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Previous Volume 328:257-265 January 28, 1993 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Most physicians and immunologists, if they think of the mast cell at all, regard it as something of a pariah. Other cells of hematopoietic origin, such as neutrophils, macrophages, and platelets, are clearly important in host defense, hemostasis, or both. In contrast, the contributions of the mast cell to pathologic conditions come to mind much more readily than any role it may have in the maintenance of health. Indeed, some would argue that an entire branch of medicine -- allergy -- deals in large part with the adverse effects produced by activation of the mast cell and the basophil, a . . . [Full Text of this Article]

Origin and Distribution of Mast Cells and Basophils

Mast-Cell Heterogeneity

Participation of Mast Cells in Acute or Persistent Inflammatory Responses

Mast Cells as Sources of Multifunctional Cytokines

Animal Model for Investigating Mast-Cell Function in Vivo

Leukocyte Infiltration at Sites of IgE-Dependent Cutaneous Reactions

TNF-, Other Cytokines, and Late-Phase Reactions

Mast-Cell-Leukocyte Cytokine Cascade

Conclusions and Therapeutic Implications

Discussion

Source Information

From the Division of Experimental Pathology, Department of Pathology, Beth Israel Hospital, and Harvard Medical School, both in Boston.

Address reprint requests to Dr. Galli at the Division of Experimental Pathology, Department of Pathology, Beth Israel Hospital, 330 Brookline Ave., Boston, MA 02215.

