Head and neck cancer was last reviewed in the Journal in 19831.At that time, there was promising new information on a possiblerole for chemotherapy1,2. During the past decade, chemotherapyhas undergone further investigation and important clinical advanceshave been made in chemoprevention, organ preservation, and thesimultaneous use of chemotherapy and radiation. In this review,we shall discuss the diagnosis of and standard therapy for headand neck cancer, as well as the status of recent basic and clinicalinvestigations.
Epidemiology
Head and neck cancer, as defined here, includes the common squamous-cellcarcinomas of the oral cavity, . . . [Full Text of this Article]
Biology
Diagnosis and Staging
Lymph-Node Metastases
Other Medical Problems in Patients with Head and Neck Cancer
Natural History and Standard Therapy
Nasopharynx
Oral Cavity
Oropharynx
Hypopharynx
Larynx
Management of Cervical Lymph Nodes
Clinical Investigations
Chemotherapy for Metastatic or Recurrent Disease
Combined Therapy for Local or Regionally Advanced Disease
Induction and Adjuvant Chemotherapy
Organ Preservation
Concomitant Chemotherapy and Radiation Therapy and Altered Fractionation Radiation Therapy
Chemoprevention
Outlook
Source Information
From the Department of Medicine, Section of Hematology/Oncology (E.E.V.), and the Department of Radiation and Cellular Oncology (E.E.V., R.R.W.), University of Chicago, Chicago, and the Department of Thoracic/ Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston (S.M.L., W.K.H.).
Address reprint requests to Dr. Vokes at the University of Chicago Medical Center, 5841 S. Maryland Ave., MC-2115, Chicago, IL 60637-1470.
References
Related Letters:
Head and Neck Cancer
Mashberg A., Russell N.S., Bartelink H., Snow G.B., Vokes E. E., Weichselbaum R. R., Lippman S. M.
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N Engl J Med 1993;
328:1783-1784, Jun 17, 1993.
Correspondence
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CRUZ, G. D., LE GEROS, R. Z., OSTROFF, J. S., HAY, J. L., KENIGSBERG, H., FRANKLIN, D. M.
(2002). Oral cancer knowledge, risk factors and characteristics of subjects in a large oral cancer screening program. Journal of the American Dental Association
133: 1064-1071
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Wenig, B. L., Werner, J. A., Castro, D. J., Sridhar, K. S., Garewal, H. S., Kehrl, W., Pluzanska, A., Arndt, O., Costantino, P. D., Mills, G. M., Dunphy II, F. R., Orenberg, E. K., Leavitt, R. D.
(2002). The Role of Intratumoral Therapy With Cisplatin/Epinephrine Injectable Gel in the Management of Advanced Squamous Cell Carcinoma of the Head and Neck. Arch Otolaryngol Head Neck Surg
128: 880-885
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Li, D., Ronson, B., Guo, M., Liu, S., Bishop, J. S., Van Echo, D. A., O'Malley, B. W. Jr.
(2002). Interleukin 2 Gene Transfer Prevents NKG2D Suppression and Enhances Antitumor Efficacy in Combination with Cisplatin for Head and Neck Squamous Cell Cancer. Cancer Res.
62: 4023-4028
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Monnerat, C., Faivre, S., Temam, S., Bourhis, J., Raymond, E.
(2002). End points for new agents in induction chemotherapy for locally advanced head and neck cancers. Ann Oncol
13: 995-1006
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Alvi, A J, Hogg, R, Rader, J S, Kuo, M J, Maher, E R, Latif, F
(2002). Mutation screening analysis of the retinoblastoma related gene RB2/p130 in sporadic ovarian cancer and head and neck squamous cell cancer. Mol. Pathol.
55: 153-155
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Joshi, B. H., Kawakami, K., Leland, P., Puri, R. K.
(2002). Heterogeneity in Interleukin-13 Receptor Expression and Subunit Structure in Squamous Cell Carcinoma of Head and Neck: Differential Sensitivity to Chimeric Fusion Proteins Comprised of Interleukin-13 and a Mutated Form of Pseudomonas Exotoxin. Clin. Cancer Res.
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Wu, X., Lippman, S. M., Lee, J. J., Zhu, Y., Wei, Q. V., Thomas, M., Hong, W. K., Spitz, M. R.
(2002). Chromosome Instability in Lymphocytes: A Potential Indicator of Predisposition to Oral Premalignant Lesions. Cancer Res.
62: 2813-2818
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Huang, S.-M., Li, J., Harari, P. M.
