Hyperkalemia has been reported in 16 to 21 percent of patientshospitalized with the acquired immunodeficiency syndrome (AIDS)1,2,3.Although renal failure often accompanies hyperkalemia,1,2 AIDSis associated with other abnormalities that impair renal excretionof potassium, such as adrenal insufficiency and hypoaldosteronism3,4,5,6,7.Adrenal insufficiency and hypoaldosteronism, however, are rarein patients with AIDS4,5.
Hyperkalemia develops in 20 to 53 percent of patients with AIDSwhile they are receiving high doses of trimethoprim in combinationwith sulfamethoxazole or dapsone for the treatment of Pneumocystiscarinii pneumonia8. We recently encountered a patient with AIDSand P. carinii pneumonia . . . [Full Text of this Article]
Case Report
Methods
Materials
Electrophysiologic Measurements
Transtubular Potassium-Concentration Gradient
Results
Discussion
Source Information
From the Philadelphia Veterans Affairs Medical Center (M.J.C., P.C.F., D.D., H.S., T.R.K.); the Renal and Electrolyte Division, Departments of Medicine (M.J.C., P.C.F., A.P., B.C.-G., D.D., H.S., T.R.K.) and Physiology (T.R.K.), University of Pennsylvania; and the Department of Medicine, Medical College of Pennsylvania (P.C.F.) -- all in Philadelphia.
Address reprint requests to Dr. Kleyman at Medical Research (151), Veterans Affairs Medical Center, Philadelphia, PA 19104.
References
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Mohan, S., Jaitly, M., Pogue, V. A., Cheng, J.-T.
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163: 402-410
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Reilly, R. F., Ellison, D. H.
(2000). Mammalian Distal Tubule: Physiology, Pathophysiology, and Molecular Anatomy. Physiol. Rev.
80: 277-313
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Kitagawa, H., Chang, H., Fujita, T.
(1995). Hyperkalemia Due to Nafamostat Mesylate. NEJM
332: 687-687
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