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Previous Volume 328:327-335 February 4, 1993 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The human immunodeficiency virus (HIV) is probably the most intensively studied virus in the history of biomedical research. A large number of distinct isolates have been cloned and sequenced, and the genes of the virus and several of the protein products of these genes have been characterized¹. Furthermore, many of the pathogenic mechanisms associated with HIV infection that lead to clinical disease have been established, such as the functional abnormalities and quantitative depletion of CD4 T lymphocytes that cause the profound immunosuppression characteristic of advanced HIV infection². It is generally agreed that HIV itself has the primary role . . . [Full Text of this Article]

The Course of HIV Infection

Acute HIV Syndrome

Clinical Latency

Clinically Apparent Disease

Immunopathogenic Mechanisms of HIV Infection

Mechanisms of CD4 T-Lymphocyte Dysfunction

Single-Cell Killing and Syncytia Formation

HIV-Specific Immune Responses

Autoimmune Mechanisms

Anergy

Superantigens

Apoptosis

Induction of HIV Expression

Role of the Lymphoid Organs in HIV Infection

Conclusions

Source Information

From the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bldg. 10, Rm. 11B13, National Institutes of Health, Bethesda, MD 20892, where reprint requests should be addressed to Dr. Fauci.

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