Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial

Volume 324:781-788		March 21, 1991		Number 12

Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial

DS Echt, PR Liebson, LB Mitchell, RW Peters, D Obias-Manno, AH Barker, D Arensberg, A Baker, L Friedman, HL Greene, and et al.

Abstract

Add to Personal Archive

Add to Citation Manager

E-mail When Cited

PubMed Citation

CAST Coordinating Center, Seattle, WA 98105.

This article has been cited by other articles:

Munshi, N. V., McAnally, J., Bezprozvannaya, S., Berry, J. M., Richardson, J. A., Hill, J. A., Olson, E. N. (2009). Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay. Development 136: 2665-2674 [Abstract] [Full Text]
Daubert, J. P. (2009). Why Are (Only) Some Infarcted Hearts Arrhythmogenic?. J Am Coll Cardiol 54: 174-175 [Full Text]
Krishnamoorthy, S., Lip, G. Y.H. (2009). How safe is the antiarrhythmic drug therapy in atrial fibrillation?. Europace 11: 837-839 [Full Text]
Gheorghiade, M., Pang, P. S. (2009). Are BNP Changes During Hospitalization for Heart Failure a Reliable Surrogate for Predicting the Effects of Therapies on Post-Discharge Mortality?. J Am Coll Cardiol 53: 2349-2352 [Full Text]
Barth, A. S., Tomaselli, G. F. (2009). Cardiac Metabolism and Arrhythmias. Circ Arrhythmia Electrophysiol 2: 327-335 [Full Text]
Taylor, D. R. (2009). The {beta}-Agonist Saga and Its Clinical Relevance: On and On It Goes. Am. J. Respir. Crit. Care Med. 179: 976-978 [Abstract] [Full Text]
Shelton, R J, Clark, A L, Goode, K, Rigby, A S, Houghton, T, Kaye, G C, Cleland, J G F (2009). A randomised, controlled study of rate versus rhythm control in patients with chronic atrial fibrillation and heart failure: (CAFE-II Study). Heart 95: 924-930 [Abstract] [Full Text]
Anter, E., Jessup, M., Callans, D. J. (2009). Atrial Fibrillation and Heart Failure: Treatment Considerations for a Dual Epidemic. Circulation 119: 2516-2525 [Full Text]
Howick, J., Glasziou, P., Aronson, J. K (2009). The evolution of evidence hierarchies: what can Bradford Hill's 'guidelines for causation' contribute?. JRSM 102: 186-194 [Full Text]
Mangat, I. (2009). Do vegetarians have to eat fish for optimal cardiovascular protection?. Am. J. Clin. Nutr. 89: 1597S-1601S [Abstract] [Full Text]
Santini, M., Russo, M., Botto, G., Lunati, M., Proclemer, A., Schmidt, B., Erdogan, A., Helmling, E., Rauhe, W., Desaga, M., Santi, E., Messier, M., Boriani, G. (2009). Clinical and arrhythmic outcomes after implantation of a defibrillator for primary prevention of sudden death in patients with post-myocardial infarction cardiomyopathy: The Survey to Evaluate Arrhythmia Rate in High-risk MI patients (SEARCH-MI). Europace 11: 476-482 [Abstract] [Full Text]
Arya, A., Silberbauer, J., Teichman, S. L., Milner, P., Sulke, N., Camm, A. J. (2009). A preliminary assessment of the effects of ATI-2042 in subjects with paroxysmal atrial fibrillation using implanted pacemaker methodology. Europace 11: 458-464 [Abstract] [Full Text]
Potet, F., Chagot, B., Anghelescu, M., Viswanathan, P. C., Stepanovic, S. Z., Kupershmidt, S., Chazin, W. J., Balser, J. R. (2009). Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin. J. Biol. Chem. 284: 8846-8854 [Abstract] [Full Text]
Lauer, M. S. (2009). Discarding Logic: 2008 Ancel Keys Memorial Lecture. Circulation 119: 1533-1537 [Full Text]
Cleland, J. G.F., Tavazzi, L., Daubert, J.-C., Tageldien, A., Freemantle, N. (2009). Cardiac resynchronization therapy are modern myths preventing appropriate use?. J Am Coll Cardiol 53: 608-611 [Full Text]