References

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• Nishida, K., Hasegawa, A., Nakae, S., Oboki, K., Saito, H., Yamasaki, S., Hirano, T. (2009). Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction. JEM 206: 1351-1364 [Abstract] [Full Text]  
• Holdsworth, S. R., Summers, S. A. (2008). Role of Mast Cells in Progressive Renal Diseases. J. Am. Soc. Nephrol. 19: 2254-2261 [Abstract] [Full Text]  
• Lee, J. H., Kim, J. W., Ko, N. Y., Mun, S. H., Kim, D. K., Kim, J. D., Won, H. S., Shin, H. S., Kim, H. S., Her, E., Kim, Y. M., Choi, W. S. (2008). Mast Cell-Mediated Allergic Response Is Suppressed by Sophorae Flos: Inhibition of Src-Family Kinase. Exp. Biol. Med. 233: 1271-1279 [Abstract] [Full Text]  
• Santone, D. J., Shahani, R., Rubin, B. B., Romaschin, A. D., Lindsay, T. F. (2008). Mast cell stabilization improves cardiac contractile function following hemorrhagic shock and resuscitation. Am. J. Physiol. Heart Circ. Physiol. 294: H2456-H2464 [Abstract] [Full Text]  
• Norman, M. U., Hwang, J., Hulliger, S., Bonder, C. S., Yamanouchi, J., Santamaria, P., Kubes, P. (2008). Mast Cells Regulate the Magnitude and the Cytokine Microenvironment of the Contact Hypersensitivity Response. Am. J. Pathol. 172: 1638-1649 [Abstract] [Full Text]  
• Veerappan, A., Reid, A. C., Estephan, R., O'Connor, N., Thadani-Mulero, M., Salazar-Rodriguez, M., Levi, R., Silver, R. B. (2008). Mast cell renin and a local renin-angiotensin system in the airway: Role in bronchoconstriction. Proc. Natl. Acad. Sci. USA 105: 1315-1320 [Abstract] [Full Text]  
• Lim, B. O., Lee, J. H., Ko, N. Y., Mun, S. H., Kim, J. W., Kim, D. K., Kim, J. D., Kim, B. K., Kim, H. S., Her, E., Lee, H. Y., Choi, W. S. (2007). Polygoni Cuspidati Radix Inhibits the Activation of Syk Kinase in Mast Cells for Antiallergic Activity. Exp. Biol. Med. 232: 1425-1431 [Abstract] [Full Text]  
• Khalaf, W. F., Yang, F.-C., Chen, S., White, H., Bessler, W., Ingram, D. A., Clapp, D. W. (2007). K-ras Is Critical for Modulating Multiple c-kit-Mediated Cellular Functions in Wild-Type and Nf1+/- Mast Cells. J. Immunol. 178: 2527-2534 [Abstract] [Full Text]  
• Redente, E. F., Orlicky, D. J., Bouchard, R. J., Malkinson, A. M. (2007). Tumor Signaling to the Bone Marrow Changes the Phenotype of Monocytes and Pulmonary Macrophages during Urethane-Induced Primary Lung Tumorigenesis in A/J Mice. Am. J. Pathol. 170: 693-708 [Abstract] [Full Text]  
• Baroni, E., Biffi, M., Benigni, F., Monno, A., Carlucci, D., Carmeliet, G., Bouillon, R., D'Ambrosio, D. (2007). VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3. J. Leukoc. Biol. 81: 250-262 [Abstract] [Full Text]  
• Gustin, S. E., Thien, C. B. F., Langdon, W. Y. (2006). Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells. J. Immunol. 177: 5980-5989 [Abstract] [Full Text]  
• Weller, K., Foitzik, K., Paus, R., Syska, W., Maurer, M. (2006). Mast cells are required for normal healing of skin wounds in mice. FASEB J. 20: 2366-2368 [Abstract] [Full Text]  
• Kabu, K., Yamasaki, S., Kamimura, D., Ito, Y., Hasegawa, A., Sato, E., Kitamura, H., Nishida, K., Hirano, T. (2006). Zinc Is Required for Fc{epsilon}RI-Mediated Mast Cell Activation. J. Immunol. 177: 1296-1305 [Abstract] [Full Text]  
• Paul, M., Poyan Mehr, A., Kreutz, R. (2006). Physiology of local Renin-Angiotensin systems.. Physiol. Rev. 86: 747-803 [Abstract] [Full Text]  
• Li, B., Power, M. R., Lin, T.-J. (2006). De novo synthesis of early growth response factor-1 is required for the full responsiveness of mast cells to produce TNF and IL-13 by IgE and antigen stimulation. Blood 107: 2814-2820 [Abstract] [Full Text]  
