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Previous Volume 328:1361-1362 May 6, 1993 Number 18

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By Edward H. Ahrens, Jr. 236 pp. New York, Oxford University Press, 1992. $29.95. ISBN 0-19-505156-4.

There is a perception among medical scientists that clinical investigation is being threatened from all quarters. Fewer investigators are engaged in patient-oriented research, research funding has become increasingly difficult to obtain, and spectacular successes in molecular biology have led many scientists to believe that the study of whole human beings is no longer necessary. Although we may eventually understand most diseases at the molecular level, studies of animals and humans will always be needed to understand the pathophysiologic manifestations of molecular defects. The application of molecular findings to clinical medicine will require investigators who have an intimate understanding of human . . . [Full Text of this Article]

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