From the Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston (P.F.J., J.S., I.H.R.); the Division of General Internal Medicine, Memorial Hospital of Rhode Island, Providence (A.G.B.); and the Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Mass. (P.W.F.W.).
Address reprint requests to Dr. Rosenberg at the Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111.
Folic Acid Fortification
Oakley G. P., Pfeiffer C. M., Gunter E. W., Miller D. T., Watkins M. L., Erickson J. D., Mulinare J., Jacques P. F., Selhub J., Rosenberg I. H.
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N Engl J Med 1999;
341:922-924, Sep 16, 1999.
Correspondence
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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84: 156-161
[Abstract][Full Text]
Elias, M. F., Robbins, M. A., Budge, M. M., Elias, P. K., Brennan, S. L., Johnston, C., Nagy, Z., Bates, C. J.
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68: 547-554
[Abstract][Full Text]
MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., Couper, J. J.
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118: 242-253
[Abstract][Full Text]
Kullo, I. J., Ding, K., Boerwinkle, E., Turner, S. T., Mosley, T. H. Jr, Kardia, S. L.R., de Andrade, M.
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37: 1703-1709
[Abstract][Full Text]
Lutsey, P. L, Steffen, L. M, Feldman, H. A, Hoelscher, D. H, Webber, L. S, Luepker, R. V, Lytle, L. A, Zive, M., Osganian, S. K
(2006). Serum homocysteine is related to food intake in adolescents: the Child and Adolescent Trial for Cardiovascular Health. Am. J. Clin. Nutr.
83: 1380-1386
[Abstract][Full Text]
Refsum, H., Nurk, E., Smith, A. D., Ueland, P. M., Gjesdal, C. G., Bjelland, I., Tverdal, A., Tell, G. S., Nygard, O., Vollset, S. E.
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136: 1731S-1740S
[Abstract][Full Text]
Tamura, T., Picciano, M. F.
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83: 993-1016
[Abstract][Full Text]
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354: 1578-1588
[Abstract][Full Text]
Yang, Q., Botto, L. D., Erickson, J. D., Berry, R. J., Sambell, C., Johansen, H., Friedman, J.M.
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113: 1335-1343
[Abstract][Full Text]
Ulrich, C. M., Potter, J. D.
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15: 189-193
[Full Text]
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52: 278-285
[Abstract][Full Text]
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(2006). Association of Plasma Homocysteine With Coronary Artery Calcification in Different Categories of Coronary Heart Disease Risk. Mayo Clin Proc.
81: 177-182
[Abstract][Full Text]
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[Abstract][Full Text]
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113: 74-80
[Abstract][Full Text]
Ganji, V., Kafai, M. R.
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136: 153-158
[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2005). Association of homocysteine with plasma amyloid {beta} protein in aging and neurodegenerative disease. Neurology
65: 1402-1408
[Abstract][Full Text]
Friedman, A. N., Hunsicker, L. G., Selhub, J., Bostom, A. G., for the Collaborative Study Group,
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16: 3397-3402
[Abstract][Full Text]
Spence, J. D., Bang, H., Chambless, L. E., Stampfer, M. J.
(2005). Vitamin Intervention for Stroke Prevention Trial: An Efficacy Analysis. Stroke
36: 2404-2409
[Abstract][Full Text]
Bailey, L. B
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82: 717-718
[Full Text]
Homocysteine Lowering Trialists' Collaboration,
(2005). Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am. J. Clin. Nutr.
82: 806-812
[Abstract][Full Text]
Kuo, H.-K., Sorond, F. A., Chen, J.-H., Hashmi, A., Milberg, W. P., Lipsitz, L. A.
(2005). The Role of Homocysteine in Multisystem Age-Related Problems: A Systematic Review. Journals of Gerontology Series A: Biological Sciences and Medical Sciences
60: 1190-1201
[Abstract][Full Text]
Ganji, V., Kafai, M. R.
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135: 2253-2256
[Abstract][Full Text]
Tamura, T., Goldenberg, R. L., Chapman, V. R., Johnston, K. E., Ramey, S. L., Nelson, K. G.
(2005). Folate Status of Mothers During Pregnancy and Mental and Psychomotor Development of Their Children at Five Years of Age. Pediatrics
116: 703-708
[Abstract][Full Text]
Rosenberg, I. H
(2005). Science-based micronutrient fortification: which nutrients, how much, and how to know?. Am. J. Clin. Nutr.
82: 279-280
[Full Text]
Pfeiffer, C. M, Caudill, S. P, Gunter, E. W, Osterloh, J., Sampson, E. J
(2005). Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am. J. Clin. Nutr.
82: 442-450
[Abstract][Full Text]
Dietrich, M., Brown, C. J.P., Block, G.
(2005). The Effect of Folate Fortification of Cereal-Grain Products on Blood Folate Status, Dietary Folate Intake, and Dietary Folate Sources among Adult Non-Supplement Users in the United States. J. Am. Coll. Nutr.
24: 266-274
[Abstract][Full Text]
Lichtenstein, A. H., Russell, R. M.
