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Correspondence
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Volume 328:1783-1784 June 17, 1993 Number 24
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Head and Neck Cancer

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 by Vokes, E. E.
To the Editor: In their review article on head and neck cancer, Vokes et al. (Jan. 21 issue)1 cite my editorial2 as indicating that oral erythroplasia is premalignant and carries a higher risk of transformation to invasive carcinoma than leukoplakia.

This is a misconception. My prospective studies3,4,5 of erythroplastic lesions have focused primarily on early invasive carcinoma. Supporting Shedd's6 original clinical observation, these studies have demonstrated that erythroplasia is the earliest clinical sign of asymptomatic squamous carcinoma, not precancer. I did not report on the transformation from precancer to cancer. The initial biopsies of the erythroplastic lesions that persisted for . . . [Full Text of this Article]

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