(2002). Molecular Inhibition of Angiogenesis and Metastatic Potential in Human Squamous Cell Carcinomas after Epidermal Growth Factor Receptor Blockade. Molecular Cancer Therapeutics
1: 507-514
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Chan, A.T.C., Teo, P.M.L., Ngan, R.K., Leung, T.W., Lau, W.H., Zee, B., Leung, S.F., Cheung, F.Y., Yeo, W., Yiu, H.H., Yu, K.H., Chiu, K.W., Chan, D.T., Mok, T., Yuen, K.T., Mo, F., Lai, M., Kwan, W.H., Choi, P., Johnson, P.J.
(2002). Concurrent Chemotherapy-Radiotherapy Compared With Radiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma: Progression-Free Survival Analysis of a Phase III Randomized Trial. JCO
20: 2038-2044
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Glisson, B. S., Murphy, B. A., Frenette, G., Khuri, F. R., Forastiere, A. A.
(2002). Phase II Trial of Docetaxel and Cisplatin Combination Chemotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck. JCO
20: 1593-1599
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Nabi, H. A., Zubeldia, J. M.
(2002). Clinical Applications of 18F-FDG in Oncology. J. Nucl. Med. Technol.
30: 3-9
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Adelstein, D. J., Saxton, J. P., Lavertu, P., Rybicki, L. A., Esclamado, R. M., Wood, B. G., Strome, M., Carroll, M. A.
(2002). Maximizing Local Control and Organ Preservation in Stage IV Squamous Cell Head and Neck Cancer With Hyperfractionated Radiation and Concurrent Chemotherapy. JCO
20: 1405-1410
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Lippman, S. M., Ki Hong, W.
(2002). Cancer Prevention by Delay : Commentary re: J. A. O'Shaughnessy et al., Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development. Clin. Cancer Res., 8: 314-346, 2002.. Clin. Cancer Res.
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O'Shaughnessy, J. A., Kelloff, G. J., Gordon, G. B., Dannenberg, A. J., Hong, W. K., Fabian, C. J., Sigman, C. C., Bertagnolli, M. M., Stratton, S. P., Lam, S., Nelson, W. G., Meyskens, F. L., Alberts, D. S., Follen, M., Rustgi, A. K., Papadimitrakopoulou, V., Scardino, P. T., Gazdar, A. F., Wattenberg, L. W., Sporn, M. B., Sakr, W. A., Lippman, S. M., Von Hoff, D. D.
(2002). Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development : Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia. Clin. Cancer Res.
8: 314-346
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Sudbo, J., Kildal, W., Johannessen, A. C., Koppang, H. S., Sudbo, A., Danielsen, H. E., Risberg, B., Reith, A.
(2002). Gross Genomic Aberrations in Precancers: Clinical Implications of a Long-Term Follow-Up Study in Oral Erythroplakias. JCO
20: 456-462
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Forastiere, A., Koch, W., Trotti, A., Sidransky, D.
(2001). Head and Neck Cancer. NEJM
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Almadori, G., Cadoni, G., Cattani, P., Galli, J., Bussu, F., Ferrandina, G., Scambia, G., Fadda, G., Maurizi, M.
(2001). Human Papillomavirus Infection and Epidermal Growth Factor Receptor Expression in Primary Laryngeal Squamous Cell Carcinoma. Clin. Cancer Res.
7: 3988-3993
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Lippman, S. M., Spitz, M. R.
(2001). Lung Cancer Chemoprevention: An Integrated Approach. JCO
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Sabio, J. M., Pasquau, J., Jimenez-Alonso, J., Klussmann, J. P., Weissenborn, S., Fuchs, P. G., Sudbo, J., Mork, J., Lehtinen, M., Dillner, J.
(2001). Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck. NEJM
345: 376-377
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Khuri, F. R., Kim, E. S., Lee, J. J., Winn, R. J., Benner, S. E., Lippman, S. M., Fu, K. K., Cooper, J. S., Vokes, E. E., Chamberlain, R. M., Williams, B., Pajak, T. F., Goepfert, H., Hong, W. K.
(2001). The Impact of Smoking Status, Disease Stage, and Index Tumor Site on Second Primary Tumor Incidence and Tumor Recurrence in the Head and Neck Retinoid Chemoprevention Trial. Cancer Epidemiol. Biomarkers Prev.
10: 823-829
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Song, J. I., Lango, M. N., Hwang, J. D., Drenning, S. D., Zeng, Q., Lamph, W. W., Grandis, J. R.
(2001). Abrogation of Transforming Growth Factor-{alpha}/Epidermal Growth Factor Receptor Autocrine Signaling by an RXR-selective Retinoid (LGD1069, Targretin) in Head and Neck Cancer Cell Lines. Cancer Res.
61: 5919-5925
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Akutsu, N., Lin, R., Bastien, Y., Bestawros, A., Enepekides, D. J., Black, M. J., White, J. H.
(2001). Regulation of Gene Expression by 1{{alpha}},25-Dihydroxyvitamin D3 and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells. Mol. Endocrinol.
15: 1127-1139
[Abstract][Full Text]
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