• Nigo, Y. I., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., Nakayama, T. (2006). Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103: 2286-2291 [Abstract] [Full Text]  
• Oka, T., Hori, M., Ozaki, H. (2005). Microtubule Disruption Suppresses Allergic Response through the Inhibition of Calcium Influx in the Mast Cell Degranulation Pathway. J. Immunol. 174: 4584-4589 [Abstract] [Full Text]  
• Sloane, D. E., Tedla, N., Awoniyi, M., MacGlashan, D. W. Jr, Borges, L., Austen, K. F., Arm, J. P. (2004). Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood 104: 2832-2839 [Abstract] [Full Text]  
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• Kandere-Grzybowska, K., Letourneau, R., Kempuraj, D., Donelan, J., Poplawski, S., Boucher, W., Athanassiou, A., Theoharides, T. C. (2003). IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells. J. Immunol. 171: 4830-4836 [Abstract] [Full Text]  
• van der Kleij, H. P. M., Ma, D., Redegeld, F. A. M., Kraneveld, A. D., Nijkamp, F. P., Bienenstock, J. (2003). Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor. J. Immunol. 171: 2074-2079 [Abstract] [Full Text]  
• Huang, M., Pang, X., Karalis, K., Theoharides, T. C. (2003). Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice. Cardiovasc Res 59: 241-249 [Abstract] [Full Text]  
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• Wen, R., Jou, S.-T., Chen, Y., Hoffmeyer, A., Wang, D. (2002). Phospholipase C{gamma}2 Is Essential for Specific Functions of Fc{epsilon}R and Fc{gamma}R. J. Immunol. 169: 6743-6752 [Abstract] [Full Text]  
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• Chen, R., Fairley, J. A., Zhao, M.-L., Giudice, G. J., Zillikens, D., Diaz, L. A., Liu, Z. (2002). Macrophages, But Not T and B Lymphocytes, Are Critical for Subepidermal Blister Formation in Experimental Bullous Pemphigoid: Macrophage-Mediated Neutrophil Infiltration Depends on Mast Cell Activation. J. Immunol. 169: 3987-3992 [Abstract] [Full Text]  
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• Hosoda, M., Yamaya, M., Suzuki, T., Yamada, N., Kamanaka, M., Sekizawa, K., Butterfield, J. H., Watanabe, T., Nishimura, H., Sasaki, H. (2002). Effects of Rhinovirus Infection on Histamine and Cytokine Production by Cell Lines from Human Mast Cells and Basophils. J. Immunol. 169: 1482-1491 [Abstract] [Full Text]  
• Huang, M., Pang, X., Letourneau, R., Boucher, W., Theoharides, T. C (2002). Acute stress induces cardiac mast cell activation and histamine release, effects that are increased in Apolipoprotein E knockout mice. Cardiovasc Res 55: 150-160 [Abstract] [Full Text]  
• Metsarinne, K. P., Vehmaan-Kreula, P., Kovanen, P. T., Saijonmaa, O., Baumann, M., Wang, Y., Nyman, T., Fyhrquist, F. Y., Eklund, K. K. (2002). Activated Mast Cells Increase the Level of Endothelin-1 mRNA in Cocultured Endothelial Cells and Degrade the Secreted Peptide. Arterioscler. Thromb. Vasc. Bio. 22: 268-273 [Abstract] [Full Text]  
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• Uckun, F. M., Thoen, J., Chen, H., Sudbeck, E., Mao, C., Malaviya, R., Liu, X.-P., Chen, C.-L. (2002). CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4'-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: Structural Basis for Inactivation by Regioselective O-Demethylation. Drug Metab. Dispos. 30: 74-85 [Abstract] [Full Text]  
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• Li, Y., Li, L., Wadley, R., Reddel, S. W., Qi, J. C., Archis, C., Collins, A., Clark, E., Cooley, M., Kouts, S., Naif, H. M., Alali, M., Cunningham, A., Wong, G. W., Stevens, R. L., Krilis, S. A. (2001). Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4. Blood 97: 3484-3490 [Abstract] [Full Text]  
