From the Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston (P.F.J., J.S., I.H.R.); the Division of General Internal Medicine, Memorial Hospital of Rhode Island, Providence (A.G.B.); and the Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Mass. (P.W.F.W.).
Address reprint requests to Dr. Rosenberg at the Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111.
Folic Acid Fortification
Oakley G. P., Pfeiffer C. M., Gunter E. W., Miller D. T., Watkins M. L., Erickson J. D., Mulinare J., Jacques P. F., Selhub J., Rosenberg I. H.
Extract |
Full Text
N Engl J Med 1999;
341:922-924, Sep 16, 1999.
Correspondence
This article has been cited by other articles:
Miller, J. W, Garrod, M. G, Allen, L. H, Haan, M. N, Green, R.
(2009). Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate. Am. J. Clin. Nutr.
90: 1586-1592
[Abstract][Full Text]
Drake, B. F., Colditz, G. A.
(2009). Assessing Cancer Prevention Studies--A Matter of Time. JAMA
302: 2152-2153
[Full Text]
Ducros, V., Barro, C., Yver, J., Pernod, G., Polack, B., Carpentier, P., Desruet, M.-D., Bosson, J.-L.
(2009). Should Plasma Homocysteine Be Used as a Biomarker of Venous Thromboembolism? A Case--Control Study. CLIN APPL THROMB HEMOST
15: 517-522
[Abstract]
Hoyo, C., Murphy, S. K, Jirtle, R. L
(2009). Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. J. Epidemiol. Community Health
63: 683-684
[Full Text]
Song, Y., Cook, N. R., Albert, C. M., Van Denburgh, M., Manson, J. E.
(2009). Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women: A Randomized, Controlled Trial. Diabetes
58: 1921-1928
[Abstract][Full Text]
Phillips, C. O., Higginbotham, E. J.
(2009). Multivitamin Supplements, Ageing, and Loss of Vision: Seeing Through the Shadows. Arch Intern Med
169: 1180-1182
[Full Text]
Ionescu-Ittu, R., Marelli, A. J, Mackie, A. S, Pilote, L.
(2009). Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada. BMJ
338: b1673-b1673
[Abstract][Full Text]
LeBoff, M. S., Narweker, R., LaCroix, A., Wu, L., Jackson, R., Lee, J., Bauer, D. C., Cauley, J., Kooperberg, C., Lewis, C., Thomas, A. M., Cummings, S.
(2009). Homocysteine Levels and Risk of Hip Fracture in Postmenopausal Women. J. Clin. Endocrinol. Metab.
94: 1207-1213
[Abstract][Full Text]
Wilson, F. A., van den Borne, J. J. G. C., Calder, A. G., O'Kennedy, N., Holtrop, G., Rees, W. D., Lobley, G. E.
(2009). Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline. Am. J. Physiol. Endocrinol. Metab.
296: E702-E713
[Abstract][Full Text]
Selhub, J., Morris, M. S., Jacques, P. F, Rosenberg, I. H
(2009). Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. Am. J. Clin. Nutr.
89: 702S-706S
[Abstract][Full Text]
Green, R.
(2009). Is it time for vitamin B-12 fortification? What are the questions?. Am. J. Clin. Nutr.
89: 712S-716S
[Abstract][Full Text]
Ganji, V., Kafai, M. R.
(2009). Demographic, Lifestyle, and Health Characteristics and Serum B Vitamin Status Are Determinants of Plasma Total Homocysteine Concentration in the Post-Folic Acid Fortification Period, 1999-2004. J. Nutr.
139: 345-352
[Abstract][Full Text]
Ganji, V., Kafai, M. R
(2009). Hemoglobin and hematocrit values are higher and prevalence of anemia is lower in the post-folic acid fortification period than in the pre-folic acid fortification period in US adults. Am. J. Clin. Nutr.
89: 363-371
[Abstract][Full Text]
Tsai, M. Y., Loria, C. M., Cao, J., Kim, Y., Siscovick, D., Schreiner, P. J., Hanson, N. Q.
(2009). Clinical Utility of Genotyping the 677C>T Variant of Methylenetetrahydrofolate Reductase in Humans Is Decreased in the Post-Folic Acid Fortification Era. J. Nutr.
