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Correspondence
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Volume 328:1425-1426 May 13, 1993 Number 19
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Meta-Analysis of Radiotherapy for Small-Cell Lung Cancer

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To the Editor: There are several errors in the meta-analysis by Pignon et al.1. Our analysis of their data fails to support their conclusion that a statistically significant benefit has been demonstrated for radiotherapy combined with chemotherapy.

Specifically, we were unable to reproduce the estimates of relative risk (odds ratios) for the individual studies and for the pooled estimate, as well as the values and variances for the observed number of deaths minus the expected number (O - E) shown in their Figure 1 when we used the (Peto) method cited2. Using the standard formula, we obtained the . . . [Full Text of this Article]

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