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Previous Volume 328:64-65 January 7, 1993 Number 1 Next

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To the Editor: Colombo et al. showed (Sept. 5, 1991, issue)¹ that yearly screening for hepatocellular carcinoma with an alpha-fetoprotein assay and real-time ultrasonography failed to improve the rate of detection of small and potentially operable tumors in Italian patients with cirrhosis. The authors suggested that more frequent screening (i.e., every four to six months) might be more effective.

From July 1987 to September 1989, 193 patients with cirrhosis (127 men and 66 women; mean age, 56 years) underwent screening for hepatocellular carcinoma at our institution. Clinical evaluation, serum alpha-fetoprotein measurements, and real-time ultrasonography were performed every six months. The . . . [Full Text of this Article]

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