139: 33-37
[Abstract][Full Text]
Kang, J. H., Cook, N., Manson, J., Buring, J. E, Albert, C. M, Grodstein, F.
(2008). A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am. J. Clin. Nutr.
88: 1602-1610
[Abstract][Full Text]
Zhang, S. M., Cook, N. R., Albert, C. M., Gaziano, J. M., Buring, J. E., Manson, J. E.
(2008). Effect of Combined Folic Acid, Vitamin B6, and Vitamin B12 on Cancer Risk in Women: A Randomized Trial. JAMA
300: 2012-2021
[Abstract][Full Text]
Humphrey, L. L., Fu, R., Rogers, K., Freeman, M., Helfand, M.
(2008). Homocysteine Level and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis. Mayo Clin Proc.
83: 1203-1212
[Abstract][Full Text]
Aisen, P. S., Schneider, L. S., Sano, M., Diaz-Arrastia, R., van Dyck, C. H., Weiner, M. F., Bottiglieri, T., Jin, S., Stokes, K. T., Thomas, R. G., Thal, L. J., for the Alzheimer Disease Cooperative Study,
(2008). High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Controlled Trial. JAMA
300: 1774-1783
[Abstract][Full Text]
Kalmbach, R. D, Choumenkovitch, S. F, Troen, A. M, D'Agostino, R., Jacques, P. F, Selhub, J.
(2008). Circulating folic acid in plasma: relation to folic acid fortification. Am. J. Clin. Nutr.
88: 763-768
[Abstract][Full Text]
Wolpin, B. M., Wei, E. K., Ng, K., Meyerhardt, J. A., Chan, J. A., Selhub, J., Giovannucci, E. L., Fuchs, C. S.
(2008). Prediagnostic Plasma Folate and the Risk of Death in Patients With Colorectal Cancer. JCO
26: 3222-3228
[Abstract][Full Text]
Garrod, M. G., Green, R., Allen, L. H., Mungas, D. M., Jagust, W. J., Haan, M. N., Miller, J. W.
(2008). Fraction of Total Plasma Vitamin B12 Bound to Transcobalamin Correlates with Cognitive Function in Elderly Latinos with Depressive Symptoms. Clin. Chem.
54: 1210-1217
[Abstract][Full Text]
Albert, C. M., Cook, N. R., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., Manson, J. E.
(2008). Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease: A Randomized Trial. JAMA
299: 2027-2036
[Abstract][Full Text]
Seshadri, S., Wolf, P. A., Beiser, A. S., Selhub, J., Au, R., Jacques, P. F., Yoshita, M., Rosenberg, I. H., D'Agostino, R. B., DeCarli, C.
(2008). Association of Plasma Total Homocysteine Levels With Subclinical Brain Injury: Cerebral Volumes, White Matter Hyperintensity, and Silent Brain Infarcts at Volumetric Magnetic Resonance Imaging in the Framingham Offspring Study. Arch Neurol
65: 642-649
[Abstract][Full Text]
Ueland, P. M., Hustad, S.
(2008). Homocysteine and Folate Status in an Era of Folic Acid Fortification: Balancing Benefits, Risks, and B-vitamins. Clin. Chem.
54: 779-781
[Full Text]
Pfeiffer, C. M., Osterloh, J. D., Kennedy-Stephenson, J., Picciano, M. F., Yetley, E. A., Rader, J. I., Johnson, C. L.
(2008). Trends in Circulating Concentrations of Total Homocysteine among US Adolescents and Adults: Findings from the 1991-1994 and 1999-2004 National Health and Nutrition Examination Surveys. Clin. Chem.
54: 801-813
[Abstract][Full Text]
Lin, J., Lee, I-M., Cook, N. R, Selhub, J., Manson, J. E, Buring, J. E, Zhang, S. M
(2008). Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am. J. Clin. Nutr.
87: 734-743
[Abstract][Full Text]
Dodds, L., Fell, D. B., Dooley, K. C., Armson, B. A., Allen, A. C., Nassar, B. A., Perkins, S., Joseph, K.S.
(2008). Effect of Homocysteine Concentration in Early Pregnancy on Gestational Hypertensive Disorders and Other Pregnancy Outcomes. Clin. Chem.
