FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 328:1416-1417 May 13, 1993 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Remarkable progress has been made over the past 25 years in understanding the biologic aspects of colorectal cancer and developing methods to detect it early or even prevent it entirely¹. Colorectal cancer arises from a precursor lesion, the adenomatous polyp, which forms in a fertile field of epithelial-cell hyperproliferation. This progression involves a multistep process, accompanied by alterations in several suppressor genes, that results in abnormalities of growth regulation and has a natural history of 10 to 15 years. Environmental factors and inherited susceptibility have major roles in this sequence of events^1,2. The long natural history provides an . . . [Full Text of this Article]

References

Related Letters:

Screening for Colorectal Cancer
Ahlquist D. A., Moertel C. G., McGill D. B., Carey W. D., Achkar E., Perlman R., Budenholzer B., Neugut A. I., Jacobson J. S., Allison J. E., Brown M. L., Mandel J. S., Church T. R., Ederer F., Winawer S. J.
Extract | Full Text  
N Engl J Med 1993; 329:1351-1354, Oct 28, 1993. Correspondence

This article has been cited by other articles:

• Mulcahy, H. E, Farthing, M. J G, O'Donoghue, D. P (1997). Fortnightly review: screening for asymptomatic colorectal cancer. BMJ 314: 285-285 [Full Text]  
• Lang, C. A., Ransohoff, D. F. (1994). Fecal Occult Blood Screening for Colorectal Cancer: Is Mortality Reduced by Chance Selection for Screening Colonoscopy?. JAMA 271: 1011-1013 [Abstract]  
• Winawer, S. J., Zauber, A. G., Ho, M. N., O'Brien, M. J., Gottlieb, L. S., Sternberg, S. S., Waye, J. D., Schapiro, M., Bond, J. H., Panish, J. F., Ackroyd, F., Shike, M., Kurtz, R. C., Hornsby-Lewis, L., Gerdes, H., Stewart, E. T., The National Polyp Study Workgroup, (1993). Prevention of Colorectal Cancer by Colonoscopic Polypectomy. NEJM 329: 1977-1981 [Abstract] [Full Text]  
• Ahlquist, D. A., Moertel, C. G., McGill, D. B., Carey, W. D., Achkar, E., Perlman, R., Budenholzer, B., Neugut, A. I., Jacobson, J. S., Allison, J. E., Brown, M. L., Mandel, J. S., Church, T. R., Ederer, F., Winawer, S. J. (1993). Screening for Colorectal Cancer. NEJM 329: 1351-1354 [Full Text]  
• Bird, D. C., Spratt, J. S., Winawer, S. J., Zauber, A. G. (1993). Post-Polypectomy Surveillance. NEJM 329: 887-888 [Full Text]  
• Eddy, D. M. (1993). Three Battles to Watch in the 1990s. JAMA 270: 520-526 [Abstract]