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• Triggiani, M., Gentile, M., Secondo, A., Granata, F., Oriente, A., Taglialatela, M., Annunziato, L., Marone, G. (2001). Histamine Induces Exocytosis and IL-6 Production from Human Lung Macrophages Through Interaction with H1 Receptors. J. Immunol. 166: 4083-4091 [Abstract] [Full Text]  
• Jamur, M. C., Grodzki, A. C. G., Moreno, A. N., de Fátima C. de Mello, L., Pastor, M. V. D., Berenstein, E. H., Siraganian, R. P., Oliver, C. (2001). Identification and Isolation of Rat Bone Marrow-derived Mast Cells Using the Mast Cell-specific Monoclonal Antibody AA4. J. Histochem. Cytochem. 49: 219-228 [Abstract] [Full Text]  
• Kolaczkowska, E., Seljelid, R., Plytycz, B. (2001). Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice. J. Leukoc. Biol. 69: 33-42 [Abstract] [Full Text]  
• Peters, W., Dupuis, M., Charo, I. F. (2000). A Mechanism for the Impaired IFN-{gamma} Production in C-C Chemokine Receptor 2 (CCR2) Knockout Mice: Role of CCR2 in Linking the Innate and Adaptive Immune Responses. J. Immunol. 165: 7072-7077 [Abstract] [Full Text]  
• de Paulis, A., De Palma, R., Di Gioia, L., Carfora, M., Prevete, N., Tosi, G., Accolla, R. S., Marone, G. (2000). Tat Protein Is an HIV-1-Encoded {beta}-Chemokine Homolog That Promotes Migration and Up-Regulates CCR3 Expression on Human Fc{epsilon}RI+ Cells. J. Immunol. 165: 7171-7179 [Abstract] [Full Text]  
• Falcone, F. H., Haas, H., Gibbs, B. F. (2000). The human basophil: a new appreciation of its role in immune responses. Blood 96: 4028-4038 [Full Text]  
• Asai, K., Fujimoto, K., Harazaki, M., Kusunoki, T., Korematsu, S., Ide, C., Ra, C., Hosoi, S. (2000). Distinct Aggregation of {beta}- and {gamma}-Chains of the High-affinity IgE Receptor on Cross-Linking. J. Histochem. Cytochem. 48: 1705-1716 [Abstract] [Full Text]  
• Malaviya, R., Chen, C.-L., Navara, C., Malaviya, R., Liu, X.-P., Keenan, M., Waurzyniak, B., Uckun, F. M. (2000). Treatment of Allergic Asthma by Targeting Janus Kinase 3-Dependent Leukotriene Synthesis in Mast Cells with 4-(3',5'-Dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). J. Pharmacol. Exp. Ther. 295: 912-926 [Abstract] [Full Text]  
• Middleton, E. Jr., Kandaswami, C., Theoharides, T. C. (2000). The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer. Pharmacol. Rev. 52: 673-751 [Abstract] [Full Text]  
• Ma, H., Kovanen, P. T. (2000). Inhibition of Mast Cell-Dependent Conversion of Cultured Macrophages Into Foam Cells With Antiallergic Drugs. Arterioscler. Thromb. Vasc. Bio. 20 : e134-e142 [Abstract] [Full Text]  
• Genovese, A., Bouvet, J.-P., Florio, G., Lamparter-Schummert, B., Bjorck, L., Marone, G. (2000). Bacterial Immunoglobulin Superantigen Proteins A and L Activate Human Heart Mast Cells by Interacting with Immunoglobulin E. Infect. Immun. 68: 5517-5524 [Abstract] [Full Text]  
• Sotlar, K, Marafioti, T, Griesser, H, Theil, J, Aepinus, C, Jaussi, R, Stein, H, Valent, P, Horny, H-P (2000). Detection of c-kit mutation Asp 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic leukaemia. Mol. Pathol. 53: 188-193 [Abstract] [Full Text]  
• Sanchez Mejia, R. O., Lam, B. K., Arm, J. P. (2000). Matrix-Associated Transforming Growth Factor-beta 1 Primes Mouse Bone Marrow-Derived Mast Cells for Increased High-Affinity Fc Receptor for Immunoglobulin E-Dependent Eicosanoid Biosynthesis. Am. J. Respir. Cell Mol. Bio. 22: 557-565 [Abstract] [Full Text]  
• Laine, P., Naukkarinen, A., Heikkila, L., Penttila, A., Kovanen, P. T. (2000). Adventitial Mast Cells Connect With Sensory Nerve Fibers in Atherosclerotic Coronary Arteries. Circulation 101: 1665-1669 [Abstract] [Full Text]  
