From the Channing Laboratory and the Division of Preventive Medicine, Department of Medicine (M.J.S., C.H.H., J.E.M., G.A.C., B.R., W.C.W.), Harvard Medical School and Brigham and Women's Hospital; and the Departments of Epidemiology (M.J.S., G.A.C., W.C.W.), Biostatistics (B.R.), and Nutrition (W.C.W.), Harvard School of Public Health -- all in Boston.
Address reprint requests to Dr. Stampfer at the Channing Laboratory, 180 Longwood Ave., Boston, MA 02115.
Prasad, K.
(2009). Vitamin E Does Not Regress Hypercholesterolemic Atherosclerosis. J CARDIOVASC PHARMACOL THER
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Pocobelli, G., Peters, U., Kristal, A. R., White, E.
(2009). Use of Supplements of Multivitamins, Vitamin C, and Vitamin E in Relation to Mortality. Am J Epidemiol
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(2009). Does reversal of oxidative stress and inflammation provide vascular protection?. Cardiovasc Res
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Paul-Clark, M. J., McMaster, S. K., Sorrentino, R., Sriskandan, S., Bailey, L. K., Moreno, L., Ryffel, B., Quesniaux, V. F., Mitchell, J. A.
(2009). Toll-like Receptor 2 Is Essential for the Sensing of Oxidants during Inflammation. Am. J. Respir. Crit. Care Med.
179: 299-306
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Sesso, H. D., Buring, J. E., Christen, W. G., Kurth, T., Belanger, C., MacFadyen, J., Bubes, V., Manson, J. E., Glynn, R. J., Gaziano, J. M.
(2008). Vitamins E and C in the Prevention of Cardiovascular Disease in Men: The Physicians' Health Study II Randomized Controlled Trial. JAMA
300: 2123-2133
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Craici, I., Wagner, S., Garovic, V. D.
(2008). Review: Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test?. Ther Adv Cardiovasc Dis
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(2008). Statin Treatment as a Confounding Factor in Human Trials with Vitamin E. J. Nutr.
138: 1179-1181
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Jenkins, D. J. A., Kendall, C. W. C., Marchie, A., Josse, A. R., Nguyen, T. H., Faulkner, D. A., Lapsley, K. G., Blumberg, J.
(2008). Almonds Reduce Biomarkers of Lipid Peroxidation in Older Hyperlipidemic Subjects. J. Nutr.
138: 908-913
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Cook, N. R., Albert, C. M., Manson, J. E., for the WACS Investigator Group,
(2008). Clinical Trials of Antioxidant Supplementation in the Prevention of Cardiovascular Events--Reply. Arch Intern Med
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Buijsse, B., Feskens, E. J. M., Kwape, L., Kok, F. J., Kromhout, D.
(2008). Both {alpha}- and -Carotene, but Not Tocopherols and Vitamin C, Are Inversely Related to 15-Year Cardiovascular Mortality in Dutch Elderly Men. J. Nutr.
138: 344-350
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Tatsioni, A., Bonitsis, N. G., Ioannidis, J. P. A.
(2007). Persistence of Contradicted Claims in the Literature. JAMA
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Siekmeier, R., Steffen, C., Marz, W.
(2007). Role of Oxidants and Antioxidants in Atherosclerosis: Results of In Vitro and In Vivo Investigations. J CARDIOVASC PHARMACOL THER
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Houston, M. C., Cooil, B., Olafsson, B. J., Raggi, P.
(2007). Juice Powder Concentrate and Systemic Blood Pressure, Progression of Coronary Artery Calcium and Antioxidant Status in Hypertensive Subjects: A Pilot Study. Evid Based Complement Alternat Med
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Fewell, Z., Davey Smith, G., Sterne, J. A. C.
(2007). The Impact of Residual and Unmeasured Confounding in Epidemiologic Studies: A Simulation Study. Am J Epidemiol
166: 646-655
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Cook, N. R., Albert, C. M., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., Manson, J. E.
