Myeloma-Associated Paraprotein Directed against the HIV-1 p24 Antigen in an HIV-1-Seropositive Patient

doi:10.1056/NEJM199306243282505

Volume 328:1817-1819		June 24, 1993		Number 25

Myeloma-Associated Paraprotein Directed against the HIV-1 p24 Antigen in an HIV-1-Seropositive Patient

Robert J. Konrad, Larry J. Kricka, David Goodman, June Goldman, and Leslie Silberstein

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The spectrum of hematologic and immunologic abnormalities inhuman immunodeficiency virus type 1 (HIV-1) infection is broad¹^,².Although the incidence of B-cell-associated neoplasms is increased,relatively few cases of multiple myeloma have been described³^,⁴.There are, however, reports of patients in whom serum paraproteinspresent as single or oligoclonal bands⁵^,⁶^,⁷^,⁸^,⁹^,¹⁰^,¹¹. Theseparaproteins have previously been thought of as part of theexuberant polyclonal response to HIV-1¹⁰^,¹¹.

In this report, we describe an HIV-1-positive patient with myelomawhose IgG- ${kappa}$ paraprotein specifically recognized the HIV-1 p24gag antigen. It is possible that an HIV-1 antigen-driven responseplayed an . . . [Full Text of this Article]

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From the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 6 Founders Bldg., 3400 Spruce St., Philadelphia, PA 19104-6082, where reprint requests should be addressed to Dr. Silberstein.

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