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Correspondence
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Volume 328:1497-1498 May 20, 1993 Number 20
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Predictors of Acute Graft-versus-Host Disease in Bone Marrow Transplantation between HLA-Identical Siblings

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To the Editor: The informative paper by Theobald et al. on the prediction of acute graft-versus-host disease (GVHD) in bone marrow transplantation between HLA-identical siblings (Dec. 3 issue) states, "No practical test is currently available to identify . . . patients who are at risk for serious acute GVHD"1.

In their discussion the authors refer to several studies2,3,4 that have attempted to predict acute GVHD, with success. All these studies were based on knowledge of the in vitro allogeneic T-cell response, including activation, proliferation, differentiation, and effector functions. All were pilot studies that followed about 80 to 90 patients . . . [Full Text of this Article]

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