z., Zhang, H., Li, H., Qiu, J., Liu, Y., Li, Y., Chen, X., Gao, R., for the CREATE (Multi-Center Registry of Excel Bio, (2009). Safety and Efficacy of Biodegradable Polymer-Coated Sirolimus-Eluting Stents in "Real-World" Practice: 18-Month Clinical and 9-Month Angiographic Outcomes. J Am Coll Cardiol Intv 2: 303-309 [Abstract] [Full Text]  
• Samady, H., McDaniel, M., Veledar, E., De Bruyne, B., Pijls, N. H., Fearon, W. F., Vaccarino, V. (2009). Baseline Fractional Flow Reserve and Stent Diameter Predict Optimal Post-Stent Fractional Flow Reserve and Major Adverse Cardiac Events After Bare-Metal Stent Deployment. J Am Coll Cardiol Intv 2: 357-363 [Abstract] [Full Text]  
• Leesar, M. A. (2009). Baseline Fractional Flow Reserve and Stent Diameter Predict Event Rates After Stenting: A Further Step, But Still Much to Learn. J Am Coll Cardiol Intv 2: 364-365 [Full Text]  
• Eisenberg, M. J., Richard, P. R., Libersan, D., Filion, K. B. (2009). Safety of Short-Term Discontinuation of Antiplatelet Therapy in Patients With Drug-Eluting Stents. Circulation 119: 1634-1642 [Abstract] [Full Text]  
• Brilakis, E. S., Lichtenwalter, C., de Lemos, J. A., Roesle, M., Obel, O., Haagen, D., Saeed, B., Gadiparthi, C., Bissett, J. K., Sachdeva, R., Voudris, V. V., Karyofillis, P., Kar, B., Rossen, J., Fasseas, P., Berger, P., Banerjee, S. (2009). A Randomized Controlled Trial of a Paclitaxel-Eluting Stent Versus a Similar Bare-Metal Stent in Saphenous Vein Graft Lesions: The SOS (Stenting Of Saphenous Vein Grafts) Trial. J Am Coll Cardiol 53: 919-928 [Abstract] [Full Text]  
• Kaul, U, Bhatia, V (2009). Choice of DES: is there a difference?. Heart Asia 2009: 11-15 [Abstract] [Full Text]  
• Serruys, P. W., Morice, M.-C., Kappetein, A. P., Colombo, A., Holmes, D. R., Mack, M. J., Stahle, E., Feldman, T. E., van den Brand, M., Bass, E. J., Van Dyck, N., Leadley, K., Dawkins, K. D., Mohr, F. W., the SYNTAX Investigators, (2009). Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease. NEJM 360: 961-972 [Abstract] [Full Text]  
• Applegate, R. J., Sacrinty, M. T., Kutcher, M. A., Santos, R. M., Gandhi, S. K., Little, W. C. (2009). 3-Year Comparison of Drug-Eluting Versus Bare-Metal Stents. J Am Coll Cardiol Intv 2: 231-239 [Abstract] [Full Text]  
• Gurbel, P. A., Bliden, K. P., Saucedo, J. F., Suarez, T. A., DiChiara, J., Antonino, M. J., Mahla, E., Singla, A., Herzog, W. R., Bassi, A. K., Hennebry, T. A., Gesheff, T. B., Tantry, U. S. (2009). Bivalirudin and Clopidogrel With and Without Eptifibatide for Elective Stenting: Effects on Platelet Function, Thrombelastographic Indexes, and Their Relation to Periprocedural Infarction Results of the CLEAR PLATELETS-2 (Clopidogrel With Eptifibatide to Arrest the Reactivity of Platelets) Study.. J Am Coll Cardiol 53: 648-657 [Abstract] [Full Text]  
• Kaltoft, A., Jensen, L. O., Maeng, M., Tilsted, H. H., Thayssen, P., Bottcher, M., Lassen, J. F., Krusell, L. R., Rasmussen, K., Hansen, K. N., Pedersen, L., Johnsen, S. P., Sorensen, H. T., Thuesen, L. (2009). 2-Year Clinical Outcomes After Implantation of Sirolimus-Eluting, Paclitaxel-Eluting, and Bare-Metal Coronary Stents Results From the WDHR (Western Denmark Heart Registry).. J Am Coll Cardiol 53: 658-664 [Abstract] [Full Text]  
