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Previous Volume 328:56-57 January 7, 1993 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Despite decades of investigation, the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) remains one of the great mysteries of medicine. During the 1970s and 1980s there was substantial progress toward unraveling one part of the puzzle, the cellular mechanisms that cause the hyperglycemia. The answer has turned out to be surprisingly complex. Under normal circumstances, glucose homeostasis is a balance between glucose production by the liver and glucose clearance into peripheral tissues, primarily muscle. The beta cell is the regulator of the system; insulin release is constantly adjusted so that glucose production and clearance change in ways that maintain normoglycemia. In . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Weir, G. C. (1993). A Defective Beta-Cell Glucose Sensor as a Cause of Diabetes. NEJM 328: 729-731 [Full Text]