Rice, L. B. (2009). Evidence-Based Evaluation of Physician Work Hour Regulations. JAMA 301: 484-484 [Full Text]
Myerburg, R. J. (2008). Implantable Cardioverter-Defibrillators after Myocardial Infarction. NEJM 359: 2245-2253 [Full Text]
Bauer, A., Malik, M., Schmidt, G., Barthel, P., Bonnemeier, H., Cygankiewicz, I., Guzik, P., Lombardi, F., Muller, A., Oto, A., Schneider, R., Watanabe, M., Wichterle, D., Zareba, W. (2008). Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use: International Society for Holter and Noninvasive Electrophysiology Consensus. J Am Coll Cardiol 52: 1353-1365 [Abstract] [Full Text]
Tung, R., Zimetbaum, P., Josephson, M. E. (2008). A Critical Appraisal of Implantable Cardioverter-Defibrillator Therapy for the Prevention of Sudden Cardiac Death. J Am Coll Cardiol 52: 1111-1121 [Abstract] [Full Text]
Aliot, E., Ruskin, J. N. (2008). Controversies in ablation of atrial fibrillation. Eur Heart J Suppl 10: H32-H54 [Abstract] [Full Text]
Marrie, R. A. (2008). You get what you measure: Evaluating endpoints in MS clinical trials. Neurology 71: 620-621 [Full Text]
Couchonnal, L. F., Anderson, M. E. (2008). The Role of Calmodulin Kinase II in Myocardial Physiology and Disease. Physiology 23: 151-159 [Abstract] [Full Text]
Karanicolas, P. J., Kunz, R., Guyatt, G. H. (2008). Point: Evidence-Based Medicine Has a Sound Scientific Base. Chest 133: 1067-1071 [Full Text]
Guyatt, G. H, Oxman, A. D, Vist, G. E, Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., Schunemann, H. J, for the GRADE Working Group, (2008). GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336: 924-926 [Full Text]
Sakabe, M., Shiroshita-Takeshita, A., Maguy, A., Brundel, B. J.J.M., Fujiki, A., Inoue, H., Nattel, S. (2008). Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia. Cardiovasc Res 78: 63-70 [Abstract] [Full Text]
Yankelson, L., Feld, Y., Bressler-Stramer, T., Itzhaki, I., Huber, I., Gepstein, A., Aronson, D., Marom, S., Gepstein, L. (2008). Cell Therapy for Modification of the Myocardial Electrophysiological Substrate. Circulation 117: 720-731 [Abstract] [Full Text]
Travin, M. I. (2008). A Potential Key Role for Radionuclide Imaging in the Prediction and Prevention of Sudden Arrhythmic Cardiac Death. JNM 49: 173-175 [Full Text]
George, C. H. (2008). Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?. Cardiovasc Res 77: 302-314 [Abstract] [Full Text]
Levy, J. H., Tanaka, K. A., Bailey, J. M. (2008). Cardiac Surgical Pharmacology. Card Surg Adult 3: 77-110 [Full Text]
von Gunten, C. F., Eappen, S., Cleary, J. F., Taylor, S. G. IV, Moots, P., Regevik, N., Cleeland, C., Cella, D. (2007). Flecainide for the treatment of chronic neuropathic pain: a Phase II trial. Palliat Med 21: 667-672 [Abstract]
Rossenbacker, T., Priori, S. G., Zipes, D. P. (2007). The fight against sudden cardiac death: consensus guidelines as a reference. Eur Heart J Suppl 9: I50-I58 [Abstract] [Full Text]
Smith, G. (2007). Matters of the heart: the physiology of cardiac function and failure. Exp Physiol 92: 973-986 [Abstract] [Full Text]
Ziegelstein, R. C., Parakh, K., Sakhuja, A., Bhat, U. (2007). Depression and Coronary Artery Disease: Is There a Platelet Link?. Mayo Clin Proc. 82: 1366-1368 [Full Text]
Macdougall, I. C., Eckardt, K.-U., Locatelli, F. (2007). Latest US KDOQI Anaemia Guidelines update what are the implications for Europe?. Nephrol Dial Transplant 22: 2738-2742 [Full Text]
Vassallo, P., Trohman, R. G. (2007). Prescribing Amiodarone: An Evidence-Based Review of Clinical Indications. JAMA 298: 1312-1322 [Abstract] [Full Text]