(2005). Essential Nutrients: Food or Supplements?: Where Should the Emphasis Be?. JAMA
294: 351-358
[Abstract][Full Text]
Vogel, J. H.K., Bolling, S. F., Costello, R. B., Guarneri, E. M., Krucoff, M. W., Longhurst, J. C., Olshansky, B., Pelletier, K. R., Tracy, C. M., Vogel, R. A., Vogel, R. A., Abrams, J., Anderson, J. L., Bates, E. R., Brodie, B. R., Grines, C. L., Danias, P. G., Gregoratos, G., Hlatky, M. A., Hochman, J. S., Kaul, S., Lichtenberg, R. C., Lindner, J. R., O'Rourke, R. A., Pohost, G. M., Schofield, R. S., Shubrooks, S. J., Tracy, C. M., Winters, W. L. Jr
(2005). Integrating Complementary Medicine Into Cardiovascular Medicine: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). J Am Coll Cardiol
46: 184-221
[Full Text]
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82: 26-31
[Abstract][Full Text]
O'DONNELL, C., STEPHENS, T.
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162: 1387-1388
[Full Text]
Cronin, S., Furie, K. L., Kelly, P. J.
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36: 1581-1587
[Abstract][Full Text]
Gamble, M. V, Ahsan, H., Liu, X., Factor-Litvak, P., Ilievski, V., Slavkovich, V., Parvez, F., Graziano, J. H
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[Abstract][Full Text]
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59: 371-376
[Abstract][Full Text]
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(2005). The Methylenetetrahydrofolate Reductase 677C->T Polymorphism and Dietary Folate Restriction Affect Plasma One-Carbon Metabolites and Red Blood Cell Folate Concentrations and Distribution in Women. J. Nutr.
135: 1040-1044
[Abstract][Full Text]
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(2005). Status of plasma folate after folic acid fortification of the food supply in pregnant African American women and the influences of diet, smoking, and alcohol consumption. Am. J. Clin. Nutr.
81: 669-677
[Abstract][Full Text]
Kullo, I. J., Ballantyne, C. M.
(2005). Conditional Risk Factors for Atherosclerosis. Mayo Clin Proc.
80: 219-230
[Abstract]
Hankey, G. J.
(2005). Secondary Prevention of Recurrent Stroke. Stroke
36: 218-221
[Full Text]
Forman, J. P., Rimm, E. B., Stampfer, M. J., Curhan, G. C.
(2005). Folate Intake and the Risk of Incident Hypertension Among US Women. JAMA
293: 320-329
[Abstract][Full Text]
Wilson, P. W.F.
(2004). CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: Ability of Inflammatory Markers to Predict Disease in Asymptomatic Patients: A Background Paper. Circulation
110: e568-e571
[Abstract][Full Text]
Kim, Y.-I.
(2004). Will mandatory folic acid fortification prevent or promote cancer?. Am. J. Clin. Nutr.
80: 1123-1128
[Abstract][Full Text]
Garcia, A., Zanibbi, K.
(2004). Homocysteine and cognitive function in elderly people. CMAJ
171: 897-904
[Abstract][Full Text]
Ramos, M. I, Allen, L. H, Haan, M. N, Green, R., Miller, J. W
(2004). Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am. J. Clin. Nutr.
80: 1024-1028
[Abstract][Full Text]
Postuma, R. B., Lang, A. E.
(2004). Homocysteine and levodopa: Should Parkinson disease patients receive preventative therapy?. Neurology
63: 886-891
[Abstract][Full Text]
Goff, D. C., Bottiglieri, T., Arning, E., Shih, V., Freudenreich, O., Evins, A. E., Henderson, D. C., Baer, L., Coyle, J.
(2004). Folate, Homocysteine, and Negative Symptoms in Schizophrenia. Am. J. Psychiatry
161: 1705-1708
[Abstract][Full Text]
Courtemanche, C., Elson-Schwab, I., Mashiyama, S. T., Kerry, N., Ames, B. N.
(2004). Folate Deficiency Inhibits the Proliferation of Primary Human CD8+ T Lymphocytes In Vitro. J. Immunol.
173: 3186-3192
[Abstract][Full Text]
Tsuda, K., Nishio, I., Kelly, P. J., Furie, K. L.
(2004). Homocysteine, Vitamin B6, and Endothelial Dysfunction in Circulatory Disorders * Response. Stroke
35: 1785-1785
[Full Text]
Hankey, G. J., Eikelboom, J. W.
(2004). Folic Acid-Based Multivitamin Therapy to Prevent Stroke: The Jury Is Still Out. Stroke
35: 1995-1998
[Full Text]
Moat, S. J., Doshi, S. N., Lang, D., McDowell, I. F. W., Lewis, M. J., Goodfellow, J.
(2004). Treatment of coronary heart disease with folic acid: is there a future?. Am. J. Physiol. Heart Circ. Physiol.
287: H1-H7
[Full Text]
Ridker, P. M, Brown, N. J., Vaughan, D. E., Harrison, D. G., Mehta, J. L.
(2004). Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events. Circulation
109: IV-6-IV-19
[Full Text]
