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Previous Volume 328:1641-1642 June 3, 1993 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The vitamin supplement used in the study by Czeizel and Dudas of the prevention of first occurrences of neural-tube defects (Dec. 24 issue)¹ contained calcium pantothenate. Pantothenate supplementation may be particularly important for women receiving valproic acid in the first trimester of pregnancy for the control of epileptic seizures refractory to other anticonvulsant drugs. The Centers for Disease Control and Prevention estimated that the risk of having a fetus with spina bifida in these women is 1.2 percent,² almost 30 times the incidence in the general population. The explanation for this adverse association may lie in the . . . [Full Text of this Article]

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