(2007). A Randomized Factorial Trial of Vitamins C and E and Beta Carotene in the Secondary Prevention of Cardiovascular Events in Women: Results From the Women's Antioxidant Cardiovascular Study. Arch Intern Med
167: 1610-1618
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Lapolla, A., Piarulli, F., Sartore, G., Ceriello, A., Ragazzi, E., Reitano, R., Baccarin, L., Laverda, B., Fedele, D.
(2007). Advanced Glycation End Products and Antioxidant Status in Type 2 Diabetic Patients With and Without Peripheral Artery Disease. Diabetes Care
30: 670-676
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Rippe, J. M., Angelopoulos, T. J., Zukley, L.
(2007). The Rationale for Intervention to Reduce the Risk of Coronary Heart Disease. AMERICAN JOURNAL OF LIFESTYLE MEDICINE
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Prentice, R. L
(2007). Clinical trials and observational studies to assess the chronic disease benefits and risks of multivitamin-multimineral supplements. Am. J. Clin. Nutr.
85: 308S-313S
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Wald, D. S, Wald, N. J, Morris, J. K, Law, M.
(2006). Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BMJ
333: 1114-1117
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Fairus, S., Nor, R. M, Cheng, H. M, Sundram, K.
(2006). Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of {alpha}-tocopherol.. Am. J. Clin. Nutr.
84: 835-842
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Dietrich, M., Traber, M. G, Jacques, P. F, Cross, C. E, Hu, Y., Block, G.
(2006). Does {gamma}-Tocopherol Play a Role in the Primary Prevention of Heart Disease and Cancer? A Review.. J. Am. Coll. Nutr.
25: 292-299
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Sharma, P., Herrmann, N., Rochon, P. A., Lee, M., Croxford, R., Rothenburg, L., Black, S. E., Lanctot, K. L.
(2006). Perceptions of Natural Health Products Among Patients Attending a Memory Clinic. AM J ALZHEIMERS DIS OTHER DEMEN
21: 156-163
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Gao, X., Wilde, P. E., Lichtenstein, A. H., Bermudez, O. I., Tucker, K. L.
(2006). The Maximal Amount of Dietary {alpha}-Tocopherol Intake in U.S. Adults (NHANES 2001-2002). J. Nutr.
136: 1021-1026
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Meyerhardt, J. A., Heseltine, D., Campos, H., Holmes, M. D., Willett, W. C., Winer, E. P., Enzinger, P. C., Bunnell, C. A., Kulke, M. H., Fuchs, C. S.
(2005). Assessment of a Dietary Questionnaire in Cancer Patients Receiving Cytotoxic Chemotherapy. JCO
23: 8453-8460
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Pham, D. Q, Plakogiannis, R.
(2005). Vitamin E Supplementation in Cardiovascular Disease and Cancer Prevention: Part 1. The Annals of Pharmacotherapy
39: 1870-1878
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Wu, D., Liu, L., Meydani, M., Meydani, S. N.
(2005). Vitamin E Increases Production of Vasodilator Prostanoids in Human Aortic Endothelial Cells through Opposing Effects on Cyclooxygenase-2 and Phospholipase A2. J. Nutr.
135: 1847-1853
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Lichtenstein, A. H., Russell, R. M.
(2005). Essential Nutrients: Food or Supplements?: Where Should the Emphasis Be?. JAMA
294: 351-358
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Ioannidis, J. P. A.
(2005). Contradicted and Initially Stronger Effects in Highly Cited Clinical Research. JAMA
294: 218-228
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Lee, I-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M, Manson, J. E., Hennekens, C. H., Buring, J. E.
(2005). Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women's Health Study: A Randomized Controlled Trial. JAMA
294: 56-65
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Redberg, R. F.