54: 326-334
[Abstract][Full Text]
Wagner, C., Koury, M. J
(2007). S-Adenosylhomocysteine a better indicator of vascular disease than homocysteine?. Am. J. Clin. Nutr.
86: 1581-1585
[Abstract][Full Text]
Hoey, L., McNulty, H., Askin, N., Dunne, A., Ward, M., Pentieva, K., Strain, J., Molloy, A. M, Flynn, C. A, Scott, J. M
(2007). Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. Am. J. Clin. Nutr.
86: 1405-1413
[Abstract][Full Text]
McCully, K. S
(2007). Homocysteine, vitamins, and vascular disease prevention. Am. J. Clin. Nutr.
86: 1563S-1568S
[Abstract][Full Text]
Wyckoff, K. F, Ganji, V.
(2007). Proportion of individuals with low serum vitamin B-12 concentrations without macrocytosis is higher in the post folic acid fortification period than in the pre folic acid fortification period. Am. J. Clin. Nutr.
86: 1187-1192
[Abstract][Full Text]
Arabelovic, S., Sam, G., Dallal, G. E., Jacques, P. F., Selhub, J., Rosenberg, I. H., Roubenoff, R.
(2007). Preliminary Evidence Shows That Folic Acid Fortification of the Food Supply Is Associated with Higher Methotrexate Dosing in Patients with Rheumatoid Arthritis. J. Am. Coll. Nutr.
26: 453-455
[Abstract][Full Text]
Pfeiffer, C. M, Johnson, C. L, Jain, R. B, Yetley, E. A, Picciano, M. F., Rader, J. I, Fisher, K. D, Mulinare, J., Osterloh, J. D
(2007). Trends in blood folate and vitamin B-12 concentrations in the United States, 1988 2004. Am. J. Clin. Nutr.
86: 718-727
[Abstract][Full Text]
He, W., Wang, H., Hartmann, L. C., Cheng, J.-X., Low, P. S.
(2007). In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry. Proc. Natl. Acad. Sci. USA
104: 11760-11765
[Abstract][Full Text]
Gilbody, S., Lightfoot, T., Sheldon, T.
(2007). Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J. Epidemiol. Community Health
61: 631-637
[Abstract][Full Text]
Mason, J. B., Dickstein, A., Jacques, P. F., Haggarty, P., Selhub, J., Dallal, G., Rosenberg, I. H.
(2007). A Temporal Association between Folic Acid Fortification and an Increase in Colorectal Cancer Rates May Be Illuminating Important Biological Principles: A Hypothesis. Cancer Epidemiol. Biomarkers Prev.
16: 1325-1329
[Abstract][Full Text]
Chattopadhyay, S., Tamari, R., Min, S. H., Zhao, R., Tsai, E., Goldman, I. D.
(2007). Commentary: A Case for Minimizing Folate Supplementation in Clinical Regimens with Pemetrexed Based on the Marked Sensitivity of the Drug to Folate Availability. The Oncologist
12: 808-815
[Abstract][Full Text]
Levy, D., Hwang, S.-J., Kayalar, A., Benjamin, E. J., Vasan, R. S., Parise, H., Larson, M. G., Wang, T. J., Selhub, J., Jacques, P. F., Vita, J. A., Keyes, M. J., Mitchell, G. F.
(2007). Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness: The Framingham Heart Study. Circulation
115: 3079-3085
[Abstract][Full Text]
Dentali, F., Gianni, M., Ageno, W.
(2007). Folic Acid Supplementation and Cardiovascular Diseases. JAMA
297: 1549-1550
[Full Text]
Steffen, L. M., Folsom, A. R., Cushman, M., Jacobs, D. R. Jr, Rosamond, W. D.
(2007). Greater Fish, Fruit, and Vegetable Intakes Are Related to Lower Incidence of Venous Thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology. Circulation
115: 188-195
[Abstract][Full Text]
Herrmann, M., Muller, S., Kindermann, I., Gunther, L., Konig, J., Bohm, M., Herrmann, W.
(2007). Plasma B vitamins and their relation to the severity of chronic heart failure. Am. J. Clin. Nutr.