Shantsila, E., Watson, T., Lip, G. Y. (2007). Drug-induced QT-interval prolongation and proarrhythmic risk in the treatment of atrial arrhythmias. Europace 9: iv37-iv44 [Abstract] [Full Text]
Conen, D., Melly, L., Kaufmann, C., Bilz, S., Ammann, P., Schaer, B., Sticherling, C., Muller, B., Osswald, S. (2007). Amiodarone-Induced Thyrotoxicosis: Clinical Course and Predictors of Outcome. J Am Coll Cardiol 49: 2350-2355 [Abstract] [Full Text]
Zimetbaum, P. J. (2007). A 59-Year-Old Man Considering Implantation of a Cardiac Defibrillator. JAMA 297: 1909-1916 [Abstract] [Full Text]
Nathan, S. D., Noble, P. W., Tuder, R. M. (2007). Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Connecting the Dots. Am. J. Respir. Crit. Care Med. 175: 875-880 [Abstract] [Full Text]
Duggan, A. E., Duggan, J. M., Assy, N., Embon, O., Evoli, A., Servidei, S., Ben Salem, C., Hmouda, H., Bouraoui, K., Leiner, S., Abramowicz, M., Hoofnagle, J. H., Seeff, L. B. (2007). Peginterferon and Ribavirin for Hepatitis C. NEJM 356: 1269-1271 [Full Text]
Bauer, A., Becker, R., Dreyhaupt, J., Voss, F., Kraft, P., Kelemen, K., Senges-Becker, J. C., Katus, H. A., Schoels, W. (2007). Role of KATP channels in repetitive induction of ventricular fibrillation. Europace 9: 154-161 [Abstract] [Full Text]
Himmelfarb, J. (2007). Continuous Renal Replacement Therapy in the Treatment of Acute Renal Failure: Critical Assessment Is Required. CJASN 2: 385-389 [Abstract] [Full Text]
Straus, S., Haynes, B., Glasziou, P., Dickersin, K., Guyatt, G. (2007). Misunderstandings, misperceptions, and mistakes. Evid. Based Med. 12: 2-3 [Full Text]
Clancy, C. E., Zhu, Z. I., Rudy, Y. (2007). Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. Am. J. Physiol. Heart Circ. Physiol. 292: H66-H75 [Abstract] [Full Text]
Corbisiero, R., Lee, M. A., Nabert, D. R., Coman, J. A., Breiter, D. J., Schwartz, M., Mckittrick, E., Zhang, Y. (2006). Performance of a new single-chamber ICD algorithm: discrimination of supraventricular and ventricular tachycardia based on vector timing and correlation. Europace 8: 1057-1061 [Abstract] [Full Text]
Cho, K. C., Himmelfarb, J., Paganini, E., Ikizler, T. A., Soroko, S. H., Mehta, R. L., Chertow, G. M. (2006). Survival by Dialysis Modality in Critically Ill Patients with Acute Kidney Injury. J. Am. Soc. Nephrol. 17: 3132-3138 [Abstract] [Full Text]
Zaloga, G. P., Harvey, K. A., Stillwell, W., Siddiqui, R. (2006). Trans Fatty Acids and Coronary Heart Disease. Nutr Clin Pract 21: 505-512 [Abstract] [Full Text]
Roberts, K., Preston, I., Hill, N. S. (2006). Pulmonary hypertension trials: current end points are flawed, but what are the alternatives?. Chest 130: 934-936 [Full Text]
Ritchie, R. H., Zeitz, C. J., Wuttke, R. D., Hii, J. T.Y., Horowitz, J. D. (2006). Attenuation of the Negative Inotropic Effects of Metoprolol at Short Cycle Lengths in Humans: Comparison With Sotalol and Verapamil. J Am Coll Cardiol 48: 1234-1241 [Abstract] [Full Text]
Simpson, S. H, Eurich, D. T, Majumdar, S. R, Padwal, R. S, Tsuyuki, R. T, Varney, J., Johnson, J. A (2006). A meta-analysis of the association between adherence to drug therapy and mortality. BMJ 333: 15- [Abstract] [Full Text]
Stevens, L. A., Greene, T., Levey, A. S. (2006). Surrogate End Points for Clinical Trials of Kidney Disease Progression. CJASN 1: 874-884 [Full Text]
Gill, S., Sargent, D. (2006). End points for adjuvant therapy trials: has the time come to accept disease-free survival as a surrogate end point for overall survival?. The Oncologist 11: 624-629 [Abstract] [Full Text]
