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Previous Volume 359:1207-1217 September 18, 2008 Number 12 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Supplementary Material Editorial by Fletcher, R. H. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article PubMed Citation

ABSTRACT

Background Computed tomographic (CT) colonography is a noninvasive option in screening for colorectal cancer. However, its accuracy as a screening tool in asymptomatic adults has not been well defined.

Methods We recruited 2600 asymptomatic study participants, 50 years of age or older, at 15 study centers. CT colonographic images were acquired with the use of standard bowel preparation, stool and fluid tagging, mechanical insufflation, and multidetector-row CT scanners (with 16 or more rows). Radiologists trained in CT colonography reported all lesions measuring 5 mm or more in diameter. Optical colonoscopy and histologic review were performed according to established clinical protocols at each center and served as the reference standard. The primary end point was detection by CT colonography of histologically confirmed large adenomas and adenocarcinomas (10 mm in diameter or larger) that had been detected by colonoscopy; detection of smaller colorectal lesions (6 to 9 mm in diameter) was also evaluated.

Results Complete data were available for 2531 participants (97%). For large adenomas and cancers, the mean (±SE) per-patient estimates of the sensitivity, specificity, positive and negative predictive values, and area under the receiver-operating-characteristic curve for CT colonography were 0.90±0.03, 0.86±0.02, 0.23±0.02, 0.99±<0.01, and 0.89±0.02, respectively. The sensitivity of 0.90 (i.e., 90%) indicates that CT colonography failed to detect a lesion measuring 10 mm or more in diameter in 10% of patients. The per-polyp sensitivity for large adenomas or cancers was 0.84±0.04. The per-patient sensitivity for detecting adenomas that were 6 mm or more in diameter was 0.78.

Conclusions In this study of asymptomatic adults, CT colonographic screening identified 90% of subjects with adenomas or cancers measuring 10 mm or more in diameter. These findings augment published data on the role of CT colonography in screening patients with an average risk of colorectal cancer. (ClinicalTrials.gov number, NCT00084929 [ClinicalTrials.gov] ; American College of Radiology Imaging Network [ACRIN] number, 6664.)

Source Information

From Mayo Clinic Arizona, Scottsdale, AZ (C.D.J., A.K.H.); Brown University Center for Statistical Sciences, Providence, RI (M.-H.C., B.A.H.); Biostatistics Consulting, Toronto (A.Y.T.); Mallinckrodt Institute of Radiology, Washington University, St. Louis (J.P.H., C.O.M.); University of Chicago, Chicago (A.D.); Scottsdale Medical Imaging, Scottsdale, AZ (M.D.K.); Beth Israel Deaconess Medical Center, Boston (B.S.); Yale University, New Haven, CT (J.I.C.); Radiology Imaging Associates, Denver (R.G.O.); Mayo Clinic Rochester, Rochester, MN (J.L.F., P.J.L.); University of California, Los Angeles, Los Angeles (P.Z.); Johns Hopkins University, Baltimore (K.M.H.); Memorial Medical Center, Springfield, IL (K.C.); University of Texas M.D. Anderson Cancer Center, Houston (R.B.I.); Virginia Commonwealth University, Richmond (R.A.H.); University of California, San Diego, San Diego (G.C.); University of California and San Francisco Veterans Affairs Medical Center, San Francisco (J.Y.); and Abbott Northwestern Hospital, Minneapolis (L.J.B.).

Full Text of this Article

Related Letters:

Accuracy of CT Colonography for Colorectal Cancer Screening
Rockey D. C., Gupta S., Matuchansky C., Sutradhar R., Paszat L., Rabeneck L., Johnson C. D., Chen M.-H., Toledano A. Y.
Extract | Full Text | PDF  
N Engl J Med 2008; 359:2842-2844, Dec 25, 2008. Correspondence

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