This issue of the Journal contains two important reports oflarge-scale prospective studies, one in men1 and one in women,2showing that the use of large doses of vitamin E supplementsis associated with a significantly decreased risk of coronaryheart disease. The study populations were enormous -- almost40,000 men and more than 80,000 women -- and the participantswere followed for four and eight years, respectively. The studieswere very carefully conducted: there was more than 95 percentfollow-up, independent validation of the dietary questionnaires,and careful documentation of end points. In both studies thebenefit of vitamin . . . [Full Text of this Article]
References
Related Letters:
Vitamin E and the Risk of Coronary Disease
O'Keefe J. H., Lavie C. J., Steiner M., Powell L. H., Black H. R., Sullivan J. L., Stampfer M. J., Rimm E. B., Willett W. C., Steinberg D.
Extract |
Full Text
N Engl J Med 1993;
329:1424-1426, Nov 4, 1993.
Correspondence
This article has been cited by other articles:
Jenkins, D. J. A., Kendall, C. W. C., Marchie, A., Josse, A. R., Nguyen, T. H., Faulkner, D. A., Lapsley, K. G., Blumberg, J.
(2008). Almonds Reduce Biomarkers of Lipid Peroxidation in Older Hyperlipidemic Subjects. J. Nutr.
138: 908-913
[Abstract][Full Text]
Brown, B. G., Cheung, M. C., Lee, A. C., Zhao, X.-Q., Chait, A.
(2002). Antioxidant Vitamins and Lipid Therapy: End of a Long Romance?. Arterioscler. Thromb. Vasc. Bio.
22: 1535-1546
[Abstract][Full Text]
Steinberg, D., Witztum, J. L.
(2002). Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?: Do the Antioxidant Trials Conducted to Date Refute the Hypothesis?. Circulation
105: 2107-2111
[Full Text]
Mulholland, C.W., Elwood, P.C., Davis, A., Thurnham, D.I., Kennedy, O., Coulter, J., Fehily, A., Strain, J.J.
(1999). Antioxidant enzymes, inflammatory indices and lifestyle factors in older men: a cohort analysis. QJM
92: 579-585
[Abstract][Full Text]
Powell, J. T
(1998). Vascular damage from smoking: disease mechanisms at the arterial wall. Vasc Med
3: 21-28
[Abstract]
Tornwall, M. E., Virtamo, J., Haukka, J. K., Aro, A., Albanes, D., Edwards, B. K., Huttunen, J. K.
(1997). Effect of {alpha}-Tocopherol (Vitamin E) and ß-Carotene Supplementation on the Incidence of Intermittent Claudication in Male Smokers. Arterioscler. Thromb. Vasc. Bio.
17: 3475-3480
[Abstract][Full Text]
Delanty, N., Reilly, M.P., Pratico, D., Lawson, J.A., McCarthy, J.F., Wood, A.E., Ohnishi, S.T., Fitzgerald, D.J., FitzGerald, G.A.
(1997). 8-Epi PGF2{alpha} Generation During Coronary Reperfusion: A Potential Quantitative Marker of Oxidant Stress In Vivo. Circulation
95: 2492-2499
[Abstract][Full Text]
Pentikainen, M. O., Lindstedt, K. A., Kovanen, P. T.
(1995). Inhibition of the Oxidative Modification of LDL by Nitecapone. Arterioscler. Thromb. Vasc. Bio.
15: 740-747
[Abstract][Full Text]
Hoffman, R. M., Garewal, H. S.
(1995). Antioxidants and the Prevention of Coronary Heart Disease. Arch Intern Med
155: 241-246
[Abstract]
Simon, H. B.
(1994). Patient-Directed, Nonprescription Approaches to Cardiovascular Disease. Arch Intern Med
154: 2283-2296
[Abstract]
Johnson, L. E.
(1994). The Emerging Role of Vitamins as Antioxidants. Arch Fam Med
3: 809-818
[Abstract]
O'Keefe, J. H., Lavie, C. J., Steiner, M., Powell, L. H., Black, H. R., Sullivan, J. L., Stampfer, M. J., Rimm, E. B., Willett, W. C., Steinberg, D.
(1993). Vitamin E and the Risk of Coronary Disease. NEJM
329: 1424-1426
[Full Text]
(1993). VITAMIN E MAY REDUCE CORONARY RISK IN MEN AND WOMEN. JWatch General
1993: 1-1
[Full Text]
Previous
