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Correspondence
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Volume 328:1424-1425 May 13, 1993 Number 19
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Bronchial Hyperresponsiveness in Heart Failure

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To the Editor: The role of bronchial hyperresponsiveness in the pathophysiology of dyspnea in congestive heart failure has been a subject of considerable interest1,2,3. Although there is no doubt that patients with heart failure have increased airways resistance, and that many have bronchial hyperreactivity to inhaled methacholine at rest, the contribution of airways obstruction to exercise limitation has not been established.

Cabanes et al. (June 18, 1992, issue)4 observed that exercise performance improved in patients with left ventricular dysfunction after they inhaled methoxamine, but did not produce evidence of exercise-induced changes in spirometric variables, and their conclusion that methoxamine . . . [Full Text of this Article]

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