85: 117-123
[Abstract][Full Text]
Luchsinger, J. A., Tang, M.-X., Miller, J., Green, R., Mayeux, R.
(2007). Relation of Higher Folate Intake to Lower Risk of Alzheimer Disease in the Elderly. Arch Neurol
64: 86-92
[Abstract][Full Text]
Gilbody, S., Lewis, S., Lightfoot, T.
(2007). Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review. Am J Epidemiol
165: 1-13
[Abstract][Full Text]
Poo-Prieto, R., Haytowitz, D. B., Holden, J. M., Rogers, G., Choumenkovitch, S. F., Jacques, P. F., Selhub, J.
(2006). Use of the Affinity/HPLC Method for Quantitative Estimation of Folic Acid in Enriched Cereal-Grain Products. J. Nutr.
136: 3079-3083
[Abstract][Full Text]
Ganji, V., Kafai, M. R
(2006). Population reference values for plasma total homocysteine concentrations in US adults after the fortification of cereals with folic acid.. Am. J. Clin. Nutr.
84: 989-994
[Abstract][Full Text]
Bentley, T. G.K., Willett, W. C., Weinstein, M. C., Kuntz, K. M.
(2006). Population-Level Changes in Folate Intake by Age, Gender, and Race/Ethnicity after Folic Acid Fortification. AJPH
96: 2040-2047
[Abstract][Full Text]
Robbins, J. M., Tilford, J. M., Bird, T.M., Cleves, M. A., Reading, J. A., Hobbs, C. A.
(2006). Hospitalizations of Newborns With Folate-Sensitive Birth Defects Before and After Fortification of Foods With Folic Acid. Pediatrics
118: 906-915
[Abstract][Full Text]
Lamers, Y., Prinz-Langenohl, R., Bramswig, S., Pietrzik, K.
(2006). Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age. Am. J. Clin. Nutr.
84: 156-161
[Abstract][Full Text]
Elias, M. F., Robbins, M. A., Budge, M. M., Elias, P. K., Brennan, S. L., Johnston, C., Nagy, Z., Bates, C. J.
(2006). Homocysteine, Folate, and Vitamins B6 and B12 Blood Levels in Relation to Cognitive Performance: The Maine-Syracuse Study. Psychosom. Med.
68: 547-554
[Abstract][Full Text]
MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., Couper, J. J.
(2006). Folate and Vitamin B6 Rapidly Normalize Endothelial Dysfunction In Children With Type 1 Diabetes Mellitus. Pediatrics
118: 242-253
[Abstract][Full Text]
Kullo, I. J., Ding, K., Boerwinkle, E., Turner, S. T., Mosley, T. H. Jr, Kardia, S. L.R., de Andrade, M.
(2006). Novel Genomic Loci Influencing Plasma Homocysteine Levels. Stroke
37: 1703-1709
[Abstract][Full Text]
Lutsey, P. L, Steffen, L. M, Feldman, H. A, Hoelscher, D. H, Webber, L. S, Luepker, R. V, Lytle, L. A, Zive, M., Osganian, S. K
(2006). Serum homocysteine is related to food intake in adolescents: the Child and Adolescent Trial for Cardiovascular Health. Am. J. Clin. Nutr.
83: 1380-1386
[Abstract][Full Text]
Refsum, H., Nurk, E., Smith, A. D., Ueland, P. M., Gjesdal, C. G., Bjelland, I., Tverdal, A., Tell, G. S., Nygard, O., Vollset, S. E.
(2006). The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease. J. Nutr.
136: 1731S-1740S
[Abstract][Full Text]
Tamura, T., Picciano, M. F.
(2006). Folate and human reproduction. Am. J. Clin. Nutr.
83: 993-1016
[Abstract][Full Text]
Bonaa, K. H., Njolstad, I., Ueland, P. M., Schirmer, H., Tverdal, A., Steigen, T., Wang, H., Nordrehaug, J. E., Arnesen, E., Rasmussen, K., the NORVIT Trial Investigators,
(2006). Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction. NEJM
354: 1578-1588
[Abstract][Full Text]
Yang, Q., Botto, L. D., Erickson, J. D., Berry, R. J., Sambell, C., Johansen, H., Friedman, J.M.