• Stefanadis, C., Toutouzas, K. (2009). Paclitaxel versus sirolimus the battle is still ongoing.. J Am Coll Cardiol 53: 665-666 [Full Text]  
• Ryan, J., Linde-Zwirble, W., Engelhart, L., Cooper, L., Cohen, D. J. (2009). Temporal Changes in Coronary Revascularization Procedures, Outcomes, and Costs in the Bare-Metal Stent and Drug-Eluting Stent Eras: Results From the US Medicare Program. Circulation 119: 952-961 [Abstract] [Full Text]  
• Kimura, T., Morimoto, T., Nakagawa, Y., Tamura, T., Kadota, K., Yasumoto, H., Nishikawa, H., Hiasa, Y., Muramatsu, T., Meguro, T., Inoue, N., Honda, H., Hayashi, Y., Miyazaki, S., Oshima, S., Honda, T., Shiode, N., Namura, M., Sone, T., Nobuyoshi, M., Kita, T., Mitsudo, K., for the j-Cypher Registry Investigators, (2009). Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation. Circulation 119: 987-995 [Abstract] [Full Text]  
• van Werkum, J. W., Heestermans, A. A.C.M., de Korte, F. I., Kelder, J. C., Suttorp, M.-J., Rensing, B. J.W.M., Zwart, B., Brueren, B. R. G., Koolen, J. J., Dambrink, J.-H. E., van't Hof, A. W.J., Verheugt, F. W.A., ten Berg, J. M. (2009). Long-Term Clinical Outcome After a First Angiographically Confirmed Coronary Stent Thrombosis: An Analysis of 431 Cases. Circulation 119: 828-834 [Abstract] [Full Text]  
• Aoki, J., Lansky, A. J., Mehran, R., Moses, J., Bertrand, M. E., McLaurin, B. T., Cox, D. A., Lincoff, A. M., Ohman, E. M., White, H. D., Parise, H., Leon, M. B., Stone, G. W. (2009). Early Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Drug-Eluting and Bare Metal Stents: The Acute Catheterization and Urgent Intervention Triage Strategy Trial. Circulation 119: 687-698 [Abstract] [Full Text]  
• Stahli, B. E., Camici, G. G., Tanner, F. C. (2009). Drug-eluting stent thrombosis. Ther Adv Cardiovasc Dis 3: 45-52 [Abstract]  
• (2009). Effect of Length and Diameter of Drug-Eluting Stents Versus Bare-Metal Stents on Late Outcomes. Circ Cardiovasc Interv 2: 35-42  
• Park, S.-J., Park, D.-W. (2009). Percutaneous Coronary Intervention With Stent Implantation Versus Coronary Artery Bypass Surgery for Treatment of Left Main Coronary Artery Disease: Is It Time to Change Guidelines?. Circ Cardiovasc Interv 2: 59-68 [Abstract] [Full Text]  
• Hassan, A. K.M., Bergheanu, S. C., Stijnen, T., van der Hoeven, B. L., Snoep, J. D., Plevier, J. W.M., Schalij, M. J., Jukema, J. W. (2009). Late stent malapposition risk is higher after drug-eluting stent compared with bare-metal stent implantation and associates with late stent thrombosis. Eur Heart J 0: ehn553v1-9 [Abstract] [Full Text]  
• Genereux, P. MD, Mehran, R. MD (2009). Are drug-eluting stents safe in the long term?. CMAJ 180: 154-155 [Full Text]  