(2005). Vitamin E and Cardiovascular Health: Does Sex Matter?. JAMA
294: 107-109
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Vogel, J. H.K., Bolling, S. F., Costello, R. B., Guarneri, E. M., Krucoff, M. W., Longhurst, J. C., Olshansky, B., Pelletier, K. R., Tracy, C. M., Vogel, R. A., Vogel, R. A., Abrams, J., Anderson, J. L., Bates, E. R., Brodie, B. R., Grines, C. L., Danias, P. G., Gregoratos, G., Hlatky, M. A., Hochman, J. S., Kaul, S., Lichtenberg, R. C., Lindner, J. R., O'Rourke, R. A., Pohost, G. M., Schofield, R. S., Shubrooks, S. J., Tracy, C. M., Winters, W. L. Jr
(2005). Integrating Complementary Medicine Into Cardiovascular Medicine: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). J Am Coll Cardiol
46: 184-221
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Brown, B. G., Crowley, J.
(2005). Is There Any Hope for Vitamin E?. JAMA
293: 1387-1390
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Trumbo, P. R.
(2005). The Level of Evidence for Permitting a Qualified Health Claim: FDA's Review of the Evidence for Selenium and Cancer and Vitamin E and Heart Disease. J. Nutr.
135: 354-356
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Morrow, J. D.
(2005). Quantification of Isoprostanes as Indices of Oxidant Stress and the Risk of Atherosclerosis in Humans. Arterioscler. Thromb. Vasc. Bio.
25: 279-286
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Esmaillzadeh, A., Mirmiran, P., Azizi, F.
(2005). Whole-grain intake and the prevalence of hypertriglyceridemic waist phenotype in Tehranian adults. Am. J. Clin. Nutr.
81: 55-63
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Hall, W. L., Jeanes, Y. M., Lodge, J. K.
(2005). Hyperlipidemic Subjects Have Reduced Uptake of Newly Absorbed Vitamin E into Their Plasma Lipoproteins, Erythrocytes, Platelets, and Lymphocytes, as Studied by Deuterium-Labeled {alpha}-Tocopherol Biokinetics. J. Nutr.
135: 58-63
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Gross, M., Steffes, M., Jacobs, D. R. Jr, Yu, X., Lewis, L., Lewis, C. E., Loria, C. M.
(2005). Plasma F2-Isoprostanes and Coronary Artery Calcification: The CARDIA Study. Clin. Chem.
51: 125-131
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Genkinger, J. M., Platz, E. A., Hoffman, S. C., Comstock, G. W., Helzlsouer, K. J.
(2004). Fruit, Vegetable, and Antioxidant Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality in a Community-dwelling Population in Washington County, Maryland. Am J Epidemiol
160: 1223-1233
[Abstract][Full Text]
Knekt, P., Ritz, J., Pereira, M. A, O'Reilly, E. J, Augustsson, K., Fraser, G. E, Goldbourt, U., Heitmann, B. L, Hallmans, G., Liu, S., Pietinen, P., Spiegelman, D., Stevens, J., Virtamo, J., Willett, W. C, Rimm, E. B, Ascherio, A.
(2004). Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Am. J. Clin. Nutr.
80: 1508-1520
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Lee, D.-H., Folsom, A. R, Harnack, L., Halliwell, B., Jacobs, D. R Jr
(2004). Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?. Am. J. Clin. Nutr.
80: 1194-1200
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Stocker, R., Keaney, J. F. Jr.
(2004). Role of Oxidative Modifications in Atherosclerosis. Physiol. Rev.
84: 1381-1478
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Jervis, K. M., Robaire, B.
(2004). The Effects of Long-Term Vitamin E Treatment on Gene Expression and Oxidative Stress Damage in the Aging Brown Norway Rat Epididymis. Biol. Reprod.
71: 1088-1095
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Prentice, R. L., Willett, W. C., Greenwald, P., Alberts, D., Bernstein, L., Boyd, N. F., Byers, T., Clinton, S. K., Fraser, G., Freedman, L., Hunter, D., Kipnis, V., Kolonel, L. N., Kristal, B. S., Kristal, A., Lampe, J. W., McTiernan, A., Milner, J., Patterson, R. E., Potter, J. D., Riboli, E., Schatzkin, A., Yates, A., Yetley, E.