Pott, C., Goldhaber, J. I. (2006). Is the Ryanodine Receptor a Target for Antiarrhythmic Therapy?. Circ. Res. 98: 1232-1233 [Full Text]
Lafuente-Lafuente, C., Mouly, S., Longas-Tejero, M. A., Mahe, I., Bergmann, J.-F. (2006). Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials.. Arch Intern Med 166: 719-728 [Abstract] [Full Text]
Enseleit, F., Duru, F. (2006). Long-term continuous external electrocardiographic recording: a review.. Europace 8: 255-266 [Abstract] [Full Text]
Shah, V. N., Wingo, T. L., Weiss, K. L., Williams, C. K., Balser, J. R., Chazin, W. J. (2006). Calcium-dependent regulation of the voltage-gated sodium channel hH1: Intrinsic and extrinsic sensors use a common molecular switch. Proc. Natl. Acad. Sci. USA 103: 3592-3597 [Abstract] [Full Text]
Hall, M C S, Todd, D M (2006). Modern management of arrhythmias. Postgrad. Med. J. 82: 117-125 [Abstract] [Full Text]
Roberts, R. (2006). Genomics and Cardiac Arrhythmias. J Am Coll Cardiol 47: 9-21 [Abstract] [Full Text]
Chang, G.-J., Su, M.-J., Kuo, S.-C., Lin, T.-P., Lee, Y.-S. (2006). Multiple Cellular Electrophysiological Effects of a Novel Antiarrhythmic Furoquinoline Derivative HA-7 [N-Benzyl-7-methoxy-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-dione] in Guinea Pig Cardiac Preparations. J. Pharmacol. Exp. Ther. 316: 380-391 [Abstract] [Full Text]
Fukuda, K., Davies, S. S., Nakajima, T., Ong, B.-H., Kupershmidt, S., Fessel, J., Amarnath, V., Anderson, M. E., Boyden, P. A., Viswanathan, P. C., Roberts, L. J. II, Balser, J. R. (2005). Oxidative Mediated Lipid Peroxidation Recapitulates Proarrhythmic Effects on Cardiac Sodium Channels. Circ. Res. 97: 1262-1269 [Abstract] [Full Text]
Christ, T., Ravens, U. (2005). Do we need new antiarrhythmic compounds in the era of implantable cardiac devices and percutaneous ablation?. Cardiovasc Res 68: 341-343 [Full Text]
Benazon, N. R., Mamdani, M. M., Coyne, J. C. (2005). Trends in the Prescribing of Antidepressants Following Acute Myocardial Infarction, 1993-2002. Psychosom. Med. 67: 916-920 [Abstract] [Full Text]
Reiffel, J. A. (2005). Drug and Drug-Device Therapy in Heart Failure Patients in the Post-COMET and SCD-HeFT Era. J CARDIOVASC PHARMACOL THER 10: S45-S58 [Abstract]
Ryan, C M, Usui, K, Floras, J S, Bradley, T D (2005). Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea. Thorax 60: 781-785 [Abstract] [Full Text]
Collins, H. L., DiCarlo, S. E. (2005). Acute exercise increases the ventricular arrhythmia threshold via the intrinsic adenosine receptor system in conscious hypertensive rats. Am. J. Physiol. Heart Circ. Physiol. 289: H1020-H1026 [Abstract] [Full Text]
Temple, R. J. (2005). Enrichment Designs: Efficiency in Development of Cancer Treatments. JCO 23: 4838-4839 [Full Text]
Martinez, E. A., Bass, E. B., Zimetbaum, P. (2005). Pharmacologic Control of Rhythm: American College of Chest Physicians Guidelines for the Prevention and Management of Postoperative Atrial Fibrillation After Cardiac Surgery. Chest 128: 48S-55S [Abstract] [Full Text]
Buxton, A. E., Moss, A. J., Buxton, A. E., Moss, A. J. (2005). Should everyone with an ejection fraction less than or equal to 30% receive an implantable cardioverter-defibrillator?. Circulation 111: 2537-2549 [Full Text]
Patwala, A Y, Wright, D J (2005). Device based treatment of heart failure. Postgrad. Med. J. 81: 286-291 [Abstract] [Full Text]
Barrett, T. D., Triggle, D. J., Walker, M. J.A., Maurice, D. H. (2005). Mechanism of Tissue-Selective Drug Action in the Cardiovascular System. Mol. Interv. 5: 84-93 [Abstract] [Full Text]
