Aspirin and the Risk of Colorectal Cancer in Women
Edward Giovannucci, M.D., Kathleen M. Egan, M.P.H., David J. Hunter, M.D., Meir J. Stampfer, M.D., Graham A. Colditz, M.D., Walter C. Willett, M.D., and Frank E. Speizer, M.D.
From the Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital (E.G., D.J.H., M.J.S., G.A.C., W.C.W., F.E.S.), and the Departments of Epidemiology (K.M.E., D.J.H., M.J.S., G.A.C., W.C.W.) and Nutrition (E.G., M.J.S., W.C.W.), Harvard School of Public Health — all in Boston.
Address reprint requests to Dr. Giovannucci at the Channing Laboratory, 180 Longwood Ave., Boston, MA 02115.
Aspirin and the Risk of Colorectal Cancer in Women
Johnson K. A., Prindiville S. A., Morgan G., Roychowdhury D. F., van Bodegraven A.A., Lourens J., Sindram J.W., Kaufmann H. J., Schuler M., Giovannucci E., Speizer F. E., Egan K., Marcus A. J.
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N Engl J Med 1996;
334:119-122, Jan 11, 1996.
Correspondence
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2004). Colorectal Adenomas: A Prototype for the Use of Surrogate End Points in the Development of Cancer Prevention Drugs. Clin. Cancer Res.
10: 3908-3918
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2003). Generating Hypotheses by Discovering Implicit Associations in the Literature: A Case Report of a Search for New Potential Therapeutic Uses for Thalidomide. J. Am. Med. Inform. Assoc.
10: 252-259
[Abstract][Full Text]
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(2003). Enhancement of colon carcinogenesis by prostaglandin E2 administration. Carcinogenesis
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[Abstract][Full Text]
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(2003). Expression of Cyclooxygenase-2 in Renal Cell Carcinoma: Correlation with Tumor Cell Proliferation, Apoptosis, Angiogenesis, Expression of Matrix Metalloproteinase-2, and Survival. Clin. Cancer Res.
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[Abstract][Full Text]
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(2003). A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer. NEJM
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[Abstract][Full Text]
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24: 605-611
[Abstract][Full Text]
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82: 82-90
[Abstract][Full Text]
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(2003). Up-Regulation of Tumor Interleukin-8 Expression by Infiltrating Macrophages: Its Correlation with Tumor Angiogenesis and Patient Survival in Non-Small Cell Lung Cancer. Clin. Cancer Res.
9: 729-737
[Abstract][Full Text]
Zhu, Y., Hua, P., Lance, P.
(2003). Cyclooxygenase-2 Expression and Prostanoid Biogenesis Reflect Clinical Phenotype in Human Colorectal Fibroblast Strains. Cancer Res.
63: 522-526
[Abstract][Full Text]
Kantarci, A., Van Dyke, T. E.
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14: 4-12
[Abstract][Full Text]
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(2002). Association of Aspirin and Nonsteroidal Anti-inflammatory Drug Use with Breast Cancer. Cancer Epidemiol. Biomarkers Prev.
11: 1586-1591
[Abstract][Full Text]
Blais, V., Zhang, J., Rivest, S.
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[Abstract][Full Text]
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(2002). Cyclooxygenase-2 Overexpression Reduces Apoptotic Susceptibility by Inhibiting the Cytochrome c-dependent Apoptotic Pathway in Human Colon Cancer Cells. Cancer Res.
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[Abstract][Full Text]
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(2002). Cyclooxygenase-2 Inhibition with Celecoxib Enhances Antitumor Efficacy and Reduces Diarrhea Side Effect of CPT-11. Cancer Res.
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[Abstract][Full Text]
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(2002). Association Between Nonsteroidal Anti-Inflammatory Drug Use and the Incidence of Pancreatic Cancer. JNCI J Natl Cancer Inst
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract]
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(2002). A Dose-finding Study of Aspirin for Chemoprevention Utilizing Rectal Mucosal Prostaglandin E2 Levels as a Biomarker. Cancer Epidemiol. Biomarkers Prev.