(2004). Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations. JNCI J Natl Cancer Inst
96: 1276-1287
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Eidelman, R. S., Hollar, D., Hebert, P. R., Lamas, G. A., Hennekens, C. H.
(2004). Randomized Trials of Vitamin E in the Treatment and Prevention of Cardiovascular Disease. Arch Intern Med
164: 1552-1556
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Butler, R. N., Sprott, R., Warner, H., Bland, J., Feuers, R., Forster, M., Fillit, H., Harman, S. M., Hewitt, M., Hyman, M., Johnson, K., Kligman, E., McClearn, G., Nelson, J., Richardson, A., Sonntag, W., Weindruch, R., Wolf, N.
(2004). Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans. Journals of Gerontology Series A: Biological Sciences and Medical Sciences
59: B560-B567
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Mares, J. A., La Rowe, T. L., Blodi, B. A.
(2004). Doctor, What Vitamins Should I Take for My Eyes?. Arch Ophthalmol
122: 628-635
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Simon, J. A., Murtaugh, M. A., Gross, M. D., Loria, C. M., Hulley, S. B., Jacobs, D. R. Jr.
(2004). Relation of Ascorbic Acid to Coronary Artery Calcium: The Coronary Artery Risk Development in Young Adults Study. Am J Epidemiol
159: 581-588
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Dwyer, J. H., Paul-Labrador, M. J., Fan, J., Shircore, A. M., Merz, C. N. B., Dwyer, K. M.
(2004). Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study. Arterioscler. Thromb. Vasc. Bio.
24: 313-319
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Leonard, S. W, Good, C. K, Gugger, E. T, Traber, M. G
(2004). Vitamin E bioavailability from fortified breakfast cereal is greater than that from encapsulated supplements. Am. J. Clin. Nutr.
79: 86-92
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Kunkel, E. J. S., Meyer, B., Daskalakis, C., Cocroft, J., Jennings-Dozier, K., Myers, R. E.
(2004). Behaviors Used by Men to Protect Themselves against Prostate Cancer. Cancer Epidemiol. Biomarkers Prev.
13: 78-86
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Wollin, S. D., Jones, P. J. H.
(2003). {alpha}-Lipoic Acid and Cardiovascular Disease. J. Nutr.
133: 3327-3330
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Nam, C. M., Oh, K. W., Lee, K. H., Jee, S. H., Cho, S. Y., Shim, W. H., Suh, I.
(2003). Vitamin C Intake and Risk of Ischemic Heart Disease in a Population with a High Prevalence of Smoking. J. Am. Coll. Nutr.
22: 372-378
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Hak, A. E., Stampfer, M. J., Campos, H., Sesso, H. D., Gaziano, J. M., Willett, W., Ma, J.
(2003). Plasma Carotenoids and Tocopherols and Risk of Myocardial Infarction in a Low-Risk Population of US Male Physicians. Circulation
108: 802-807
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Dutta, A., Dutta, S. K.
(2003). Vitamin E and its Role in the Prevention of Atherosclerosis and Carcinogenesis: A Review. J. Am. Coll. Nutr.
22: 258-268
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Holmquist, C., Larsson, S., Wolk, A., de Faire, U.
(2003). Multivitamin Supplements Are Inversely Associated with Risk of Myocardial Infarction in Men and Women--Stockholm Heart Epidemiology Program (SHEEP). J. Nutr.
133: 2650-2654
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Frei, B.
(2003). To C or not to C, that is the question!. J Am Coll Cardiol
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Morris, C. D., Carson, S.
(2003). Routine Vitamin Supplementation To Prevent Cardiovascular Disease: A Summary of the Evidence for the U.S. Preventive Services Task Force. ANN INTERN MED
139: 56-70
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Plotnick, G. D., Corretti, M. C., Vogel, R. A., Hesslink, R. Jr, Wise, J. A.
