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Previous Volume 328:729-731 March 11, 1993 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Non-insulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and abnormal beta-cell function. The underlying cause is probably the combined effects of a Western lifestyle (corpulence and sedentary behavior) and as-yet-unidentified susceptibility genes¹. However, in an unusual form of NIDDM, known as maturity-onset diabetes of the young, insulin resistance is usually not present, raising the likelihood that deficient insulin production is the culprit. Within the past year, as part of the search for candidate genes in NIDDM -- discussed only two months ago in the Journal² -- mutations of glucokinase, the putative glucose sensor of the beta cell, have . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Limesand, S. W., Jensen, J., Hutton, J. C., Hay, W. W. Jr. (2005). Diminished {beta}-cell replication contributes to reduced {beta}-cell mass in fetal sheep with intrauterine growth restriction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288: R1297-R1305 [Abstract] [Full Text]  
• Ma, Z., Landt, M., Bohrer, A., Ramanadham, S., Kipnis, D. M., Turk, J. (1997). Interleukin-1 Reduces the Glycolytic Utilization of Glucose by Pancreatic Islets and Reduces Glucokinase mRNA Content and Protein Synthesis by a Nitric Oxide-dependent Mechanism. J. Biol. Chem. 272: 17827-17835 [Abstract] [Full Text]