• Cissel, D. S., Beaven, M. A. (2000). Disruption of Raf-1/Heat Shock Protein 90 Complex and Raf Signaling by Dexamethasone in Mast Cells. J. Biol. Chem. 275: 7066-7070 [Abstract] [Full Text]  
• Patella, V., Florio, G., Petraroli, A., Marone, G. (2000). HIV-1 gp120 Induces IL-4 and IL-13 Release from Human Fc{epsilon}RI+ Cells Through Interaction with the VH3 Region of IgE. J. Immunol. 164: 589-595 [Abstract] [Full Text]  
• Vincent, A.J., Zhang, J., Ostor, A., Rogers, P.A.W., Affandi, B., Kovacs, G., Salamonsen, L.A. (2000). Matrix metalloproteinase-1 and -3 and mast cells are present in the endometrium of women using progestin-only contraceptives. Hum Reprod 15: 123-130 [Abstract] [Full Text]  
• Lorentz, A., Schwengberg, S., Sellge, G., Manns, M. P., Bischoff, S. C. (2000). Human Intestinal Mast Cells Are Capable of Producing Different Cytokine Profiles: Role of IgE Receptor Cross-Linking and IL-4. J. Immunol. 164: 43-48 [Abstract] [Full Text]  
• Hoshino, K., Kashiwamura, S.-i., Kuribayashi, K., Kodama, T., Tsujimura, T., Nakanishi, K., Matsuyama, T., Takeda, K., Akira, S. (1999). The Absence of Interleukin 1 Receptor-Related T1/St2 Does Not Affect T Helper Cell Type 2 Development and Its Effector Function. JEM 190: 1541-1548 [Abstract] [Full Text]  
• HAMADA, H., TERAI, M., KIMURA, H., HIRANO, K., OANA, S., NIIMI, H. (1999). Increased Expression of Mast Cell Chymase in the Lungs of Patients with Congenital Heart Disease Associated with Early Pulmonary Vascular Disease. Am. J. Respir. Crit. Care Med. 160: 1303-1308 [Abstract] [Full Text]  
• Romagnani, P., De Paulis, A., Beltrame, C., Annunziato, F., Dente, V., Maggi, E., Romagnani, S., Marone, G. (1999). Tryptase-Chymase Double-Positive Human Mast Cells Express the Eotaxin Receptor CCR3 and Are Attracted by CCR3-Binding Chemokines. Am. J. Pathol. 155: 1195-1204 [Abstract] [Full Text]  
• Malaviya, R., Zhu, D., Dibirdik, I., Uckun, F. M. (1999). Targeting Janus Kinase 3 in Mast Cells Prevents Immediate Hypersensitivity Reactions and Anaphylaxis. J. Biol. Chem. 274: 27028-27038 [Abstract] [Full Text]  
• Rozniecki, J. J., Letourneau, R., Sugiultzoglu, M., Spanos, C., Gorbach, J., Theoharides, T. C. (1999). Differential Effect of Histamine 3 Receptor-Active Agents on Brain, but not Peritoneal, Mast Cell Activation. J. Pharmacol. Exp. Ther. 290: 1427-1435 [Abstract] [Full Text]  
• HAMELMANN, E., CIESLEWICZ, G., SCHWARZE, J., ISHIZUKA, T., JOETHAM, A., HEUSSER, C., GELFAND, E. W. (1999). Anti-interleukin 5 But Not Anti-IgE Prevents Airway Inflammation and Airway Hyperresponsiveness. Am. J. Respir. Crit. Care Med. 160: 934-941 [Abstract] [Full Text]  
• Befus, A. D., Mowat, C., Gilchrist, M., Hu, J., Solomon, S., Bateman, A. (1999). Neutrophil Defensins Induce Histamine Secretion from Mast Cells: Mechanisms of Action. J. Immunol. 163: 947-953 [Abstract] [Full Text]  
• Malaviya, R., Gao, Z., Thankavel, K., van der Merwe, P. A., Abraham, S. N. (1999). The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. Proc. Natl. Acad. Sci. USA 96: 8110-8115 [Abstract] [Full Text]  
• Murphy, P. G., Borthwick, L. S., Johnston, R. S., Kuchel, G., Richardson, P. M. (1999). Nature of the Retrograde Signal from Injured Nerves that Induces Interleukin-6 mRNA in Neurons. J. Neurosci. 19: 3791-3800 [Abstract] [Full Text]  
• Bischoff, S C, Lorentz, A, Schwengberg, S, Weier, G, Raab, R, Manns, M P (1999). Mast cells are an important cellular source of tumour necrosis factor alpha  in human intestinal tissue. Gut 44: 643-652 [Abstract] [Full Text]  
