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Correspondence
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Volume 328:1499 May 20, 1993 Number 20
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Primary Prophylaxis against Pneumocystis carinii Pneumonia

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To the Editor: Schneider et al. (Dec. 24 issue)1 concluded that a single dose (either 480 mg or 960 mg) of trimethoprim-sulfamethoxazole once a day is superior to aerosolized pentamidine once a month for the prevention of Pneumocystis carinii pneumonia (PCP) in patients with human immunodeficiency virus (HIV) infection.

All the patients had comparable base-line CD4 cell counts. The authors do not report CD4 cell counts for the follow-up period. Zidovudine,2,3,4 which was used by many patients in this study, may increase the CD4 cell count and therefore diminish the risk of PCP. In the three groups of patients, were . . . [Full Text of this Article]

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