Hodgkinson, K. A., Parfrey, P. S., Bassett, A. S., Kupprion, C., Drenckhahn, J., Norman, M. W., Thierfelder, L., Stuckless, S. N., Dicks, E. L., McKenna, W. J., Connors, S. P. (2005). The impact of implantable cardioverter-defibrillator therapy on survival in autosomal-dominant arrhythmogenic right ventricular cardiomyopathy (ARVD5). J Am Coll Cardiol 45: 400-408 [Abstract] [Full Text]
DiDomenico, R. J., Massad, M. G. (2005). Pharmacologic Strategies for Prevention of Atrial Fibrillation After Open Heart Surgery. Ann. Thorac. Surg. 79: 728-740 [Abstract] [Full Text]
Hlatky, M. A., Sanders, G. D., Owens, D. K. (2005). Evidence-Based Medicine And Policy: The Case Of The Implantable Cardioverter Defibrillator. Health Aff (Millwood) 24: 42-51 [Abstract] [Full Text]
Fleming, T. R. (2005). Surrogate Endpoints And FDA's Accelerated Approval Process. Health Aff (Millwood) 24: 67-78 [Abstract] [Full Text]
Borer, J. S. (2004). Development of cardiovascular drugs: The U.S. regulatory milieu from the perspective of a participating nonregulator. J Am Coll Cardiol 44: 2285-2292 [Abstract] [Full Text]
Dorian, P., Borggrefe, M., Al-Khalidi, H. R., Hohnloser, S. H., Brum, J. M., Tatla, D. S., Brachmann, J., Myerburg, R. J., Cannom, D. S., van der Laan, M., Holroyde, M. J., Singer, I., Pratt, C. M., on Behalf of the SHock Inhibition Evaluation with, (2004). Placebo-Controlled, Randomized Clinical Trial of Azimilide for Prevention of Ventricular Tachyarrhythmias in Patients With an Implantable Cardioverter Defibrillator. Circulation 110: 3646-3654 [Abstract] [Full Text]
Bauer, A., McDonald, A. D., Nasir, K., Peller, L., Rade, J. J., Miller, J. M., Heldman, A. W., Donahue, J. K. (2004). Inhibitory G Protein Overexpression Provides Physiologically Relevant Heart Rate Control in Persistent Atrial Fibrillation. Circulation 110: 3115-3120 [Abstract] [Full Text]
Bahnson, T. D., Grant, A. O. (2004). To Be or Not To Be in Normal Sinus Rhythm: What Do We Really Know?. ANN INTERN MED 141: 727-729 [Full Text]
Kaufman, E. S., Zimmermann, P. A., Wang, T., Dennish, G. W. III, Barrell, P. D., Chandler, M. L., Greene, H. L., AFFIRM Investigators, (2004). Risk of proarrhythmic events in the atrial fibrillation follow-up investigation of rhythm management (AFFIRM) study: A multivariate analysis. J Am Coll Cardiol 44: 1276-1282 [Abstract] [Full Text]
Palin, C. A., Kailasam, R., Hogue, C. W. Jr (2004). Atrial Fibrillation After Cardiac Surgery: Pathophysiology and Treatment. SEMIN CARDIOTHORAC VASC ANESTH 8: 175-183 [Abstract]
Canyon, S. J., Dobson, G. P. (2004). Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat. Am. J. Physiol. Heart Circ. Physiol. 287: H1286-H1295 [Abstract] [Full Text]
Michell, A. W., Lewis, S. J. G., Foltynie, T., Barker, R. A. (2004). Biomarkers and Parkinson's disease. Brain 127: 1693-1705 [Abstract] [Full Text]
Thompson, A., Balser, J. R. (2004). Perioperative cardiac arrhythmias. Br J Anaesth 93: 86-94 [Abstract] [Full Text]
(2004). Grading quality of evidence and strength of recommendations. BMJ 328: 1490- [Abstract] [Full Text]
Josephson, M., Wellens, H. J.J. (2004). Implantable Defibrillators and Sudden Cardiac Death. Circulation 109: 2685-2691 [Full Text]
Brody, A. S. (2004). Scoring Systems for CT in Cystic Fibrosis: Who Cares?. Radiology 231: 296-298 [Full Text]
Amabile, C. M., Spencer, A. P. (2004). Keeping Your Patient With Heart Failure Safe: A Review of Potentially Dangerous Medications. Arch Intern Med 164: 709-720 [Full Text]

Comments and questions? Please contact us.