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Previous Volume 361:145-151 July 9, 2009 Number 2 Next

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ABSTRACT

Background From 2001 through March 2006, Planned Parenthood health centers throughout the United States provided medical abortion (abortion by means of medication) principally by a regimen of oral mifepristone followed 24 to 48 hours later by vaginal misoprostol. In response to concern about serious infections, in early 2006 Planned Parenthood changed the route of misoprostol administration from vaginal to buccal and required either routine provision of antibiotics or universal screening and treatment for chlamydia; in July 2007, Planned Parenthood began requiring routine treatment with antibiotics for all medical abortions.

Methods We performed a retrospective analysis assessing the rates of serious infection after medical abortion during a time when misoprostol was administered vaginally (through March 2006), as compared with rates after a change to buccal administration of misoprostol and after initiation of additional infection-reduction measures.

Results Rates of serious infection dropped significantly after the joint change to buccal misoprostol from vaginal misoprostol and to either testing for sexually transmitted infection or routine provision of antibiotics as part of the medical abortion regimen. The rate declined 73%, from 0.93 per 1000 abortions to 0.25 per 1000 (absolute reduction, 0.67 per 1000; 95% confidence interval [CI], 0.44 to 0.94; P<0.001). The subsequent change to routine provision of antibiotics led to a further significant reduction in the rate of serious infection — a 76% decline, from 0.25 per 1000 abortions to 0.06 per 1000 (absolute reduction, 0.19 per 1000; 95% CI, 0.02 to 0.34; P=0.03).

Conclusions The rate of serious infection after medical abortion declined by 93% after a change from vaginal to buccal administration of misoprostol combined with routine administration of antibiotics.

Source Information

From the Planned Parenthood Federation of America (M.F., V.C.) and the Reproductive Health Program, Population Council (I.S.) — both in New York; the Office of Population Research, Princeton University, Princeton, NJ (J.T.); the Hull York Medical School, University of Hull, Hull, United Kingdom (J.T.); and Northwestern University Feinberg School of Medicine, Chicago (E.S.L.).

Address reprint requests to Ms. Fjerstad at Ipas, P.O. Box 5027, Chapel Hill, NC 27514, or at fjerstadm{at}ipas.org.

Full Text of this Article

Related Letters:

Rates of Serious Infection after Medical Abortion
Kapp N., Winikoff B., Blumenthal P. D., Fjerstad M., Trussell J., Sivin I.
Extract | Full Text | PDF  
N Engl J Med 2009; 361:1511-1512, Oct 8, 2009. Correspondence

This article has been cited by other articles:

• Kapp, N., Winikoff, B., Blumenthal, P. D., Fjerstad, M., Trussell, J., Sivin, I. (2009). Rates of Serious Infection after Medical Abortion. NEJM 361: 1511-1512 [Full Text]  
• (2009). All you need to read in the other general journals. BMJ 339: b2820-b2820 [Full Text]  
• (2009). Enhancing the Safety of Medical Abortion. JWatch Women's Health 2009: 1-1 [Full Text]