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[Abstract][Full Text]
Kakiuchi, Y., Tsuji, S., Tsujii, M., Murata, H., Kawai, N., Yasumaru, M., Kimura, A., Komori, M., Irie, T., Miyoshi, E., Sasaki, Y., Hayashi, N., Kawano, S., Hori, M.
(2002). Cyclooxygenase-2 Activity Altered the Cell-Surface Carbohydrate Antigens on Colon Cancer Cells and Enhanced Liver Metastasis. Cancer Res.
62: 1567-1572
[Abstract][Full Text]
Roberts, R. O., Jacobson, D. J., Girman, C. J., Rhodes, T., Lieber, M. M., Jacobsen, S. J.
(2002). A Population-Based Study of Daily Nonsteroidal Anti-inflammatory Drug Use and Prostate Cancer. Mayo Clin Proc.
77: 219-225
[Abstract]
Thun, M. J., Henley, S. J., Patrono, C.
(2002). Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues. JNCI J Natl Cancer Inst
94: 252-266
[Abstract][Full Text]
O'Shaughnessy, J. A., Kelloff, G. J., Gordon, G. B., Dannenberg, A. J., Hong, W. K., Fabian, C. J., Sigman, C. C., Bertagnolli, M. M., Stratton, S. P., Lam, S., Nelson, W. G., Meyskens, F. L., Alberts, D. S., Follen, M., Rustgi, A. K., Papadimitrakopoulou, V., Scardino, P. T., Gazdar, A. F., Wattenberg, L. W., Sporn, M. B., Sakr, W. A., Lippman, S. M., Von Hoff, D. D.
(2002). Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development : Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia. Clin. Cancer Res.
8: 314-346
[Abstract][Full Text]
Mills, G. B.
(2002). Mechanisms Underlying Chemoprevention of Ovarian Cancer. Clin. Cancer Res.
8: 7-10
[Abstract][Full Text]
Rodriguez-Burford, C., Barnes, M. N., Oelschlager, D. K., Myers, R. B., Talley, L. I., Partridge, E. E., Grizzle, W. E.
(2002). Effects of Nonsteroidal Anti-Inflammatory Agents (NSAIDs) on Ovarian Carcinoma Cell Lines: Preclinical Evaluation of NSAIDs as Chemopreventive Agents. Clin. Cancer Res.
8: 202-209
[Abstract][Full Text]
Jiang, Q., Christen, S., Shigenaga, M. K, Ames, B. N
(2001). {gamma}-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am. J. Clin. Nutr.
74: 714-722
[Abstract][Full Text]
Cao, Y., Dave, K. B., Doan, T. P., Prescott, S. M.
(2001). Fatty Acid CoA Ligase 4 Is Up-Regulated in Colon Adenocarcinoma. Cancer Res.
61: 8429-8434
[Abstract][Full Text]
Ladabaum, U., Chopra, C. L., Huang, G., Scheiman, J. M., Chernew, M. E., Fendrick, A. M.
(2001). Aspirin as an Adjunct to Screening for Prevention of Sporadic Colorectal Cancer: A Cost-Effectiveness Analysis. ANN INTERN MED
135: 769-781
[Abstract][Full Text]
Han, Z., Pantazis, P., Wyche, J. H., Kouttab, N., Kidd, V. J., Hendrickson, E. A.
(2001). A Fas-associated Death Domain Protein-dependent Mechanism Mediates the Apoptotic Action of Non-steroidal Anti-inflammatory Drugs in the Human Leukemic Jurkat Cell Line. J. Biol. Chem.
276: 38748-38754
[Abstract][Full Text]
Klimp, A. H., Hollema, H., Kempinga, C., van der Zee, A. G. J., de Vries, E. G. E., Daemen, T.
(2001). Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Human Ovarian Tumors and Tumor-associated Macrophages. Cancer Res.
61: 7305-7309
[Abstract][Full Text]