(2003). Effect of supplemental phytonutrients on impairment of the flow-mediated brachialartery vasoactivity after a single high-fat meal. J Am Coll Cardiol
41: 1744-1749
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Gotto, A. M. Jr
(2003). Antioxidants, statins, and atherosclerosis. J Am Coll Cardiol
41: 1205-1210
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Alper, C. M., Mattes, R. D.
(2003). Peanut Consumption Improves Indices of Cardiovascular Disease Risk in Healthy Adults. J. Am. Coll. Nutr.
22: 133-141
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Kennedy, S.
(2003). Nutrition. Integr Cancer Ther
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Liu, M., Wallmon, A., Olsson-Mortlock, C., Wallin, R., Saldeen, T.
(2003). Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am. J. Clin. Nutr.
77: 700-706
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Morrow, J. D.
(2003). Is Oxidant Stress a Connection Between Obesity and Atherosclerosis?. Arterioscler. Thromb. Vasc. Bio.
23: 368-370
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Gross, M., Yu, X., Hannan, P., Prouty, C., Jacobs, D. R Jr
(2003). Lipid standardization of serum fat-soluble antioxidant concentrations: the YALTA study. Am. J. Clin. Nutr.
77: 458-466
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van Dam, B., van Hinsbergh, V. W.M, Stehouwer, C. D.A, Versteilen, A., Dekker, H., Buytenhek, R., Princen, H. M, Schalkwijk, C. G
(2003). Vitamin E inhibits lipid peroxidation-induced adhesion molecule expression in endothelial cells and decreases soluble cell adhesion molecules in healthy subjects. Cardiovasc Res
57: 563-571
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Parmley, W. W.
(2003). In the statin era, how important are intense lifestyle changes?. J Am Coll Cardiol
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Mooradian, A. D.
(2003). Cardiovascular Disease in Type 2 Diabetes Mellitus: Current Management Guidelines. Arch Intern Med
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Chen, J., He, J., Hamm, L., Batuman, V., Whelton, P. K.
(2002). Serum Antioxidant Vitamins and Blood Pressure in the United States Population. Hypertension
40: 810-816
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Waters, D. D., Alderman, E. L., Hsia, J., Howard, B. V., Cobb, F. R., Rogers, W. J., Ouyang, P., Thompson, P., Tardif, J. C., Higginson, L., Bittner, V., Steffes, M., Gordon, D. J., Proschan, M., Younes, N., Verter, J. I.
(2002). Effects of Hormone Replacement Therapy and Antioxidant Vitamin Supplements on Coronary Atherosclerosis in Postmenopausal Women: A Randomized Controlled Trial. JAMA
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Schwenke, D. C., Rudel, L. L., Sorci-Thomas, M. G., Thomas, M. J.
(2002). {alpha}-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits. J. Lipid Res.
43: 1927-1938
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Lonn, E., Yusuf, S., Hoogwerf, B., Pogue, J., Yi, Q., Zinman, B., Bosch, J., Dagenais, G., Mann, J. F.E., Gerstein, H. C.
(2002). Effects of Vitamin E on Cardiovascular and Microvascular Outcomes in High-Risk Patients With Diabetes: Results of the HOPE Study and MICRO-HOPE Substudy. Diabetes Care
25: 1919-1927
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Venugopal, S. K., Devaraj, S., Yang, T., Jialal, I.
(2002). {alpha}-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-{alpha}. Diabetes
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Brown, B. G., Cheung, M. C., Lee, A. C., Zhao, X.-Q., Chait, A.
(2002). Antioxidant Vitamins and Lipid Therapy: End of a Long Romance?. Arterioscler. Thromb. Vasc. Bio.
22: 1535-1546
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Hodis, H. N., Mack, W. J., LaBree, L., Mahrer, P. R., Sevanian, A., Liu, C.-r., Liu, C.-h., Hwang, J., Selzer, R. H., Azen, S. P., for the VEAPS Research Group,
(2002). Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis: The Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation
106: 1453-1459
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Huang, H.-Y., Appel, L. J, Croft, K. D, Miller, E. R III, Mori, T. A, Puddey, I. B
(2002). Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. Am. J. Clin. Nutr.
