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Previous Volume 358:2698-2703 June 19, 2008 Number 25 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Supplementary Material Perspective by Weiner, L. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

SUMMARY

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

Source Information

From the Fred Hutchinson Cancer Research Center (N.N.H., H.W., J.C., D.W.H., J.Z.R., R.R., C.Y.) and the University of Washington (J.A.T., C.Y.) — both in Seattle; and the Ludwig Institute for Cancer Research (New York Branch), Memorial Sloan-Kettering Cancer Center, New York (A.J., S.G.).

Address reprint requests to Dr. Yee at the Fred Hutchinson Cancer Research Center, Room D3-100, 1100 Fairview Ave. N., Seattle, WA 98109, or at cyee{at}fhcrc.org.

Full Text of this Article

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Cancer Immunotherapy
Rosenberg S. A., Dudley M. E., Restifo N. P., Prestwich R., Vile R., Melcher A., Weiner L. M.
Extract | Full Text | PDF  
N Engl J Med 2008; 359:1072-1073, Sep 4, 2008. Correspondence

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