• Hamilos, M., Sarma, J., Ostojic, M., Cuisset, T., Sarno, G., Melikian, N., Ntalianis, A., Muller, O., Barbato, E., Beleslin, B., Sagic, D., De Bruyne, B., Bartunek, J., Wijns, W. (2008). Interference of Drug-Eluting Stents With Endothelium-Dependent Coronary Vasomotion: Evidence for Device-Specific Responses. Circ Cardiovasc Interv 1: 193-200 [Abstract] [Full Text]  
• Ferenc, M., Gick, M., Kienzle, R.-P., Bestehorn, H.-P., Werner, K.-D., Comberg, T., Kuebler, P., Buttner, H. J., Neumann, F.-J. (2008). Randomized trial on routine vs. provisional T-stenting in the treatment of de novo coronary bifurcation lesions. Eur Heart J 29: 2859-2867 [Abstract] [Full Text]  
• Go, A. S., Magid, D. J., Wells, B., Sung, S. H., Cassidy-Bushrow, A. E., Greenlee, R. T., Langer, R. D., Lieu, T. A., Margolis, K. L., Masoudi, F. A., McNeal, C. J., Murata, G. H., Newton, K. M., Novotny, R., Reynolds, K., Roblin, D. W., Smith, D. H., Vupputuri, S., White, R. E., Olson, J., Rumsfeld, J. S., Gurwitz, J. H. (2008). The Cardiovascular Research Network: A New Paradigm for Cardiovascular Quality and Outcomes Research. Circ Cardiovasc Qual Outcomes 1: 138-147 [Abstract] [Full Text]  
• Byrne, R. A., Kastrati, A. (2008). Duration of antiplatelet therapy following intracoronary stenting: are changes needed?. Eur Heart J Suppl 10: I25-I29 [Abstract] [Full Text]  
• Mauri, L., Silbaugh, T. S., Wolf, R. E., Zelevinsky, K., Lovett, A., Zhou, Z., Resnic, F. S., Normand, S.-L. T. (2008). Long-Term Clinical Outcomes After Drug-Eluting and Bare-Metal Stenting in Massachusetts. Circulation 118: 1817-1827 [Abstract] [Full Text]  
• King, S. B. III, Hannan, E. L. (2008). Mounting Evidence for Safety and Improved Outcomes of Drug-Eluting Stenting: But Is It the Stent?. Circulation 118: 1783-1784 [Full Text]  
• Wiviott, S. D., Braunwald, E., Angiolillo, D. J., Meisel, S., Dalby, A. J., Verheugt, F. W.A., Goodman, S. G., Corbalan, R., Purdy, D. A., Murphy, S. A., McCabe, C. H., Antman, E. M., for the TRITON-TIMI 38 Investigators, (2008). Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38. Circulation 118: 1626-1636 [Abstract] [Full Text]  
• Park, D.-W., Yun, S.-C., Lee, S.-W., Kim, Y.-H., Lee, C. W., Hong, M.-K., Cheong, S.-S., Kim, J.-J., Park, S.-W., Park, S.-J. (2008). Stent Thrombosis, Clinical Events, and Influence of Prolonged Clopidogrel Use After Placement of Drug-Eluting Stent: Data From an Observational Cohort Study of Drug-Eluting Versus Bare-Metal Stents. J Am Coll Cardiol Intv 1: 494-503 [Abstract] [Full Text]  
• Wenaweser, P., Daemen, J., Zwahlen, M., van Domburg, R., Juni, P., Vaina, S., Hellige, G., Tsuchida, K., Morger, C., Boersma, E., Kukreja, N., Meier, B., Serruys, P. W., Windecker, S. (2008). Incidence and Correlates of Drug-Eluting Stent Thrombosis in Routine Clinical Practice: 4-Year Results From a Large 2-Institutional Cohort Study. J Am Coll Cardiol 52: 1134-1140 [Abstract] [Full Text]  
• Chieffo, A., Park, S.-J., Meliga, E., Sheiban, I., Lee, M. S., Latib, A., Kim, Y.-H., Valgimigli, M., Sillano, D., Magni, V., Biondi-Zoccai, G., Montorfano, M., Airoldi, F., Rogacka, R., Carlino, M., Michev, I., Lee, C.-W., Hong, M.-K., Park, S.-W., Moretti, C., Bonizzoni, E., Sangiorgi, G. M., Tobis, J., Serruys, P. W., Colombo, A. (2008). Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry. Eur Heart J 29: 2108-2115 [Abstract] [Full Text]  