• Yamaguchi, M., Sayama, K., Yano, K., Lantz, C. S., Noben-Trauth, N., Ra, C., Costa, J. J., Galli, S. J. (1999). IgE Enhances Fc{epsilon} Receptor I Expression and IgE-Dependent Release of Histamine and Lipid Mediators from Human Umbilical Cord Blood-Derived Mast Cells: Synergistic Effect of IL-4 and IgE on Human Mast Cell Fc{epsilon} Receptor I Expression and Mediator Release. J. Immunol. 162: 5455-5465 [Abstract] [Full Text]  
• Kim, H.-M., Lee, Y.-M. (1999). Role of TGF-{beta}1 on the IgE-Dependent Anaphylaxis Reaction. J. Immunol. 162: 4960-4965 [Abstract] [Full Text]  
• Talkington, J., Nickell, S. P. (1999). Borrelia burgdorferi Spirochetes Induce Mast Cell Activation and Cytokine Release. Infect. Immun. 67: 1107-1115 [Abstract] [Full Text]  
• Kim, Y.-K., Uno, M., Hamilos, D. L., Beck, L., Bochner, B., Schleimer, R., Denburg, J. A. (1999). Immunolocalization of CD34 in Nasal Polyposis . Effect of Topical Corticosteroids. Am. J. Respir. Cell Mol. Bio. 20: 388-397 [Abstract] [Full Text]  
• Singh, L. K., Boucher, W., Pang, X., Letourneau, R., Seretakis, D., Green, M., Theoharides, T. C. (1999). Potent Mast Cell Degranulation and Vascular Permeability Triggered by Urocortin Through Activation of Corticotropin-Releasing Hormone Receptors. J. Pharmacol. Exp. Ther. 288: 1349-1356 [Abstract] [Full Text]  
• Banu, Y., Watanabe, T. (1999). Augmentation of Antigen Receptor-mediated Responses by Histamine H1 Receptor Signaling. JEM 189: 673-682 [Abstract] [Full Text]  
• Ishizuka, T., Chayama, K., Takeda, K., Hamelmann, E., Terada, N., Keller, G. M., Johnson, G. L., Gelfand, E. W. (1999). Mitogen-Activated Protein Kinase Activation Through Fc{epsilon} Receptor I and Stem Cell Factor Receptor Is Differentially Regulated by Phosphatidylinositol 3-Kinase and Calcineurin in Mouse Bone Marrow-Derived Mast Cells. J. Immunol. 162: 2087-2094 [Abstract] [Full Text]  
• Laine, P., Kaartinen, M., Penttila, A., Panula, P., Paavonen, T., Kovanen, P. T. (1999). Association Between Myocardial Infarction and the Mast Cells in the Adventitia of the Infarct-Related Coronary Artery. Circulation 99: 361-369 [Abstract] [Full Text]  
• Noviski, N., Brewer, J. P., Skornik, W. A., Galli, S. J., Drazen, J. M., Martin, T. R. (1999). Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice. J. Appl. Physiol. 86: 202-210 [Abstract] [Full Text]  
• Thomson, A. J., Telfer, J. F., Young, A., Campbell, S., Stewart, C. J.R., Cameron, I. T., Greer, I. A., Norman, J. E. (1999). Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Hum Reprod 14: 229-236 [Abstract] [Full Text]  
• Kozik, A., Moore, R. B., Potempa, J., Imamura, T., Rapala-Kozik, M., Travis, J. (1998). A Novel Mechanism for Bradykinin Production at Inflammatory Sites. DIVERSE EFFECTS OF A MIXTURE OF NEUTROPHIL ELASTASE AND MAST CELL TRYPTASE VERSUS TISSUE AND PLASMA KALLIKREINS ON NATIVE AND OXIDIZED KININOGENS. J. Biol. Chem. 273: 33224-33229 [Abstract] [Full Text]  
• Johnson, J. L., Jackson, C. L., Angelini, G. D., George, S. J. (1998). Activation of Matrix-Degrading Metalloproteinases by Mast Cell Proteases in Atherosclerotic Plaques. Arterioscler. Thromb. Vasc. Bio. 18: 1707-1715 [Abstract] [Full Text]  
• Moritz, D. R., Rodewald, H.-R., Gheyselinck, J., Klemenz, R. (1998). The IL-1 Receptor-Related T1 Antigen Is Expressed on Immature and Mature Mast Cells and on Fetal Blood Mast Cell Progenitors. J. Immunol. 161: 4866-4874 [Abstract] [Full Text]  
• Bockamp, E.-O., Fordham, J. L., Gottgens, B., Murrell, A. M., Sanchez, M.-J., Green, A. R. (1998). Transcriptional Regulation of the Stem Cell Leukemia Gene by PU.1 and Elf-1. J. Biol. Chem. 273: 29032-29042 [Abstract] [Full Text]  