76: 549-555
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McKeown, N. M, Meigs, J. B, Liu, S., Wilson, P. W., Jacques, P. F
(2002). Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am. J. Clin. Nutr.
76: 390-398
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Muntwyler, J., Hennekens, C. H., Manson, J. E., Buring, J. E., Gaziano, J. M.
(2002). Vitamin Supplement Use in a Low-Risk Population of US Male Physicians and Subsequent Cardiovascular Mortality. Arch Intern Med
162: 1472-1476
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Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Wilson, R. S.
(2002). Vitamin E and Cognitive Decline in Older Persons. Arch Neurol
59: 1125-1132
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Fairfield, K. M., Fletcher, R. H.
(2002). Vitamins for Chronic Disease Prevention in Adults: Scientific Review. JAMA
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Desideri, G., Marinucci, M. C., Tomassoni, G., Masci, P. G., Santucci, A., Ferri, C.
(2002). Vitamin E Supplementation Reduces Plasma Vascular Cell Adhesion Molecule-1 and von Willebrand Factor Levels and Increases Nitric Oxide Concentrations in Hypercholesterolemic Patients. J. Clin. Endocrinol. Metab.
87: 2940-2945
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Wedekind, K. J., Zicker, S., Lowry, S., Paetau-Robinson, I.
(2002). Antioxidant Status of Adult Beagles Is Affected by Dietary Antioxidant Intake. J. Nutr.
132: 1658S-1660
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Cho, H.-J., Jeong, H. G., Lee, J.-S., Woo, E.-R., Hyun, J.-W., Chung, M.-H., You, H. J.
(2002). Oncogenic H-Ras Enhances DNA Repair through the Ras/Phosphatidylinositol 3-Kinase/Rac1 Pathway in NIH3T3 Cells. EVIDENCE FOR ASSOCIATION WITH REACTIVE OXYGEN SPECIES. J. Biol. Chem.
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de Lorgeril, M., Salen, P., Defaye, P., Mabo, P., Paillard, F.
(2002). Dietary prevention of sudden cardiac death. Eur Heart J
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(2002). Unproven Therapies. Clin. Diabetes
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(2002). Free Radicals in the Physiological Control of Cell Function. Physiol. Rev.
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Franz, M. J., Bantle, J. P., Beebe, C. A., Brunzell, J. D., Chiasson, J.-L., Garg, A., Holzmeister, L. A., Hoogwerf, B., Mayer-Davis, E., Mooradian, A. D., Purnell, J. Q., Wheeler, M.
(2002). Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications. Diabetes Care
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Jiang, Q., Christen, S., Shigenaga, M. K, Ames, B. N
(2001). {gamma}-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am. J. Clin. Nutr.
74: 714-722
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Lonn, E.
(2001). Do antioxidant vitamins protect against atherosclerosis? The proof is still lacking. J Am Coll Cardiol
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Park, K. S., Kim, J. H., Kim, M. S., Kim, J. M., Kim, S. K., Choi, J. Y., Chung, M. H., Han, B., Kim, S. Y., Lee, H. K.
(2001). Effects of Insulin and Antioxidant on Plasma 8-Hydroxyguanine and Tissue 8-Hydroxydeoxyguanosine in Streptozotocin-Induced Diabetic Rats. Diabetes
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(2001). Vitamin E: protective role of a Janus molecule. FASEB J.
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Chernoff, R.
(2001). Nutrition and Health Promotion in Older Adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences
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Nicolosi, R. J., Wilson, T. A., Lawton, C., Handelman, G. J.
(2001). Dietary Effects on Cardiovascular Disease Risk Factors: Beyond Saturated Fatty Acids and Cholesterol. J. Am. Coll. Nutr.
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