• Hamdalla, H., Moliterno, D. J. (2008). Late drug-eluting stent thrombosis in unprotected left main coronary artery lesions--sometimes possible, but rarely definite or probable. Eur Heart J 29: 2064-2066 [Full Text]  
• Stettler, C., Allemann, S., Wandel, S., Kastrati, A., Morice, M. C., Schomig, A., Pfisterer, M. E, Stone, G. W, Leon, M. B, Lezo, J. S. d., Goy, J.-J., Park, S.-J., Sabate, M., Suttorp, M. J, Kelbaek, H., Spaulding, C., Menichelli, M., Vermeersch, P., Dirksen, M. T, Cervinka, P., Carlo, M. D., Erglis, A., Chechi, T., Ortolani, P., Schalij, M. J, Diem, P., Meier, B., Windecker, S., Juni, P. (2008). Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis. BMJ 337: a1331-a1331 [Abstract] [Full Text]  
• Kastrati, A., Neumann, F.-J., Mehilli, J., Byrne, R. A., Iijima, R., Buttner, H. J., Khattab, A. A., Schulz, S., Blankenship, J. C., Pache, J., Minners, J., Seyfarth, M., Graf, I., Skelding, K. A., Dirschinger, J., Richardt, G., Berger, P. B., Schomig, A., the ISAR-REACT 3 Trial Investigators, (2008). Bivalirudin versus Unfractionated Heparin during Percutaneous Coronary Intervention. NEJM 359: 688-696 [Abstract] [Full Text]  
• Rastan, A. J., Boudriot, E., Falk, V., Kappetein, A. P., Borger, M. A., Serruys, P. W., Schuler, G., Mohr, F. W. (2008). Frequency and pattern of de-novo three-vessel and left main coronary artery disease; insights from single center enrolment in the SYNTAX study. Eur. J. Cardiothorac. Surg. 34: 376-383 [Abstract] [Full Text]  
• Shinke, T., Li, J., Chen, J. P., Pendyala, L., Goodchild, T., Jabara, R., Geva, S., Ueno, T., Chronos, N., Robinson, K., Hou, D. (2008). High Incidence of Intramural Thrombus After Overlapping Paclitaxel-Eluting Stent Implantation: Angioscopic and Histopathologic Analysis in Porcine Coronary Arteries. Circ Cardiovasc Interv 1: 28-35 [Abstract] [Full Text]  
• Holmes, D. R. Jr, Williams, D. O. (2008). Catheter-Based Treatment of Coronary Artery Disease: Past, Present, and Future. Circ Cardiovasc Interv 1: 60-73 [Abstract] [Full Text]  
• Holmes, D. R. Jr, Teirstein, P. S., Satler, L., Sketch, M. H. Jr, Popma, J. J., Mauri, L., Wang, H., Schleckser, P. A., Cohen, S. A., SISR Investigators, (2008). 3-Year Follow-Up of the SISR (Sirolimus-Eluting Stents Versus Vascular Brachytherapy for In-Stent Restenosis) Trial. J Am Coll Cardiol Intv 1: 439-448 [Abstract] [Full Text]  
• Newsome, L. T., Kutcher, M. A., Royster, R. L. (2008). Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention. Anesth. Analg. 107: 552-569 [Abstract] [Full Text]  
• Booth, J., Clayton, T., Pepper, J., Nugara, F., Flather, M., Sigwart, U., Stables, R. H., on Behalf of the SoS Investigators, (2008). Randomized, Controlled Trial of Coronary Artery Bypass Surgery Versus Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease: Six-Year Follow-Up From the Stent or Surgery Trial (SoS). Circulation 118: 381-388 [Abstract] [Full Text]  