(2006). Improvement in Stroke Mortality in Canada and the United States, 1990 to 2002. Circulation
113: 1335-1343
[Abstract][Full Text]
Ulrich, C. M., Potter, J. D.
(2006). Folate supplementation: too much of a good thing?. Cancer Epidemiol. Biomarkers Prev.
15: 189-193
[Full Text]
Miller, J. W., Garrod, M. G., Rockwood, A. L., Kushnir, M. M., Allen, L. H., Haan, M. N., Green, R.
(2006). Measurement of Total Vitamin B12 and Holotranscobalamin, Singly and in Combination, in Screening for Metabolic Vitamin B12 Deficiency. Clin. Chem.
52: 278-285
[Abstract][Full Text]
Kullo, I. J., Li, G., Bielak, L. F., Bailey, K. R., Sheedy, P. F. II, Peyser, P. A., Turner, S. T., Kardia, S. L. R.
(2006). Association of Plasma Homocysteine With Coronary Artery Calcification in Different Categories of Coronary Heart Disease Risk. Mayo Clin Proc.
81: 177-182
[Abstract][Full Text]
Ho, G. Y.-H., Eikelboom, J. W., Hankey, G. J., Wong, C.-R., Tan, S.-L., Chan, J. B.-C., Chen, C. P.L.-H.
(2006). Methylenetetrahydrofolate Reductase Polymorphisms and Homocysteine-Lowering Effect of Vitamin Therapy in Singaporean Stroke Patients. Stroke
37: 456-460
[Abstract][Full Text]
McNulty, H., Dowey, L. R. C., Strain, J.J., Dunne, A., Ward, M., Molloy, A. M., McAnena, L. B., Hughes, J. P., Hannon-Fletcher, M., Scott, J. M.
(2006). Riboflavin Lowers Homocysteine in Individuals Homozygous for the MTHFR 677C->T Polymorphism. Circulation
113: 74-80
[Abstract][Full Text]
Ganji, V., Kafai, M. R.
(2006). Trends in Serum Folate, RBC Folate, and Circulating Total Homocysteine Concentrations in the United States: Analysis of Data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-2002. J. Nutr.
136: 153-158
[Abstract][Full Text]
Stott, D. J, MacIntosh, G., Lowe, G. D., Rumley, A., McMahon, A. D, Langhorne, P., Tait, R C., O'Reilly, D. S. J, Spilg, E. G, MacDonald, J. B, MacFarlane, P. W, Westendorp, R. G.
(2005). Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am. J. Clin. Nutr.
82: 1320-1326
[Abstract][Full Text]
Ramos, M. I, Allen, L. H, Mungas, D. M, Jagust, W. J, Haan, M. N, Green, R., Miller, J. W
(2005). Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. Am. J. Clin. Nutr.
82: 1346-1352
[Abstract][Full Text]
Cole, P. D., Drachtman, R. A., Smith, A. K., Cate, S., Larson, R. A., Hawkins, D. S., Holcenberg, J., Kelly, K., Kamen, B. A.
(2005). Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia. Clin. Cancer Res.
11: 8089-8096
[Abstract][Full Text]
Irizarry, M. C., Gurol, M. E., Raju, S., Diaz-Arrastia, R., Locascio, J. J., Tennis, M., Hyman, B. T., Growdon, J. H., Greenberg, S. M., Bottiglieri, T.
(2005). Association of homocysteine with plasma amyloid {beta} protein in aging and neurodegenerative disease. Neurology
65: 1402-1408
[Abstract][Full Text]
Friedman, A. N., Hunsicker, L. G., Selhub, J., Bostom, A. G., for the Collaborative Study Group,
(2005). Total Plasma Homocysteine and Arteriosclerotic Outcomes in Type 2 Diabetes with Nephropathy. J. Am. Soc. Nephrol.
16: 3397-3402
[Abstract][Full Text]
Spence, J. D., Bang, H., Chambless, L. E., Stampfer, M. J.
(2005). Vitamin Intervention for Stroke Prevention Trial: An Efficacy Analysis. Stroke
36: 2404-2409
[Abstract][Full Text]
Bailey, L. B
(2005). Do low doses of folic acid result in maximum lowering of homocysteine?. Am. J. Clin. Nutr.