• Pang, X., Alexacos, N., Letourneau, R., Seretakis, D., Gao, W., Boucher, W., Cochrane, D. E., Theoharides, T. C. (1998). A Neurotensin Receptor Antagonist Inhibits Acute Immobilization Stress-Induced Cardiac Mast Cell Degranulation, a Corticotropin-Releasing Hormone-Dependent Process. J. Pharmacol. Exp. Ther. 287: 307-314 [Abstract] [Full Text]  
• Kaartinen, M., van der Wal, A. C., van der Loos, C. M., Piek, J. J., Koch, K. T., Becker, A. E., Kovanen, P. T. (1998). Mast cell infiltration in acute coronary syndromes: implications for plaque rupture. J Am Coll Cardiol 32: 606-612 [Abstract] [Full Text]  
• Gächter, T., Moritz, D. R., Gheyselinck, J., Klemenz, R. (1998). GATA-Dependent Expression of the Interleukin-1 Receptor-Related T1 Gene in Mast Cells. Mol. Cell. Biol. 18: 5320-5331 [Abstract] [Full Text]  
• Frangogiannis, N. G., Perrard, J. L., Mendoza, L. H., Burns, A. R., Lindsey, M. L., Ballantyne, C. M., Michael, L. H., Smith, C. W., Entman, M. L. (1998). Stem Cell Factor Induction Is Associated With Mast Cell Accumulation After Canine Myocardial Ischemia and Reperfusion. Circulation 98: 687-698 [Abstract] [Full Text]  
• Frangogiannis, N. G., Lindsey, M. L., Michael, L. H., Youker, K. A., Bressler, R. B., Mendoza, L. H., Spengler, R. N., Smith, C. W., Entman, M. L. (1998). Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-{alpha}, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion. Circulation 98: 699-710 [Abstract] [Full Text]  
• Kawakami, Y., Hartman, S. E., Holland, P. M., Cooper, J. A., Kawakami, T. (1998). Multiple Signaling Pathways for the Activation of JNK in Mast Cells: Involvement of Bruton's Tyrosine Kinase, Protein Kinase C, and JNK Kinases, SEK1 and MKK7. J. Immunol. 161: 1795-1802 [Abstract] [Full Text]  
• Kanwar, S., Hickey, M. J., Kubes, P. (1998). Postischemic inflammation: a role for mast cells in intestine but not in skeletal muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 275: G212-G218 [Abstract] [Full Text]  
• TAYLOR, D. A., MCGRATH, J. L., O'CONNOR, B. J., BARNES, P. J. (1998). Allergen-induced Early and Late Asthmatic Responses Are Not Affected by Inhibition of Endogenous Nitric Oxide. Am. J. Respir. Crit. Care Med. 158: 99-106 [Abstract] [Full Text]  
• Calderon, G. M., Torres-Lopez, J., Lin, T.-J., Chavez, B., Hernandez, M., Munoz, O., Befus, A. D., Enciso, J. A. (1998). Effects of Toxin A from Clostridium difficile on Mast Cell Activation and Survival. Infect. Immun. 66: 2755-2761 [Abstract] [Full Text]  
• Trautmann, A., Krohne, G., Brocker, E.-B., Klein, C. E. (1998). Human Mast Cells Augment Fibroblast Proliferation by Heterotypic Cell-Cell Adhesion and Action of IL-4. J. Immunol. 160: 5053-5057 [Abstract] [Full Text]  
• Hata, D., Kitaura, J., Hartman, S. E., Kawakami, Y., Yokota, T., Kawakami, T. (1998). Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells. DEPENDENCE ON THE c-Jun N-TERMINAL KINASE ACTIVATION PATHWAY. J. Biol. Chem. 273: 10979-10987 [Abstract] [Full Text]  
• Hakonarson, H., Grunstein, M. M. (1998). Autologously up-regulated Fc receptor expression and action in airway smooth muscle mediates its altered responsiveness in the atopic asthmatic sensitized state. Proc. Natl. Acad. Sci. USA 95: 5257-5262 [Abstract] [Full Text]  
• Hata, D., Kawakami, Y., Inagaki, N., Lantz, C. S., Kitamura, T., Khan, W. N., Maeda-Yamamoto, M., Miura, T., Han, W., Hartman, S. E., Yao, L., Nagai, H., Goldfeld, A. E., Alt, F. W., Galli, S. J., Witte, O. N., Kawakami, T. (1998). Involvement of Bruton's Tyrosine Kinase in Fc{varepsilon}RI-dependent Mast Cell Degranulation and Cytokine Production. JEM 187: 1235-1247 [Abstract] [Full Text]