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Previous Volume 328:207-209 January 21, 1993 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The report by Mattson et al. (Sept. 10 issue)¹ that carbamazepine is more effective than valproate for the treatment of complex partial seizures is at variance with previous comparative trials^2,3,4,5. Mattson and the Veterans Affairs group suggest that this is due to the greater power of their study. We question their conclusions and explanation.

In a prospective, randomized study we found no differences after three years in efficacy between phenobarbital, phenytoin, carbamazepine, and valproate in children and adults with newly diagnosed primary generalized or partial seizures with or without secondary generalization^4,5. Table 1 shows that . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Kwan, P., Brodie, M. J. (2003). Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsy. Neurology 60: S2-12 [Abstract] [Full Text]