Deficiency of one or more anterior pituitary hormones may followtreatment with external radiation when the hypothalamic-pituitaryaxis falls within the fields of radiation. Hypopituitarism hasbeen described in patients who received radiation therapy fornasopharyngeal carcinoma,1,2 tumors of the pituitary gland3,4or nearby structures, and primary brain tumors,5,6 as well asin children who underwent prophylactic cranial irradiation foracute lymphoblastic leukemia or total-body irradiation for avariety of tumors and other diseases.
On the basis of their studies of children and adults with braintumors who underwent cranial irradiation, Constine et al. concludein this issue of the . . . [Full Text of this Article]
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(2003). Risk Factors for the Development of Obesity in Children Surviving Brain Tumors. J. Clin. Endocrinol. Metab.
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Peacey, S. R., Toogood, A. A., Veldhuis, J. D., Thorner, M. O., Shalet, S. M.
(2001). The Relationship between 24-Hour Growth Hormone Secretion and Insulin-Like Growth Factor I in Patients with Successfully Treated Acromegaly: Impact of Surgery or Radiotherapy. J. Clin. Endocrinol. Metab.
86: 259-266
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Pfeilschifter, J., Diel, I. J.
(2000). Osteoporosis Due to Cancer Treatment: Pathogenesis and Management. JCO
18: 1570-1593
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(1999). Degree of Fatness after Treatment for Acute Lymphoblastic Leukemia in Childhood. J. Clin. Endocrinol. Metab.
84: 4591-4596
[Abstract][Full Text]
Shalet, S. M., Toogood, A., Rahim, A., Brennan, B. M. D.
(1998). The Diagnosis of Growth Hormone Deficiency in Children and Adults. Endocr. Rev.
19: 203-223
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Toogood, A. A., Nass, R. M., Pezzoli, S. S., O'Neill, P. A., Thorner, M. O., Shalet, S. M.
(1997). Preservation of Growth Hormone Pulsatility Despite Pituitary Pathology, Surgery, and Irradiation. J. Clin. Endocrinol. Metab.
82: 2215-2221
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