Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9-year-old girl, with no evidence of graft-versus-host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy.
Source Information
From the Centre for Kidney Research (S.I.A., M.H.); the Children's Hospital at Westmead and the Department of Paediatrics and Child Health, University of Sydney (S.I.A., N.S., A. Shun, S.D., A. Smith, B.W., P.J.S., A.L., M.O.S.); and the Australian National Liver Transplant Unit (D.V., A. Shun, S.D., M.O.S.) — all in Sydney.
Address reprint requests to Dr. Stormon at the Department of Gastroenterology, Children's Hospital at Westmead, Locked Bag 4001, 2145, Sydney, Australia, or at michaes6{at}chw.edu.au.
Related Letters:
Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant
Lund T., Tolar J., Alexander S. I., Reddel R. R., Stormon M. O.
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N Engl J Med 2008;
358:2075, May 8, 2008.
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