• Ellis, S. G., O'Shaughnessy, C. D., Martin, S. L., Kent, K., McGarry, T., Turco, M. A., Kereiakes, D. J., Popma, J. J., Friedman, M., Koglin, J., Stone, G. W., for the TAXUS V ISR Investigators, (2008). Two-year clinical outcomes after paclitaxel-eluting stent or brachytherapy treatment for bare metal stent restenosis: the TAXUS V ISR trial. Eur Heart J 29: 1625-1634 [Abstract] [Full Text]  
• Malenka, D. J., Kaplan, A. V., Lucas, F. L., Sharp, S. M., Skinner, J. S. (2008). Outcomes Following Coronary Stenting in the Era of Bare-Metal vs the Era of Drug-Eluting Stents. JAMA 299: 2868-2876 [Abstract] [Full Text]  
• Dixon, S. R., Grines, C. L., O'Neill, W. W. (2008). The year in interventional cardiology.. J Am Coll Cardiol 51: 2355-2369 [Full Text]  
• Brar, S. S., Kim, J., Brar, S. K., Zadegan, R., Ree, M., Liu, I.-L. A., Mansukhani, P., Aharonian, V., Hyett, R., Shen, A. Y.-J. (2008). Long-term outcomes by clopidogrel duration and stent type in a diabetic population with de novo coronary artery lesions.. J Am Coll Cardiol 51: 2220-2227 [Abstract] [Full Text]  
• Choi, S.-H., Prasad, A., Tsimikas, S. (2008). The evolution of thienopyridine therapy clopidogrel duration, diabetes, and drug-eluting stents.. J Am Coll Cardiol 51: 2228-2229 [Full Text]  
• White, A. J., Kedia, G., Mirocha, J. M., Lee, M. S., Forrester, J. S., Morales, W. C., Dohad, S., Kar, S., Czer, L. S., Fontana, G. P., Trento, A., Shah, P. K., Makkar, R. R. (2008). Comparison of Coronary Artery Bypass Surgery and Percutaneous Drug-Eluting Stent Implantation for Treatment of Left Main Coronary Artery Stenosis. J Am Coll Cardiol Intv 1: 236-245 [Abstract] [Full Text]  
• Li, J., Jabara, R., Pendyala, L., Otsuka, Y., Shinke, T., Hou, D., Robinson, K., Chronos, N. (2008). Abnormal Vasomotor Function of Porcine Coronary Arteries Distal to Sirolimus-Eluting Stents. J Am Coll Cardiol Intv 1: 279-285 [Abstract] [Full Text]  
• Becker, R. C., Meade, T. W., Berger, P. B., Ezekowitz, M., O'Connor, C. M., Vorchheimer, D. A., Guyatt, G. H., Mark, D. B., Harrington, R. A. (2008). The Primary and Secondary Prevention of Coronary Artery Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 776S-814S [Abstract] [Full Text]  
• Kelbaek, H., Klovgaard, L., Helqvist, S., Lassen, J. F., Krusell, L. R., Engstrom, T., Botker, H. E., Jorgensen, E., Saunamaki, K., Aljabbari, S., Thayssen, P., Galloe, A., Jensen, G. V.H., Thuesen, L. (2008). Long-Term Outcome in Patients Treated With Sirolimus-Eluting Stents in Complex Coronary Artery Lesions: 3-Year Results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) Trial. J Am Coll Cardiol 51: 2011-2016 [Abstract] [Full Text]  
• Antman, E. M., Wiviott, S. D., Murphy, S. A., Voitk, J., Hasin, Y., Widimsky, P., Chandna, H., Macias, W., McCabe, C. H., Braunwald, E. (2008). Early and Late Benefits of Prasugrel in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: A TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolysis In Myocardial Infarction) Analysis. J Am Coll Cardiol 51: 2028-2033 [Abstract] [Full Text]  
