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Previous Volume 328:1792 June 17, 1993 Number 24 Next

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By Stuart B. Levy. 279 pp., illustrated. New York, Plenum, 1992. $24.95. ISBN 0-306-44331-7.

There is ample reason to be alarmed about the emergence of antibiotic-resistant microorganisms. Stuart Levy provides an informed account of how the antibiotic miracle, which began only 50 years ago, is now threatened by the extraordinarily casual manner in which these drugs are used. After a brief exposition of the development of antibiotics and their role in the control of infectious diseases, Levy moves on to describe how the heavy selective pressure of excessive use, combined with the remarkable genetic plasticity of microbes, has led to this problem. After an overview of plasmid-mediated multiple-drug resistance, he addresses the irrational demand . . . [Full Text of this Article]

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