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Previous Volume 328:1502 May 20, 1993 Number 20 Next

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To the Editor: Ursodiol has been approved by the Food and Drug Administration for the dissolution of gallstones, but it is also widely used to treat chronic cholestatic liver diseases, such as primary biliary cirrhosis and sclerosing cholangitis^1,2,3,4. Despite increasing experience with this medication, there have been remarkably few adverse reactions noted. We report two patients in whom severe right-upper-quadrant pain developed on repeated occasions within hours after taking ursodiol.

A 61-year-old woman was found to have primary biliary cirrhosis in January 1991. As part of her initial therapy, the patient was given 300 mg of ursodiol twice a . . . [Full Text of this Article]

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