82: 717-718
[Full Text]
Homocysteine Lowering Trialists' Collaboration,
(2005). Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am. J. Clin. Nutr.
82: 806-812
[Abstract][Full Text]
Kuo, H.-K., Sorond, F. A., Chen, J.-H., Hashmi, A., Milberg, W. P., Lipsitz, L. A.
(2005). The Role of Homocysteine in Multisystem Age-Related Problems: A Systematic Review. Journals of Gerontology Series A: Biological Sciences and Medical Sciences
60: 1190-1201
[Abstract][Full Text]
Ganji, V., Kafai, M. R.
(2005). Population References for Plasma Total Homocysteine Concentrations for U.S. Children and Adolescents in the Post-Folic Acid Fortification Era. J. Nutr.
135: 2253-2256
[Abstract][Full Text]
Tamura, T., Goldenberg, R. L., Chapman, V. R., Johnston, K. E., Ramey, S. L., Nelson, K. G.
(2005). Folate Status of Mothers During Pregnancy and Mental and Psychomotor Development of Their Children at Five Years of Age. Pediatrics
116: 703-708
[Abstract][Full Text]
Rosenberg, I. H
(2005). Science-based micronutrient fortification: which nutrients, how much, and how to know?. Am. J. Clin. Nutr.
82: 279-280
[Full Text]
Pfeiffer, C. M, Caudill, S. P, Gunter, E. W, Osterloh, J., Sampson, E. J
(2005). Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am. J. Clin. Nutr.
82: 442-450
[Abstract][Full Text]
Dietrich, M., Brown, C. J.P., Block, G.
(2005). The Effect of Folate Fortification of Cereal-Grain Products on Blood Folate Status, Dietary Folate Intake, and Dietary Folate Sources among Adult Non-Supplement Users in the United States. J. Am. Coll. Nutr.
24: 266-274
[Abstract][Full Text]
Lichtenstein, A. H., Russell, R. M.
(2005). Essential Nutrients: Food or Supplements?: Where Should the Emphasis Be?. JAMA
294: 351-358
[Abstract][Full Text]
Vogel, J. H.K., Bolling, S. F., Costello, R. B., Guarneri, E. M., Krucoff, M. W., Longhurst, J. C., Olshansky, B., Pelletier, K. R., Tracy, C. M., Vogel, R. A., Vogel, R. A., Abrams, J., Anderson, J. L., Bates, E. R., Brodie, B. R., Grines, C. L., Danias, P. G., Gregoratos, G., Hlatky, M. A., Hochman, J. S., Kaul, S., Lichtenberg, R. C., Lindner, J. R., O'Rourke, R. A., Pohost, G. M., Schofield, R. S., Shubrooks, S. J., Tracy, C. M., Winters, W. L. Jr
(2005). Integrating Complementary Medicine Into Cardiovascular Medicine: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). J Am Coll Cardiol
46: 184-221
[Full Text]
Williams, C., Kingwell, B. A, Burke, K., McPherson, J., Dart, A. M
(2005). Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am. J. Clin. Nutr.
82: 26-31
[Abstract][Full Text]
O'DONNELL, C., STEPHENS, T.
(2005). The Significance of Homocysteine Levels in Schizophrenia. Am. J. Psychiatry
162: 1387-1388
[Full Text]
Cronin, S., Furie, K. L., Kelly, P. J.
(2005). Dose-Related Association of MTHFR 677T Allele With Risk of Ischemic Stroke: Evidence From a Cumulative Meta-Analysis. Stroke
36: 1581-1587
[Abstract][Full Text]
Gamble, M. V, Ahsan, H., Liu, X., Factor-Litvak, P., Ilievski, V., Slavkovich, V., Parvez, F., Graziano, J. H
(2005). Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh. Am. J. Clin. Nutr.
81: 1372-1377
[Abstract][Full Text]
Hickling, S., Hung, J., Knuiman, M., Jamrozik, K., McQuillan, B., Beilby, J., Thompson, P.