• Trenk, D., Hochholzer, W., Fromm, M. F., Chialda, L.-E., Pahl, A., Valina, C. M., Stratz, C., Schmiebusch, P., Bestehorn, H.-P., Buttner, H. J., Neumann, F.-J. (2008). Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents. J Am Coll Cardiol 51: 1925-1934 [Abstract] [Full Text]  
• Garg, P., Cohen, D. J., Gaziano, T., Mauri, L. (2008). Balancing the Risks of Restenosis and Stent Thrombosis in Bare-Metal Versus Drug-Eluting Stents: Results of a Decision Analytic Model. J Am Coll Cardiol 51: 1844-1853 [Abstract] [Full Text]  
• Bhatt, S. H, Hauser, T. H (2008). Very Late Stent Thrombosis After Dual Antiplatelet Therapy Discontinuation in a Patient with a History of Acute Stent Thrombosis. The Annals of Pharmacotherapy 42: 708-712 [Abstract] [Full Text]  
• Mauri, L., Normand, S.-L. T. (2008). Studies of Drug-Eluting Stents: To Each His Own?. Circulation 117: 2047-2050 [Full Text]  
• Price, M. J., Endemann, S., Gollapudi, R. R., Valencia, R., Stinis, C. T., Levisay, J. P., Ernst, A., Sawhney, N. S., Schatz, R. A., Teirstein, P. S. (2008). Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation. Eur Heart J 29: 992-1000 [Abstract] [Full Text]  
• Zellweger, M. J., Kaiser, C., Brunner-La Rocca, H. P., Buser, P. T., Osswald, S., Weiss, P., Mueller-Brand, J., Pfisterer, M. E., for the BASKET Investigators, (2008). Value and Limitations of Target-Vessel Ischemia in Predicting Late Clinical Events After Drug-Eluting Stent Implantation. JNM 49: 550-556 [Abstract] [Full Text]  
• Salanti, G., Kavvoura, F. K., Ioannidis, J. P.A. (2008). Exploring the Geometry of Treatment Networks. ANN INTERN MED 148: 544-553 [Abstract] [Full Text]  
• Pinto Slottow, T. L., Waksman, R. (2008). Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel Meeting on the Endeavor Zotarolimus-Eluting Coronary Stent. Circulation 117: 1603-1608 [Full Text]  
• de la Torre-Hernandez, J. M., Alfonso, F., Hernandez, F., Elizaga, J., Sanmartin, M., Pinar, E., Lozano, I., Vazquez, J. M., Botas, J., Perez de Prado, A., Hernandez, J. M., Sanchis, J., Ruiz Nodar, J. M., Gomez-Jaume, A., Larman, M., Diarte, J. A., Rodriguez-Collado, J., Rumoroso, J. R., Lopez-Minguez, J. R., Mauri, J., for the ESTROFA Study Group, (2008). Drug-eluting stent thrombosis: results from the multicenter Spanish registry ESTROFA (Estudio ESpanol sobre TROmbosis de stents FArmacoactivos).. J Am Coll Cardiol 51: 986-990 [Abstract] [Full Text]  
• Kirtane, A. J., Ellis, S. G., Dawkins, K. D., Colombo, A., Grube, E., Popma, J. J., Fahy, M., Leon, M. B., Moses, J. W., Mehran, R., Stone, G. W. (2008). Paclitaxel-Eluting Coronary Stents in Patients With Diabetes Mellitus Pooled Analysis From 5 Randomized Trials.. J Am Coll Cardiol 51: 708-715 [Abstract] [Full Text]  
• Applegate, R. J., Sacrinty, M. T., Kutcher, M. A., Santos, R. M., Gandhi, S. K., Baki, T. T., Little, W. C. (2008). "Off-label" stent therapy 2-year comparison of drug-eluting versus bare-metal stents.. J Am Coll Cardiol 51: 607-614 [Abstract] [Full Text]