To the Editor: When a person enters zero gravity, a large amountof fluid (1 to 2 liters) shifts toward the head. The responseto this shift includes the principal cardiovascular effectsof spaceflight -- e.g., hypovolemia, dehydration, and postflightorthostatic intolerance1. On earth, a similar headward shiftof fluid increases central venous pressure2; in space, however,peripheral antecubital venous pressure does not increase3,4.It is not known whether such peripheral measurements reflectcentral venous pressure. Only direct, continuous measurementsrecorded during a change from earth's gravity (1 g) to zerogravity can resolve these controversies. In . . . [Full Text of this Article]
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