(2005). Impact of voluntary folate fortification on plasma homocysteine and serum folate in Australia from 1995 to 2001: a population based cohort study. J. Epidemiol. Community Health
59: 371-376
[Abstract][Full Text]
Davis, S. R., Quinlivan, E. P., Shelnutt, K. P., Maneval, D. R., Ghandour, H., Capdevila, A., Coats, B. S., Wagner, C., Selhub, J., Bailey, L. B., Shuster, J. J., Stacpoole, P. W., Gregory, J. F. III
(2005). The Methylenetetrahydrofolate Reductase 677C->T Polymorphism and Dietary Folate Restriction Affect Plasma One-Carbon Metabolites and Red Blood Cell Folate Concentrations and Distribution in Women. J. Nutr.
135: 1040-1044
[Abstract][Full Text]
Stark, K. D, Pawlosky, R. J, Beblo, S., Murthy, M., Flanagan, V. P, Janisse, J., Buda-Abela, M., Rockett, H., Whitty, J. E, Sokol, R. J, Hannigan, J. H, Salem, N. Jr
(2005). Status of plasma folate after folic acid fortification of the food supply in pregnant African American women and the influences of diet, smoking, and alcohol consumption. Am. J. Clin. Nutr.
81: 669-677
[Abstract][Full Text]
Kullo, I. J., Ballantyne, C. M.
(2005). Conditional Risk Factors for Atherosclerosis. Mayo Clin Proc.
80: 219-230
[Abstract]
Hankey, G. J.
(2005). Secondary Prevention of Recurrent Stroke. Stroke
36: 218-221
[Full Text]
Forman, J. P., Rimm, E. B., Stampfer, M. J., Curhan, G. C.
(2005). Folate Intake and the Risk of Incident Hypertension Among US Women. JAMA
293: 320-329
[Abstract][Full Text]
Wilson, P. W.F.
(2004). CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: Ability of Inflammatory Markers to Predict Disease in Asymptomatic Patients: A Background Paper. Circulation
110: e568-e571
[Abstract][Full Text]
Kim, Y.-I.
(2004). Will mandatory folic acid fortification prevent or promote cancer?. Am. J. Clin. Nutr.
80: 1123-1128
[Abstract][Full Text]
Garcia, A., Zanibbi, K.
(2004). Homocysteine and cognitive function in elderly people. CMAJ
171: 897-904
[Abstract][Full Text]
Ramos, M. I, Allen, L. H, Haan, M. N, Green, R., Miller, J. W
(2004). Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am. J. Clin. Nutr.
80: 1024-1028
[Abstract][Full Text]
Postuma, R. B., Lang, A. E.
(2004). Homocysteine and levodopa: Should Parkinson disease patients receive preventative therapy?. Neurology
63: 886-891
[Abstract][Full Text]
Goff, D. C., Bottiglieri, T., Arning, E., Shih, V., Freudenreich, O., Evins, A. E., Henderson, D. C., Baer, L., Coyle, J.
(2004). Folate, Homocysteine, and Negative Symptoms in Schizophrenia. Am. J. Psychiatry
161: 1705-1708
[Abstract][Full Text]
Courtemanche, C., Elson-Schwab, I., Mashiyama, S. T., Kerry, N., Ames, B. N.
(2004). Folate Deficiency Inhibits the Proliferation of Primary Human CD8+ T Lymphocytes In Vitro. J. Immunol.
173: 3186-3192
[Abstract][Full Text]
Tsuda, K., Nishio, I., Kelly, P. J., Furie, K. L.
(2004). Homocysteine, Vitamin B6, and Endothelial Dysfunction in Circulatory Disorders * Response. Stroke
35: 1785-1785
[Full Text]
Hankey, G. J., Eikelboom, J. W.
(2004). Folic Acid-Based Multivitamin Therapy to Prevent Stroke: The Jury Is Still Out. Stroke
35: 1995-1998
[Full Text]
Moat, S. J., Doshi, S. N., Lang, D., McDowell, I. F. W., Lewis, M. J., Goodfellow, J.
(2004). Treatment of coronary heart disease with folic acid: is there a future?. Am. J. Physiol. Heart Circ. Physiol.
287: H1-H7
[Full Text]
Ridker, P. M, Brown, N. J., Vaughan, D. E., Harrison, D. G., Mehta, J. L.
(2004). Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events. Circulation
109: IV-6-IV-19
[Full Text]
